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▸ Helicobacter pylori
▸ NSAIDs
▸
▸Robbins Cotran Pathologic Basis of Disease: The Gastrointestinal Tract
the world’s human population has H. pylori infection
Recent developments in the epidemiology of Helicobacter pylori. Gastroenterol Clin North Am 2000
UreaseLPSPorins
IL-12
Th0 cell
Th1 cell
VacA
Disruption of epithelial barrier
TNF-αIL-1β
Apoptosis
Fas expression
Th0 cell
UreaseLPSPorins
IL-12 Th1 cell
VacA
Disruption of epithelial barrier
TNF-αIL-1β
Apoptosis
Fas expression
Increase gastrinsecretion
IFN-γ
Fundus
Body
Antrumgastrin
H+
H+
H+H+
Ulceration &gastric metaplasia
Helicobacter pylori Infection. NEJM clinical Practice
Normal gastric mucosa
Acute H. pylori infection
Chronic H. pylori infection
Antral- predominant gastritis
Non atrophic pangastritis
Corpus- predominant atrophic gastritis
Asymptomatic H. pylori infection
Duodenal ulcer
MALT lymphoma
Gastric ulcer
Gastric cancer
Helicobacter pylori Infection. NEJM Review Article
▸ Zollinger-Ellison syndrome (Gastrinoma)
▸ Antral G cell hyperfunction
▸ Basophilia in myeloproliferative disease
▸ Systemic mastocytosis
UpToDate:Etiologies and disease associations for peptic ulcer ;台⼤內科學:消化性潰瘍