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Dr. Cady reviews the science and the facts of weight gain, weight loss, and the new genomically focused weight loss program from Pharmanex: TR90. In this program, Dr. Cady relentlessly dissects the errors of the "low fat" way to eat, targets high glycemic eating and protein deficient diets as the main culprits in our society's weight gain, and proposes a common-sense and rational way to eat to achieve any of the following goals: (a) not gain any more weight, (b) maintain your current weight, (c ) lose weight. The genomic science behind the technology used by Pharmanex to develop TR-90 is reviewed. TR90 is the only genomically focused, nutritionally sound weight management available for sale today. The genomic science behind this product is established. Multiple scientific papers (one of which is referenced in this presentation) unequivocally show that what you eat in your diet alters gene expression. As of the release of this slide deck on 4/19/2014, the three month TR90 system will only be available for sale in the US for one day on April 23rd at 11 a.m. CST. It is estimated that the entire manufactured run available for the US will sell out in 60 - 90 minutes. It will not be available for sale in this country for six months after this date. Please contact the office at Cady Wellness Institute if you are interested in securing a three month supply. (812) 429-0772.
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Louis B. Cady, MD, FAPA – CEO & Founder – Cady Louis B. Cady, MD, FAPA – CEO & Founder – Cady Wellness Institute Wellness Institute Adjunct Clinical Lecturer – Indiana University School of Medicine Department of Psychiatry
Wellness Medicine & Functional Neuropsychiatry – Evansville, Indiana
TR 90: A Revolutionary Genomic Based Weight Loss Approach
Focus of this review• What most people do not know about why
they are (a) gaining weight and (b) can’t lose weight.
• How does this eating and insulin thing work?
• Why calorie restriction and typical diets don’t work.
• Is the problem “all in your glands”?
• “What is TR 90?”
Calorie restriction
• The foundational principle of the “yo-yo diet”
• The FAILURE of calorie restriction only– Starve yourself – Lose fat and muscle– Go off diet– Put on all the weight, and then some, because
of loss of muscle– Repeat ad infinitum. And get bigger and
heavier.
Techniques of (net) calorie reduction part I: cut calories
• Using diet books, weighing portions, counting calories, increasing activity
• Join Weight Watchers. • Diet pills & supplements• Fen-Phen disaster – heart valve abnormalities• Stimulant problems –
– Stresses adrenals– Potential for adverse cardiac events
• Lap band (surgical complications), muscle with fat loss, toxins
WEIGHT STATS
ADULTS 70%
OVERWEIGHT
CHILDREN 20%
OBESE
OBESITY IS A KILLER
UP TO 40% OF THE WEIGHT LOSS IN TYPICAL DIETS IS MUSCLE LOSS
Muscle
Muscle
Metabolic
Burn
Metabolic
Burn
LEAN MUSCLE = METABOLIC ENGINE
• Traditional calorie restricted diet• Lose lean muscle as well as fat
• Protein heavy, calorie restricted
• Maintain more lean muscle
Metabolic burn = rate at which body burns calories at rest
Muscle
Muscle
Metabolic Burn
Metabolic Burn
Glycemic index
• A measure of how fast a carbohydrate triggers a rise in circulating blood sugar.
• The higher the number, the greater the blood sugar response.
Selenium, the Thyroid, and You
• “T3” is the ACTIVE form of thyroid
• Conversion of T4 to T3 is selenium dependent
• LP & LP Nano have 200% of RDA of selenium
Se+
The Old FDA Food pyramid – R.I.P 2005
June 1, 2011
“Pyramid Power”
USDA Food PyramidZone Food Pyramid
Vegetables
Fruits
Low-fat Protein
Monounsaturated Fat
Grains and Starches(Use in Moderation)
How to lose it?
FAT LOSS SECRET #1
Source: http://win.niddk.nih.gov/statistics/index.htm#overweight
FAT LOSS SECRET #2
Source: http://win.niddk.nih.gov/statistics/index.htm#overweight
FAT LOSS SECRET #3
Source: http://win.niddk.nih.gov/statistics/index.htm#overweight
The top weight loss secret from Tim Ferris
“Consume 30 grams of protein within one hour of waking up.”
ageLOC – a novel mechanism to target and reset “youth gene clusters”
Old Gene Expression
Young Gene ExpressionTARGET
Old Gene Expression
RESET
1 Transcriptional Biomarkers of Mitochondrial Aging and Modulation by Cordyceps Sinensis Cs-4. Gordon Research Conference, Biology of Aging, Determinants of Health-Span: From Cells to Humans, August 22-27, 2010. Les Diablerets Conference Center, Les Diablerets, Switzerland.
“Youth Gene Clusters” – bogus or bonanza?
Comparative genomics of fungal allergens and epitopes show widespread distribution of closely related allergen and epitope
orthologues. Bower P, et al, BMC Genomics. 2006; 7:251.
Yeast species
SPECIFIC genes
Prostate Cancer – more relevant?
Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention. Ornish, Dean
et al. Proc Natl Acad Sci USA 2008 June 17; 105(24):8369-8374
Pre-invention gene expression
Post-intervention gene expression
TRANSLATION: What you eat talks to your genes and
CHANGES THEIR EXPRESSION.
Comparison of Genetic Profiles of Adipose Tissue in Identical Twins
Pietiläinen et al. PLoS Med. 2008 Mar 11;5(3):e51.
Same DNA
Different Expression of Genes
Normal Weight Twin Overweight Twin
Compared to their normal weight twin, overweight twins exhibited down regulation of gene expression pathways related to:
• Fat Regulation (storage versus utilization)• Muscle Protein Synthesis
Ghrelin
LeptinInsulin
References:
Gene Expression relates to the Appetite Control Center of the Brain
• Appetite Control• Eating Behavior• Regulation of energy intake
1. Smeets et al. Proceeding of the Nutrition Society. 2012;71:511-520.
2. Guthoff M, et al. J Clin Endocrinol Metab. 2010;95:748-755.
3. De Silva, et al. Cell Metab. 2011;14:700-706.
4. Malik S, et al. Cell Metab. 2008;7:400-409.
5. Farooqi IS, et al. Science. 2007;317:1355
6. Suzuki K, et al. Experimental Diabetes Research. 2012:1-19.
7. Viquerie N, et al. Diabetologia. 2005;48(1):123-131.
8. Mager et al. European Journal of Endocrinology. 2008;158:
9. Mutch DM, et al. Am J Clin Nutr. 2011;94(6):1399-1409.
Carbohydrates(260g)
Proteins(90g)
Fats(67g)
Normal Calorie Diet – 2000 kcalF
at Burning
Foods
Fat
Sto
ring
Foo
dsF
at Storing
Foods
Carbohydrates(260 g)
Proteins(90 g)
Fats(67 g)
Carbohydrates(260g)
Proteins(90g)
Fats(67g)
Typical Reduced Calorie Diet – 2000 kcalF
at Burning
Foods
Fat
Sto
ring
Foo
dsF
at Storing
Foods
Carbohydrates(180 g)
– 1200 kcal
Fats(33 g)
Proteins(45 g)
Carbohydrates(260g)
Proteins(90g)
Fats(67g)
Fat B
urning F
oods
Fat
Sto
ring
Foo
dsF
at Storing
Foods
Carbohydrates(120 g)
Fats(40 g)
Muscle Retention Eating Plan – 1200 kcal
Proteins(90 g)
Eating Most of Your Protein with Only One Meal of the Day Limits Duration of Metabolic Burn
FA
T S
TO
RIN
GF
AT
ST
OR
ING
FA
T B
UR
NIN
GF
AT
BU
RN
ING
Time in Metabolic Burn Zone = Only 3 hours/day
Adapted from: 1.Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86.2.Layman DL. Nutrition and Metabolism, 2009; 6:12.
Breakfast Lunch Dinner
ZO
NE
S
Eating Protein with Each Meal Accelerates Metabolic Burn
FA
T S
TO
RIN
GF
AT
ST
OR
ING
FA
T B
UR
NIN
GF
AT
BU
RN
ING
Adapted from: 1.Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86.2.Layman DL. Nutrition and Metabolism, 2009; 6:12.
Breakfast Lunch Dinner
Time in Metabolic Burn Zone = 9 hours/day
ZO
NE
S
The TR90 Eating Plan Based on:Protein Science & Nutrition Science
• Supports metabolically-active lean muscle and inhibits fat storage1
Reference: Wycherley TP, et al. AJCN. 2012;96(6):1281-98.
• An eating plan designed to complement the supplements.
--- previous eating plan, TR 90, Oct 2013 ---
HOW MANY GRAMS?
H - 36
Benefits of low-glycemic eating
78 pounds gone forever!78 pounds gone forever!
Tina Clark
TINA CLARK
DENNY PRETZ
October 5th, 2013
TR 90 – a look back
October 28, 2013 January 28, 2014Jan 29, 2014
Withings WS-50 Smart Body Analyzer
(Start weight: 168.5 lbs – Oct 28th)
10 lbs of total weight loss = 6% body weight
(43.1 lbs – Oct 28th)
7.7lbs of fat loss
10 lbs of total loss= 77% of weight
loss was FAT loss
Pre-TR90 172 -169
Start June 28th-Oct 28th
4 months, 3 lbs= ¾ lb/mo
Oct 28th-Jan 28th
3 mo’s, ll lbs = 3.7 lbs / mo = 5 X the wt. loss rate
TR90 – (done imperfectly) -169-158
Post TR90158 to 155
Jan 28th –April 17th 2.75 mo’s, 3lbs
= 1.1 lbs/mo
“What happens after I finish 3 months of TR-90?”
“When you change the way you look at things, the things that you look at change.”
-John Assaraf
Key down-home principles• Jump start your genes.• Eliminate the junk. Pitch it. If you don’t have it, you can’t eat
it.• Develop a taste for [low glycemic] fruit.• Ostrich jerky (GNC) or balance protein/carb bars• 30 grams of protein in the a.m. within ½ - 1 hour of awakening• Eat real food• Minimize eating out. • NO FAST FOOD!! NO FAST FOOD!!• Axiom: If you’re full of the good stuff, you won’t crave the bad
stuff.
Personal collection Louis B. Cady,
M.D.
The Question: What Will You Do About It?
