Cholinergic blocking agents (เพจจากใจหมอยาๆๆๆ)

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Antimuscarinic drugs Cholinergic blocking agents Acetylcholine Acetylcholine muscarinic receptor Antiparasympathetic spasmolytic agents Acetylcholine ( )

SAR n = 1 2 N C carbonyl 5 Ao N tertiary amine quaternary ammonium Ref. ; CM473 315 (Spasmolytic formula)

Antimuscarinic drugsAtropine 2 enantiomer ; Hyoscyamine levorotary isomer atropine Scopolamine Hyoscine Hyoscyamine epoxy ring Atropine Hyoscine Atropa belladonna Hyoscine Scopolia Solanaceae () Atropine , Hyoscyamine Scopolamine ( Hyoscine) Tropane alkaloidsAtropine Atropine Sulfate organophosphate carbamates muscarinic receptor , digitalis beta blockers , cholinergic Atropine sulfate enantiomer atropine

Epoxy ring(Hyoscine)Ref. 1. ; CM473 315-317 2. http://med.mahidol.ac.th/poisoncenter/th/anti-cov/atropine

Atropine sulfate Atropine sulfate

http://www.phargarden.com/main.php?action=viewpage&pid=105 Datura metel L. var. fastuosa(Bernh.) Danert. Datura fastuosaL. Solanaceae: 30 7 hyoscine, hyoscyamine

Herbal antimuscarinic drugs

http://flipper.diff.org/app/items/4260

Hyoscine-n-butyl bromide (BuscopanR)

n-butyl groupSemisynthetic antimuscarinic drugs

Hyoscine-n-butyl bromide Butylscopolamine quaternary ammonium Scopolamine Hyoscine n-butyl group N blood brain barrier hyoscine , (Irritable bowel syndrome :IBS) , Hyoscine-n-butyl bromidehttp://www.yaandyou.net/index.php/component/drug/?nsetidT=4806&drugname=HYOSCINE+%5BBUTYLBROMIDE%5D&drugtype=g ://flipper.diff.org/app/items/4260

Dicyclomine Hydrochloride

Synthetic antimuscarinic drugs

Flavoxate Hydrochloride

Antimuscarinic drugs Acetyl group Acetylcholine N Dicyclomine HCl Mefenamic acid DicyclomineHCl Flavoxate HCl 100 . 200 . Ref. ; CM473 317Flavoxate HCl flavoxate HCl 12 ( http://www.yaandyou.net/index.php/component/drug/?nsetidT=1604&drugname=FLAVOXATE+%5BHYDROCHLORIDE%5D&drugtype=g

Antispasmodic drug But Not Anticholinergic drugDrotaverine enzyme Phosphodiesterase-4 (PDE-4) cyclic adenosine monophosphate (cAMP) AMP cAMP myosin light chain kinase antichloinergic effects related to papaverine drotaverine , porphyria , http://drug.pharmacy.psu.ac.th/Question.asp?ID=13339&gid=7