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UAIPD 13-0018
Inventors: Dr. Qiaoli Liang, Dr. Yuping Bao, and Dr. Carolyn Cassady
Iron Oxide Nanoparticles with Surface Capping Molecules
Current Problems• Matrix-Assisted Laser Desorption Ionization
(MALDI) is used ionization technique for analysis of biomolecules and polymers by mass spectrometry (MS)
• The sample is mixed with an excess of matrix compound– Transferring laser energy to the sample– Causing desorption and ionization of analytes– Analyte ions enter the mass spectrometer, where
molecular mass and structural information are obtained– The choice of matrix is crucial for the success of a
MALDI experiment, but selection is often by trial and error
• Iron oxide nanoparticles with capping molecules • Non-crystalline structure increases level of control over
matrices construction and reduces self-clustering• Matrices are versatile and selective due to varying
the surface capping molecule • Yields different chemical preferences and targets
different analytes in a sample
Technology
• Preliminary data shows nanoparticle matrix capped with dopamine only ionizes glycans– Transparent to proteins in the test sample. – This characteristic is very useful when analyzing
target molecules from a mixture or a tissue slide for imaging.
• Nanoparticle matrices allow facile energy transfer to the sample. – Able to absorb and transfer energy from the laser– Causes abundant fragmentation of sample ions by in-
source decay (ISD).
Advantages
• Dr. Qiaoli Liang– Mass Spectrometry
Facility Manager– 3 publications
• Department– Chemistry
• Dr. Carolyn Cassady– Professor– 10 publications
• Department:– Chemistry
Inventors
• Dr. Yuping Bao– Associate Professor– 13 publications
• Departments:– Center for Materials for Information
Technologies– Chemical and Biological Engineering
Inventor
