Mapping of complex traits

Jei Kim, MD

2010. 4. 9

(Adopted from Dr. T. A. Manolio’s slides)

(Atherosclerosis 2009;207:144-149)

(BMC Med Genet 2007;8(suppl 1): S11)

(BMC Med Genet 2007;8(suppl 1): S17)

GWAS in stroke fields

1. Single-gene disorders

2. Disorders having complex inher-itance - complex interaction between 1) genotype at one or more loci 2) a variety of environmental expo-sures

Inherited dis-eases

Mendelian disorders vs. Common disor-ders (ref. 2)1. Mendelian disorders

- rare and highly heritable- variation in single gene is both necessary and sufficient to cause disease

2. Common disorders- influenced by several genetic and environmental factors (ref. 2, 3)- cluster in families (ref. 3)