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Цитокинодиагностика: прошлое, настоящее и будущее. Тотолян Арег Артемович Санкт-Петербургский НИИ эпидемиологии и микробиологии имени Пастера Национальные дни лабораторной медицины России-2011 Москва, 5 октября 2011 года. - PowerPoint PPT Presentation
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: ,
-
-2011
, 5 2011
, ,
(2) IN VIVO
IN VITRO ( in vivo)
IN VITRO (, ) (, ..)
(3) IN VITRO
IL-8
1
201570
*
*
-
-
--
IL-8 ng/ml
1
GBSLPS
2095800
-1525750
-720600
--0.10.3100
GBSLPS
2095800
-1525750
-720600
--00.3100
GBSLPS
95800
-25750
-20600
--1100
LPS
800
-750
-600
--100
1
000
000
000
000
GBS
LPS
IL-8 ng/ml
IL-8
2
*
-
-
--
IL-8 ng/ml
LPS
3
*
*
*
-
-
--
IL-8 ng/ml
GBS
*
*
-
-
--
IL-8 ng/ml
IL-8
2
9525201
*
*
*
-
-
--
IL-8 ng/ml
GBS
1
GBSLPS
2095800
-1525750
-720600
--0.10.3100
GBSLPS
2095800
-1525750
-720600
--00.3100
GBSLPS
95800
-25750
-20600
--1100
LPS
800
-750
-600
--100
1
000
000
000
000
GBS
LPS
IL-8 ng/ml
IL-8
2
*
-
-
--
IL-8 ng/ml
LPS
3
*
*
*
-
-
--
IL-8 ng/ml
GBS
*
*
-
-
--
IL-8 ng/ml
IL-8
3
800750600100
*
-
-
--
IL-8 ng/ml
LPS
1
GBSLPS
2095800
-1525750
-720600
--0.10.3100
GBSLPS
2095800
-1525750
-720600
--00.3100
GBSLPS
95800
-25750
-20600
--1100
LPS
800
-750
-600
--100
1
000
000
000
000
GBS
LPS
IL-8 ng/ml
IL-8
2
*
-
-
--
IL-8 ng/ml
LPS
3
*
*
*
-
-
--
IL-8 ng/ml
GBS
*
*
-
-
--
IL-8 ng/ml
IL-8
xMap 100 = 100 xMap
() 100
- Luminex-100Luminex-200MAGPIXLuminex FLEXMAP 3D
()
..
Th1 Th2
, Me [LQ; HQ]
, Me [LQ; HQ]
IL-8 (/)
1
407925991047
10 / 1 / 1
2200620540440010401800
38010808003002500840
1100240066070004400940
80017002200620034003000
1100220026023006201500
20002200940540017001060
10
480340740660094003000
012404060017001500
351284413533098561
2500116023003400100001160
70094026083501800400
11401100116036004000
-8 ( 10 )
-8 ( 10 )
.
/ 1 / 1
2200620540440010401800
012404060017001500
1100240066070004400940
1100220026023006201500
20002200940540017001060
11401100116036004000
70094026083501800400
80017002200620034003000
480340740660094003000
38010808003002500840
2500116023003400100001160
351284413533098561
.
Ig Q
1
(, , , , )
/ 1 / 1
700940260835018004005608.333333333321601450
800120022006200340030001316.66666666671593.3333333333810
1100240066070004400940
20002200940540017001060
2200620540440010401800
1100220026023006201500
( , . , / ,
25001160230034001000011602250.65339.61412.2
4803407406600940030002250.6789.6864.2
351284413533098561
38010808003002500840
012404060017001500
LFS
group 1560821601250
group 2225053391350
NW
group 116161500810
group 22250789764
1
Ig
Ig
group 1
group 2
before RL 24h after 5 days after
IL-8 dynamics in sinuses lavage fluid
group 1
group 2
before RL 24h after 5 days after
IL-8 dynamics in nasal washes
(, , , , )
Q(IgA)Q(IgM)Q(IgG)Q(sIgA)
/ 1 / 1 / 1 / 1
6.55.82.50.90.010.013.70.92.4
33.46.92.14.429.249.91.43.974.5715.920184.5
-13.668.413.61.180.434.180.21.22.817.817.120
12.616.163.30.010.182.4104.63.517.852068
14.84.832.40.890.480.091.268.2023.830.516.2
64.471.317.64.471.440.7913.82.16071.813.512.6
6944314.396.160.8241.13.94.8392512.2
15.38.74.030.010.010.010.682.33.818.42107.1
21.722.913.61.450.910.29194623324930
36.131.7131.610.29
16.925.4291.530.81.22000.78509242504577
9232.628.540.71.251.4000
45.973.56.693.631.410.542.755.3913021687599.7
31.817.716.75.282.82.152.500
64.930.69.681.160.790.084.781.354.535.433.422.78
2.34.81.70011.7
140.664.1411.563.60.442.516.133.62539542384278
..17.698.6436.10.310.640.04
38.855555555634.88540.69666666671.85944444442.83944444444.24
1-2
1-3
( , . , / ,
75.220.2222.560.010.011414.10.7228.5717.424
42.972.3137.23.81.030.850.711.790.25
10.1317.259.40.010.010.011.081.484.2416
30.215.119.113.50.010.018.13.42.526.81916
36.417.19.20004.428.3
39.134.541.52.192.092.083.546.253.467110714
25.328818.42.542.51.5841.15.91.519.296.836.8
23.1781.113.131.3241.71.160.9629.61.3
23.329.940.91.751.652.2401.261.4353506696
1833.628.70.690.640.632.100.4853565017712090
..17.5284.531.313.911.21.023.08
29.27.899.382.120.060.241.080.280
5.092.413.034.894.824.74
31.857.526.40.5222.90.460.01
20.733.836.91.672.1411.30.44
2.4213.93.50.976.74.239.506
9.6114.2131.125.30.6750.14.53.37
50.8251.933.53.6512.61.081.044.991.8
15.54236.21.032.690.655.84.50.138.327.320.5
7.6814.92.092.5158.60.91308070275.85
26.7864.7227.982.969.9931250.99375
1-20.046
1-30.856
407925991047
9581061697
acute phase of the disease
subacute phase of the disease
reconvalescents
IL-8 (pg/ml)
(, , , , )
IgA /IgM /IgG /sIgA /IgE / /
/ 1 / 1 / 1 / 1 / 1 / 1
9.846.542.71.590011.828.466.062.470.780.390.1660.0420.12
86.459.88556.0643.885.8660.4863.53427.20.070.080.7000.050.1351.65
-30.64127.2821.80.841.062.2216.7819.6456.320.050.060.060.390.160.460.0080.0470.11
7.224.8458.200.483.38.2210.3218.480.050.060.170000.010.20.15
68.517.210.120.80.423.412.20.050.320
109.532.8228.626.481.561.593.048.647.020.280.050.073.510.781.390.140.250.14
126.3654.246.6813.3818.542.1642.4855.89.720.090.070.050.490.450.151.730.1410.175
44.7623.0490.300016.6213.0822.50.070.30.090.160.10.0280.0930.157
75.46107.8352.253.642.730.9340.6923.184.869.0913.4828.990.10.020
54.1948.2637.811.861.070.3956.5531.7613.09
345.7674.4219.763.10.941.937.7228.9627.0215.4311.7311.58000.03
36.1555.8241.480.972.071.4622.3748.5536.73000
119.88216.130.845.082.241.26192.1642.5632.164.8614.684.420.140.10.2
47.9762.8152.246.296.736.67129.48151.768.120.100
10.8620.0423.49007.7434.4424.83.8000
125.16155.022.912.917.650.8465.01169.8326.554.8110.563.67000
..39.1275.92227.061.170.941.96153.7810.5230.56
78.691176470668.352941176558.89764705883.18647058825.30647058827.38687559.1242.560588235349.3868753.485.64111111115.0010.77222222220.291250.27666666670.1940.10369230770.2101538462
1-20.613
1-30.293
55.6219.6228.142.460040.869.780.080.040.060.1700.140.60.60.03
79.82116.46215.371.41.591.299.4512.958.160.10.080.220.030.070.01
8.16.69.7800014.585.344.740.040000.040.060.16
61.9239.0635.8814.700119.9414.586.960.110.040.080.230.080.060.3380.1390.104
10.969.90008.826.183.20.1100.1970.119
156.24128.46122.522.521.861.531.3815.368.640.30.30.072.290.870.420.140.250.14
78.7812356.823.7832.762.4648.12141.2432.760.050.30.1400.1801.730.240.06
84.12283.8622.982.1655.50.7241.1362.826.60.5461.110.240.041.150.05
68.4882.79118.871.861.652.8760.3356.4266.2916.0517.4100.060.07
67.73100.51105.591.240.140.1912.610.311.5824.0659.2117.41
..140.22143.76106.3811.0170.0200.012011.21.023.08
1.080.280
5.092.413.03
102.48158.6787.481.841.490.9102.81368.8230.690000.13
25.525.5633.61.028.130.080.420.017
17.2536.7164.051.91.157.7562.6540.9520468.8663.7250.280.3900.24
5.7193.625.0463.391225.1441.820.13.11.6620.190.14
113.2675.12834.5221.541.8326.5172.615.330.120.080.12
33.8469.7278.122.644.21.3236.334.0828.620.180.090.090.210.1600.2090.1070
25.243.267.282.4161.81.136.5417.58.711.8520.3823.4000
66.4388235294121.356470588273.491253.39532.331251.68562544.0811111111155.642530.4918756.58510.057.33254.84866666678.62613333333.79571428571.447750.44468750.4538125
1-20.260.0670.162
1-30.930.1910.283
0.150.150.15
78.768.3558.893.185.317.3859.1242.649.383.485.650.770.290.270.190.10.21
66.43121.473.53.3932.331.6844.08155.630.496.510.17.334.848.63.791.440.440.45
IgA78.768.3558.89
IgG59.1242.649
IgM3.1857
sIgA35.65
IgA66.43121.473.5
IgG44.0816030.49
IgM3.3932.331.68
sIgA6.5107.33
acute and subacute phase of the disease56.13
reconvalescents2.79
acute phase of the disease958
4079subacute phase of the disease1061
2599reconvalescents697
1047
&A
&P
&A
Page &P
IgA
IgG
IgM
sIgA
btforeRL 24h after 5 days after
mg/l
mg/l
group 1
IgA
IgG
IgM
sIgA
before RL 24h after 5 days after
mg/l
mg/l
group 2
acute and subacute phase of the disease
reconvalescents
The level of TNF- in lavage fluid from sinusis
The level of IL-8 in lavage fluid from sinusis patients with acute suppurative sinusitis
acute phase of the disease
subacute phase of the disease
reconvalescents
The level of IL-8 in nasal washes patients with acute suppurative sinusitis
acute phase of the disease
subacute phase of the disease
reconvalescents
The level of IL-8 in nasal washes patients with acute suppurative sinusitis
(, , , , )
IgA /IgM /IgG /IgE /sIgA / /
/ 1 / 1 / 1 / 1 / 1 / 1
?64.0283.8237663.4215.3102.9630.42236.221241.58 0003.040.3851.21
-23.5418.32217.083.523.3836.9861.0456.2354.120.270.516.471.195.7237.80.870.3613.76
8.423.9453.640.62.287.3811.9415.1228.62000.116.5427.4629.840.0890.660.2
301.2132.54933.514.43.5204.2280829.162.240.790.671.130.04
63.7828.9887.965.424.5414.82130.6282.8649.3215.920.8306.4201.072.50.570.37
?18.96322.3429.0212.7897.6212.4209.22259.4443.149.0911.50.41.320.084
?19.6228.9866.6030.78015.782112.4802.340.10.053.850.016
105.898.375.0373.6755.7428.08378.281.620.512.292.2123.59.232.940.37
57.466.6855.9149.0454.2919-Jan16319874911.70.45
1863.36540.1251.38168.68131.223.961855.08646.65.6278.1754.382.531.9238.40.125
49.6353.6861.5646.317.5617.61032.6350.64219.788.70.1230.363
18.96322.3329.0212.7897.6212.411.7611.948.8411.6851.3645.572.98.670.3
62.8156.429.43107.357.8733.95476.230025093.6322.36168.210.81.40.77
16884.811778.542.46.5467111210115.773.180.2546.85.1613.778.81.520.294
93726.2651639514815323
114.515548.8462.764.8936291.21240.48106.9100.8806.4201.071.578.360.66
290.156.6434.2650.132.15.8250.132.15.8220.0418.413.910.8650.7460.155
160.5622.9847.2823.585.580.72151.5621.248.11.380.610.11
199.45117.3964705882125.232352941252.493333333344.976111111119.3611111111347.7738888889185.58153.323888888910.25666666675.3481.11129.31818.70542.7263.895.0890.545
1-20.0430.0590.6880.2930.658
1-30.00890.028690.0530.4490.042
30.8441.5815.94.3819.38013.246.446.541.6417.910.850.2911.750.12
164.22250116.52354.84389.566.96327.423409.4815.9223.310.115.40.33
300239.34110.1196.2203.9435.04103.26350.64219.789.162.240.7935.1312.194.487.63.20.812
49.6353.6861.5646.3175.617.644.4673.328.581.9723.520.46100.9843.8533.480.559.60.55
28.98443.7167.5211.04108.6610.6876.44970.86124.740.090.410.151.9920.10.8122.1750.323
160.5444.3354.610112019125514603141691559.56.0850.31
105.95135.675.46.4211.687.9158.1107.39127.1633100.6516.770.240.280.42
99.59443.06125.044046.8115.85112.58217.5844.2185.5932.25341.1710.13
..
101.34112.669261.14526.6696.95.580.63
43.266.4283.2812.668.972.42113252.75197.46126.53136.5773.841.936.63.26
94146100224261992621161.250.610.06
7995560.3615123141510.811.890.13
5983.5663.9511629871251.60.90.621.90.170.1
74106682120.4425569114.931.41.10.2250.44
17437513112.9844.119200511240.7928.480
..226115004688406119277
99.140625227.92375127.3762.668666666790.609333333314.564190.34625437.665103.54687522.574444444428.131.508888888976.2565.132.512.182.910.54
1-20.01360.0006420.003480.2610.6550.5025045977
1-30.4530.060.19650.260.0460.0398477097
293.761246.89186.780.2118.483300.84319.380.940.530
169.0220.76663.625.863.928.8680.4622.02245.880.070.030.14
199.115117.39125.1252.544.919.3634718515310.25.31.129.318.742.73.85.10.5
99.14227.9127.462.6790.6114.6190.36437.66103.5422.5728.131.576.2565.132.512.182.910.54
0.150.150.15
group 1199.115117.39125.1252.544.919.3634718515329.318.742.7
group 299.14227.9127.462.6790.6114.6190.36437.66103.5476.2565.132.51
IgA199.115123125.12
IgG347185153
IgM52.544.919.3
sIgA291842
IgA99.14227.9127.4
IgG190.36440103.54
IgM52.696.619
sIgA76.2565.132.51
&A
&P
&A
&P
&A
&P
&A
&P
&A
&P
&A
&P
&A
&P
&A
&P
&A
&P
&A
&P
&A
&P
&A
&P
before RL 24h after 5 days after
g/l
Albumin level in sinuses lavage fluid
IgA
IgG
IgM
sIgA
before RL 24h after 5 days after
mg/l
mg/l
group1
IgA
IgG
IgM
sIgA
before RL 24h after 5 days after
mg/l
mg/l
group 2
IL-1, IL-6, IFN-, G-CSF (/) **
**
**
***
*
1
18.043.47
Sheet1
IL-6
18.04
3.47
1
0.3260.055
3.4210.779
1.6140.403
Sheet1
IL-1betaIFN-gammaG-CSF
0.3263.4211.614
0.0550.7790.403
IL-1, IL-6, IFN- (/) , , IgG/IgM
: 1 - - 2 - IgG - 3 - IgG/IgM*p
(n=105)* (n=61)** (n=15)*
1
16.39
18.03
21.31
21.9
29.5
43.8
49.5
50.8
50.8
68.5
79
80
% /
Sheet1
IFN-gamma*G-CSF*IL-1beta* IL-6*-**
% / 16.3918.0321.3121.929.543.849.550.850.868.57980
******* p20
00.21.40.7
201.21.81.3
MIP-10.71.21.81.4
MIP-10.51.30.51.9
RANTES0.31.91.21.6
IL80.71.41.31.3
PASI < 10PASI (10-20)PASI>20
02.354.96.6
202.354.96.6
MIP-14.610.511.817.4
MIP-13.26.410.99.5
RANTES9.812.113.815.8
IL83.55.86.49.9
PASI < 10PASI (10-20)PASI>20
02,351,54,92,36,63,4
202,351,54,92,36,63,4
MIP-14,61,610,51,311,81,917,42,4
MIP-18,22,16,41,810,91,64,53,1
RANTES9,82,312,11,913,81,715,83,6
IL83,51,25,82,66,41,49,94,5
PASI < 10PASI (10-20)PASI>20
R124.331.935.436.4
R315.624.923.226.9
R512.417.321.625.4
XCR1010.917.719
XCR205.913.217.2
PASI < 10PASI (10-20)PASI>20
R131,31,831,92,535,43,136,42,2
R320,13,624,92,723,22,926,92,4
R513,42,617,31,821,61,425,43,5
XCR1010,91,617,71,819,02,5
XCR205,91,413,21,517,24,3
PASI < 10PASI (10-20)PASI>20
R131.329.636.439.2
R320.122.727.229.5
R513.615.820.621.1
XCR108.710.921.9
XCR2020.919.322.6
PASI < 10PASI (10-20)PASI>20
R131,31,829,62,933,51,939,21,4
R320,13,622,73,127,21,829,52,1
R513,42,615,81,520,61,821,12,3
XCR108,71,810,91,921,93,4
XCR2020,91,919,32,422,65,4
PASI < 10PASI (10-20)PASI>20
R12.32.21.40.7
R33.51.21.81.3
R50.61.21.81.4
XCR101.31.71.9
XCR201.91.21.6
005.3
2004.8
MIP-10012.5
MIP-11.3307.4
RANTES10.397.915.4
IL86.390.86.4
R124.31.834.2
R315.64.923.7
R512.42.219.3
XCR106.516.5
XCR202.211.3
R1001.4
R3001.8
R50.601.8
XCR10.801.7
XCR20.40.91.2
R10.31.21.4
R30.51.21.8
R50.81.21.8
XCR10.60.31.7
XCR201.21.2
R101.41.4
004.3
2004.1
MIP-14.6012.3
MIP-13.206.3
RANTES9.80.914.5
IL83.58.310.5
R12.37.634.7
R33.52.924.4
R50.612.117.5
XCR100.712.4
XCR205.720.8
R1001.4
R3001.8
R50.201.8
XCR10.801.7
XCR20.40.91.2
R10.31.21.4
R30.51.21.8
R50.81.21.8
XCR10.60.31.7
XCR200.21.2
R101.41.4
+
00000.80.8
001.21.22.12.1
002.32.31.31.3
00005.65.6
00001.91.9
PASI < 10
% -
000.20.21.91.9
001.21.22.12.1
001.21.200
003.63.600
PASI20
% -
00000.20.2001.41.40.70.7
00001.21.2001.81.81.31.3
00001.21.20.70.71.81.81.41.4
00001.31.30.50.50.50.51.91.9
00001.91.90.30.31.21.21.61.6
00001.41.40.70.71.31.31.31.3
PASI < 10
PASI (10-20)
PASI>20
% -
00002.32.32.22.21.41.40.70.7
00003.53.51.21.21.81.81.31.3
00000.60.61.21.21.81.81.41.4
0000001.31.31.71.71.91.9
0000001.91.91.21.21.61.6
PASI < 10
PASI (10-20)
PASI>20
% -
00002.32.32.22.21.41.40.70.7
00003.53.51.21.21.81.81.31.3
00000.60.61.21.21.81.81.41.4
0000001.31.31.71.71.91.9
0000001.91.91.21.21.61.6
PASI < 10
PASI (10-20)
PASI>20
% -
00000001.41.4
00000001.81.8
0000.60.6001.81.8
0000.80.8001.71.7
0000.40.40.90.91.21.2
0000.30.31.21.21.41.4
0000.50.51.21.21.81.8
0000.80.81.21.21.81.8
0000.60.60.30.31.71.7
000001.21.21.21.2
000001.41.41.41.4
% -
0001.41.40000
0001.81.80000
0001.81.8000.20.2
0001.71.7000.80.8
0001.21.20.90.90.40.4
0001.41.41.21.20.30.3
0001.81.81.21.20.50.5
0001.81.81.21.20.80.8
0001.71.70.30.30.60.6
0001.21.20.20.200
0001.41.41.41.400
%
000
000
000
000
000
000
000
000
000
000
000
% -
MBD00071D09.unknown
MBD0007F351.unknown
MBD00081C11.unknown
MBD0007C0E9.unknown
MBD000600F4.unknown
***** p20
% -
1
actinCCR1CCR3CCR5eotaxineotaxin 2MIP alphaMIP betaRANTESCXCR1CXCR2IL8
/-IL2IL4IL6IL8IL10GM-CSFIFN gammaTNF alpha-IL2IL4IL6IL8IL10GM-CSFIFN gammaTNF alpha
21.09.2007 ( R1)0457.636.38.134.25.15.66.44.23.502.10003.345.66.834.51.61.8 000.510.740000.11
7.09.2007 ( R1) 0.2801.340.800.1850.43 0.1101.090.120000
44.715.511.4003.8151.7722.65.3
3.07.2007 ..99.599.879.652.781.251.785.939.71.32.71.2046.831.290.51.97.605454.385.696.11.227.3 008.0644.85100.95.40
3.07.2007 .. 002.5480006.30
94.993.196.994.640.438.813.347.413.172.595.721.3
7.09.2007 ( R1)38.381.253.347.135.532.517.78.410.6035.320.30.2051.611.971.145.666.698.326.536.4
6.02.2007 ( 1)31.13.592.93.7604.331.71.500000024.200039.7074.701.50 000.3960.576000.5130.081
6.02.2007 ()90.90475157.659.112.663.11.4001.7020.104.21.93.42.17.6201.66.374.6 0.0903.0420.87301.3862.2860.306-0.253.590.020.420.240.852.910.56
6.02.2007 ( )90.288.662.699.45.477.731.835.101.405.4023.7023.2014.618.558.716.250.97.98.6 001.7550.2160000
( )68.357.534.318.938.123.533.339.98.500.33.700009.610.604.307.703 001.4850.0990000-0.253.680.082.020.250.592.990.5
28.02.2007 ()( , ) 0.02700.2610.39600.2071.4040.243
?????????
28.02.2007 ( 2 )015011.414.88.124.312.596.56488.451.299.7373.81.645.811.499.431.485.734.8293.9 0.1801.1520.9630.090.5765.310.819-0.133.1958.261.420.191.111.490.44
0003.26701.1254.50
28.02.2007 (3) ( , ) 0.0900.5850.63900.3330.6660.099-0.172.892.092.830.260.741.910
?????
28.02.2007 ()-0.424.52.2126.170.180.811.660.44
16.03.2007 (7)14.1027.73.123.9022.11.71.213.102.51.33.32.118.35.87559.318.322.51.91.71.5 0.09900.4230.36900.1531.9890.351
6.03.2007 (5. )45.35031.879.243.47317.93.317.22.304.842.9014.1547.1544.54.8084.321.924.8-0.554.070.271.290.180.851.250.63
6.03.2007 (6)48.615.534.427.545.424.573.421.16.52.431.311.14.901.702.17.668.32.525.623.23.51.3 0.05401.5480.14400.3061.4760.333-0.162.640.392.290.251.042.820.13
16.03.2007 (8)12.595.452.94519.630.119.513.52.601.50011.31261.31.506.23.879.818.629.4
16.03.2007 (9)54.468.110.672.5265.317.246.44.93.25.25.17.541.73.448.37.85013.602.237.9
( )45.350.731.843.49.217.97317.23.302.342.94.814.107.15544.844.584.3024.821.93.5 001.0710.81000.0720
( )58.240.467.911.729.58.422.49.77.43.76.717.72.91.337.451.136.112.431.982.99939.412.38.3?
15.05.2007 0012.38410.8902.02500
15.05.200718.235.79.45.716.72.123.925.421.32.131.510.344.8027.21.964.51.772.617.926.210.326.3 007.48810.7910.376000
13.97418.63.63.545.110.767.49.13.45.35.66.63.42.34.913.224.47.990.48.671.403.2-0.296.2900.270.4501.830.31
72.318.741.480.446.66521.447.51.35.16.124.436.67.64.1111.311.91.83.11.610.201.5-0.420.080.230.310.10.192.320.69
37.4042.831.235.130.347.541.61.63.129.47.111.62.245.424.94.720.735.511.514.85.71.80.6
3.06.2007 ..42.719.967.442.843.242.43.420.42.73.144.810.315.801.215.675.517.913.71.31.611.71.35.4
3.06.2007 ..
3.06.2007 ..( , )56.853.319.820.36.44022.4020.42.71.51.323.24.112.61.427.56.2626.894.617.5?
000.380.48005.250.37 001.164.540000.08
3.06.2007 ..
22.06.2007 ..
22.06.2007 .. 003.8883.86100.6754.052.14
3.07.2007 ..( )90.418.740.921.455.838.543.621.91.37.99.404.5022.907.53.841.422.657.130.43.22.8
3.07.2007 .. (.)
7.09.2007 .. ()
19.09.2007
()70.588.835.275.716.853.17.51000002.32.92.17.5001.512.6012.700
21.09.2007 ( )
21.09.2007 0.0800.310.570000.08
26.09.2007 .. ( CCR1)
6068701.3000065640
26.09.2007 ..39.599.480.910.72.21.510.910.7081.391.227.2
16.10.2007 ,.59.6844.450.95.430.92.35.11.31.60000023.66.102.316.94.334.61.94.5 0.4402.690.5500.6600.6 0.0600.2210.110000
16.10.2007 .. ( )049.31.914.41.53.401.603.901.101.200005.612.5060.201.5 0.183.540.511.370.1000
16.10.2007 ..11.450.46.525.10000001.200102.1011.92.411.9052.701.6 3.8607.90.331.299.5926.750.78 0.0901.817.560000.05
-0.170.130.156000.4100.31
!!!!!!!
0010.082.0791.83307.20
!!!!!!!
2
PASI . .ValidSpearmant(N-2)p-level
CCR1 & PASI ..80.03682714620.09026895080.9310115099
CCR1 & PASI ..80.8224729323.54188458830.0121910762
CCR3 & PASI ..9001
R & PASI ..90.74797253672.98155919120.0204695927
CCR5 & PASI ..9-0.1787638715-0.4807079890.6453844436
R5 & PASI ..90.82571883483.87292454390.0061085546
eot1 & PASI ..90.69668299132.5694223210.0370390716
eot1 & PASI ..90.38894571911.11700594230.3008592463
eot2 & PASI ..90.4848530281.46673556260.1858817473
eot2 & PASI ..90.52901952711.64934974010.1430637466
MIPa & PASI ..90.50216920761.53638052460.1683257398
MIPa & PASI ..9-0.0933563871-0.24808121480.811191803
MIPb & PASI ..90.16956521740.45521944340.6627346079
MIPb & PASI ..90.25974269360.71163956340.4997100774
Rant & PASI ..90.08446530270.2242756520.8289484345
Rant & PASI ..9-0.4242463995-1.23952784950.2550916494
CXCR1 & PASI ..9-0.1362010449-0.36374374190.7267871165
CXCR1 & PASI ..90.56182931031.79686300130.1154130722
CXCR2 & PASI ..90.08658089790.22993497040.8247169625
CXCR2 & PASI ..90.21281413270.57625368650.5824894531
IL8 & PASI ..90.42562826541.24445673540.2533805931
IL8 & PASI ..90.45967852661.36945735640.2131705724
PASI . Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
CCR165.570.529.5-0.26255251580.7928956805-0.26274578230.7927467003880.7984459984
CCR1617525-0.73514704410.4622504918-0.73514704410.4622504918880.5053613054
CCR3767731-0.48112522430.6304278382-0.48142030270.6302181289980.6729740847
R9261251.05847549350.28983951171.05977503420.2892477371980.3212669683
CCR58370340.19245008970.84738977450.19245008970.8473897745980.8883587001
R58172360101981.0374331551
eot11094482.69430125620.00705400533.01648200390.0025574646980.0055121349
eot11094482.69430125620.00705400533.01648200390.0025574646980.0055121349
eot210548122.30940107680.02092196772.70222379210.0068881011980.0206499383
eot210152161.92450089730.05429270682.38795018370.0169432133980.0592348828
MIPa 97.555.519.51.58771324030.1123521731.77756975230.0754754719980.1139448787
MIPa 9459231.25092558320.2109625171.46370455410.1432756692980.2358700123
MIPb 97.555.519.51.58771324030.1123521731.77893658810.0752510855980.1139448787
MIPb 99.553.517.51.780163330.07505016351.99303275260.0462587059980.0744549568
Rant 569711-2.40562612160.0161453403-2.42050335760.0154995879980.015220074
Rant 599414-2.1169509870.0342647732-2.12215874640.0338251724980.035952283
CXCR11134043.07920143570.00207573853.33409952880.0008558574980.000987248
CXCR1 1134043.07920143570.00207573853.33409952880.0008558574980.000987248
CXCR2 10548122.30940107680.02092196772.70222379210.0068881011980.0206499383
CXCR2 1134043.07920143570.00207573853.33409952880.0008558574980.000987248
IL8 61.591.516.5-1.87638837490.0606028648-1.87753918050.0604451248980.0592348828
IL8 70.582.525.5-1.01036297110.3123221656-1.01098263560.312025492980.3212669683
PASI ..001011000
PASI Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
R1 6060240.46291004990.64342914520.46291004990.6434291452780.6943278943
R1 27.563.512.5-1.09788758210.2722544207-1.09939878390.2715949701580.2843822844
R3 5055190.64549722440.51860549240.64620773340.5181453188680.5727605728
R3 5451151.16189500390.24527899981.163173920.244759803680.2823842824
R5 446123-0.12909944490.8972790453-0.12909944490.8972790453680.9497169497
R5 386717-0.90369611410.3661572284-0.90369611410.3661572284680.4135864136
eot1 5748121.54919333850.12133626722.15564572940.0311120762680.1418581419
eot1 614482.0655911180.03886790192.58732542860.0096728549680.0426240426
eot2 614482.0655911180.03886790192.58732542860.0096728549680.0426240426
eot2 5748121.54919333850.12133626722.15564572940.0311120762680.1418581419
MIPa 52.552.516.50.96824583660.33292236371.21280879470.2252038288680.344988345
MIPa 46.544.58.51.68342762580.09229328571.91940280890.0549342526580.0932400932
MIP b 5748121.54919333850.12133626721.80546434260.0710029759680.1418581419
MIPb 5649131.42009389360.15558132891.65500898080.0979236765680.1811521812
Rantes 30759-1.93649167310.0528083802-1.93649167310.0528083802680.0592740593
Rantes 366915-1.16189500390.2452789998-1.16189500390.2452789998680.2823842824
CXCR1 654042.58198889750.0098237143.00910723770.0026203699680.007992008
XCR1 693603.0983866770.00194594223.43126578770.0006008475680.0006660007
CXCR2 614482.0655911180.03886790192.58732542860.0096728549680.0426240426
CXCR2 693603.0983866770.00194594223.43126578770.0006008475680.0006660007
IL8 23688-1.75662013130.07898352-1.75662013130.07898352580.0932400932
IL8 406519-0.64549722440.5186054924-0.64549722440.5186054924680.5727605728
PASI ValidSpearmant(N-2)p-level
R1 & PASI 70.16840826740.3820287240.7181381627
R1 & PASI 5-0.158113883-0.27735009810.7995251549
R3 & PASI 6001
R3 & PASI 6-0.7406560798-2.20471301840.0921672644
R5 & PASI 6-0.7944613466-2.61630854880.0590276005
R5 & PASI 6-0.6789347398-1.84945794750.1380761794
eot1 & PASI 6-0.3751832397-0.80949990880.4636309931
eot1 & PASI 6-0.5322906474-1.25753542650.2769718828
eot2 & PASI 6-0.9404032586-5.53078614450.0052218202
eot2 & PASI 6-0.4262867933-0.94249926370.3993023153
MIPa & PASI 6-0.9379580992-5.4100178080.0056543905
MIPa & PASI 50.3162277660.57735026920.6041812895
MIP b & PASI 6-0.8508410435-3.23868864140.0317133189
MIPb & PASI 6-0.17221168-0.34964709950.7442361229
Rantes & PASI 6-0.088273483-0.17723885740.8679337052
Rantes & PASI 6-0.7406560798-2.20471301840.0921672644
CXCR1 & PASI 6-0.088273483-0.17723885740.8679337052
XCR1 & PASI 6-0.5246313899-1.23249903710.28525221
CXCR2 & PASI 6-0.9404032586-5.53078614450.0052218202
CXCR2 & PASI 60.33946736990.72179658640.5103587366
IL8 & PASI 5-0.158113883-0.27735009810.7995251549
IL8 & PASI 60.46291004991.04446593570.3552324136
PASI ValidSpearmant(N-2)p-level
R1 & PASI 70.10811249550.24317220260.8175332615
CCR1 & PASI 7-0.4865062299-1.2451522330.2682485448
CCR3 & PASI 80.09639253850.23721716050.8203804014
CCR3 & PASI 8-0.4217173561-1.13925354520.2980286785
R5 & PASI 8-0.1084416059-0.26720234140.7982604
CCR5 & PASI 8-0.265079481-0.67339927490.5257681465
eot1 & PASI 80.23636797740.59586561410.5730406536
eot1 & PASI 80.07229440390.17754898690.8649195662
eot2 & PASI 80.494011761.39176430260.2133973153
eot2 & PASI 80.36970375950.97463905450.367379716
MIPa & PASI 80.44581549081.21996438480.2682500617
MIPa & PASI 8-0.1325397405-0.32754443270.7543830278
MIPb & PASI 80.45682493851.2579165610.2551604757
MIPb & PASI 8-0.1084416059-0.26720234140.7982604
Rantes & PASI 80.57835523131.73657905270.133138587
Rantes & PASI 8-0.23030726-0.57971930820.5832007003
CXCR1 & PASI 80.14458880780.35792999180.7326507551
CXCR1 & PASI 8-0.3976192215-1.06148292060.3293169048
CXCR2 & PASI 80.05454645630.13381019740.8979280851
CXCR2 & PASI 8-0.3735210869-0.98632457810.3620625958
IL8 & PASI 8-0.0602453366-0.14783886850.8873130155
IL8 & PASI 8-0.3132757503-0.8080407250.4499082053
PASI Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
R1 65.554.518.51.09941136850.27158951051.10039430240.2711611594780.280963481
CCR1 6852161.38873014970.16491578221.38873014970.1649157822780.1892773893
CCR3 6967310.10502100630.91635920320.10509831290.9162978671880.9591297591
CCR3 77.558.522.50.99769955990.31842583610.99917000950.3177131068880.3282051282
R5 8353171.57531509450.11518473151.57531509450.1151847315880.1303807304
CCR5 8155191.36527308190.17216821811.36527308190.1721682181880.1948717949
eot1964042.94058817650.00327613153.24326741760.0011817935880.0018648019
eot1964042.94058817650.00327613153.24037034920.0011938674880.0018648019
eot2 964042.94058817650.00327613153.24037034920.0011938674880.0018648019
eot2 924482.52050415130.01171916732.89626475220.003776592880.0104118104
MIPa 89.546.510.52.25795163550.02394934322.41182593950.0158734153880.0206682207
MIPa 88.547.511.52.15293062920.031324872.29964798880.0214688094880.0281274281
MIPb 82.553.517.51.52280459140.12780863321.74982662110.0801491808880.1303807304
MIPb 88.547.511.52.15293062920.031324872.29964798880.0214688094880.0281274281
Rantes 6967310.10502100630.91635920320.10502100630.9163592032880.9591297591
Rantes 617525-0.73514704410.4622504918-0.73568819030.4619210054880.5053613054
CXCR1 1003603.36067220170.00077762123.58969442160.0003311153880.0001554002
CXCR1 1003603.36067220170.00077762123.58969442160.0003311153880.0001554002
CXCR2 964042.94058817650.00327613153.24326741760.0011817935880.0018648019
CXCR2 1003603.36067220170.00077762123.58969442160.0003311153880.0001554002
IL8 7660240.84016805040.40081481980.84016805040.4008148198880.4418026418
IL8 72.563.527.50.47259452840.6365027990.47294240810.6362545833880.6453768454
3
. eot1p. eot2 p. MIPa p. CXCR1 p. CXCR1. CXCR2p. CXCR2p
143.2872064145.64585328721327.40721175911420.52107600591416.80439502951415.32712348371433.1244912878
4
PASI FoxValidSpearmant(N-2)p-level
Fox & PASI cp24-0.607294-3.585330.001649
Fox & PASI cp24-0.203798-0.976390.339487
5
eotax Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
eotax22.00000474.000012.00000-2.474870.013329-2.519990.0117364270.009852
eotax Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
24.00000472.000014.00000-2.357020.018423-2.411360.0158944270.015319
eot2 Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
eot218.00000333.00008.000000-2.558410.010516-2.597330.0093964220.007090
eot2 Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
NewVar322.00000329.000012.00000-2.274140.022958-2.341130.0192264220.020736
MiPa Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
NewVar426.00000470.000016.00000-2.239170.025145-2.307160.0210474270.022819
MiPa Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
NewVar516.00000260.00006.000000-2.595540.009445-2.632210.0084834190.006098
MiPb Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
NewVar618.00000258.00008.000000-2.433320.014962-2.486730.0128934190.011971
MiPb Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
NewVar124.00000301.000014.00000-2.075500.037941-2.170220.0299914210.038103
+
ValidSpearmant(N-2)p-level
eotaxin1 & 16-0.165929-0.629580.539111
eotaxin1 & 16-0.068099-0.255400.802131
eotaxin2 & 16-0.228893-0.879800.393821
& 140.0745360.258920.800086
eotaxin 2 & 160.5411492.407810.030410
MIPa & 160.1133350.426810.676007
MIPa & 16-0.644399-3.153070.007048
MIPb & 160.0373130.139710.890878
MIPb & 160.0654160.245290.809791
R5 & 16-0.264449-1.026000.322292
R5 & 160.1628460.617560.546782
R3 & 16-0.277783-1.081950.297560
R3 & 160.1406400.531510.603398
Rantes & 160.2639411.023890.323257
Rantes & 16-0.141055-0.533110.602318
CXCR1 & 160.0482910.180900.859038
XCR1 & 160.0614830.230480.821051
CXCR2 & 16-0.328859-1.302950.213616
XCR2 & 160.1820910.692910.499701
IL8 & 160.3400061.352780.197571
IL8 & 160.2872011.121870.280790
ValidSpearmant(N-2)p-level
eotaxin1 & 16-0.037232-0.139410.891114
eotaxin1 & 16-0.247041-0.953910.356310
eotaxin2 & 16-0.050636-0.189710.852262
& 140.0373930.129620.899011
eotaxin 2 & 160.4128391.695980.112004
MIPa & 160.2278620.875620.396013
MIPa & 16-0.531365-2.346930.034163
MIPb & 160.0742690.278660.784580
MIPb & 16-0.099018-0.372320.715229
R5 & 16-0.440087-1.833780.088029
R5 & 160.1532850.580400.570871
R3 & 16-0.244989-0.945480.360448
R3 & 160.1651900.626700.540944
Rantes & 160.0239170.089510.929941
Rantes & 16-0.019404-0.072620.943139
CXCR1 & 160.0604950.226770.823883
XCR1 & 160.1072290.403540.692646
CXCR2 & 160.1004510.377760.711272
XCR2 & 160.4777122.034610.061286
IL8 & 160.1720140.653350.524113
IL8 & 160.4836652.067640.057677
ValidSpearmant(N-2)p-level
eotaxin1 & 160.1521730.576090.573701
eotaxin1 & 16-0.267627-1.039280.316292
eotaxin2 & 160.1574990.596750.560199
& 14-0.095545-0.332500.745249
eotaxin 2 & 160.0304570.114010.910847
MIPa & 160.1377160.520240.611022
MIPa & 16-0.189112-0.720600.483017
MIPb & 16-0.027595-0.103290.919197
MIPb & 16-0.152920-0.578980.571799
R5 & 16-0.578256-2.651980.018956
R5 & 160.0745100.279570.783898
R3 & 16-0.308910-1.215270.244359
R3 & 160.0790720.296790.770986
Rantes & 16-0.255833-0.990190.338887
Rantes & 160.2531660.979160.344119
CXCR1 & 16-0.088521-0.332520.744422
XCR1 & 160.4063011.663760.118375
CXCR2 & 160.3569361.429710.174737
XCR2 & 160.4029611.647410.121726
IL8 & 160.0365210.136740.893182
IL8 & 160.3193271.260830.227979
ValidSpearmant(N-2)p-level
eotaxin1 & -0.246671-0.952390.357055
eotaxin1 & 16-0.405806-1.661330.118867
eotaxin2 & 160.6347273.073400.008257
& 140.2094630.742060.472325
eotaxin 2 & 16-0.231048-0.888550.389259
MIPa & 160.1090470.410460.687679
MIPa & 16-0.021104-0.078980.938165
MIPb & 160.1500140.567730.579213
MIPb & 16-0.477872-2.035490.061187 eotaxin 2 0,30,8eotaxin 2 00
R5 & 16-0.335413-1.332170.204085RANTES13,91,3RANTES9,82,3
R5 & 16-0.302100-1.185760.255453CXCR110,95,6CXCR100
R3 & 16-0.165450-0.627710.540299CXCR25,91,9CXCR200
R3 & 16-0.049599-0.185810.855259IL85,42,1IL83,51,2
Rantes & 16-0.333635-1.324220.206642
Rantes & 160.0723560.271440.790011
CXCR1 & 16-0.428426-1.774090.097790
XCR1 & 160.3000671.176980.258826
CXCR2 & 160.1938130.739200.472000 eotaxin 2 0,30,8eotaxin 2 00
XCR2 & 160.2179330.835510.417460RANTES13,91,3RANTES9,82,3
IL8 & 16-0.455740-1.915740.076049CXCR110,95,6CXCR100
IL8 & 160.2930821.146980.270614CXCR25,91,9CXCR200
IL85,42,1IL83,51,2
ValidSpearmant(N-2)p-level
PASI & 160.5557232.501090.025413 PASI < 10
PASI & 160.4145021.704220.110422-200.3
PASI & 160.1877260.715120.486290IL-83.55.4
PASI & 16-0.242875-0.936810.364738RANTES9.813.9
PASI & 16-0.415855-1.710940.109147CXCR1010.9
CXCR205.9
5.61.9
00.8
1.22.1
2.31.3
05.6
01.9
PASI20
00.391.49.3
203.072.89.7
MIP-1087.821.8
MIP-11.338.34.58.2
RANTES10.3913.911.222.2
IL86.395.46.38.9
PASI < 10PASI (10-20)PASI>20
00.21.40.7
201.21.81.3
MIP-10.71.21.81.4
MIP-10.51.30.51.9
RANTES0.31.91.21.6
IL80.71.41.31.3
PASI < 10PASI (10-20)PASI>20
02.354.96.6
202.354.96.6
MIP-14.610.511.817.4
MIP-13.26.410.99.5
RANTES9.812.113.815.8
IL83.55.86.49.9
PASI < 10PASI (10-20)PASI>20
02,351,54,92,36,63,4
202,351,54,92,36,63,4
MIP-14,61,610,51,311,81,917,42,4
MIP-18,22,16,41,810,91,64,53,1
RANTES9,82,312,11,913,81,715,83,6
IL83,51,25,82,66,41,49,94,5
PASI < 10PASI (10-20)PASI>20
R124.331.935.436.4
R315.624.923.226.9
R512.417.321.625.4
XCR1010.917.719
XCR205.913.217.2
PASI < 10PASI (10-20)PASI>20
R131,31,831,92,535,43,136,42,2
R320,13,624,92,723,22,926,92,4
R513,42,617,31,821,61,425,43,5
XCR1010,91,617,71,819,02,5
XCR205,91,413,21,517,24,3
PASI < 10PASI (10-20)PASI>20
R131.329.636.439.2
R320.122.727.229.5
R513.615.820.621.1
XCR108.710.921.9
XCR2020.919.322.6
PASI < 10PASI (10-20)PASI>20
R131,31,829,62,933,51,939,21,4
R320,13,622,73,127,21,829,52,1
R513,42,615,81,520,61,821,12,3
XCR108,71,810,91,921,93,4
XCR2020,91,919,32,422,65,4
PASI < 10PASI (10-20)PASI>20
R12.32.21.40.7
R33.51.21.81.3
R50.61.21.81.4
XCR101.31.71.9
XCR201.91.21.6
005.3
2004.8
MIP-10012.5
MIP-11.3307.4
RANTES10.397.915.4
IL86.390.86.4
R124.31.834.2
R315.64.923.7
R512.42.219.3
XCR106.516.5
XCR202.211.3
R1001.4
R3001.8
R50.601.8
XCR10.801.7
XCR20.40.91.2
R10.31.21.4
R30.51.21.8
R50.81.21.8
XCR10.60.31.7
XCR201.21.2
R101.41.4
004.3
2004.1
MIP-14.6012.3
MIP-13.206.3
RANTES9.80.914.5
IL83.58.310.5
R12.37.634.7
R33.52.924.4
R50.612.117.5
XCR100.712.4
XCR205.720.8
R1001.4
R3001.8
R50.201.8
XCR10.801.7
XCR20.40.91.2
R10.31.21.4
R30.51.21.8
R50.81.21.8
XCR10.60.31.7
XCR200.21.2
R101.41.4
+
00000.80.8
001.21.22.12.1
002.32.31.31.3
00005.65.6
00001.91.9
PASI < 10
% -
000.20.21.91.9
001.21.22.12.1
001.21.200
003.63.600
PASI20
% -
00000.20.2001.41.40.70.7
00001.21.2001.81.81.31.3
00001.21.20.70.71.81.81.41.4
00001.31.30.50.50.50.51.91.9
00001.91.90.30.31.21.21.61.6
00001.41.40.70.71.31.31.31.3
PASI < 10
PASI (10-20)
PASI>20
% -
00002.32.32.22.21.41.40.70.7
00003.53.51.21.21.81.81.31.3
00000.60.61.21.21.81.81.41.4
0000001.31.31.71.71.91.9
0000001.91.91.21.21.61.6
PASI < 10
PASI (10-20)
PASI>20
% -
00002.32.32.22.21.41.40.70.7
00003.53.51.21.21.81.81.31.3
00000.60.61.21.21.81.81.41.4
0000001.31.31.71.71.91.9
0000001.91.91.21.21.61.6
PASI < 10
PASI (10-20)
PASI>20
% -
00000001.41.4
00000001.81.8
0000.60.6001.81.8
0000.80.8001.71.7
0000.40.40.90.91.21.2
0000.30.31.21.21.41.4
0000.50.51.21.21.81.8
0000.80.81.21.21.81.8
0000.60.60.30.31.71.7
000001.21.21.21.2
000001.41.41.41.4
% -
0001.41.40000
0001.81.80000
0001.81.8000.20.2
0001.71.7000.80.8
0001.21.20.90.90.40.4
0001.41.41.21.20.30.3
0001.81.81.21.20.50.5
0001.81.81.21.20.80.8
0001.71.70.30.30.60.6
0001.21.20.20.200
0001.41.41.41.400
%
000
000
000
000
000
000
000
000
000
000
000
% -
MBD00071D09.unknown
MBD0007F351.unknown
MBD00081C11.unknown
MBD0007C0E9.unknown
MBD000600F4.unknown
4
24.331.935.436.42.32.32.22.21.41.40.70.7
15.624.923.226.93.53.51.21.21.81.81.31.3
12.417.321.625.40.60.61.21.21.81.81.41.4
010.917.719001.31.31.71.71.91.9
05.913.217.2001.91.91.21.21.61.6
PASI < 10
PASI (10-20)
PASI>20
% -
1
actinCCR1CCR3CCR5eotaxineotaxin 2MIP alphaMIP betaRANTESCXCR1CXCR2IL8
/-IL2IL4IL6IL8IL10GM-CSFIFN gammaTNF alpha-IL2IL4IL6IL8IL10GM-CSFIFN gammaTNF alpha
21.09.2007 ( R1)0457.636.38.134.25.15.66.44.23.502.10003.345.66.834.51.61.8 000.510.740000.11
7.09.2007 ( R1) 0.2801.340.800.1850.43 0.1101.090.120000
44.715.511.4003.8151.7722.65.3
3.07.2007 ..99.599.879.652.781.251.785.939.71.32.71.2046.831.290.51.97.605454.385.696.11.227.3 008.0644.85100.95.40
3.07.2007 .. 002.5480006.30
94.993.196.994.640.438.813.347.413.172.595.721.3
7.09.2007 ( R1)38.381.253.347.135.532.517.78.410.6035.320.30.2051.611.971.145.666.698.326.536.4
6.02.2007 ( 1)31.13.592.93.7604.331.71.500000024.200039.7074.701.50 000.3960.576000.5130.081
6.02.2007 ()90.90475157.659.112.663.11.4001.7020.104.21.93.42.17.6201.66.374.6 0.0903.0420.87301.3862.2860.306-0.253.590.020.420.240.852.910.56
6.02.2007 ( )90.288.662.699.45.477.731.835.101.405.4023.7023.2014.618.558.716.250.97.98.6 001.7550.2160000
( )68.357.534.318.938.123.533.339.98.500.33.700009.610.604.307.703 001.4850.0990000-0.253.680.082.020.250.592.990.5
28.02.2007 ()( , ) 0.02700.2610.39600.2071.4040.243
?????????
28.02.2007 ( 2 )015011.414.88.124.312.596.56488.451.299.7373.81.645.811.499.431.485.734.8293.9 0.1801.1520.9630.090.5765.310.819-0.133.1958.261.420.191.111.490.44
0003.26701.1254.50
28.02.2007 (3) ( , ) 0.0900.5850.63900.3330.6660.099-0.172.892.092.830.260.741.910
?????
28.02.2007 ()-0.424.52.2126.170.180.811.660.44
16.03.2007 (7)14.1027.73.123.9022.11.71.213.102.51.33.32.118.35.87559.318.322.51.91.71.5 0.09900.4230.36900.1531.9890.351
6.03.2007 (5. )45.35031.879.243.47317.93.317.22.304.842.9014.1547.1544.54.8084.321.924.8-0.554.070.271.290.180.851.250.63
6.03.2007 (6)48.615.534.427.545.424.573.421.16.52.431.311.14.901.702.17.668.32.525.623.23.51.3 0.05401.5480.14400.3061.4760.333-0.162.640.392.290.251.042.820.13
16.03.2007 (8)12.595.452.94519.630.119.513.52.601.50011.31261.31.506.23.879.818.629.4
16.03.2007 (9)54.468.110.672.5265.317.246.44.93.25.25.17.541.73.448.37.85013.602.237.9
( )45.350.731.843.49.217.97317.23.302.342.94.814.107.15544.844.584.3024.821.93.5 001.0710.81000.0720
( )58.240.467.911.729.58.422.49.77.43.76.717.72.91.337.451.136.112.431.982.99939.412.38.3?
15.05.2007 0012.38410.8902.02500
15.05.200718.235.79.45.716.72.123.925.421.32.131.510.344.8027.21.964.51.772.617.926.210.326.3 007.48810.7910.376000
13.97418.63.63.545.110.767.49.13.45.35.66.63.42.34.913.224.47.990.48.671.403.2-0.296.2900.270.4501.830.31
72.318.741.480.446.66521.447.51.35.16.124.436.67.64.1111.311.91.83.11.610.201.5-0.420.080.230.310.10.192.320.69
37.4042.831.235.130.347.541.61.63.129.47.111.62.245.424.94.720.735.511.514.85.71.80.6
3.06.2007 ..42.719.967.442.843.242.43.420.42.73.144.810.315.801.215.675.517.913.71.31.611.71.35.4
3.06.2007 ..
3.06.2007 ..( , )56.853.319.820.36.44022.4020.42.71.51.323.24.112.61.427.56.2626.894.617.5?
000.380.48005.250.37 001.164.540000.08
3.06.2007 ..
22.06.2007 ..
22.06.2007 .. 003.8883.86100.6754.052.14
3.07.2007 ..( )90.418.740.921.455.838.543.621.91.37.99.404.5022.907.53.841.422.657.130.43.22.8
3.07.2007 .. (.)
7.09.2007 .. ()
19.09.2007
()70.588.835.275.716.853.17.51000002.32.92.17.5001.512.6012.700
21.09.2007 ( )
21.09.2007 0.0800.310.570000.08
26.09.2007 .. ( CCR1)
6068701.3000065640
26.09.2007 ..39.599.480.910.72.21.510.910.7081.391.227.2
16.10.2007 ,.59.6844.450.95.430.92.35.11.31.60000023.66.102.316.94.334.61.94.5 0.4402.690.5500.6600.6 0.0600.2210.110000
16.10.2007 .. ( )049.31.914.41.53.401.603.901.101.200005.612.5060.201.5 0.183.540.511.370.1000
16.10.2007 ..11.450.46.525.10000001.200102.1011.92.411.9052.701.6 3.8607.90.331.299.5926.750.78 0.0901.817.560000.05
-0.170.130.156000.4100.31
!!!!!!!
0010.082.0791.83307.20
!!!!!!!
2
PASI . .ValidSpearmant(N-2)p-level
CCR1 & PASI ..80.03682714620.09026895080.9310115099
CCR1 & PASI ..80.8224729323.54188458830.0121910762
CCR3 & PASI ..9001
R & PASI ..90.74797253672.98155919120.0204695927
CCR5 & PASI ..9-0.1787638715-0.4807079890.6453844436
R5 & PASI ..90.82571883483.87292454390.0061085546
eot1 & PASI ..90.69668299132.5694223210.0370390716
eot1 & PASI ..90.38894571911.11700594230.3008592463
eot2 & PASI ..90.4848530281.46673556260.1858817473
eot2 & PASI ..90.52901952711.64934974010.1430637466
MIPa & PASI ..90.50216920761.53638052460.1683257398
MIPa & PASI ..9-0.0933563871-0.24808121480.811191803
MIPb & PASI ..90.16956521740.45521944340.6627346079
MIPb & PASI ..90.25974269360.71163956340.4997100774
Rant & PASI ..90.08446530270.2242756520.8289484345
Rant & PASI ..9-0.4242463995-1.23952784950.2550916494
CXCR1 & PASI ..9-0.1362010449-0.36374374190.7267871165
CXCR1 & PASI ..90.56182931031.79686300130.1154130722
CXCR2 & PASI ..90.08658089790.22993497040.8247169625
CXCR2 & PASI ..90.21281413270.57625368650.5824894531
IL8 & PASI ..90.42562826541.24445673540.2533805931
IL8 & PASI ..90.45967852661.36945735640.2131705724
PASI . Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
CCR165.570.529.5-0.26255251580.7928956805-0.26274578230.7927467003880.7984459984
CCR1617525-0.73514704410.4622504918-0.73514704410.4622504918880.5053613054
CCR3767731-0.48112522430.6304278382-0.48142030270.6302181289980.6729740847
R9261251.05847549350.28983951171.05977503420.2892477371980.3212669683
CCR58370340.19245008970.84738977450.19245008970.8473897745980.8883587001
R58172360101981.0374331551
eot11094482.69430125620.00705400533.01648200390.0025574646980.0055121349
eot11094482.69430125620.00705400533.01648200390.0025574646980.0055121349
eot210548122.30940107680.02092196772.70222379210.0068881011980.0206499383
eot210152161.92450089730.05429270682.38795018370.0169432133980.0592348828
MIPa 97.555.519.51.58771324030.1123521731.77756975230.0754754719980.1139448787
MIPa 9459231.25092558320.2109625171.46370455410.1432756692980.2358700123
MIPb 97.555.519.51.58771324030.1123521731.77893658810.0752510855980.1139448787
MIPb 99.553.517.51.780163330.07505016351.99303275260.0462587059980.0744549568
Rant 569711-2.40562612160.0161453403-2.42050335760.0154995879980.015220074
Rant 599414-2.1169509870.0342647732-2.12215874640.0338251724980.035952283
CXCR11134043.07920143570.00207573853.33409952880.0008558574980.000987248
CXCR1 1134043.07920143570.00207573853.33409952880.0008558574980.000987248
CXCR2 10548122.30940107680.02092196772.70222379210.0068881011980.0206499383
CXCR2 1134043.07920143570.00207573853.33409952880.0008558574980.000987248
IL8 61.591.516.5-1.87638837490.0606028648-1.87753918050.0604451248980.0592348828
IL8 70.582.525.5-1.01036297110.3123221656-1.01098263560.312025492980.3212669683
PASI ..001011000
PASI Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
R1 6060240.46291004990.64342914520.46291004990.6434291452780.6943278943
R1 27.563.512.5-1.09788758210.2722544207-1.09939878390.2715949701580.2843822844
R3 5055190.64549722440.51860549240.64620773340.5181453188680.5727605728
R3 5451151.16189500390.24527899981.163173920.244759803680.2823842824
R5 446123-0.12909944490.8972790453-0.12909944490.8972790453680.9497169497
R5 386717-0.90369611410.3661572284-0.90369611410.3661572284680.4135864136
eot1 5748121.54919333850.12133626722.15564572940.0311120762680.1418581419
eot1 614482.0655911180.03886790192.58732542860.0096728549680.0426240426
eot2 614482.0655911180.03886790192.58732542860.0096728549680.0426240426
eot2 5748121.54919333850.12133626722.15564572940.0311120762680.1418581419
MIPa 52.552.516.50.96824583660.33292236371.21280879470.2252038288680.344988345
MIPa 46.544.58.51.68342762580.09229328571.91940280890.0549342526580.0932400932
MIP b 5748121.54919333850.12133626721.80546434260.0710029759680.1418581419
MIPb 5649131.42009389360.15558132891.65500898080.0979236765680.1811521812
Rantes 30759-1.93649167310.0528083802-1.93649167310.0528083802680.0592740593
Rantes 366915-1.16189500390.2452789998-1.16189500390.2452789998680.2823842824
CXCR1 654042.58198889750.0098237143.00910723770.0026203699680.007992008
XCR1 693603.0983866770.00194594223.43126578770.0006008475680.0006660007
CXCR2 614482.0655911180.03886790192.58732542860.0096728549680.0426240426
CXCR2 693603.0983866770.00194594223.43126578770.0006008475680.0006660007
IL8 23688-1.75662013130.07898352-1.75662013130.07898352580.0932400932
IL8 406519-0.64549722440.5186054924-0.64549722440.5186054924680.5727605728
PASI ValidSpearmant(N-2)p-level
R1 & PASI 70.16840826740.3820287240.7181381627
R1 & PASI 5-0.158113883-0.27735009810.7995251549
R3 & PASI 6001
R3 & PASI 6-0.7406560798-2.20471301840.0921672644
R5 & PASI 6-0.7944613466-2.61630854880.0590276005
R5 & PASI 6-0.6789347398-1.84945794750.1380761794
eot1 & PASI 6-0.3751832397-0.80949990880.4636309931
eot1 & PASI 6-0.5322906474-1.25753542650.2769718828
eot2 & PASI 6-0.9404032586-5.53078614450.0052218202
eot2 & PASI 6-0.4262867933-0.94249926370.3993023153
MIPa & PASI 6-0.9379580992-5.4100178080.0056543905
MIPa & PASI 50.3162277660.57735026920.6041812895
MIP b & PASI 6-0.8508410435-3.23868864140.0317133189
MIPb & PASI 6-0.17221168-0.34964709950.7442361229
Rantes & PASI 6-0.088273483-0.17723885740.8679337052
Rantes & PASI 6-0.7406560798-2.20471301840.0921672644
CXCR1 & PASI 6-0.088273483-0.17723885740.8679337052
XCR1 & PASI 6-0.5246313899-1.23249903710.28525221
CXCR2 & PASI 6-0.9404032586-5.53078614450.0052218202
CXCR2 & PASI 60.33946736990.72179658640.5103587366
IL8 & PASI 5-0.158113883-0.27735009810.7995251549
IL8 & PASI 60.46291004991.04446593570.3552324136
PASI ValidSpearmant(N-2)p-level
R1 & PASI 70.10811249550.24317220260.8175332615
CCR1 & PASI 7-0.4865062299-1.2451522330.2682485448
CCR3 & PASI 80.09639253850.23721716050.8203804014
CCR3 & PASI 8-0.4217173561-1.13925354520.2980286785
R5 & PASI 8-0.1084416059-0.26720234140.7982604
CCR5 & PASI 8-0.265079481-0.67339927490.5257681465
eot1 & PASI 80.23636797740.59586561410.5730406536
eot1 & PASI 80.07229440390.17754898690.8649195662
eot2 & PASI 80.494011761.39176430260.2133973153
eot2 & PASI 80.36970375950.97463905450.367379716
MIPa & PASI 80.44581549081.21996438480.2682500617
MIPa & PASI 8-0.1325397405-0.32754443270.7543830278
MIPb & PASI 80.45682493851.2579165610.2551604757
MIPb & PASI 8-0.1084416059-0.26720234140.7982604
Rantes & PASI 80.57835523131.73657905270.133138587
Rantes & PASI 8-0.23030726-0.57971930820.5832007003
CXCR1 & PASI 80.14458880780.35792999180.7326507551
CXCR1 & PASI 8-0.3976192215-1.06148292060.3293169048
CXCR2 & PASI 80.05454645630.13381019740.8979280851
CXCR2 & PASI 8-0.3735210869-0.98632457810.3620625958
IL8 & PASI 8-0.0602453366-0.14783886850.8873130155
IL8 & PASI 8-0.3132757503-0.8080407250.4499082053
PASI Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
R1 65.554.518.51.09941136850.27158951051.10039430240.2711611594780.280963481
CCR1 6852161.38873014970.16491578221.38873014970.1649157822780.1892773893
CCR3 6967310.10502100630.91635920320.10509831290.9162978671880.9591297591
CCR3 77.558.522.50.99769955990.31842583610.99917000950.3177131068880.3282051282
R5 8353171.57531509450.11518473151.57531509450.1151847315880.1303807304
CCR5 8155191.36527308190.17216821811.36527308190.1721682181880.1948717949
eot1964042.94058817650.00327613153.24326741760.0011817935880.0018648019
eot1964042.94058817650.00327613153.24037034920.0011938674880.0018648019
eot2 964042.94058817650.00327613153.24037034920.0011938674880.0018648019
eot2 924482.52050415130.01171916732.89626475220.003776592880.0104118104
MIPa 89.546.510.52.25795163550.02394934322.41182593950.0158734153880.0206682207
MIPa 88.547.511.52.15293062920.031324872.29964798880.0214688094880.0281274281
MIPb 82.553.517.51.52280459140.12780863321.74982662110.0801491808880.1303807304
MIPb 88.547.511.52.15293062920.031324872.29964798880.0214688094880.0281274281
Rantes 6967310.10502100630.91635920320.10502100630.9163592032880.9591297591
Rantes 617525-0.73514704410.4622504918-0.73568819030.4619210054880.5053613054
CXCR1 1003603.36067220170.00077762123.58969442160.0003311153880.0001554002
CXCR1 1003603.36067220170.00077762123.58969442160.0003311153880.0001554002
CXCR2 964042.94058817650.00327613153.24326741760.0011817935880.0018648019
CXCR2 1003603.36067220170.00077762123.58969442160.0003311153880.0001554002
IL8 7660240.84016805040.40081481980.84016805040.4008148198880.4418026418
IL8 72.563.527.50.47259452840.6365027990.47294240810.6362545833880.6453768454
3
. eot1p. eot2 p. MIPa p. CXCR1 p. CXCR1. CXCR2p. CXCR2p
143.2872064145.64585328721327.40721175911420.52107600591416.80439502951415.32712348371433.1244912878
4
PASI FoxValidSpearmant(N-2)p-level
Fox & PASI cp24-0.607294-3.585330.001649
Fox & PASI cp24-0.203798-0.976390.339487
5
eotax Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
eotax22.00000474.000012.00000-2.474870.013329-2.519990.0117364270.009852
eotax Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
24.00000472.000014.00000-2.357020.018423-2.411360.0158944270.015319
eot2 Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
eot218.00000333.00008.000000-2.558410.010516-2.597330.0093964220.007090
eot2 Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
NewVar322.00000329.000012.00000-2.274140.022958-2.341130.0192264220.020736
MiPa Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
NewVar426.00000470.000016.00000-2.239170.025145-2.307160.0210474270.022819
MiPa Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
NewVar516.00000260.00006.000000-2.595540.009445-2.632210.0084834190.006098
MiPb Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
NewVar618.00000258.00008.000000-2.433320.014962-2.486730.0128934190.011971
MiPb Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided
NewVar124.00000301.000014.00000-2.075500.037941-2.170220.0299914210.038103
+
ValidSpearmant(N-2)p-level
eotaxin1 & 16-0.165929-0.629580.539111
eotaxin1 & 16-0.068099-0.255400.802131
eotaxin2 & 16-0.228893-0.879800.393821
& 140.0745360.258920.800086
eotaxin 2 & 160.5411492.407810.030410
MIPa & 160.1133350.426810.676007
MIPa & 16-0.644399-3.153070.007048
MIPb & 160.0373130.139710.890878
MIPb & 160.0654160.245290.809791
R5 & 16-0.264449-1.026000.322292
R5 & 160.1628460.617560.546782
R3 & 16-0.277783-1.081950.297560
R3 & 160.1406400.531510.603398
Rantes & 160.2639411.023890.323257
Rantes & 16-0.141055-0.533110.602318
CXCR1 & 160.0482910.180900.859038
XCR1 & 160.0614830.230480.821051
CXCR2 & 16-0.328859-1.302950.213616
XCR2 & 160.1820910.692910.499701
IL8 & 160.3400061.352780.197571
IL8 & 160.2872011.121870.280790
ValidSpearmant(N-2)p-level
eotaxin1 & 16-0.037232-0.139410.891114
eotaxin1 & 16-0.247041-0.953910.356310
eotaxin2 & 16-0.050636-0.189710.852262
& 140.0373930.129620.899011
eotaxin 2 & 160.4128391.695980.112004
MIPa & 160.2278620.875620.396013
MIPa & 16-0.531365-2.346930.034163
MIPb & 160.0742690.278660.784580
MIPb & 16-0.099018-0.372320.715229
R5 & 16-0.440087-1.833780.088029
R5 & 160.1532850.580400.570871
R3 & 16-0.244989-0.945480.360448
R3 & 160.1651900.626700.540944
Rantes & 160.0239170.089510.929941
Rantes & 16-0.019404-0.072620.943139
CXCR1 & 160.0604950.226770.823883
XCR1 & 160.1072290.403540.692646
CXCR2 & 160.1004510.377760.711272
XCR2 & 160.4777122.034610.061286
IL8 & 160.1720140.653350.524113
IL8 & 160.4836652.067640.057677
ValidSpearmant(N-2)p-level
eotaxin1 & 160.1521730.576090.573701
eotaxin1 & 16-0.267627-1.039280.316292
eotaxin2 & 160.1574990.596750.560199
& 14-0.095545-0.332500.745249
eotaxin 2 & 160.0304570.114010.910847
MIPa & 160.1377160.520240.611022
MIPa & 16-0.189112-0.720600.483017
MIPb & 16-0.027595-0.103290.919197
MIPb & 16-0.152920-0.578980.571799
R5 & 16-0.578256-2.651980.018956
R5 & 160.0745100.279570.783898
R3 & 16-0.308910-1.215270.244359
R3 & 160.0790720.296790.770986
Rantes & 16-0.255833-0.990190.338887
Rantes & 160.2531660.979160.344119
CXCR1 & 16-0.088521-0.332520.744422
XCR1 & 160.4063011.663760.118375
CXCR2 & 160.3569361.429710.174737
XCR2 & 160.4029611.647410.121726
IL8 & 160.0365210.136740.893182
IL8 & 160.3193271.260830.227979
ValidSpearmant(N-2)p-level
eotaxin1 & -0.246671-0.952390.357055
eotaxin1 & 16-0.405806-1.661330.118867
eotaxin2 & 160.6347273.073400.008257
& 140.2094630.742060.472325
eotaxin 2 & 16-0.231048-0.888550.389259
MIPa & 160.1090470.410460.687679
MIPa & 16-0.021104-0.078980.938165
MIPb & 160.1500140.567730.579213
MIPb & 16-0.477872-2.035490.061187 eotaxin 2 0,30,8eotaxin 2 00
R5 & 16-0.335413-1.332170.204085RANTES13,91,3RANTES9,82,3
R5 & 16-0.302100-1.185760.255453CXCR110,95,6CXCR100
R3 & 16-0.165450-0.627710.540299CXCR25,91,9CXCR200
R3 & 16-0.049599-0.185810.855259IL85,42,1IL83,51,2
Rantes & 16-0.333635-1.324220.206642
Rantes & 160.0723560.271440.790011
CXCR1 & 16-0.428426-1.774090.097790
XCR1 & 160.3000671.176980.258826
CXCR2 & 160.1938130.739200.472000 eotaxin 2 0,30,8eotaxin 2 00
XCR2 & 160.2179330.835510.417460RANTES13,91,3RANTES9,82,3
IL8 & 16-0.455740-1.915740.076049CXCR110,95,6CXCR100
IL8 & 160.2930821.146980.270614CXCR25,91,9CXCR200
IL85,42,1IL83,51,2
ValidSpearmant(N-2)p-level
PASI & 160.5557232.501090.025413 PASI < 10
PASI & 160.4145021.704220.110422-200.3
PASI & 160.1877260.715120.486290IL-83.55.4
PASI & 16-0.242875-0.936810.364738RANTES9.813.9
PASI & 16-0.415855-1.710940.109147CXCR1010.9
CXCR205.9
5.61.9
00.8
1.22.1
2.31.3
05.6
01.9
PASI20
00.391.49.3
203.072.89.7
MIP-1087.821.8
MIP-11.338.34.58.2
RANTES10.3913.911.222.2
IL86.395.46.38.9
PASI < 10PASI (10-20)PASI>20
00.21.40.7
201.21.81.3
MIP-10.71.21.81.4
MIP-10.51.30.51.9
RANTES0.31.91.21.6
IL80.71.41.31.3
PASI < 10PASI (10-20)PASI>20
02.354.96.6
202.354.96.6
MIP-14.610.511.817.4
MIP-13.26.410.99.5
RANTES9.812.113.815.8
IL83.55.86.49.9
PASI < 10PASI (10-20)PASI>20
02,351,54,92,36,63,4
202,351,54,92,36,63,4
MIP-14,61,610,51,311,81,917,42,4
MIP-18,22,16,41,810,91,64,53,1
RANTES9,82,312,11,913,81,715,83,6
IL83,51,25,82,66,41,49,94,5
PASI < 10PASI (10-20)PASI>20
R124.331.935.436.4
R315.624.923.226.9
R512.417.321.625.4
XCR1010.917.719
XCR205.913.217.2
PASI < 10PASI (10-20)PASI>20
R131,31,831,92,535,43,136,42,2
R320,13,624,92,723,22,926,92,4
R513,42,617,31,821,61,425,43,5
XCR1010,91,617,71,819,02,5
XCR205,91,413,21,517,24,3
PASI < 10PASI (10-20)PASI>20
R131.329.636.439.2
R320.122.727.229.5
R513.615.820.621.1
XCR108.710.921.9
XCR2020.919.322.6
PASI < 10PASI (10-20)PASI>20
R131,31,829,62,933,51,939,21,4
R320,13,622,73,127,21,829,52,1
R513,42,615,81,520,61,821,12,3
XCR108,71,810,91,921,93,4
XCR2020,91,919,32,422,65,4
PASI < 10PASI (10-20)PASI>20
R12.32.21.40.7
R33.51.21.81.3
R50.61.21.81.4
XCR101.31.71.9
XCR201.91.21.6
005.3
2004.8
MIP-10012.5
MIP-11.3307.4
RANTES10.397.915.4
IL86.390.86.4
R124.31.834.2
R315.64.923.7
R512.42.219.3
XCR106.516.5
XCR202.211.3
R1001.4
R3001.8
R50.601.8
XCR10.801.7
XCR20.40.91.2
R10.31.21.4
R30.51.21.8
R50.81.21.8
XCR10.60.31.7
XCR201.21.2
R101.41.4
004.3
2004.1
MIP-14.6012.3
MIP-13.206.3
RANTES9.80.914.5
IL83.58.310.5
R12.37.634.7
R33.52.924.4
R50.612.117.5
XCR100.712.4
XCR205.720.8
R1001.4
R3001.8
R50.201.8
XCR10.801.7
XCR20.40.91.2
R10.31.21.4
R30.51.21.8
R50.81.21.8
XCR10.60.31.7
XCR200.21.2
R101.41.4
+
00000.80.8
001.21.22.12.1
002.32.31.31.3
00005.65.6
00001.91.9
PASI < 10
% -
000.20.21.91.9
001.21.22.12.1
001.21.200
003.63.600
PASI20
% -
00000.20.2001.41.40.70.7
00001.21.2001.81.81.31.3
00001.21.20.70.71.81.81.41.4
00001.31.30.50.50.50.51.91.9
00001.91.90.30.31.21.21.61.6
00001.41.40.70.71.31.31.31.3
PASI < 10
PASI (10-20)
PASI>20
% -
00002.32.32.22.21.41.40.70.7
00003.53.51.21.21.81.81.31.3
00000.60.61.21.21.81.81.41.4
0000001.31.31.71.71.91.9
0000001.91.91.21.21.61.6
PASI < 10
PASI (10-20)
PASI>20
% -
00002.32.32.22.21.41.40.70.7
00003.53.51.21.21.81.81.31.3
00000.60.61.21.21.81.81.41.4
0000001.31.31.71.71.91.9
0000001.91.91.21.21.61.6
PASI < 10
PASI (10-20)
PASI>20
% -
00000001.41.4
00000001.81.8
0000.60.6001.81.8
0000.80.8001.71.7
0000.40.40.90.91.21.2
0000.30.31.21.21.41.4
0000.50.51.21.21.81.8
0000.80.81.21.21.81.8
0000.60.60.30.31.71.7
000001.21.21.21.2
000001.41.41.41.4
% -
0001.41.40000
0001.81.80000
0001.81.8000.20.2
0001.71.7000.80.8
0001.21.20.90.90.40.4
0001.41.41.21.20.30.3
0001.81.81.21.20.50.5
0001.81.81.21.20.80.8
0001.71.70.30.30.60.6
0001.21.20.20.200
0001.41.41.41.400
%
000
000
000
000
000
000
000
000
000
000
000
% -
MBD00071D09.unknown
MBD0007F351.unknown
MBD00081C11.unknown
MBD0007C0E9.unknown
MBD000600F4.unknown
MCP-1
F1 F2 F3 F1 F2 F3
1
24.220.526
36.580.81
179.5
8.70.45
10.11
4.414.53
0.0090
0.030
4.0340
/
p=0,044
p=0,031
p=0,035
SampleWellsNumberTNF alphaIFN gammaGM-CSFIL-13IL-12IL-10IL-5IL-4IL-2 -
Un36A677 0.59510.71815.3950.0770.3110.0000.0000.0001.243
Un37B688 0.1540.00013.8740.0290.0000.0000.0000.0000.000
Un38C699 5 0.3170.0000.0000.0000.0000.0000.0004.5420.000
Un39D61010 1.45711.46818.4300.3640.6290.0020.0000.0006.325
Un40E61111 5 0.8491.66436.5291.2063.6460.0100.00010.10712.744
Un06C24040 14.04781.137301.9706.37428.2230.0740.05321.79796.344
Un07D24141 0.0000.0003.1440.0000.1040.0000.0000.0003.139
Un08E24242 5 0.4990.0000.0000.0000.0000.0000.0009.7030.000
Un09F24343 0.1543.9074.6910.0000.0000.0000.0007.7240.000
Un78C114444 5 46.934385.22367.93465.2171.5400.0260.0240.00010.171
Un10G21414 0.3173.9076.2320.0000.0000.0000.0009.5021.873
Un11H21515 0.3614.8857.7670.0040.0000.0000.0009.5020.000
Un12A31616 5 0.1933.9070.0000.0000.0000.0000.0000.0001.243
Un13B31717 0.5470.0006.2320.0000.0000.0000.0005.0842.505
Un14C31818 5 0.1170.0000.0000.0000.0000.0000.0000.0003.774
Un15D32424 0.4990.0003.1440.0000.1680.0000.0000.0000.617
Un16E32525 25.36619.00836.5290.3021.2530.0010.0000.00025.677 -
Un17F32626 5 0.1547.5454.6910.0400.0000.0000.00014.0613.139
Un19H33535 2.3691.66410.8270.0190.0000.0030.0000.0004.410
Un20A43636 1.1180.0006.2320.0110.0000.0000.0000.2980.000
Un21B43737 5 1.6920.0006.2320.0000.0000.0010.0000.4190.000
Un22C43838 5.86615.713150.8790.1062.7690.0020.0000.00010.171
Un43H65151 2.2430.00012.3520.0000.0000.0010.0004.7220.617
Un44A75252 2.7560.0000.0000.0290.0000.0000.0000.0001.243
Un45B75353 5 0.4520.0003.1440.0190.0000.0000.0000.0003.139
Un46C75454 0.4990.0004.6910.0000.0000.0000.0000.0003.774
Un47D75555 1.1181.66418.4300.0910.7130.0000.0000.0005.048
Un48E75656 0.4993.90715.3950.0290.0000.0000.0000.0001.243
Un49F75757 5 7.48572.106171.5034.62414.7320.0520.0298.31078.598
Un50G75858 4.90330.903170.0312.32010.8700.0080.0186.57262.860
Un51H75959 5 1.28515.03063.4620.9701.8360.0000.0000.00020.492
Un24E44545 238.92416.38722.9710.0000.0000.0010.0002.4829.528
Un25F44646 1.0080.0004.6910.0290.0000.0010.0005.4500.000
Un26G44747 5 3.90526.920105.0690.8855.2670.0050.0020.00043.899
Un27H44848 0.7970.00021.4590.1060.0450.0000.0010.00010.813
Un28A54949 5 0.5950.00015.3950.0000.0000.0000.0000.0005.048
Un30C511 1.06312.2037.7670.0000.0000.0010.0000.0000.000
Un31D522 7.01519.00896.1760.6212.1400.0000.0002.00141.290
Un32E533 5 23.0062.85129.0070.1530.7130.3660.0005.0840.000
Un33F544 3.4910.00038.0310.2241.4430.0040.0000.08115.968
Un34G555 5 1.0089.95342.5320.2430.3870.0010.00011.33416.613
Un52A83030 0.5950.00022.9710.2240.0450.0000.0001.53710.813
Un53B83131 0.7451.66419.9450.0910.3110.0000.0002.48212.744
Un54C83232 5 3.28723.96893.2091.2675.2670.0050.0020.08150.429
Un55D83333 1.2855.81019.9450.3430.4650.0000.0000.00010.813
Un56E83434 5 6.32161.366206.7844.89615.4410.0270.01665.09683.852
Un01F11919 26.6620.000131.69548.4586.1114.4600.0114.3630.000
Un02G12020 5.64110.71872.4023.0100.5460.1720.0510.00025.028
Un03H12121 5 0.5950.0009.2980.0770.1680.0010.0000.0003.774
Un04A22222 0.6951.6646.2320.0000.0000.0000.0007.7240.617
Un05B22323 3.49124.56678.3541.1165.1480.0030.0010.00034.124
Un57F8NemikhNemikh 0.6450.0006.2320.2050.0000.0000.0000.0002.505
Un58G8GurievaGurieva 0.4990.0006.2320.0190.1680.0000.0000.0003.139
Un59H8SokolovaSokolova 0.4060.0007.7670.1210.0000.0000.0000.0001.873
Un60A9KraevaKraeva 0.4064.88522.4820.3640.4650.0000.0000.00010.813
Un61B9PavlovPavlov 0.1930.0000.0000.0190.0000.0000.0006.3104.410
Un62C9LozovskayaLozovskaya 1.0080.00012.3521.9960.0000.0010.0000.0004.410
Un18G32929 468.59010.71815.3950.0000.4650.0060.0002.32010.171
Un23D43939 178.29610.7186.2320.0040.0000.0000.0006.9530.000
Un29B55050 1.7511.66425.9910.0640.0001.2370.0007.9195.048
Un35H566 2.11818.36316.9130.1060.0000.0000.0000.0002.505
Un41F61212 1.6329.95329.0070.4301.4430.0120.0006.19417.259
TNF alphaIFN gammaGM-CSFIL-13IL-12IL-10IL-5IL-4IL-2
130.47710.28318.7080.1210.3820.2510.0004.6776.997
203.87159409255.91736661879.0686280550.17838497690.62657425740.55121320743.36978511186.861442873
0.07439777720.00242475540.04517442680.18515218390.16392565820.14439571170.03670321230.2252217881
Un42G61313 20.2431.66413.8740.0290.0000.0000.0004.7221.873
IFN
NumberIFN gamma
385.22
0
1.664
00
7 81.1370
8 3.9070
9 5 0.00010.7180
10 19.0081.6644.885
11 5 7.54500
16.3870
12.203
81.1373.90710.7181.6640.0000.000
0.0004.8850.0000.0000.0000.000
5 0.0003.9070.0000.0000.0001.664
3.9070.00011.46815.7130.00036.75457142860.8141666667
5 385.2230.0001.664102.51490537611.9942928989
0.1241608531
0.031
16.38712.2030.0000.0001.664
0.00019.0081.66410.7183.907
5 26.9202.85123.9680.00072.106
0.0000.0005.8101.66430.903
5 0.0009.95361.36624.56615.030
Nemikh 0.000
Gurieva 0.000
Sokolova 0.0006.05812.5971027423
Kraeva 4.8857.545
Pavlov 0.0000
Lozovskaya 31.4601.66
3.068
6.05134.7056.0517.6999183567
0.9777.0597.83
0.7811.747263517625.16928.8927415452
6.2187.07787562067.67512.1983042355
128.962221.929806885722.18323.6315994804
6,0534,716,057,70
0,982,197,067,836,0612,60
5 0,781,7525,1728,89
6,227,087,6812,20
5 128,96221,9322,1823,63
16.387
12.2033.9071.664
0.00010.71881.137
0.0001.6640.000
1.66416.387
12.203
0.000
1.664
0.000
5.8186.350968282527.60046.3715778504
81.1371.664
3.9070.000
10.7181.664
16.387
12.203
0.000
20.72530.17801606911.1090.9607108479
0.003
0.0000.01
0.00081.137
0.0003.907
0.00010.718
0.0001.664
0.0000.001
0.00016.387
0.00012.203
0.0000.001
0.0000.000
0.0001.664
0.0004.800
IFN
00000
00000
00000
00000
00000
TNF
00000
00000
00000
00000
00000
GM-CSF
0
0
0
0
0
0
0
0
0
0
0
0
0
\
TNF-
IL-10
NumberTNF alpha
46.93
0.117
0.849
0.499
7 14.047
8 0.317
9 5 0.4990.595
10 25.3662.369
11 5 0.1542.2430.645
238.9240.499
1.0630.406
14.0470.3170.5952.3692.2430.5950.406
0.0000.3610.1541.1182.75626.6620.193
5 0.4990.1930.3171.6920.4521.1181.008
0.1540.5471.4575.8660.49924.0230.526
5 46.9340.1170.84963.32477129690.2781736268
38.75342148760.1982011599
238.9241.0630.59526.6621.1180.035
1.0087.0150.7455.6410.499
5 3.90523.0063.2870.5957.485
0.7973.4911.2850.6954.903
5 0.5951.0086.3213.4911.285
Nemikh 0.64553.672104.1569024707
Gurieva 0.4992.9823.0984473208
Sokolova 0.4067.6568.9256319552
Kraeva 0.4062.2341.8733459905
Pavlov 0.1932.5402.3929811951
Lozovskaya 1.008
0.5260.2781736268
3,915,7453,67104,160,530,28
0,881,132,983,10
5 0,630,617,668,93
1,712,382,231,87
5 15,9726,822,542,39
3.9145.7404513063
0.8781.13433160940.31714.047
0.6310.60531504190.5952.369
1.7052.3757327922238.9242.243
15.96726.8211.063
0.595
26.662
1.118
38.46888.91978890686.2206.7789622608
2.24314.047
26.6620.317
1.1180.595
238.924
1.063
0.595
10.00814.43404033342.59096.3331725968
( )
11.00814.0471.008
11.0080.3171.008
11.0080.5001.008
11.0082.5691.008
11.0082.0431.008
11.00823.8921.008
11.0081.0631.008
11.0080.5001.008
11.00826.6621.008
11.0081.6181.008
0.51.0080.1931.008
2.51.0080.6451.008
0.193
0.645
IL-10
00000
00000
00000
00000
00000
IL-13
00000
00000
00000
00000
00000
IL-12
0010
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
#!
( )
TNF-alpha /
TNF-alpha
IL-5
0
0
0
0
0
0
0
0
0
0
0
0
0
0
/
TNF
IL-4
NumberGM-CSF
67.93
0
36.5
7 3.1446.232
8 301.96.232
9 5 3.1446.2327.767
10 36.52915.39524.482
11 5 4.69110.8270.000
9.51112.35212.352
22.971
301.9706.23215.39510.82712.3527.767
3.1447.76713.8746.2320.00022.971
5 0.0000.0000.0006.2323.144131.695
4.6916.23218.430150.8794.69118.430
5 67.9340.00036.52947.00814285719.511
81.10204886238.33314419450.1482738328
22.9717.76722.971131.69518.430
4.69196.17619.94572.40215.3950.357
5 105.06929.00793.2099.298171.503
21.45938.03119.9456.232170.0313.144
5 15.39542.532206.78478.35463.4623.97
6.232
15.395
10.827
Nemikh 6.23212.352
Gurieva 6.23222.971
Sokolova 7.7679.5118.33314419457.767
Kraeva 24.48222.971
Pavlov 0.000100.000
Lozovskaya 12.35218.430
24.400
69,36130,0840,7751,21
6,205,2241,7240,149,518,3324.400
5 1,882,7981,6264,73
36,9863,9351,1467,41
5 34,8234,0081,3174,03
301.9703.1440.0004.69167.93422.9714.691105.06921.45915.395
6.2327.7670.0006.2320.0007.76796.17629.00738.03142.532
15.39513.8740.00018.43036.52922.97119.94593.20919.945206.784
10.8276.2326.232150.879131.69572.4029.2986.23278.354
12.3520.0003.1444.69118.43015.395171.503170.03163.462
301.9706.232
10.82715.395
12.35222.971
7.767
22.971
131.695
18.430
108.383167.652993808632.20944.3714112416
301.97010.827
6.232131.695
15.39518.430
22.971
7.767
22.971
62.884117.346281106253.65167.6951983255
IL-4
000000
000000
000000
000000
000000
IL-2
00000
00000
00000
00000
00000
NumberIL-10
0.01
0.026
0
7 00.000
8 0.0740.000
9 5 0.0000.0740.0000.0030.0010.0000.000
10 0.0000.0000.0000.0000.0000.0030.000
11 5 5 0.0000.0000.0000.0010.0000.0010.000
0.0020.0000.0000.0020.0000.0010.000
40 5 0.0100.0260.0000.0010.000
41 0.0000
42 5 0.000
43 0.000
44 5
0.00892307690.2095488804
14 0.0208744722
15 0.121
16 5
17
18 5
24 0.000
25 0.001 -
26 5 0.000
35
36
37 5
38
51
52
53 5
54
55
56
57 5 0.0010.0010.0004.4600.000
58 0.0010.0000.0000.1720.000
59 5 5 0.0050.3660.0050.0010.052
0.0000.0040.0000.0000.008
45 5 0.0000.0010.0270.0030.000
46
47 5
48
49 5
1
2
3 5
4
5 5
30
31
32 5
33
34 5
19
20
21 5
22
23 0.0000.0000.0000.0000.0000.0010.0010.0050.0000.000
0.0000.0000.0000.0010.0000.0010.0000.3660.0040.000
0.0020.0000.0000.0020.0000.0000.0000.0050.0000.001
4.4600.1720.0010.0000.027
0.0000.0000.0520.0080.003
0.0000.010
0.0740.026
Nemikh 0.0000.0000.000
Gurieva 0.0000.003
Sokolova 0.0000.001
Kraeva 0.000
Pavlov 0.000Descriptive Statistics
Lozovskaya 0.001NMinimumMaximumMeanStd. Deviation
IL10500.0740.01560.0326695577
IL105300.0260.0120.013114877
Valid N (listwise)3
0,020,030,891,990Descriptive Statistics
00,030,08NMinimumMaximumMeanStd. Deviation
5 00,090,16IL10504.460.89241.9943490918
00IL101500.1720.03460.0768101556
5 0,010,010,000,01IL10550.0010.3660.08580.158037021
IL10500.0080.00240.0035777088
IL105500.0270.00620.0116918775
Valid N (listwise)5
00.0740.0030.000
00.0034.4600.074
0.0000.0010.0000.000
4.4600.001
0.0000.001
0.0010.000
0.001
1.4882.57411661220.0130.0300510676
0.63742857141.68559562740.0260.0415812458
00000
00000
00000
00000
00000
_
NumberIL-13
65.217
1.206
0
6.3740.0770.0000.0190.00000.205
8 0.0000.0290.0040.0110.0296.3740.019
9 5 5 0.0000.0000.0000.0000.0190.0770.1210.001
10 0.0000.3640.0000.1060.00000.3646.37
11 5 5 6.5001.2060.0000.0190.0190.077
01.9960.001
00.019
41 2.56900.001
42 5 0.2240.001
43 48.460.001
44 5 0.0910.224
8.69057142860.45448.46
14 20.72978404170.7664468670.091
15 0.4490.019
16 5 0.23006329731.9
17 0.019
18 5 1.9
24 0.000
25 0.302 -
26 5 0.040
35
36
37 5
38
51
52
53 5
54
55 0.0000.0000.22448.4580.091
56 0.0290.6210.0913.0100.029
57 5 5 0.8850.1531.2670.0774.624
58 0.1060.2240.3430.0002.320
59 5 5 0.0000.2434.8961.1160.970
45
46
47 5
48
49 5
1
2
3 5
4
5 5
30
31
32 5
33
34 5
19
20
21 5
22
23
6.3740.0000.0000.00065.2170.0000.0290.8850.1060.000
0.0770.0290.0000.3641.2060.0000.6210.1530.2240.243
0.0000.0040.0000.0000.0000.2240.0911.2670.3434.896
0.0190.0110.0000.10648.4583.0100.0770.0001.116
Nemikh 0.2050.0000.0290.0190.0000.0910.0294.6242.3200.970
Gurieva 0.0190.4540.766446867
Sokolova 0.121Descriptive Statistics
Kraeva 0.364Descriptive StatisticsNMinimumMaximumMeanStd. Deviation
Pavlov 0.019NMinimumMaximumMeanStd. DeviationIL135048.4589.754621.6360527546
Lozovskaya 1.996IL13506.3741.2942.8399817781IL13150.0293.010.7561.2843309542
L131500.0290.01460.0137222447IL13550.0774.6241.40121.8696537647
IL135500.0190.00380.0084970583IL13502.320.59860.9708052328
IL13500.3640.0940.1577593103IL135504.8961.4451.9859566964
IL1353065.21722.14137.3097834488Valid N (listwise)5
Valid N (listwise)3
1,292,849,7521,64
0,010,010,761,280,450,77Descriptive Statistics
5 0,000,011,401,87NMinimumMaximumMeanStd. Deviation
0,100,160,600,97IL135048.4589.754621.6360527546
5 22,1437,311,451,99IL13150.0293.010.7561.2843309542
IL13550.0774.6241.40121.8696537647
IL13502.320.59860.9708052328
IL135504.8961.4451.9859566964
Valid N (listwise)5
6.3740.077
0.0000.000
0.0190.000
0.000
0.224
48.458
0.091
2.1313.674558068736.581770831218.2908854156
6.3740.019
0.07748.458
0.0000.091
0.000
0.000
0.224
1.1132.579071286316.18927.9455082676
NumberIL-12
1.54
3.646
0
7 28.330.000
8 0.3110.168
9 5 00.000
10 00.465
11 5 28.2230.3110.0000.0000.00000.000
0.1040.0000.0000.0000.00000.000
40 5 0.0000.0000.0000.0000.00000.106
41 0.0000.6290.0002.7690.0000.0450.1885033156
42 5 5 1.5403.6460.0006.111
43 0.713
44 5 3.13046153850.1830956386
7.7932021084
14
15 0.353
16 5
17 20
18 5 0.311
0
24 0.168 0
25 1.253 -0
26 5 0.0000
0
35 0.045
36 6.111
37 5 0.9
38
51
52
53 5
54
55
56
57 5 0.0000.0000.0456.1110.713
58 0.0002.1400.3110.5460.000
59 5 5 5.2670.7135.2670.16814.732
0.0451.4430.4650.00010.870
45 5 0.0000.38715.4415.1481.836
46
47 5
48
49 5
1
2
3 5
4
5 5
30
31
32 5
33
34 5
19
20
21 5
22 0.3110.1040.0000.0001.5400.0000.0005.2670.0450.000
23 28.2230.0000.0000.6293.6460.0002.1400.7131.4430.387
0.0000.0000.0000.0000.0000.0450.3115.2670.46515.441
0.0000.0000.0002.7696.1110.5460.1680.0005.148
0.0000.0000.0000.0000.7130.00014.73210.8701.836
Descriptive StatisticsDescriptive Statistics
Nemikh 0.000NMinimumMaximumMeanStd. DeviationNMinimumMaximumMeanStd. Deviation
Gurieva 0.168IL125028.2235.706812.5876588252IL12506.1111.37382.6654306781
Sokolova 0.0000.1060.1885033156IL121500.1040.02080.0465102139IL121502.140.59940.8913522312
Kraeva 0.465IL12550000IL12550.16814.7325.22945.8377622682
Pavlov 0.000IL12502.7690.67961.19934578IL125010.872.56464.6789831481
Lozovskaya 0.000IL125303.6461.72866666671.8303074423IL1255015.4414.56246.410335038
Valid N (listwise)3Valid N (listwise)5
5,7112,591,372,67
0,020,050,600,890,110,19
5 05,235,84
0,681,202,564,68
5 1,731,834,566,41
0.31128.223
0.0000.000
0.7130.000
6.111
0.045
0.000
0.000
1.0262.25783109169.40816.2945566473
0.00028.223
6.1110.311
0.7130.000
0.000
0.000
0.045
2.2753.34143417314.76311.4935628491
00000
00000
00000
00000
00000
NumberIL-5
0
0.024
0
7 00
8 0.00530
9 5 0.0000.0530.0000.0000.0000.0000.000
10 0.0000.0000.0000.0000.0000.0000.000
11 5 5 0.0000.0000.0000.0000.0000.0000.000
0.0000.0000.0000.0000.0000.0000.000
40 5 0.0000.0240.0000.000
41 0.000
42 5 0.000
43 0.011
44 5 0.0000.1638662041
0.0028785714
14 0.0068448946
15
16 5 0.376
17
18 5
24 0.000
25 0.000 -
26 5 0.000
35
36
37 5
38
51
52
53 5
54
55
56
57 5 0.0000.0000.0000.0110.000
58 0.0000.0000.0000.0510.000
59 5 5 0.0020.0000.0020.0000.029
0.0010.0000.0000.0000.018
45 5 0.0000.0000.0160.0010.000
46
47 5
48
49 5
1
2
3 5
4
5 5
30
31
32 5
33
34 5
19
20
21 5
22
23
0.0000.0000.0000.0000.0000.0000.0000.0020.0010.000
0.0000.0000.0000.0000.0000.0000.0000.0000.0000.000
0.0000.0000.0000.0000.0000.0000.0000.0020.0000.016
0.0110.0510.0000.0000.001
Nemikh 0.0000.0000.0000.0290.0180.000
Gurieva 0.0000.0000.000
Sokolova 0.0000.0530.024
Kraeva 0.0000.0000.000
Pavlov 0.0000.000
Lozovskaya 0.0000.000
Descriptive Statistics
NMinimumMaximumMeanStd. Deviation
IL5_500.0530.01060.0237023206
IL55300.0240.0080.0138564065
Valid N (listwise)3
0,010,020Descriptive Statistics
00,010,020NMinimumMaximumMeanStd. Deviation
5 00,000,01IL5500.0110.00220.0049193496
00,000,01IL51500.0510.01020.0228078934
5 0,010,010,000,01IL55500.0290.00660.012561847
IL5500.0180.00380.0079498428
L55500.0160.00340.0070569115
Valid N (listwise)5
0.0000.053
Recommended