Цитокинодиагностика: прошлое, настоящее и будущее

: ,

-

-2011

, 5 2011

(2) IN VIVO

IN VITRO ( in vivo)

IN VITRO (, ) (, ..)

(3) IN VITRO

IL-8

1

201570

*

*

-

-

--

IL-8 ng/ml

1

GBSLPS

2095800

-1525750

-720600

--0.10.3100

GBSLPS

2095800

-1525750

-720600

--00.3100

GBSLPS

95800

-25750

-20600

--1100

LPS

800

-750

-600

--100

1

000

000

000

000

GBS

LPS

IL-8 ng/ml

IL-8

2

*

-

-

--

IL-8 ng/ml

LPS

3

*

*

*

-

-

--

IL-8 ng/ml

GBS

*

*

-

-

--

IL-8 ng/ml

IL-8

2

9525201

*

*

*

-

-

--

IL-8 ng/ml

GBS

1

GBSLPS

2095800

-1525750

-720600

--0.10.3100

GBSLPS

2095800

-1525750

-720600

--00.3100

GBSLPS

95800

-25750

-20600

--1100

LPS

800

-750

-600

--100

1

000

000

000

000

GBS

LPS

IL-8 ng/ml

IL-8

2

*

-

-

--

IL-8 ng/ml

LPS

3

*

*

*

-

-

--

IL-8 ng/ml

GBS

*

*

-

-

--

IL-8 ng/ml

IL-8

3

800750600100

*

-

-

--

IL-8 ng/ml

LPS

1

GBSLPS

2095800

-1525750

-720600

--0.10.3100

GBSLPS

2095800

-1525750

-720600

--00.3100

GBSLPS

95800

-25750

-20600

--1100

LPS

800

-750

-600

--100

1

000

000

000

000

GBS

LPS

IL-8 ng/ml

IL-8

2

*

-

-

--

IL-8 ng/ml

LPS

3

*

*

*

-

-

--

IL-8 ng/ml

GBS

*

*

-

-

--

IL-8 ng/ml

IL-8

xMap 100 = 100 xMap

() 100

- Luminex-100Luminex-200MAGPIXLuminex FLEXMAP 3D

()

..

Th1 Th2

, Me [LQ; HQ]

IL-8 (/)

1

407925991047

10 / 1 / 1

2200620540440010401800

38010808003002500840

1100240066070004400940

80017002200620034003000

1100220026023006201500

20002200940540017001060

10

480340740660094003000

012404060017001500

351284413533098561

2500116023003400100001160

70094026083501800400

11401100116036004000

-8 ( 10 )

-8 ( 10 )

.

/ 1 / 1

2200620540440010401800

012404060017001500

1100240066070004400940

1100220026023006201500

20002200940540017001060

11401100116036004000

70094026083501800400

80017002200620034003000

480340740660094003000

38010808003002500840

2500116023003400100001160

351284413533098561

.

Ig Q

1

(, , , , )

/ 1 / 1

700940260835018004005608.333333333321601450

800120022006200340030001316.66666666671593.3333333333810

1100240066070004400940

20002200940540017001060

2200620540440010401800

1100220026023006201500

( , . , / ,

25001160230034001000011602250.65339.61412.2

4803407406600940030002250.6789.6864.2

351284413533098561

38010808003002500840

012404060017001500

LFS

group 1560821601250

group 2225053391350

NW

group 116161500810

group 22250789764

1

Ig

Ig

group 1

group 2

before RL 24h after 5 days after

IL-8 dynamics in sinuses lavage fluid

group 1

group 2


IL-8 dynamics in nasal washes

(, , , , )

Q(IgA)Q(IgM)Q(IgG)Q(sIgA)

/ 1 / 1 / 1 / 1

6.55.82.50.90.010.013.70.92.4

33.46.92.14.429.249.91.43.974.5715.920184.5

-13.668.413.61.180.434.180.21.22.817.817.120

12.616.163.30.010.182.4104.63.517.852068

14.84.832.40.890.480.091.268.2023.830.516.2

64.471.317.64.471.440.7913.82.16071.813.512.6

6944314.396.160.8241.13.94.8392512.2

15.38.74.030.010.010.010.682.33.818.42107.1

21.722.913.61.450.910.29194623324930

36.131.7131.610.29

16.925.4291.530.81.22000.78509242504577

9232.628.540.71.251.4000

45.973.56.693.631.410.542.755.3913021687599.7

31.817.716.75.282.82.152.500

64.930.69.681.160.790.084.781.354.535.433.422.78

2.34.81.70011.7

140.664.1411.563.60.442.516.133.62539542384278

..17.698.6436.10.310.640.04

38.855555555634.88540.69666666671.85944444442.83944444444.24

1-2

1-3

( , . , / ,

75.220.2222.560.010.011414.10.7228.5717.424

42.972.3137.23.81.030.850.711.790.25

10.1317.259.40.010.010.011.081.484.2416

30.215.119.113.50.010.018.13.42.526.81916

36.417.19.20004.428.3

39.134.541.52.192.092.083.546.253.467110714

25.328818.42.542.51.5841.15.91.519.296.836.8

23.1781.113.131.3241.71.160.9629.61.3

23.329.940.91.751.652.2401.261.4353506696

1833.628.70.690.640.632.100.4853565017712090

..17.5284.531.313.911.21.023.08

29.27.899.382.120.060.241.080.280

5.092.413.034.894.824.74

31.857.526.40.5222.90.460.01

20.733.836.91.672.1411.30.44

2.4213.93.50.976.74.239.506

9.6114.2131.125.30.6750.14.53.37

50.8251.933.53.6512.61.081.044.991.8

15.54236.21.032.690.655.84.50.138.327.320.5

7.6814.92.092.5158.60.91308070275.85

26.7864.7227.982.969.9931250.99375

1-20.046

1-30.856

407925991047

9581061697

acute phase of the disease

subacute phase of the disease

reconvalescents

IL-8 (pg/ml)

(, , , , )

IgA /IgM /IgG /sIgA /IgE / /

/ 1 / 1 / 1 / 1 / 1 / 1

9.846.542.71.590011.828.466.062.470.780.390.1660.0420.12

86.459.88556.0643.885.8660.4863.53427.20.070.080.7000.050.1351.65

-30.64127.2821.80.841.062.2216.7819.6456.320.050.060.060.390.160.460.0080.0470.11

7.224.8458.200.483.38.2210.3218.480.050.060.170000.010.20.15

68.517.210.120.80.423.412.20.050.320

109.532.8228.626.481.561.593.048.647.020.280.050.073.510.781.390.140.250.14

126.3654.246.6813.3818.542.1642.4855.89.720.090.070.050.490.450.151.730.1410.175

44.7623.0490.300016.6213.0822.50.070.30.090.160.10.0280.0930.157

75.46107.8352.253.642.730.9340.6923.184.869.0913.4828.990.10.020

54.1948.2637.811.861.070.3956.5531.7613.09

345.7674.4219.763.10.941.937.7228.9627.0215.4311.7311.58000.03

36.1555.8241.480.972.071.4622.3748.5536.73000

119.88216.130.845.082.241.26192.1642.5632.164.8614.684.420.140.10.2

47.9762.8152.246.296.736.67129.48151.768.120.100

10.8620.0423.49007.7434.4424.83.8000

125.16155.022.912.917.650.8465.01169.8326.554.8110.563.67000

..39.1275.92227.061.170.941.96153.7810.5230.56

78.691176470668.352941176558.89764705883.18647058825.30647058827.38687559.1242.560588235349.3868753.485.64111111115.0010.77222222220.291250.27666666670.1940.10369230770.2101538462

1-20.613

1-30.293

55.6219.6228.142.460040.869.780.080.040.060.1700.140.60.60.03

79.82116.46215.371.41.591.299.4512.958.160.10.080.220.030.070.01

8.16.69.7800014.585.344.740.040000.040.060.16

61.9239.0635.8814.700119.9414.586.960.110.040.080.230.080.060.3380.1390.104

10.969.90008.826.183.20.1100.1970.119

156.24128.46122.522.521.861.531.3815.368.640.30.30.072.290.870.420.140.250.14

78.7812356.823.7832.762.4648.12141.2432.760.050.30.1400.1801.730.240.06

84.12283.8622.982.1655.50.7241.1362.826.60.5461.110.240.041.150.05

68.4882.79118.871.861.652.8760.3356.4266.2916.0517.4100.060.07

67.73100.51105.591.240.140.1912.610.311.5824.0659.2117.41

..140.22143.76106.3811.0170.0200.012011.21.023.08

1.080.280

5.092.413.03

102.48158.6787.481.841.490.9102.81368.8230.690000.13

25.525.5633.61.028.130.080.420.017

17.2536.7164.051.91.157.7562.6540.9520468.8663.7250.280.3900.24

5.7193.625.0463.391225.1441.820.13.11.6620.190.14

113.2675.12834.5221.541.8326.5172.615.330.120.080.12

33.8469.7278.122.644.21.3236.334.0828.620.180.090.090.210.1600.2090.1070

25.243.267.282.4161.81.136.5417.58.711.8520.3823.4000

66.4388235294121.356470588273.491253.39532.331251.68562544.0811111111155.642530.4918756.58510.057.33254.84866666678.62613333333.79571428571.447750.44468750.4538125

1-20.260.0670.162

1-30.930.1910.283

0.150.150.15

78.768.3558.893.185.317.3859.1242.649.383.485.650.770.290.270.190.10.21

66.43121.473.53.3932.331.6844.08155.630.496.510.17.334.848.63.791.440.440.45

IgA78.768.3558.89

IgG59.1242.649

IgM3.1857

sIgA35.65

IgA66.43121.473.5

IgG44.0816030.49

IgM3.3932.331.68

sIgA6.5107.33

acute and subacute phase of the disease56.13

reconvalescents2.79

acute phase of the disease958

4079subacute phase of the disease1061

2599reconvalescents697

1047

&A

&P

&A

Page &P

IgA

IgG

IgM

sIgA

btforeRL 24h after 5 days after

mg/l

mg/l

group 1

IgA

IgG

IgM

sIgA


mg/l

mg/l

group 2

acute and subacute phase of the disease

reconvalescents

The level of TNF- in lavage fluid from sinusis

The level of IL-8 in lavage fluid from sinusis patients with acute suppurative sinusitis



reconvalescents

The level of IL-8 in nasal washes patients with acute suppurative sinusitis



reconvalescents

The level of IL-8 in nasal washes patients with acute suppurative sinusitis

(, , , , )

IgA /IgM /IgG /IgE /sIgA / /

/ 1 / 1 / 1 / 1 / 1 / 1

?64.0283.8237663.4215.3102.9630.42236.221241.58 0003.040.3851.21

-23.5418.32217.083.523.3836.9861.0456.2354.120.270.516.471.195.7237.80.870.3613.76

8.423.9453.640.62.287.3811.9415.1228.62000.116.5427.4629.840.0890.660.2

301.2132.54933.514.43.5204.2280829.162.240.790.671.130.04

63.7828.9887.965.424.5414.82130.6282.8649.3215.920.8306.4201.072.50.570.37

?18.96322.3429.0212.7897.6212.4209.22259.4443.149.0911.50.41.320.084

?19.6228.9866.6030.78015.782112.4802.340.10.053.850.016

105.898.375.0373.6755.7428.08378.281.620.512.292.2123.59.232.940.37

57.466.6855.9149.0454.2919-Jan16319874911.70.45

1863.36540.1251.38168.68131.223.961855.08646.65.6278.1754.382.531.9238.40.125

49.6353.6861.5646.317.5617.61032.6350.64219.788.70.1230.363

18.96322.3329.0212.7897.6212.411.7611.948.8411.6851.3645.572.98.670.3

62.8156.429.43107.357.8733.95476.230025093.6322.36168.210.81.40.77

16884.811778.542.46.5467111210115.773.180.2546.85.1613.778.81.520.294

93726.2651639514815323

114.515548.8462.764.8936291.21240.48106.9100.8806.4201.071.578.360.66

290.156.6434.2650.132.15.8250.132.15.8220.0418.413.910.8650.7460.155

160.5622.9847.2823.585.580.72151.5621.248.11.380.610.11

199.45117.3964705882125.232352941252.493333333344.976111111119.3611111111347.7738888889185.58153.323888888910.25666666675.3481.11129.31818.70542.7263.895.0890.545

1-20.0430.0590.6880.2930.658

1-30.00890.028690.0530.4490.042

30.8441.5815.94.3819.38013.246.446.541.6417.910.850.2911.750.12

164.22250116.52354.84389.566.96327.423409.4815.9223.310.115.40.33

300239.34110.1196.2203.9435.04103.26350.64219.789.162.240.7935.1312.194.487.63.20.812

49.6353.6861.5646.3175.617.644.4673.328.581.9723.520.46100.9843.8533.480.559.60.55

28.98443.7167.5211.04108.6610.6876.44970.86124.740.090.410.151.9920.10.8122.1750.323

160.5444.3354.610112019125514603141691559.56.0850.31

105.95135.675.46.4211.687.9158.1107.39127.1633100.6516.770.240.280.42

99.59443.06125.044046.8115.85112.58217.5844.2185.5932.25341.1710.13

..

101.34112.669261.14526.6696.95.580.63

43.266.4283.2812.668.972.42113252.75197.46126.53136.5773.841.936.63.26

94146100224261992621161.250.610.06

7995560.3615123141510.811.890.13

5983.5663.9511629871251.60.90.621.90.170.1

74106682120.4425569114.931.41.10.2250.44

17437513112.9844.119200511240.7928.480

..226115004688406119277

99.140625227.92375127.3762.668666666790.609333333314.564190.34625437.665103.54687522.574444444428.131.508888888976.2565.132.512.182.910.54

1-20.01360.0006420.003480.2610.6550.5025045977

1-30.4530.060.19650.260.0460.0398477097

293.761246.89186.780.2118.483300.84319.380.940.530

169.0220.76663.625.863.928.8680.4622.02245.880.070.030.14

199.115117.39125.1252.544.919.3634718515310.25.31.129.318.742.73.85.10.5

99.14227.9127.462.6790.6114.6190.36437.66103.5422.5728.131.576.2565.132.512.182.910.54

0.150.150.15

group 1199.115117.39125.1252.544.919.3634718515329.318.742.7

group 299.14227.9127.462.6790.6114.6190.36437.66103.5476.2565.132.51

IgA199.115123125.12

IgG347185153

IgM52.544.919.3

sIgA291842

IgA99.14227.9127.4

IgG190.36440103.54

IgM52.696.619

sIgA76.2565.132.51

&A

&P

&A

&P

&A

&P

&A

&P

&A

&P

&A

&P

&A

&P

&A

&P

&A

&P

&A

&P

&A

&P

&A

&P


g/l

Albumin level in sinuses lavage fluid

IgA

IgG

IgM

sIgA


mg/l

mg/l

group1

IgA

IgG

IgM

sIgA


mg/l

mg/l

group 2

IL-1, IL-6, IFN-, G-CSF (/) **

**

**

***

*

1

18.043.47

Sheet1

IL-6

18.04

3.47

1

0.3260.055

3.4210.779

1.6140.403

Sheet1

IL-1betaIFN-gammaG-CSF

0.3263.4211.614

0.0550.7790.403

IL-1, IL-6, IFN- (/) , , IgG/IgM

: 1 - - 2 - IgG - 3 - IgG/IgM*p

(n=105)* (n=61)** (n=15)*

1

16.39

18.03

21.31

21.9

29.5

43.8

49.5

50.8

50.8

68.5

79

80

% /

Sheet1

IFN-gamma*G-CSF*IL-1beta* IL-6*-**

% / 16.3918.0321.3121.929.543.849.550.850.868.57980

(/) , , p

IL-2, IL-6, IL-10, GM-CSF, IFN- TNF- (/) PASI , p

(/) , - , p

IL-8, IL-10, GM-CSF, IFN- TNF- (/) PASI , p

IL-6 (r=0,4, p

*********- p

******* p20

00.21.40.7

201.21.81.3

MIP-10.71.21.81.4

MIP-10.51.30.51.9

RANTES0.31.91.21.6

IL80.71.41.31.3

PASI < 10PASI (10-20)PASI>20

02.354.96.6

202.354.96.6

MIP-14.610.511.817.4

MIP-13.26.410.99.5

RANTES9.812.113.815.8

IL83.55.86.49.9


02,351,54,92,36,63,4

202,351,54,92,36,63,4

MIP-14,61,610,51,311,81,917,42,4

MIP-18,22,16,41,810,91,64,53,1

RANTES9,82,312,11,913,81,715,83,6

IL83,51,25,82,66,41,49,94,5


R124.331.935.436.4

R315.624.923.226.9

R512.417.321.625.4

XCR1010.917.719

XCR205.913.217.2


R131,31,831,92,535,43,136,42,2

R320,13,624,92,723,22,926,92,4

R513,42,617,31,821,61,425,43,5

XCR1010,91,617,71,819,02,5

XCR205,91,413,21,517,24,3


R131.329.636.439.2

R320.122.727.229.5

R513.615.820.621.1

XCR108.710.921.9

XCR2020.919.322.6


R131,31,829,62,933,51,939,21,4

R320,13,622,73,127,21,829,52,1

R513,42,615,81,520,61,821,12,3

XCR108,71,810,91,921,93,4

XCR2020,91,919,32,422,65,4


R12.32.21.40.7

R33.51.21.81.3

R50.61.21.81.4

XCR101.31.71.9

XCR201.91.21.6

005.3

2004.8

MIP-10012.5

MIP-11.3307.4

RANTES10.397.915.4

IL86.390.86.4

R124.31.834.2

R315.64.923.7

R512.42.219.3

XCR106.516.5

XCR202.211.3

R1001.4

R3001.8

R50.601.8

XCR10.801.7

XCR20.40.91.2

R10.31.21.4

R30.51.21.8

R50.81.21.8

XCR10.60.31.7

XCR201.21.2

R101.41.4

004.3

2004.1

MIP-14.6012.3

MIP-13.206.3

RANTES9.80.914.5

IL83.58.310.5

R12.37.634.7

R33.52.924.4

R50.612.117.5

XCR100.712.4

XCR205.720.8

R1001.4

R3001.8

R50.201.8

XCR10.801.7

XCR20.40.91.2

R10.31.21.4

R30.51.21.8

R50.81.21.8

XCR10.60.31.7

XCR200.21.2

R101.41.4

+

00000.80.8

001.21.22.12.1

002.32.31.31.3

00005.65.6

00001.91.9

PASI < 10

% -

000.20.21.91.9

001.21.22.12.1

001.21.200

003.63.600

PASI20

% -

00000.20.2001.41.40.70.7

00001.21.2001.81.81.31.3

00001.21.20.70.71.81.81.41.4

00001.31.30.50.50.50.51.91.9

00001.91.90.30.31.21.21.61.6

00001.41.40.70.71.31.31.31.3

PASI < 10

PASI (10-20)

PASI>20

% -

00002.32.32.22.21.41.40.70.7

00003.53.51.21.21.81.81.31.3

00000.60.61.21.21.81.81.41.4

0000001.31.31.71.71.91.9

0000001.91.91.21.21.61.6

PASI < 10

PASI (10-20)

PASI>20

% -

00002.32.32.22.21.41.40.70.7

00003.53.51.21.21.81.81.31.3

00000.60.61.21.21.81.81.41.4

0000001.31.31.71.71.91.9

0000001.91.91.21.21.61.6

PASI < 10

PASI (10-20)

PASI>20

% -

00000001.41.4

00000001.81.8

0000.60.6001.81.8

0000.80.8001.71.7

0000.40.40.90.91.21.2

0000.30.31.21.21.41.4

0000.50.51.21.21.81.8

0000.80.81.21.21.81.8

0000.60.60.30.31.71.7

000001.21.21.21.2

000001.41.41.41.4

% -

0001.41.40000

0001.81.80000

0001.81.8000.20.2

0001.71.7000.80.8

0001.21.20.90.90.40.4

0001.41.41.21.20.30.3

0001.81.81.21.20.50.5

0001.81.81.21.20.80.8

0001.71.70.30.30.60.6

0001.21.20.20.200

0001.41.41.41.400

%

000

000

000

000

000

000

000

000

000

000

000

% -

MBD00071D09.unknown

MBD0007F351.unknown

MBD00081C11.unknown

MBD0007C0E9.unknown

MBD000600F4.unknown

***** p20

% -

1

actinCCR1CCR3CCR5eotaxineotaxin 2MIP alphaMIP betaRANTESCXCR1CXCR2IL8

/-IL2IL4IL6IL8IL10GM-CSFIFN gammaTNF alpha-IL2IL4IL6IL8IL10GM-CSFIFN gammaTNF alpha

21.09.2007 ( R1)0457.636.38.134.25.15.66.44.23.502.10003.345.66.834.51.61.8 000.510.740000.11

7.09.2007 ( R1) 0.2801.340.800.1850.43 0.1101.090.120000

44.715.511.4003.8151.7722.65.3

3.07.2007 ..99.599.879.652.781.251.785.939.71.32.71.2046.831.290.51.97.605454.385.696.11.227.3 008.0644.85100.95.40

3.07.2007 .. 002.5480006.30

94.993.196.994.640.438.813.347.413.172.595.721.3

7.09.2007 ( R1)38.381.253.347.135.532.517.78.410.6035.320.30.2051.611.971.145.666.698.326.536.4

6.02.2007 ( 1)31.13.592.93.7604.331.71.500000024.200039.7074.701.50 000.3960.576000.5130.081

6.02.2007 ()90.90475157.659.112.663.11.4001.7020.104.21.93.42.17.6201.66.374.6 0.0903.0420.87301.3862.2860.306-0.253.590.020.420.240.852.910.56

6.02.2007 ( )90.288.662.699.45.477.731.835.101.405.4023.7023.2014.618.558.716.250.97.98.6 001.7550.2160000

( )68.357.534.318.938.123.533.339.98.500.33.700009.610.604.307.703 001.4850.0990000-0.253.680.082.020.250.592.990.5

28.02.2007 ()( , ) 0.02700.2610.39600.2071.4040.243

?????????

28.02.2007 ( 2 )015011.414.88.124.312.596.56488.451.299.7373.81.645.811.499.431.485.734.8293.9 0.1801.1520.9630.090.5765.310.819-0.133.1958.261.420.191.111.490.44

0003.26701.1254.50

28.02.2007 (3) ( , ) 0.0900.5850.63900.3330.6660.099-0.172.892.092.830.260.741.910

?????

28.02.2007 ()-0.424.52.2126.170.180.811.660.44

16.03.2007 (7)14.1027.73.123.9022.11.71.213.102.51.33.32.118.35.87559.318.322.51.91.71.5 0.09900.4230.36900.1531.9890.351

6.03.2007 (5. )45.35031.879.243.47317.93.317.22.304.842.9014.1547.1544.54.8084.321.924.8-0.554.070.271.290.180.851.250.63

6.03.2007 (6)48.615.534.427.545.424.573.421.16.52.431.311.14.901.702.17.668.32.525.623.23.51.3 0.05401.5480.14400.3061.4760.333-0.162.640.392.290.251.042.820.13

16.03.2007 (8)12.595.452.94519.630.119.513.52.601.50011.31261.31.506.23.879.818.629.4

16.03.2007 (9)54.468.110.672.5265.317.246.44.93.25.25.17.541.73.448.37.85013.602.237.9

( )45.350.731.843.49.217.97317.23.302.342.94.814.107.15544.844.584.3024.821.93.5 001.0710.81000.0720

( )58.240.467.911.729.58.422.49.77.43.76.717.72.91.337.451.136.112.431.982.99939.412.38.3?

15.05.2007 0012.38410.8902.02500

15.05.200718.235.79.45.716.72.123.925.421.32.131.510.344.8027.21.964.51.772.617.926.210.326.3 007.48810.7910.376000

13.97418.63.63.545.110.767.49.13.45.35.66.63.42.34.913.224.47.990.48.671.403.2-0.296.2900.270.4501.830.31

72.318.741.480.446.66521.447.51.35.16.124.436.67.64.1111.311.91.83.11.610.201.5-0.420.080.230.310.10.192.320.69

37.4042.831.235.130.347.541.61.63.129.47.111.62.245.424.94.720.735.511.514.85.71.80.6

3.06.2007 ..42.719.967.442.843.242.43.420.42.73.144.810.315.801.215.675.517.913.71.31.611.71.35.4

3.06.2007 ..

3.06.2007 ..( , )56.853.319.820.36.44022.4020.42.71.51.323.24.112.61.427.56.2626.894.617.5?

000.380.48005.250.37 001.164.540000.08

3.06.2007 ..

22.06.2007 ..

22.06.2007 .. 003.8883.86100.6754.052.14

3.07.2007 ..( )90.418.740.921.455.838.543.621.91.37.99.404.5022.907.53.841.422.657.130.43.22.8

3.07.2007 .. (.)

7.09.2007 .. ()

19.09.2007

()70.588.835.275.716.853.17.51000002.32.92.17.5001.512.6012.700

21.09.2007 ( )

21.09.2007 0.0800.310.570000.08

26.09.2007 .. ( CCR1)

6068701.3000065640

26.09.2007 ..39.599.480.910.72.21.510.910.7081.391.227.2

16.10.2007 ,.59.6844.450.95.430.92.35.11.31.60000023.66.102.316.94.334.61.94.5 0.4402.690.5500.6600.6 0.0600.2210.110000

16.10.2007 .. ( )049.31.914.41.53.401.603.901.101.200005.612.5060.201.5 0.183.540.511.370.1000

16.10.2007 ..11.450.46.525.10000001.200102.1011.92.411.9052.701.6 3.8607.90.331.299.5926.750.78 0.0901.817.560000.05

-0.170.130.156000.4100.31

!!!!!!!

0010.082.0791.83307.20

!!!!!!!

2

PASI . .ValidSpearmant(N-2)p-level

CCR1 & PASI ..80.03682714620.09026895080.9310115099

CCR1 & PASI ..80.8224729323.54188458830.0121910762

CCR3 & PASI ..9001

R & PASI ..90.74797253672.98155919120.0204695927

CCR5 & PASI ..9-0.1787638715-0.4807079890.6453844436

R5 & PASI ..90.82571883483.87292454390.0061085546

eot1 & PASI ..90.69668299132.5694223210.0370390716

eot1 & PASI ..90.38894571911.11700594230.3008592463

eot2 & PASI ..90.4848530281.46673556260.1858817473

eot2 & PASI ..90.52901952711.64934974010.1430637466

MIPa & PASI ..90.50216920761.53638052460.1683257398

MIPa & PASI ..9-0.0933563871-0.24808121480.811191803

MIPb & PASI ..90.16956521740.45521944340.6627346079

MIPb & PASI ..90.25974269360.71163956340.4997100774

Rant & PASI ..90.08446530270.2242756520.8289484345

Rant & PASI ..9-0.4242463995-1.23952784950.2550916494

CXCR1 & PASI ..9-0.1362010449-0.36374374190.7267871165

CXCR1 & PASI ..90.56182931031.79686300130.1154130722

CXCR2 & PASI ..90.08658089790.22993497040.8247169625

CXCR2 & PASI ..90.21281413270.57625368650.5824894531

IL8 & PASI ..90.42562826541.24445673540.2533805931

IL8 & PASI ..90.45967852661.36945735640.2131705724

PASI . Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided

CCR165.570.529.5-0.26255251580.7928956805-0.26274578230.7927467003880.7984459984

CCR1617525-0.73514704410.4622504918-0.73514704410.4622504918880.5053613054

CCR3767731-0.48112522430.6304278382-0.48142030270.6302181289980.6729740847

R9261251.05847549350.28983951171.05977503420.2892477371980.3212669683

CCR58370340.19245008970.84738977450.19245008970.8473897745980.8883587001

R58172360101981.0374331551

eot11094482.69430125620.00705400533.01648200390.0025574646980.0055121349

eot11094482.69430125620.00705400533.01648200390.0025574646980.0055121349

eot210548122.30940107680.02092196772.70222379210.0068881011980.0206499383

eot210152161.92450089730.05429270682.38795018370.0169432133980.0592348828

MIPa 97.555.519.51.58771324030.1123521731.77756975230.0754754719980.1139448787

MIPa 9459231.25092558320.2109625171.46370455410.1432756692980.2358700123

MIPb 97.555.519.51.58771324030.1123521731.77893658810.0752510855980.1139448787

MIPb 99.553.517.51.780163330.07505016351.99303275260.0462587059980.0744549568

Rant 569711-2.40562612160.0161453403-2.42050335760.0154995879980.015220074

Rant 599414-2.1169509870.0342647732-2.12215874640.0338251724980.035952283

CXCR11134043.07920143570.00207573853.33409952880.0008558574980.000987248

CXCR1 1134043.07920143570.00207573853.33409952880.0008558574980.000987248

CXCR2 10548122.30940107680.02092196772.70222379210.0068881011980.0206499383

CXCR2 1134043.07920143570.00207573853.33409952880.0008558574980.000987248

IL8 61.591.516.5-1.87638837490.0606028648-1.87753918050.0604451248980.0592348828

IL8 70.582.525.5-1.01036297110.3123221656-1.01098263560.312025492980.3212669683

PASI ..001011000

PASI Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided

R1 6060240.46291004990.64342914520.46291004990.6434291452780.6943278943

R1 27.563.512.5-1.09788758210.2722544207-1.09939878390.2715949701580.2843822844

R3 5055190.64549722440.51860549240.64620773340.5181453188680.5727605728

R3 5451151.16189500390.24527899981.163173920.244759803680.2823842824

R5 446123-0.12909944490.8972790453-0.12909944490.8972790453680.9497169497

R5 386717-0.90369611410.3661572284-0.90369611410.3661572284680.4135864136

eot1 5748121.54919333850.12133626722.15564572940.0311120762680.1418581419

eot1 614482.0655911180.03886790192.58732542860.0096728549680.0426240426

eot2 614482.0655911180.03886790192.58732542860.0096728549680.0426240426

eot2 5748121.54919333850.12133626722.15564572940.0311120762680.1418581419

MIPa 52.552.516.50.96824583660.33292236371.21280879470.2252038288680.344988345

MIPa 46.544.58.51.68342762580.09229328571.91940280890.0549342526580.0932400932

MIP b 5748121.54919333850.12133626721.80546434260.0710029759680.1418581419

MIPb 5649131.42009389360.15558132891.65500898080.0979236765680.1811521812

Rantes 30759-1.93649167310.0528083802-1.93649167310.0528083802680.0592740593

Rantes 366915-1.16189500390.2452789998-1.16189500390.2452789998680.2823842824

CXCR1 654042.58198889750.0098237143.00910723770.0026203699680.007992008

XCR1 693603.0983866770.00194594223.43126578770.0006008475680.0006660007

CXCR2 614482.0655911180.03886790192.58732542860.0096728549680.0426240426

CXCR2 693603.0983866770.00194594223.43126578770.0006008475680.0006660007

IL8 23688-1.75662013130.07898352-1.75662013130.07898352580.0932400932

IL8 406519-0.64549722440.5186054924-0.64549722440.5186054924680.5727605728

PASI ValidSpearmant(N-2)p-level

R1 & PASI 70.16840826740.3820287240.7181381627

R1 & PASI 5-0.158113883-0.27735009810.7995251549

R3 & PASI 6001

R3 & PASI 6-0.7406560798-2.20471301840.0921672644

R5 & PASI 6-0.7944613466-2.61630854880.0590276005

R5 & PASI 6-0.6789347398-1.84945794750.1380761794

eot1 & PASI 6-0.3751832397-0.80949990880.4636309931

eot1 & PASI 6-0.5322906474-1.25753542650.2769718828

eot2 & PASI 6-0.9404032586-5.53078614450.0052218202

eot2 & PASI 6-0.4262867933-0.94249926370.3993023153

MIPa & PASI 6-0.9379580992-5.4100178080.0056543905

MIPa & PASI 50.3162277660.57735026920.6041812895

MIP b & PASI 6-0.8508410435-3.23868864140.0317133189

MIPb & PASI 6-0.17221168-0.34964709950.7442361229

Rantes & PASI 6-0.088273483-0.17723885740.8679337052

Rantes & PASI 6-0.7406560798-2.20471301840.0921672644

CXCR1 & PASI 6-0.088273483-0.17723885740.8679337052

XCR1 & PASI 6-0.5246313899-1.23249903710.28525221

CXCR2 & PASI 6-0.9404032586-5.53078614450.0052218202

CXCR2 & PASI 60.33946736990.72179658640.5103587366

IL8 & PASI 5-0.158113883-0.27735009810.7995251549

IL8 & PASI 60.46291004991.04446593570.3552324136


R1 & PASI 70.10811249550.24317220260.8175332615

CCR1 & PASI 7-0.4865062299-1.2451522330.2682485448

CCR3 & PASI 80.09639253850.23721716050.8203804014

CCR3 & PASI 8-0.4217173561-1.13925354520.2980286785

R5 & PASI 8-0.1084416059-0.26720234140.7982604

CCR5 & PASI 8-0.265079481-0.67339927490.5257681465

eot1 & PASI 80.23636797740.59586561410.5730406536

eot1 & PASI 80.07229440390.17754898690.8649195662

eot2 & PASI 80.494011761.39176430260.2133973153

eot2 & PASI 80.36970375950.97463905450.367379716

MIPa & PASI 80.44581549081.21996438480.2682500617

MIPa & PASI 8-0.1325397405-0.32754443270.7543830278

MIPb & PASI 80.45682493851.2579165610.2551604757

MIPb & PASI 8-0.1084416059-0.26720234140.7982604

Rantes & PASI 80.57835523131.73657905270.133138587

Rantes & PASI 8-0.23030726-0.57971930820.5832007003

CXCR1 & PASI 80.14458880780.35792999180.7326507551

CXCR1 & PASI 8-0.3976192215-1.06148292060.3293169048

CXCR2 & PASI 80.05454645630.13381019740.8979280851

CXCR2 & PASI 8-0.3735210869-0.98632457810.3620625958

IL8 & PASI 8-0.0602453366-0.14783886850.8873130155

IL8 & PASI 8-0.3132757503-0.8080407250.4499082053


R1 65.554.518.51.09941136850.27158951051.10039430240.2711611594780.280963481

CCR1 6852161.38873014970.16491578221.38873014970.1649157822780.1892773893

CCR3 6967310.10502100630.91635920320.10509831290.9162978671880.9591297591

CCR3 77.558.522.50.99769955990.31842583610.99917000950.3177131068880.3282051282

R5 8353171.57531509450.11518473151.57531509450.1151847315880.1303807304

CCR5 8155191.36527308190.17216821811.36527308190.1721682181880.1948717949

eot1964042.94058817650.00327613153.24326741760.0011817935880.0018648019

eot1964042.94058817650.00327613153.24037034920.0011938674880.0018648019

eot2 964042.94058817650.00327613153.24037034920.0011938674880.0018648019

eot2 924482.52050415130.01171916732.89626475220.003776592880.0104118104

MIPa 89.546.510.52.25795163550.02394934322.41182593950.0158734153880.0206682207

MIPa 88.547.511.52.15293062920.031324872.29964798880.0214688094880.0281274281

MIPb 82.553.517.51.52280459140.12780863321.74982662110.0801491808880.1303807304

MIPb 88.547.511.52.15293062920.031324872.29964798880.0214688094880.0281274281

Rantes 6967310.10502100630.91635920320.10502100630.9163592032880.9591297591

Rantes 617525-0.73514704410.4622504918-0.73568819030.4619210054880.5053613054

CXCR1 1003603.36067220170.00077762123.58969442160.0003311153880.0001554002

CXCR1 1003603.36067220170.00077762123.58969442160.0003311153880.0001554002

CXCR2 964042.94058817650.00327613153.24326741760.0011817935880.0018648019

CXCR2 1003603.36067220170.00077762123.58969442160.0003311153880.0001554002

IL8 7660240.84016805040.40081481980.84016805040.4008148198880.4418026418

IL8 72.563.527.50.47259452840.6365027990.47294240810.6362545833880.6453768454

3

. eot1p. eot2 p. MIPa p. CXCR1 p. CXCR1. CXCR2p. CXCR2p

143.2872064145.64585328721327.40721175911420.52107600591416.80439502951415.32712348371433.1244912878

4

PASI FoxValidSpearmant(N-2)p-level

Fox & PASI cp24-0.607294-3.585330.001649

Fox & PASI cp24-0.203798-0.976390.339487

5

eotax Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided

eotax22.00000474.000012.00000-2.474870.013329-2.519990.0117364270.009852


24.00000472.000014.00000-2.357020.018423-2.411360.0158944270.015319

eot2 Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided

eot218.00000333.00008.000000-2.558410.010516-2.597330.0093964220.007090


NewVar322.00000329.000012.00000-2.274140.022958-2.341130.0192264220.020736

MiPa Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided

NewVar426.00000470.000016.00000-2.239170.025145-2.307160.0210474270.022819


NewVar516.00000260.00006.000000-2.595540.009445-2.632210.0084834190.006098

MiPb Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided

NewVar618.00000258.00008.000000-2.433320.014962-2.486730.0128934190.011971


NewVar124.00000301.000014.00000-2.075500.037941-2.170220.0299914210.038103

+

ValidSpearmant(N-2)p-level

eotaxin1 & 16-0.165929-0.629580.539111

eotaxin1 & 16-0.068099-0.255400.802131

eotaxin2 & 16-0.228893-0.879800.393821

& 140.0745360.258920.800086

eotaxin 2 & 160.5411492.407810.030410

MIPa & 160.1133350.426810.676007

MIPa & 16-0.644399-3.153070.007048

MIPb & 160.0373130.139710.890878

MIPb & 160.0654160.245290.809791

R5 & 16-0.264449-1.026000.322292

R5 & 160.1628460.617560.546782

R3 & 16-0.277783-1.081950.297560

R3 & 160.1406400.531510.603398

Rantes & 160.2639411.023890.323257

Rantes & 16-0.141055-0.533110.602318

CXCR1 & 160.0482910.180900.859038

XCR1 & 160.0614830.230480.821051

CXCR2 & 16-0.328859-1.302950.213616

XCR2 & 160.1820910.692910.499701

IL8 & 160.3400061.352780.197571

IL8 & 160.2872011.121870.280790


eotaxin1 & 16-0.037232-0.139410.891114

eotaxin1 & 16-0.247041-0.953910.356310

eotaxin2 & 16-0.050636-0.189710.852262

& 140.0373930.129620.899011

eotaxin 2 & 160.4128391.695980.112004

MIPa & 160.2278620.875620.396013

MIPa & 16-0.531365-2.346930.034163

MIPb & 160.0742690.278660.784580

MIPb & 16-0.099018-0.372320.715229

R5 & 16-0.440087-1.833780.088029

R5 & 160.1532850.580400.570871

R3 & 16-0.244989-0.945480.360448

R3 & 160.1651900.626700.540944

Rantes & 160.0239170.089510.929941

Rantes & 16-0.019404-0.072620.943139

CXCR1 & 160.0604950.226770.823883

XCR1 & 160.1072290.403540.692646

CXCR2 & 160.1004510.377760.711272

XCR2 & 160.4777122.034610.061286

IL8 & 160.1720140.653350.524113

IL8 & 160.4836652.067640.057677


eotaxin1 & 160.1521730.576090.573701

eotaxin1 & 16-0.267627-1.039280.316292

eotaxin2 & 160.1574990.596750.560199

& 14-0.095545-0.332500.745249

eotaxin 2 & 160.0304570.114010.910847

MIPa & 160.1377160.520240.611022

MIPa & 16-0.189112-0.720600.483017

MIPb & 16-0.027595-0.103290.919197

MIPb & 16-0.152920-0.578980.571799

R5 & 16-0.578256-2.651980.018956

R5 & 160.0745100.279570.783898

R3 & 16-0.308910-1.215270.244359

R3 & 160.0790720.296790.770986

Rantes & 16-0.255833-0.990190.338887

Rantes & 160.2531660.979160.344119

CXCR1 & 16-0.088521-0.332520.744422

XCR1 & 160.4063011.663760.118375

CXCR2 & 160.3569361.429710.174737

XCR2 & 160.4029611.647410.121726

IL8 & 160.0365210.136740.893182

IL8 & 160.3193271.260830.227979


eotaxin1 & -0.246671-0.952390.357055

eotaxin1 & 16-0.405806-1.661330.118867

eotaxin2 & 160.6347273.073400.008257

& 140.2094630.742060.472325

eotaxin 2 & 16-0.231048-0.888550.389259

MIPa & 160.1090470.410460.687679

MIPa & 16-0.021104-0.078980.938165

MIPb & 160.1500140.567730.579213

MIPb & 16-0.477872-2.035490.061187 eotaxin 2 0,30,8eotaxin 2 00

R5 & 16-0.335413-1.332170.204085RANTES13,91,3RANTES9,82,3

R5 & 16-0.302100-1.185760.255453CXCR110,95,6CXCR100

R3 & 16-0.165450-0.627710.540299CXCR25,91,9CXCR200

R3 & 16-0.049599-0.185810.855259IL85,42,1IL83,51,2

Rantes & 16-0.333635-1.324220.206642

Rantes & 160.0723560.271440.790011

CXCR1 & 16-0.428426-1.774090.097790

XCR1 & 160.3000671.176980.258826

CXCR2 & 160.1938130.739200.472000 eotaxin 2 0,30,8eotaxin 2 00

XCR2 & 160.2179330.835510.417460RANTES13,91,3RANTES9,82,3

IL8 & 16-0.455740-1.915740.076049CXCR110,95,6CXCR100

IL8 & 160.2930821.146980.270614CXCR25,91,9CXCR200

IL85,42,1IL83,51,2


PASI & 160.5557232.501090.025413 PASI < 10

PASI & 160.4145021.704220.110422-200.3

PASI & 160.1877260.715120.486290IL-83.55.4

PASI & 16-0.242875-0.936810.364738RANTES9.813.9

PASI & 16-0.415855-1.710940.109147CXCR1010.9

CXCR205.9

5.61.9

00.8

1.22.1

2.31.3

05.6

01.9

PASI20

00.391.49.3

203.072.89.7

MIP-1087.821.8

MIP-11.338.34.58.2

RANTES10.3913.911.222.2

IL86.395.46.38.9


00.21.40.7

201.21.81.3

MIP-10.71.21.81.4

MIP-10.51.30.51.9

RANTES0.31.91.21.6

IL80.71.41.31.3


02.354.96.6

202.354.96.6

MIP-14.610.511.817.4

MIP-13.26.410.99.5

RANTES9.812.113.815.8

IL83.55.86.49.9


02,351,54,92,36,63,4

202,351,54,92,36,63,4

MIP-14,61,610,51,311,81,917,42,4

MIP-18,22,16,41,810,91,64,53,1

RANTES9,82,312,11,913,81,715,83,6

IL83,51,25,82,66,41,49,94,5


R124.331.935.436.4

R315.624.923.226.9

R512.417.321.625.4

XCR1010.917.719

XCR205.913.217.2


R131,31,831,92,535,43,136,42,2

R320,13,624,92,723,22,926,92,4

R513,42,617,31,821,61,425,43,5

XCR1010,91,617,71,819,02,5

XCR205,91,413,21,517,24,3


R131.329.636.439.2

R320.122.727.229.5

R513.615.820.621.1

XCR108.710.921.9

XCR2020.919.322.6


R131,31,829,62,933,51,939,21,4

R320,13,622,73,127,21,829,52,1

R513,42,615,81,520,61,821,12,3

XCR108,71,810,91,921,93,4

XCR2020,91,919,32,422,65,4


R12.32.21.40.7

R33.51.21.81.3

R50.61.21.81.4

XCR101.31.71.9

XCR201.91.21.6

005.3

2004.8

MIP-10012.5

MIP-11.3307.4

RANTES10.397.915.4

IL86.390.86.4

R124.31.834.2

R315.64.923.7

R512.42.219.3

XCR106.516.5

XCR202.211.3

R1001.4

R3001.8

R50.601.8

XCR10.801.7

XCR20.40.91.2

R10.31.21.4

R30.51.21.8

R50.81.21.8

XCR10.60.31.7

XCR201.21.2

R101.41.4

004.3

2004.1

MIP-14.6012.3

MIP-13.206.3

RANTES9.80.914.5

IL83.58.310.5

R12.37.634.7

R33.52.924.4

R50.612.117.5

XCR100.712.4

XCR205.720.8

R1001.4

R3001.8

R50.201.8

XCR10.801.7

XCR20.40.91.2

R10.31.21.4

R30.51.21.8

R50.81.21.8

XCR10.60.31.7

XCR200.21.2

R101.41.4

+

00000.80.8

001.21.22.12.1

002.32.31.31.3

00005.65.6

00001.91.9

PASI < 10

% -

000.20.21.91.9

001.21.22.12.1

001.21.200

003.63.600

PASI20

% -

00000.20.2001.41.40.70.7

00001.21.2001.81.81.31.3

00001.21.20.70.71.81.81.41.4

00001.31.30.50.50.50.51.91.9

00001.91.90.30.31.21.21.61.6

00001.41.40.70.71.31.31.31.3

PASI < 10

PASI (10-20)

PASI>20

% -

00002.32.32.22.21.41.40.70.7

00003.53.51.21.21.81.81.31.3

00000.60.61.21.21.81.81.41.4

0000001.31.31.71.71.91.9

0000001.91.91.21.21.61.6

PASI < 10

PASI (10-20)

PASI>20

% -

00002.32.32.22.21.41.40.70.7

00003.53.51.21.21.81.81.31.3

00000.60.61.21.21.81.81.41.4

0000001.31.31.71.71.91.9

0000001.91.91.21.21.61.6

PASI < 10

PASI (10-20)

PASI>20

% -

00000001.41.4

00000001.81.8

0000.60.6001.81.8

0000.80.8001.71.7

0000.40.40.90.91.21.2

0000.30.31.21.21.41.4

0000.50.51.21.21.81.8

0000.80.81.21.21.81.8

0000.60.60.30.31.71.7

000001.21.21.21.2

000001.41.41.41.4

% -

0001.41.40000

0001.81.80000

0001.81.8000.20.2

0001.71.7000.80.8

0001.21.20.90.90.40.4

0001.41.41.21.20.30.3

0001.81.81.21.20.50.5

0001.81.81.21.20.80.8

0001.71.70.30.30.60.6

0001.21.20.20.200

0001.41.41.41.400

%

000

000

000

000

000

000

000

000

000

000

000

% -

MBD00071D09.unknown

MBD0007F351.unknown

MBD00081C11.unknown

MBD0007C0E9.unknown

MBD000600F4.unknown

4

24.331.935.436.42.32.32.22.21.41.40.70.7

15.624.923.226.93.53.51.21.21.81.81.31.3

12.417.321.625.40.60.61.21.21.81.81.41.4

010.917.719001.31.31.71.71.91.9

05.913.217.2001.91.91.21.21.61.6

PASI < 10

PASI (10-20)

PASI>20

% -

1

actinCCR1CCR3CCR5eotaxineotaxin 2MIP alphaMIP betaRANTESCXCR1CXCR2IL8

/-IL2IL4IL6IL8IL10GM-CSFIFN gammaTNF alpha-IL2IL4IL6IL8IL10GM-CSFIFN gammaTNF alpha

21.09.2007 ( R1)0457.636.38.134.25.15.66.44.23.502.10003.345.66.834.51.61.8 000.510.740000.11

7.09.2007 ( R1) 0.2801.340.800.1850.43 0.1101.090.120000

44.715.511.4003.8151.7722.65.3

3.07.2007 ..99.599.879.652.781.251.785.939.71.32.71.2046.831.290.51.97.605454.385.696.11.227.3 008.0644.85100.95.40

3.07.2007 .. 002.5480006.30

94.993.196.994.640.438.813.347.413.172.595.721.3

7.09.2007 ( R1)38.381.253.347.135.532.517.78.410.6035.320.30.2051.611.971.145.666.698.326.536.4

6.02.2007 ( 1)31.13.592.93.7604.331.71.500000024.200039.7074.701.50 000.3960.576000.5130.081

6.02.2007 ()90.90475157.659.112.663.11.4001.7020.104.21.93.42.17.6201.66.374.6 0.0903.0420.87301.3862.2860.306-0.253.590.020.420.240.852.910.56

6.02.2007 ( )90.288.662.699.45.477.731.835.101.405.4023.7023.2014.618.558.716.250.97.98.6 001.7550.2160000

( )68.357.534.318.938.123.533.339.98.500.33.700009.610.604.307.703 001.4850.0990000-0.253.680.082.020.250.592.990.5

28.02.2007 ()( , ) 0.02700.2610.39600.2071.4040.243

?????????

28.02.2007 ( 2 )015011.414.88.124.312.596.56488.451.299.7373.81.645.811.499.431.485.734.8293.9 0.1801.1520.9630.090.5765.310.819-0.133.1958.261.420.191.111.490.44

0003.26701.1254.50

28.02.2007 (3) ( , ) 0.0900.5850.63900.3330.6660.099-0.172.892.092.830.260.741.910

?????

28.02.2007 ()-0.424.52.2126.170.180.811.660.44

16.03.2007 (7)14.1027.73.123.9022.11.71.213.102.51.33.32.118.35.87559.318.322.51.91.71.5 0.09900.4230.36900.1531.9890.351

6.03.2007 (5. )45.35031.879.243.47317.93.317.22.304.842.9014.1547.1544.54.8084.321.924.8-0.554.070.271.290.180.851.250.63

6.03.2007 (6)48.615.534.427.545.424.573.421.16.52.431.311.14.901.702.17.668.32.525.623.23.51.3 0.05401.5480.14400.3061.4760.333-0.162.640.392.290.251.042.820.13

16.03.2007 (8)12.595.452.94519.630.119.513.52.601.50011.31261.31.506.23.879.818.629.4

16.03.2007 (9)54.468.110.672.5265.317.246.44.93.25.25.17.541.73.448.37.85013.602.237.9

( )45.350.731.843.49.217.97317.23.302.342.94.814.107.15544.844.584.3024.821.93.5 001.0710.81000.0720

( )58.240.467.911.729.58.422.49.77.43.76.717.72.91.337.451.136.112.431.982.99939.412.38.3?

15.05.2007 0012.38410.8902.02500

15.05.200718.235.79.45.716.72.123.925.421.32.131.510.344.8027.21.964.51.772.617.926.210.326.3 007.48810.7910.376000

13.97418.63.63.545.110.767.49.13.45.35.66.63.42.34.913.224.47.990.48.671.403.2-0.296.2900.270.4501.830.31

72.318.741.480.446.66521.447.51.35.16.124.436.67.64.1111.311.91.83.11.610.201.5-0.420.080.230.310.10.192.320.69

37.4042.831.235.130.347.541.61.63.129.47.111.62.245.424.94.720.735.511.514.85.71.80.6

3.06.2007 ..42.719.967.442.843.242.43.420.42.73.144.810.315.801.215.675.517.913.71.31.611.71.35.4

3.06.2007 ..

3.06.2007 ..( , )56.853.319.820.36.44022.4020.42.71.51.323.24.112.61.427.56.2626.894.617.5?

000.380.48005.250.37 001.164.540000.08

3.06.2007 ..

22.06.2007 ..

22.06.2007 .. 003.8883.86100.6754.052.14

3.07.2007 ..( )90.418.740.921.455.838.543.621.91.37.99.404.5022.907.53.841.422.657.130.43.22.8

3.07.2007 .. (.)

7.09.2007 .. ()

19.09.2007

()70.588.835.275.716.853.17.51000002.32.92.17.5001.512.6012.700

21.09.2007 ( )

21.09.2007 0.0800.310.570000.08

26.09.2007 .. ( CCR1)

6068701.3000065640

26.09.2007 ..39.599.480.910.72.21.510.910.7081.391.227.2

16.10.2007 ,.59.6844.450.95.430.92.35.11.31.60000023.66.102.316.94.334.61.94.5 0.4402.690.5500.6600.6 0.0600.2210.110000

16.10.2007 .. ( )049.31.914.41.53.401.603.901.101.200005.612.5060.201.5 0.183.540.511.370.1000

16.10.2007 ..11.450.46.525.10000001.200102.1011.92.411.9052.701.6 3.8607.90.331.299.5926.750.78 0.0901.817.560000.05

-0.170.130.156000.4100.31

!!!!!!!

0010.082.0791.83307.20

!!!!!!!

2

PASI . .ValidSpearmant(N-2)p-level

CCR1 & PASI ..80.03682714620.09026895080.9310115099

CCR1 & PASI ..80.8224729323.54188458830.0121910762

CCR3 & PASI ..9001

R & PASI ..90.74797253672.98155919120.0204695927

CCR5 & PASI ..9-0.1787638715-0.4807079890.6453844436

R5 & PASI ..90.82571883483.87292454390.0061085546

eot1 & PASI ..90.69668299132.5694223210.0370390716

eot1 & PASI ..90.38894571911.11700594230.3008592463

eot2 & PASI ..90.4848530281.46673556260.1858817473

eot2 & PASI ..90.52901952711.64934974010.1430637466

MIPa & PASI ..90.50216920761.53638052460.1683257398

MIPa & PASI ..9-0.0933563871-0.24808121480.811191803

MIPb & PASI ..90.16956521740.45521944340.6627346079

MIPb & PASI ..90.25974269360.71163956340.4997100774

Rant & PASI ..90.08446530270.2242756520.8289484345

Rant & PASI ..9-0.4242463995-1.23952784950.2550916494

CXCR1 & PASI ..9-0.1362010449-0.36374374190.7267871165

CXCR1 & PASI ..90.56182931031.79686300130.1154130722

CXCR2 & PASI ..90.08658089790.22993497040.8247169625

CXCR2 & PASI ..90.21281413270.57625368650.5824894531

IL8 & PASI ..90.42562826541.24445673540.2533805931

IL8 & PASI ..90.45967852661.36945735640.2131705724

PASI . Rank SumRank SumUZp-levelZp-levelValid NValid N2*1sided

CCR165.570.529.5-0.26255251580.7928956805-0.26274578230.7927467003880.7984459984

CCR1617525-0.73514704410.4622504918-0.73514704410.4622504918880.5053613054

CCR3767731-0.48112522430.6304278382-0.48142030270.6302181289980.6729740847

R9261251.05847549350.28983951171.05977503420.2892477371980.3212669683

CCR58370340.19245008970.84738977450.19245008970.8473897745980.8883587001

R58172360101981.0374331551

eot11094482.69430125620.00705400533.01648200390.0025574646980.0055121349

eot11094482.69430125620.00705400533.01648200390.0025574646980.0055121349

eot210548122.30940107680.02092196772.70222379210.0068881011980.0206499383

eot210152161.92450089730.05429270682.38795018370.0169432133980.0592348828

MIPa 97.555.519.51.58771324030.1123521731.77756975230.0754754719980.1139448787

MIPa 9459231.25092558320.2109625171.46370455410.1432756692980.2358700123

MIPb 97.555.519.51.58771324030.1123521731.77893658810.0752510855980.1139448787

MIPb 99.553.517.51.780163330.07505016351.99303275260.0462587059980.0744549568

Rant 569711-2.40562612160.0161453403-2.42050335760.0154995879980.015220074

Rant 599414-2.1169509870.0342647732-2.12215874640.0338251724980.035952283

CXCR11134043.07920143570.00207573853.33409952880.0008558574980.000987248

CXCR1 1134043.07920143570.00207573853.33409952880.0008558574980.000987248

CXCR2 10548122.30940107680.02092196772.70222379210.0068881011980.0206499383

CXCR2 1134043.07920143570.00207573853.33409952880.0008558574980.000987248

IL8 61.591.516.5-1.87638837490.0606028648-1.87753918050.0604451248980.0592348828

IL8 70.582.525.5-1.01036297110.3123221656-1.01098263560.312025492980.3212669683

PASI ..001011000


R1 6060240.46291004990.64342914520.46291004990.6434291452780.6943278943

R1 27.563.512.5-1.09788758210.2722544207-1.09939878390.2715949701580.2843822844

R3 5055190.64549722440.51860549240.64620773340.5181453188680.5727605728

R3 5451151.16189500390.24527899981.163173920.244759803680.2823842824

R5 446123-0.12909944490.8972790453-0.12909944490.8972790453680.9497169497

R5 386717-0.90369611410.3661572284-0.90369611410.3661572284680.4135864136

eot1 5748121.54919333850.12133626722.15564572940.0311120762680.1418581419

eot1 614482.0655911180.03886790192.58732542860.0096728549680.0426240426

eot2 614482.0655911180.03886790192.58732542860.0096728549680.0426240426

eot2 5748121.54919333850.12133626722.15564572940.0311120762680.1418581419

MIPa 52.552.516.50.96824583660.33292236371.21280879470.2252038288680.344988345

MIPa 46.544.58.51.68342762580.09229328571.91940280890.0549342526580.0932400932

MIP b 5748121.54919333850.12133626721.80546434260.0710029759680.1418581419

MIPb 5649131.42009389360.15558132891.65500898080.0979236765680.1811521812

Rantes 30759-1.93649167310.0528083802-1.93649167310.0528083802680.0592740593

Rantes 366915-1.16189500390.2452789998-1.16189500390.2452789998680.2823842824

CXCR1 654042.58198889750.0098237143.00910723770.0026203699680.007992008

XCR1 693603.0983866770.00194594223.43126578770.0006008475680.0006660007

CXCR2 614482.0655911180.03886790192.58732542860.0096728549680.0426240426

CXCR2 693603.0983866770.00194594223.43126578770.0006008475680.0006660007

IL8 23688-1.75662013130.07898352-1.75662013130.07898352580.0932400932

IL8 406519-0.64549722440.5186054924-0.64549722440.5186054924680.5727605728


R1 & PASI 70.16840826740.3820287240.7181381627

R1 & PASI 5-0.158113883-0.27735009810.7995251549

R3 & PASI 6001

R3 & PASI 6-0.7406560798-2.20471301840.0921672644

R5 & PASI 6-0.7944613466-2.61630854880.0590276005

R5 & PASI 6-0.6789347398-1.84945794750.1380761794

eot1 & PASI 6-0.3751832397-0.80949990880.4636309931

eot1 & PASI 6-0.5322906474-1.25753542650.2769718828

eot2 & PASI 6-0.9404032586-5.53078614450.0052218202

eot2 & PASI 6-0.4262867933-0.94249926370.3993023153

MIPa & PASI 6-0.9379580992-5.4100178080.0056543905

MIPa & PASI 50.3162277660.57735026920.6041812895

MIP b & PASI 6-0.8508410435-3.23868864140.0317133189

MIPb & PASI 6-0.17221168-0.34964709950.7442361229

Rantes & PASI 6-0.088273483-0.17723885740.8679337052

Rantes & PASI 6-0.7406560798-2.20471301840.0921672644

CXCR1 & PASI 6-0.088273483-0.17723885740.8679337052

XCR1 & PASI 6-0.5246313899-1.23249903710.28525221

CXCR2 & PASI 6-0.9404032586-5.53078614450.0052218202

CXCR2 & PASI 60.33946736990.72179658640.5103587366

IL8 & PASI 5-0.158113883-0.27735009810.7995251549

IL8 & PASI 60.46291004991.04446593570.3552324136


R1 & PASI 70.10811249550.24317220260.8175332615

CCR1 & PASI 7-0.4865062299-1.2451522330.2682485448

CCR3 & PASI 80.09639253850.23721716050.8203804014

CCR3 & PASI 8-0.4217173561-1.13925354520.2980286785

R5 & PASI 8-0.1084416059-0.26720234140.7982604

CCR5 & PASI 8-0.265079481-0.67339927490.5257681465

eot1 & PASI 80.23636797740.59586561410.5730406536

eot1 & PASI 80.07229440390.17754898690.8649195662

eot2 & PASI 80.494011761.39176430260.2133973153

eot2 & PASI 80.36970375950.97463905450.367379716

MIPa & PASI 80.44581549081.21996438480.2682500617

MIPa & PASI 8-0.1325397405-0.32754443270.7543830278

MIPb & PASI 80.45682493851.2579165610.2551604757

MIPb & PASI 8-0.1084416059-0.26720234140.7982604

Rantes & PASI 80.57835523131.73657905270.133138587

Rantes & PASI 8-0.23030726-0.57971930820.5832007003

CXCR1 & PASI 80.14458880780.35792999180.7326507551

CXCR1 & PASI 8-0.3976192215-1.06148292060.3293169048

CXCR2 & PASI 80.05454645630.13381019740.8979280851

CXCR2 & PASI 8-0.3735210869-0.98632457810.3620625958

IL8 & PASI 8-0.0602453366-0.14783886850.8873130155

IL8 & PASI 8-0.3132757503-0.8080407250.4499082053


R1 65.554.518.51.09941136850.27158951051.10039430240.2711611594780.280963481

CCR1 6852161.38873014970.16491578221.38873014970.1649157822780.1892773893

CCR3 6967310.10502100630.91635920320.10509831290.9162978671880.9591297591

CCR3 77.558.522.50.99769955990.31842583610.99917000950.3177131068880.3282051282

R5 8353171.57531509450.11518473151.57531509450.1151847315880.1303807304

CCR5 8155191.36527308190.17216821811.36527308190.1721682181880.1948717949

eot1964042.94058817650.00327613153.24326741760.0011817935880.0018648019

eot1964042.94058817650.00327613153.24037034920.0011938674880.0018648019

eot2 964042.94058817650.00327613153.24037034920.0011938674880.0018648019

eot2 924482.52050415130.01171916732.89626475220.003776592880.0104118104

MIPa 89.546.510.52.25795163550.02394934322.41182593950.0158734153880.0206682207

MIPa 88.547.511.52.15293062920.031324872.29964798880.0214688094880.0281274281

MIPb 82.553.517.51.52280459140.12780863321.74982662110.0801491808880.1303807304

MIPb 88.547.511.52.15293062920.031324872.29964798880.0214688094880.0281274281

Rantes 6967310.10502100630.91635920320.10502100630.9163592032880.9591297591

Rantes 617525-0.73514704410.4622504918-0.73568819030.4619210054880.5053613054

CXCR1 1003603.36067220170.00077762123.58969442160.0003311153880.0001554002

CXCR1 1003603.36067220170.00077762123.58969442160.0003311153880.0001554002

CXCR2 964042.94058817650.00327613153.24326741760.0011817935880.0018648019

CXCR2 1003603.36067220170.00077762123.58969442160.0003311153880.0001554002

IL8 7660240.84016805040.40081481980.84016805040.4008148198880.4418026418

IL8 72.563.527.50.47259452840.6365027990.47294240810.6362545833880.6453768454

3

. eot1p. eot2 p. MIPa p. CXCR1 p. CXCR1. CXCR2p. CXCR2p

143.2872064145.64585328721327.40721175911420.52107600591416.80439502951415.32712348371433.1244912878

4

PASI FoxValidSpearmant(N-2)p-level

Fox & PASI cp24-0.607294-3.585330.001649

Fox & PASI cp24-0.203798-0.976390.339487

5


eotax22.00000474.000012.00000-2.474870.013329-2.519990.0117364270.009852


24.00000472.000014.00000-2.357020.018423-2.411360.0158944270.015319


eot218.00000333.00008.000000-2.558410.010516-2.597330.0093964220.007090


NewVar322.00000329.000012.00000-2.274140.022958-2.341130.0192264220.020736


NewVar426.00000470.000016.00000-2.239170.025145-2.307160.0210474270.022819


NewVar516.00000260.00006.000000-2.595540.009445-2.632210.0084834190.006098


NewVar618.00000258.00008.000000-2.433320.014962-2.486730.0128934190.011971


NewVar124.00000301.000014.00000-2.075500.037941-2.170220.0299914210.038103

+


eotaxin1 & 16-0.165929-0.629580.539111

eotaxin1 & 16-0.068099-0.255400.802131

eotaxin2 & 16-0.228893-0.879800.393821

& 140.0745360.258920.800086

eotaxin 2 & 160.5411492.407810.030410

MIPa & 160.1133350.426810.676007

MIPa & 16-0.644399-3.153070.007048

MIPb & 160.0373130.139710.890878

MIPb & 160.0654160.245290.809791

R5 & 16-0.264449-1.026000.322292

R5 & 160.1628460.617560.546782

R3 & 16-0.277783-1.081950.297560

R3 & 160.1406400.531510.603398

Rantes & 160.2639411.023890.323257

Rantes & 16-0.141055-0.533110.602318

CXCR1 & 160.0482910.180900.859038

XCR1 & 160.0614830.230480.821051

CXCR2 & 16-0.328859-1.302950.213616

XCR2 & 160.1820910.692910.499701

IL8 & 160.3400061.352780.197571

IL8 & 160.2872011.121870.280790


eotaxin1 & 16-0.037232-0.139410.891114

eotaxin1 & 16-0.247041-0.953910.356310

eotaxin2 & 16-0.050636-0.189710.852262

& 140.0373930.129620.899011

eotaxin 2 & 160.4128391.695980.112004

MIPa & 160.2278620.875620.396013

MIPa & 16-0.531365-2.346930.034163

MIPb & 160.0742690.278660.784580

MIPb & 16-0.099018-0.372320.715229

R5 & 16-0.440087-1.833780.088029

R5 & 160.1532850.580400.570871

R3 & 16-0.244989-0.945480.360448

R3 & 160.1651900.626700.540944

Rantes & 160.0239170.089510.929941

Rantes & 16-0.019404-0.072620.943139

CXCR1 & 160.0604950.226770.823883

XCR1 & 160.1072290.403540.692646

CXCR2 & 160.1004510.377760.711272

XCR2 & 160.4777122.034610.061286

IL8 & 160.1720140.653350.524113

IL8 & 160.4836652.067640.057677


eotaxin1 & 160.1521730.576090.573701

eotaxin1 & 16-0.267627-1.039280.316292

eotaxin2 & 160.1574990.596750.560199

& 14-0.095545-0.332500.745249

eotaxin 2 & 160.0304570.114010.910847

MIPa & 160.1377160.520240.611022

MIPa & 16-0.189112-0.720600.483017

MIPb & 16-0.027595-0.103290.919197

MIPb & 16-0.152920-0.578980.571799

R5 & 16-0.578256-2.651980.018956

R5 & 160.0745100.279570.783898

R3 & 16-0.308910-1.215270.244359

R3 & 160.0790720.296790.770986

Rantes & 16-0.255833-0.990190.338887

Rantes & 160.2531660.979160.344119

CXCR1 & 16-0.088521-0.332520.744422

XCR1 & 160.4063011.663760.118375

CXCR2 & 160.3569361.429710.174737

XCR2 & 160.4029611.647410.121726

IL8 & 160.0365210.136740.893182

IL8 & 160.3193271.260830.227979


eotaxin1 & -0.246671-0.952390.357055

eotaxin1 & 16-0.405806-1.661330.118867

eotaxin2 & 160.6347273.073400.008257

& 140.2094630.742060.472325

eotaxin 2 & 16-0.231048-0.888550.389259

MIPa & 160.1090470.410460.687679

MIPa & 16-0.021104-0.078980.938165

MIPb & 160.1500140.567730.579213

MIPb & 16-0.477872-2.035490.061187 eotaxin 2 0,30,8eotaxin 2 00

R5 & 16-0.335413-1.332170.204085RANTES13,91,3RANTES9,82,3

R5 & 16-0.302100-1.185760.255453CXCR110,95,6CXCR100

R3 & 16-0.165450-0.627710.540299CXCR25,91,9CXCR200

R3 & 16-0.049599-0.185810.855259IL85,42,1IL83,51,2

Rantes & 16-0.333635-1.324220.206642

Rantes & 160.0723560.271440.790011

CXCR1 & 16-0.428426-1.774090.097790

XCR1 & 160.3000671.176980.258826

CXCR2 & 160.1938130.739200.472000 eotaxin 2 0,30,8eotaxin 2 00

XCR2 & 160.2179330.835510.417460RANTES13,91,3RANTES9,82,3

IL8 & 16-0.455740-1.915740.076049CXCR110,95,6CXCR100

IL8 & 160.2930821.146980.270614CXCR25,91,9CXCR200

IL85,42,1IL83,51,2


PASI & 160.5557232.501090.025413 PASI < 10

PASI & 160.4145021.704220.110422-200.3

PASI & 160.1877260.715120.486290IL-83.55.4

PASI & 16-0.242875-0.936810.364738RANTES9.813.9

PASI & 16-0.415855-1.710940.109147CXCR1010.9

CXCR205.9

5.61.9

00.8

1.22.1

2.31.3

05.6

01.9

PASI20

00.391.49.3

203.072.89.7

MIP-1087.821.8

MIP-11.338.34.58.2

RANTES10.3913.911.222.2

IL86.395.46.38.9


00.21.40.7

201.21.81.3

MIP-10.71.21.81.4

MIP-10.51.30.51.9

RANTES0.31.91.21.6

IL80.71.41.31.3


02.354.96.6

202.354.96.6

MIP-14.610.511.817.4

MIP-13.26.410.99.5

RANTES9.812.113.815.8

IL83.55.86.49.9


02,351,54,92,36,63,4

202,351,54,92,36,63,4

MIP-14,61,610,51,311,81,917,42,4

MIP-18,22,16,41,810,91,64,53,1

RANTES9,82,312,11,913,81,715,83,6

IL83,51,25,82,66,41,49,94,5


R124.331.935.436.4

R315.624.923.226.9

R512.417.321.625.4

XCR1010.917.719

XCR205.913.217.2


R131,31,831,92,535,43,136,42,2

R320,13,624,92,723,22,926,92,4

R513,42,617,31,821,61,425,43,5

XCR1010,91,617,71,819,02,5

XCR205,91,413,21,517,24,3


R131.329.636.439.2

R320.122.727.229.5

R513.615.820.621.1

XCR108.710.921.9

XCR2020.919.322.6


R131,31,829,62,933,51,939,21,4

R320,13,622,73,127,21,829,52,1

R513,42,615,81,520,61,821,12,3

XCR108,71,810,91,921,93,4

XCR2020,91,919,32,422,65,4


R12.32.21.40.7

R33.51.21.81.3

R50.61.21.81.4

XCR101.31.71.9

XCR201.91.21.6

005.3

2004.8

MIP-10012.5

MIP-11.3307.4

RANTES10.397.915.4

IL86.390.86.4

R124.31.834.2

R315.64.923.7

R512.42.219.3

XCR106.516.5

XCR202.211.3

R1001.4

R3001.8

R50.601.8

XCR10.801.7

XCR20.40.91.2

R10.31.21.4

R30.51.21.8

R50.81.21.8

XCR10.60.31.7

XCR201.21.2

R101.41.4

004.3

2004.1

MIP-14.6012.3

MIP-13.206.3

RANTES9.80.914.5

IL83.58.310.5

R12.37.634.7

R33.52.924.4

R50.612.117.5

XCR100.712.4

XCR205.720.8

R1001.4

R3001.8

R50.201.8

XCR10.801.7

XCR20.40.91.2

R10.31.21.4

R30.51.21.8

R50.81.21.8

XCR10.60.31.7

XCR200.21.2

R101.41.4

+

00000.80.8

001.21.22.12.1

002.32.31.31.3

00005.65.6

00001.91.9

PASI < 10

% -

000.20.21.91.9

001.21.22.12.1

001.21.200

003.63.600

PASI20

% -

00000.20.2001.41.40.70.7

00001.21.2001.81.81.31.3

00001.21.20.70.71.81.81.41.4

00001.31.30.50.50.50.51.91.9

00001.91.90.30.31.21.21.61.6

00001.41.40.70.71.31.31.31.3

PASI < 10

PASI (10-20)

PASI>20

% -

00002.32.32.22.21.41.40.70.7

00003.53.51.21.21.81.81.31.3

00000.60.61.21.21.81.81.41.4

0000001.31.31.71.71.91.9

0000001.91.91.21.21.61.6

PASI < 10

PASI (10-20)

PASI>20

% -

00002.32.32.22.21.41.40.70.7

00003.53.51.21.21.81.81.31.3

00000.60.61.21.21.81.81.41.4

0000001.31.31.71.71.91.9

0000001.91.91.21.21.61.6

PASI < 10

PASI (10-20)

PASI>20

% -

00000001.41.4

00000001.81.8

0000.60.6001.81.8

0000.80.8001.71.7

0000.40.40.90.91.21.2

0000.30.31.21.21.41.4

0000.50.51.21.21.81.8

0000.80.81.21.21.81.8

0000.60.60.30.31.71.7

000001.21.21.21.2

000001.41.41.41.4

% -

0001.41.40000

0001.81.80000

0001.81.8000.20.2

0001.71.7000.80.8

0001.21.20.90.90.40.4

0001.41.41.21.20.30.3

0001.81.81.21.20.50.5

0001.81.81.21.20.80.8

0001.71.70.30.30.60.6

0001.21.20.20.200

0001.41.41.41.400

%

000

000

000

000

000

000

000

000

000

000

000

% -

MBD00071D09.unknown

MBD0007F351.unknown

MBD00081C11.unknown

MBD0007C0E9.unknown

MBD000600F4.unknown

MCP-1

F1 F2 F3 F1 F2 F3

1

24.220.526

36.580.81

179.5

8.70.45

10.11

4.414.53

0.0090

0.030

4.0340

/

p=0,044

p=0,031

p=0,035

SampleWellsNumberTNF alphaIFN gammaGM-CSFIL-13IL-12IL-10IL-5IL-4IL-2 -

Un36A677 0.59510.71815.3950.0770.3110.0000.0000.0001.243

Un37B688 0.1540.00013.8740.0290.0000.0000.0000.0000.000

Un38C699 5 0.3170.0000.0000.0000.0000.0000.0004.5420.000

Un39D61010 1.45711.46818.4300.3640.6290.0020.0000.0006.325

Un40E61111 5 0.8491.66436.5291.2063.6460.0100.00010.10712.744

Un06C24040 14.04781.137301.9706.37428.2230.0740.05321.79796.344

Un07D24141 0.0000.0003.1440.0000.1040.0000.0000.0003.139

Un08E24242 5 0.4990.0000.0000.0000.0000.0000.0009.7030.000

Un09F24343 0.1543.9074.6910.0000.0000.0000.0007.7240.000

Un78C114444 5 46.934385.22367.93465.2171.5400.0260.0240.00010.171

Un10G21414 0.3173.9076.2320.0000.0000.0000.0009.5021.873

Un11H21515 0.3614.8857.7670.0040.0000.0000.0009.5020.000

Un12A31616 5 0.1933.9070.0000.0000.0000.0000.0000.0001.243

Un13B31717 0.5470.0006.2320.0000.0000.0000.0005.0842.505

Un14C31818 5 0.1170.0000.0000.0000.0000.0000.0000.0003.774

Un15D32424 0.4990.0003.1440.0000.1680.0000.0000.0000.617

Un16E32525 25.36619.00836.5290.3021.2530.0010.0000.00025.677 -

Un17F32626 5 0.1547.5454.6910.0400.0000.0000.00014.0613.139

Un19H33535 2.3691.66410.8270.0190.0000.0030.0000.0004.410

Un20A43636 1.1180.0006.2320.0110.0000.0000.0000.2980.000

Un21B43737 5 1.6920.0006.2320.0000.0000.0010.0000.4190.000

Un22C43838 5.86615.713150.8790.1062.7690.0020.0000.00010.171

Un43H65151 2.2430.00012.3520.0000.0000.0010.0004.7220.617

Un44A75252 2.7560.0000.0000.0290.0000.0000.0000.0001.243

Un45B75353 5 0.4520.0003.1440.0190.0000.0000.0000.0003.139

Un46C75454 0.4990.0004.6910.0000.0000.0000.0000.0003.774

Un47D75555 1.1181.66418.4300.0910.7130.0000.0000.0005.048

Un48E75656 0.4993.90715.3950.0290.0000.0000.0000.0001.243

Un49F75757 5 7.48572.106171.5034.62414.7320.0520.0298.31078.598

Un50G75858 4.90330.903170.0312.32010.8700.0080.0186.57262.860

Un51H75959 5 1.28515.03063.4620.9701.8360.0000.0000.00020.492

Un24E44545 238.92416.38722.9710.0000.0000.0010.0002.4829.528

Un25F44646 1.0080.0004.6910.0290.0000.0010.0005.4500.000

Un26G44747 5 3.90526.920105.0690.8855.2670.0050.0020.00043.899

Un27H44848 0.7970.00021.4590.1060.0450.0000.0010.00010.813

Un28A54949 5 0.5950.00015.3950.0000.0000.0000.0000.0005.048

Un30C511 1.06312.2037.7670.0000.0000.0010.0000.0000.000

Un31D522 7.01519.00896.1760.6212.1400.0000.0002.00141.290

Un32E533 5 23.0062.85129.0070.1530.7130.3660.0005.0840.000

Un33F544 3.4910.00038.0310.2241.4430.0040.0000.08115.968

Un34G555 5 1.0089.95342.5320.2430.3870.0010.00011.33416.613

Un52A83030 0.5950.00022.9710.2240.0450.0000.0001.53710.813

Un53B83131 0.7451.66419.9450.0910.3110.0000.0002.48212.744

Un54C83232 5 3.28723.96893.2091.2675.2670.0050.0020.08150.429

Un55D83333 1.2855.81019.9450.3430.4650.0000.0000.00010.813

Un56E83434 5 6.32161.366206.7844.89615.4410.0270.01665.09683.852

Un01F11919 26.6620.000131.69548.4586.1114.4600.0114.3630.000

Un02G12020 5.64110.71872.4023.0100.5460.1720.0510.00025.028

Un03H12121 5 0.5950.0009.2980.0770.1680.0010.0000.0003.774

Un04A22222 0.6951.6646.2320.0000.0000.0000.0007.7240.617

Un05B22323 3.49124.56678.3541.1165.1480.0030.0010.00034.124

Un57F8NemikhNemikh 0.6450.0006.2320.2050.0000.0000.0000.0002.505

Un58G8GurievaGurieva 0.4990.0006.2320.0190.1680.0000.0000.0003.139

Un59H8SokolovaSokolova 0.4060.0007.7670.1210.0000.0000.0000.0001.873

Un60A9KraevaKraeva 0.4064.88522.4820.3640.4650.0000.0000.00010.813

Un61B9PavlovPavlov 0.1930.0000.0000.0190.0000.0000.0006.3104.410

Un62C9LozovskayaLozovskaya 1.0080.00012.3521.9960.0000.0010.0000.0004.410

Un18G32929 468.59010.71815.3950.0000.4650.0060.0002.32010.171

Un23D43939 178.29610.7186.2320.0040.0000.0000.0006.9530.000

Un29B55050 1.7511.66425.9910.0640.0001.2370.0007.9195.048

Un35H566 2.11818.36316.9130.1060.0000.0000.0000.0002.505

Un41F61212 1.6329.95329.0070.4301.4430.0120.0006.19417.259

TNF alphaIFN gammaGM-CSFIL-13IL-12IL-10IL-5IL-4IL-2

130.47710.28318.7080.1210.3820.2510.0004.6776.997

203.87159409255.91736661879.0686280550.17838497690.62657425740.55121320743.36978511186.861442873

0.07439777720.00242475540.04517442680.18515218390.16392565820.14439571170.03670321230.2252217881

Un42G61313 20.2431.66413.8740.0290.0000.0000.0004.7221.873

IFN

NumberIFN gamma

385.22

0

1.664

00

7 81.1370

8 3.9070

9 5 0.00010.7180

10 19.0081.6644.885

11 5 7.54500

16.3870

12.203

81.1373.90710.7181.6640.0000.000

0.0004.8850.0000.0000.0000.000

5 0.0003.9070.0000.0000.0001.664

3.9070.00011.46815.7130.00036.75457142860.8141666667

5 385.2230.0001.664102.51490537611.9942928989

0.1241608531

0.031

16.38712.2030.0000.0001.664

0.00019.0081.66410.7183.907

5 26.9202.85123.9680.00072.106

0.0000.0005.8101.66430.903

5 0.0009.95361.36624.56615.030

Nemikh 0.000

Gurieva 0.000

Sokolova 0.0006.05812.5971027423

Kraeva 4.8857.545

Pavlov 0.0000

Lozovskaya 31.4601.66

3.068

6.05134.7056.0517.6999183567

0.9777.0597.83

0.7811.747263517625.16928.8927415452

6.2187.07787562067.67512.1983042355

128.962221.929806885722.18323.6315994804

6,0534,716,057,70

0,982,197,067,836,0612,60

5 0,781,7525,1728,89

6,227,087,6812,20

5 128,96221,9322,1823,63

16.387

12.2033.9071.664

0.00010.71881.137

0.0001.6640.000

1.66416.387

12.203

0.000

1.664

0.000

5.8186.350968282527.60046.3715778504

81.1371.664

3.9070.000

10.7181.664

16.387

12.203

0.000

20.72530.17801606911.1090.9607108479

0.003

0.0000.01

0.00081.137

0.0003.907

0.00010.718

0.0001.664

0.0000.001

0.00016.387

0.00012.203

0.0000.001

0.0000.000

0.0001.664

0.0004.800

IFN

00000

00000

00000

00000

00000

TNF

00000

00000

00000

00000

00000

GM-CSF

0

0

0

0

0

0

0

0

0

0

0

0

0

\

TNF-

IL-10

NumberTNF alpha

46.93

0.117

0.849

0.499

7 14.047

8 0.317

9 5 0.4990.595

10 25.3662.369

11 5 0.1542.2430.645

238.9240.499

1.0630.406

14.0470.3170.5952.3692.2430.5950.406

0.0000.3610.1541.1182.75626.6620.193

5 0.4990.1930.3171.6920.4521.1181.008

0.1540.5471.4575.8660.49924.0230.526

5 46.9340.1170.84963.32477129690.2781736268

38.75342148760.1982011599

238.9241.0630.59526.6621.1180.035

1.0087.0150.7455.6410.499

5 3.90523.0063.2870.5957.485

0.7973.4911.2850.6954.903

5 0.5951.0086.3213.4911.285

Nemikh 0.64553.672104.1569024707

Gurieva 0.4992.9823.0984473208

Sokolova 0.4067.6568.9256319552

Kraeva 0.4062.2341.8733459905

Pavlov 0.1932.5402.3929811951

Lozovskaya 1.008

0.5260.2781736268

3,915,7453,67104,160,530,28

0,881,132,983,10

5 0,630,617,668,93

1,712,382,231,87

5 15,9726,822,542,39

3.9145.7404513063

0.8781.13433160940.31714.047

0.6310.60531504190.5952.369

1.7052.3757327922238.9242.243

15.96726.8211.063

0.595

26.662

1.118

38.46888.91978890686.2206.7789622608

2.24314.047

26.6620.317

1.1180.595

238.924

1.063

0.595

10.00814.43404033342.59096.3331725968

( )

11.00814.0471.008

11.0080.3171.008

11.0080.5001.008

11.0082.5691.008

11.0082.0431.008

11.00823.8921.008

11.0081.0631.008

11.0080.5001.008

11.00826.6621.008

11.0081.6181.008

0.51.0080.1931.008

2.51.0080.6451.008

0.193

0.645

IL-10

00000

00000

00000

00000

00000

IL-13

00000

00000

00000

00000

00000

IL-12

0010

0000

0000

0000

0000

0000

0000

0000

0000

0000

0000

0000

#!

( )

TNF-alpha /

TNF-alpha

IL-5

0

0

0

0

0

0

0

0

0

0

0

0

0

0

/

TNF

IL-4

NumberGM-CSF

67.93

0

36.5

7 3.1446.232

8 301.96.232

9 5 3.1446.2327.767

10 36.52915.39524.482

11 5 4.69110.8270.000

9.51112.35212.352

22.971

301.9706.23215.39510.82712.3527.767

3.1447.76713.8746.2320.00022.971

5 0.0000.0000.0006.2323.144131.695

4.6916.23218.430150.8794.69118.430

5 67.9340.00036.52947.00814285719.511

81.10204886238.33314419450.1482738328

22.9717.76722.971131.69518.430

4.69196.17619.94572.40215.3950.357

5 105.06929.00793.2099.298171.503

21.45938.03119.9456.232170.0313.144

5 15.39542.532206.78478.35463.4623.97

6.232

15.395

10.827

Nemikh 6.23212.352

Gurieva 6.23222.971

Sokolova 7.7679.5118.33314419457.767

Kraeva 24.48222.971

Pavlov 0.000100.000


24.400

69,36130,0840,7751,21

6,205,2241,7240,149,518,3324.400

5 1,882,7981,6264,73

36,9863,9351,1467,41

5 34,8234,0081,3174,03

301.9703.1440.0004.69167.93422.9714.691105.06921.45915.395

6.2327.7670.0006.2320.0007.76796.17629.00738.03142.532

15.39513.8740.00018.43036.52922.97119.94593.20919.945206.784

10.8276.2326.232150.879131.69572.4029.2986.23278.354

12.3520.0003.1444.69118.43015.395171.503170.03163.462

301.9706.232

10.82715.395

12.35222.971

7.767

22.971

131.695

18.430

108.383167.652993808632.20944.3714112416

301.97010.827

6.232131.695

15.39518.430

22.971

7.767

22.971

62.884117.346281106253.65167.6951983255

IL-4

000000

000000

000000

000000

000000

IL-2

00000

00000

00000

00000

00000

NumberIL-10

0.01

0.026

0

7 00.000

8 0.0740.000

9 5 0.0000.0740.0000.0030.0010.0000.000

10 0.0000.0000.0000.0000.0000.0030.000

11 5 5 0.0000.0000.0000.0010.0000.0010.000

0.0020.0000.0000.0020.0000.0010.000

40 5 0.0100.0260.0000.0010.000

41 0.0000

42 5 0.000

43 0.000

44 5

0.00892307690.2095488804

14 0.0208744722

15 0.121

16 5

17

18 5

24 0.000

25 0.001 -

26 5 0.000

35

36

37 5

38

51

52

53 5

54

55

56

57 5 0.0010.0010.0004.4600.000

58 0.0010.0000.0000.1720.000

59 5 5 0.0050.3660.0050.0010.052

0.0000.0040.0000.0000.008

45 5 0.0000.0010.0270.0030.000

46

47 5

48

49 5

1

2

3 5

4

5 5

30

31

32 5

33

34 5

19

20

21 5

22

23 0.0000.0000.0000.0000.0000.0010.0010.0050.0000.000

0.0000.0000.0000.0010.0000.0010.0000.3660.0040.000

0.0020.0000.0000.0020.0000.0000.0000.0050.0000.001

4.4600.1720.0010.0000.027

0.0000.0000.0520.0080.003

0.0000.010

0.0740.026

Nemikh 0.0000.0000.000

Gurieva 0.0000.003

Sokolova 0.0000.001

Kraeva 0.000

Pavlov 0.000Descriptive Statistics

Lozovskaya 0.001NMinimumMaximumMeanStd. Deviation

IL10500.0740.01560.0326695577

IL105300.0260.0120.013114877

Valid N (listwise)3

0,020,030,891,990Descriptive Statistics

00,030,08NMinimumMaximumMeanStd. Deviation

5 00,090,16IL10504.460.89241.9943490918

00IL101500.1720.03460.0768101556

5 0,010,010,000,01IL10550.0010.3660.08580.158037021

IL10500.0080.00240.0035777088

IL105500.0270.00620.0116918775

Valid N (listwise)5

00.0740.0030.000

00.0034.4600.074

0.0000.0010.0000.000

4.4600.001

0.0000.001

0.0010.000

0.001

1.4882.57411661220.0130.0300510676

0.63742857141.68559562740.0260.0415812458

00000

00000

00000

00000

00000

_

NumberIL-13

65.217

1.206

0

6.3740.0770.0000.0190.00000.205

8 0.0000.0290.0040.0110.0296.3740.019

9 5 5 0.0000.0000.0000.0000.0190.0770.1210.001

10 0.0000.3640.0000.1060.00000.3646.37

11 5 5 6.5001.2060.0000.0190.0190.077

01.9960.001

00.019

41 2.56900.001

42 5 0.2240.001

43 48.460.001

44 5 0.0910.224

8.69057142860.45448.46

14 20.72978404170.7664468670.091

15 0.4490.019

16 5 0.23006329731.9

17 0.019

18 5 1.9

24 0.000

25 0.302 -

26 5 0.040

35

36

37 5

38

51

52

53 5

54

55 0.0000.0000.22448.4580.091

56 0.0290.6210.0913.0100.029

57 5 5 0.8850.1531.2670.0774.624

58 0.1060.2240.3430.0002.320

59 5 5 0.0000.2434.8961.1160.970

45

46

47 5

48

49 5

1

2

3 5

4

5 5

30

31

32 5

33

34 5

19

20

21 5

22

23

6.3740.0000.0000.00065.2170.0000.0290.8850.1060.000

0.0770.0290.0000.3641.2060.0000.6210.1530.2240.243

0.0000.0040.0000.0000.0000.2240.0911.2670.3434.896

0.0190.0110.0000.10648.4583.0100.0770.0001.116

Nemikh 0.2050.0000.0290.0190.0000.0910.0294.6242.3200.970

Gurieva 0.0190.4540.766446867

Sokolova 0.121Descriptive Statistics

Kraeva 0.364Descriptive StatisticsNMinimumMaximumMeanStd. Deviation

Pavlov 0.019NMinimumMaximumMeanStd. DeviationIL135048.4589.754621.6360527546

Lozovskaya 1.996IL13506.3741.2942.8399817781IL13150.0293.010.7561.2843309542

L131500.0290.01460.0137222447IL13550.0774.6241.40121.8696537647

IL135500.0190.00380.0084970583IL13502.320.59860.9708052328

IL13500.3640.0940.1577593103IL135504.8961.4451.9859566964

IL1353065.21722.14137.3097834488Valid N (listwise)5

Valid N (listwise)3

1,292,849,7521,64

0,010,010,761,280,450,77Descriptive Statistics

5 0,000,011,401,87NMinimumMaximumMeanStd. Deviation

0,100,160,600,97IL135048.4589.754621.6360527546

5 22,1437,311,451,99IL13150.0293.010.7561.2843309542

IL13550.0774.6241.40121.8696537647

IL13502.320.59860.9708052328

IL135504.8961.4451.9859566964

Valid N (listwise)5

6.3740.077

0.0000.000

0.0190.000

0.000

0.224

48.458

0.091

2.1313.674558068736.581770831218.2908854156

6.3740.019

0.07748.458

0.0000.091

0.000

0.000

0.224

1.1132.579071286316.18927.9455082676

NumberIL-12

1.54

3.646

0

7 28.330.000

8 0.3110.168

9 5 00.000

10 00.465

11 5 28.2230.3110.0000.0000.00000.000

0.1040.0000.0000.0000.00000.000

40 5 0.0000.0000.0000.0000.00000.106

41 0.0000.6290.0002.7690.0000.0450.1885033156

42 5 5 1.5403.6460.0006.111

43 0.713

44 5 3.13046153850.1830956386

7.7932021084

14

15 0.353

16 5

17 20

18 5 0.311

0

24 0.168 0

25 1.253 -0

26 5 0.0000

0

35 0.045

36 6.111

37 5 0.9

38

51

52

53 5

54

55

56

57 5 0.0000.0000.0456.1110.713

58 0.0002.1400.3110.5460.000

59 5 5 5.2670.7135.2670.16814.732

0.0451.4430.4650.00010.870

45 5 0.0000.38715.4415.1481.836

46

47 5

48

49 5

1

2

3 5

4

5 5

30

31

32 5

33

34 5

19

20

21 5

22 0.3110.1040.0000.0001.5400.0000.0005.2670.0450.000

23 28.2230.0000.0000.6293.6460.0002.1400.7131.4430.387

0.0000.0000.0000.0000.0000.0450.3115.2670.46515.441

0.0000.0000.0002.7696.1110.5460.1680.0005.148

0.0000.0000.0000.0000.7130.00014.73210.8701.836

Descriptive StatisticsDescriptive Statistics

Nemikh 0.000NMinimumMaximumMeanStd. DeviationNMinimumMaximumMeanStd. Deviation

Gurieva 0.168IL125028.2235.706812.5876588252IL12506.1111.37382.6654306781

Sokolova 0.0000.1060.1885033156IL121500.1040.02080.0465102139IL121502.140.59940.8913522312

Kraeva 0.465IL12550000IL12550.16814.7325.22945.8377622682

Pavlov 0.000IL12502.7690.67961.19934578IL125010.872.56464.6789831481

Lozovskaya 0.000IL125303.6461.72866666671.8303074423IL1255015.4414.56246.410335038

Valid N (listwise)3Valid N (listwise)5

5,7112,591,372,67

0,020,050,600,890,110,19

5 05,235,84

0,681,202,564,68

5 1,731,834,566,41

0.31128.223

0.0000.000

0.7130.000

6.111

0.045

0.000

0.000

1.0262.25783109169.40816.2945566473

0.00028.223

6.1110.311

0.7130.000

0.000

0.000

0.045

2.2753.34143417314.76311.4935628491

00000

00000

00000

00000

00000

NumberIL-5

0

0.024

0

7 00

8 0.00530

9 5 0.0000.0530.0000.0000.0000.0000.000

10 0.0000.0000.0000.0000.0000.0000.000

11 5 5 0.0000.0000.0000.0000.0000.0000.000

0.0000.0000.0000.0000.0000.0000.000

40 5 0.0000.0240.0000.000

41 0.000

42 5 0.000

43 0.011

44 5 0.0000.1638662041

0.0028785714

14 0.0068448946

15

16 5 0.376

17

18 5

24 0.000

25 0.000 -

26 5 0.000

35

36

37 5

38

51

52

53 5

54

55

56

57 5 0.0000.0000.0000.0110.000

58 0.0000.0000.0000.0510.000

59 5 5 0.0020.0000.0020.0000.029

0.0010.0000.0000.0000.018

45 5 0.0000.0000.0160.0010.000

46

47 5

48

49 5

1

2

3 5

4

5 5

30

31

32 5

33

34 5

19

20

21 5

22

23

0.0000.0000.0000.0000.0000.0000.0000.0020.0010.000

0.0000.0000.0000.0000.0000.0000.0000.0000.0000.000

0.0000.0000.0000.0000.0000.0000.0000.0020.0000.016

0.0110.0510.0000.0000.001

Nemikh 0.0000.0000.0000.0290.0180.000

Gurieva 0.0000.0000.000

Sokolova 0.0000.0530.024

Kraeva 0.0000.0000.000

Pavlov 0.0000.000


Descriptive Statistics

NMinimumMaximumMeanStd. Deviation

IL5_500.0530.01060.0237023206

IL55300.0240.0080.0138564065

Valid N (listwise)3

0,010,020Descriptive Statistics

00,010,020NMinimumMaximumMeanStd. Deviation

5 00,000,01IL5500.0110.00220.0049193496

00,000,01IL51500.0510.01020.0228078934

5 0,010,010,000,01IL55500.0290.00660.012561847

IL5500.0180.00380.0079498428

L55500.0160.00340.0070569115

Valid N (listwise)5

0.0000.053

Documents

Цитокинодиагностика: прошлое, настоящее и будущее