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7/26/2019 2008 Laptop
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:
-
Ca
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AOYIOOIKH TAINOMHH
MYOKAPIAKH IXAIMIA
O2
O2
M 1 2
KATHOPIE THAXH
A
Prinzmetal
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:
= 2 2
AV 2
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2
2
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ACa++
,
,
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,
,
,
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A Ca
++
Ca2+
Ca2+
VSM
VOC 3
L, N, T
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1) A
Ca
++
, (
1
L )
2) E
Ca
++
3) E
Ca
++
Ca
++
??
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Ca
++
??
4) E Ca
++
5)
Ca
++
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+
-
Ca++
Ca++-
Ca++
-
- Ca++
Ca++-
-
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~
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Ca++ ?
I. A O2A.
.
II. E O2
(verapamil).
(Verapamil).
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Ca++
X , :)
)
Nifedipine, Nicardipine & Nimodipine ,
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: Nifedipine, Nicardipine & Nimodipine
, ,
:,
+-
,
+
+ ,
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E Ca++
1)
2) O
3) K
4) A:
K
K
5) Y
7)
8) Y
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Salim Yusuf calcium blockers
AmlodipineAmlodipine
,
: diuretics beta-blockers, ACEinhibitors
, CHF,
;
;
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Calcium blockers
Salim Yusuf
;
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Dihydropyridine calcium blockers
(nifedipine, nicardipine, and isradipine)
,
Yusuf S. Circulation 1995;92:1079-1082.
Kloner RA. Circulation 1995;92:1074-1078.
28 randomized trials involving 19,000 patients with
MI and unstable angina
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Verapamil and Diltiazem?
Searle: , 15,000-
CONVINCE trial (Controlled ONset VerapamilINvestigation of Cardiovascular Endpoints)
Verapamil COER-24
,
-
,
(2001).
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, , ,
(,
)
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-
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GTN ISDN 5-ISMN
T1/2 (min) 3 10 280
(L/min) 50 4 0,1
Vd (L/kg) 3 4 0,6
-
~ 0 20 100
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:
NO
P N
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Finding Nitric Oxide Dr. Ferid Murad
Bubbled NO gas through tissuecontaining guanylyl cyclase-> cGMPlevels increased in that tissue.Was well known that nitroglycerinactivated the same enzyme-> mustrelease NO.
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APMAKOOIKE ENEPEIE NITPIKN
A
+
~ CO
~ HR
,
: >>BP
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- O2
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(
)
Trimetazidine: a new metabolic approach in angina
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Trimetazidine: a new metabolic approach in angina
.
(long-
chain 3-ketoacyl-CoA-thiolase) FFA
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IIYPIYPIAMOAMOHH
A
,
IOAZINH
IYPIAMOH
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H
, ,
[]
2- ( )
cAMP
,
M
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A PGI
E
IYPIAMOH
Nicorandil for Angina Pectoris (Icorel*)
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Nicorandil for Angina Pectoris (Icorel*)
+
R-3 cGMP free calcium in VSM
P
+ VOC Ca2+ Ca2+
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(
)-
(
)
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Nitronaproxen & nitrofenac
-80933
ROS
-
Alzheimer: Selegiline
-
-
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,
. (11 )
. Ca
,
. - (3 )
(10 )
(Rlopresor)
Nicorandil
Trimetazidine
, , , ,
.
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