Chapter 23 Digestive System Lecture 11 Part 2: Small Intestine Marieb’s Human Anatomy and...

Chapter 23Digestive System

Lecture 11

Part 2: Small Intestine

Marieb’s HumanAnatomy and

PhysiologyNinth Edition

Marieb Hoehn

2

Three Parts of Small Intestine

Main functions of small intestine: 1) chemical digestion 2) absorption of nutrients (90%) from chyme

“Mixing bowl”; acid neutralization

Bulk of chemical digestion and nutrient absorption occurs here

Vitamin B12 absorption

The ‘bowel’ consists of the small and large intestines.

3

Blood Supply and Drainage of Small Intestine

Figure from: Martini, Anatomy & Physiology, Prentice Hall, 2001

4

Wall of Small IntestinePlicae circulares – permanent circular folds of mucosa that further increase surface area for absorption – do not flatten out with distention like rugae of stomach.

Especially prominent in lower duodenum and upper jejunum

Submucosa of duodenum contains mucus-secreting glands (Brunner’s glands) that protect the small intestine

5

Intestinal Villi & Glands

Intestinal glands secrete an abundant watery fluid that helps absorb products of digestion. They also contain enteroendocrine cells (enterokinase, gastrin, secretin, CCK)

Figure from: Saladin, Anatomy & Physiology, McGraw Hill, 2007 Enterocyte = Intestinal Cell

6

Intestinal Epithelium

Microvilli further increase the surface area available for absorption in the small intestine

Form a ‘brush border’ on the intestine

Digestive enzymes are embedded in the membrane of microvilli

Main function of plicae, villi, and microvilli is to increase the surface area for absorption (from about 3.6 ft2 to about 2200 ft2!)

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Secretions of Small Intestine• peptidase – breaks down peptides into amino acids

• sucrase, maltase, lactase – break down disaccharides into monosaccharides

• intestinal lipase – breaks down fats into fatty acids and glycerol

• enterokinase – converts trypsinogen to trypsin

• gastrin/somatostatin – hormones that stimulate/inhibit acid secretion by stomach

• cholecystokinin (CCK) – hormone that inhibits gastric glands, stimulates pancreas to release enzymes in pancreatic juice, stimulates gallbladder to release bile, and relaxes hepatopancreatic sphincter (of Oddi)

• secretin – stimulates pancreas to release bicarbonate ions in pancreatic juice; stimulates gall bladder to release bicarbonate-rich bile

See Table 23.32 in Marieb for summary of digestive enzymes – great to use for XC!!

Brush border

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Movements of the Small Intestine

• peristalsis – pushing movements

• segmentation – ringlike contractions that aid in mixing and slowing peristalsis

• overdistended or irritated wall triggers “peristaltic rush” resulting in diarrhea

Movements in local segments can occur without stimulation by parasympathetic NS. However, nervous stimulation accelerates segmentation and peristalsis.

“Long distance” movements are triggered by stomach filling: - gastroenteric reflex (↑ motility and secretion along length of small intestine) - gastroileal reflex (relaxation of ileocecal sphincter)

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Absorption in the Small Intestine

• monosaccharides and amino acids

• through facilitated diffusion and active transport• absorbed into blood

• electrolytes and water• through diffusion, osmosis, and active transport• absorbed into blood

• vitamins• fat-soluble dissolve in dietary fats (vit A,D,E,K)•Water-soluble through diffusion, except B12 (active transport)• Vitamin K (large intestine) – with other lipids• absorbed into blood

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Absorption of Fats in the Small Intestine

• fatty acids and glycerol

• several steps• absorbed into lymph into blood

Chylomicrons contain TG, cholesterol, and phospholipids