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Kingdom of Saudi Arabia
King Faisal University
College of Clinical Pharmacy
المملكة العربية السعودية
جامعة الملك فيصل
كلية الصيدلة اإلكلينيكية
1
Table of Contents
Therapeutics-1 ................................................................................................................... 3
Biopharmaceutics ............................................................................................................ 12
Medicinal chemistry 3 ...................................................................................................... 19
Pharmaceutical Delivery Systems ..................................................................................... 27
Pharmaceutical Care 2 ...................................................................................................... 32
Pharmacology 4 ................................................................................................................ 40
2
3
Kingdom of Saudi Arabia
Ministry of Higher Education
King Faisal University College of Clinical Pharmacy DEPARTMENT OF PHARMACY PRACTICE
Course Plan: Therapeutics-1 2013-2014
A: General Information
Course Coordinator/Instructor: Dr. Afzal Haq Asif
Course Instructors: 1. Dr. Maitham Alhawwaj
2. Dr Mays Hassan (Practical female)
3. Dr. Khaled Alhussain (Practical male)
Contacts: 1. Dr Afzal: ahasif@kfu.edu.sa, afzalhaqasif@gmail.com
Office No. Room No. 1022 Phone: 035899790 (direct) Office hours: Sunday: 9:30-10:30 , Tuesday: 9:30-10:30
2. Dr. Maitham: maitham_hawaj@hotmail.com Office hours: Office No. Old Classroom No. 1 Phone No. N/A Office hours: Monday: 12:30 PM–01:30 PM, Tuesday: 08:30 AM–09:30 AM
3. Dr Mays: maysh.1986@hotmail.com
Office No with Phone: Office hours
4. Dr. Khaled: khaled_al-hussain@hotmail.com Office No with Phone: Office hours
Department: Department of Pharmacy Practice, College of Clinical Pharmacy,
Course title and code: Therapeutics-1, P-4 (departmental Code),
3030311 (University Code)
Year and Semester: 3rd
year Semester 1
Credit hours: 4+1
4
Pre-requisite: Pharmacology-2, 2010211
Schedule: Male: Lecture: 7:30 to 9:30 am on Wednesday and Thursday, Practical: 11:30-2:30 Sunday Female: Lecture: 7:30 to 9:20 am, on Sunday and Monday, Practical: 11:30—2:30 Thursday
B: Course Description & Objectives
1. Aims of the Course:
This course is designed to consolidate students’ knowledge and skill in therapeutic planning, rational selection and use of drugs prescribed in common cardiovascular disorders, based on underlying pathophysiologic mechanisms of the diseases and the best evidence available. Therapeutic management of critically ill patient like shock and management of dyslipidaemias, Anemias and sickle cell disease, which will provide students with a sound foundation for all the subsequent courses in therapeutics and also for Advanced Pharmacy Practice Experience. Clinical case discussions/presentation and maintaining of clinical case portfolio will improve communication, analytical and decision making skills of the students.
3. Course Objectives: After successful completion of the course, the student will be able to:
A. Describe and correlate pathophysiology of the diseases included in this course (cardiovascular and coagulation disorders including dyslipidaemia), with clinical presentation and pharmacotherapy.
B. Describe the Clinical (history symptoms and signs) and laboratory data to diagnose the disease. C. Constitute therapeutic objectives, treatment plan with best evidence available and follow up
evaluation plan for diseases included in the course. D. Write and present the case in SOAP format
B: Learning Resources
1. Required Textbook(s) : 2. Pharmacotherapy: Handbook. By BG well, JT Dipiro TL Schwinghammer and CW Hamilton Appleton and
Lange 8th
ed.(2011) 3. Applied Therapeutics: The Clinical Use of Drugs by Mary Anne Koda-Kimble,Lloyd Yee Young, Wayne A.
Kradjan, B. Joseph Guglielmo, Brian K. Alldredge Robin L. Corelli PharmDBradley R. Williams: Lippincott Williams & Wilkins; Ninth edition (August 20, 2010)
4. Pharmacotherapy Casebook, A Patient Focused Approach TL Schwinghammer , BG well, JT Dipiro and CW Hamilton: Appleton and Lange (8
th Edition)
2. Additional References :
Pharmacotherapy: A Pathophysiologic Approach, by Joseph DiPiro, Robert L. Talbert, Gary Yee, Gary Matzke, Barbara Wells, L. Michael Posey McGraw-Hill Medical; 8 edition (April 4, 2011)
3.Electronic Materials, Web Sites, etc. www.PubMed.com, www.medscape.com/pharmacist, www.guidelines.com
5- Other learning material such as computer-based programs/CD, professional standards/ regulations:
5
Note: Each lecture (L) will consist of two 50 minutes sessions, with 10 minutes interval between both
Week Lecture
Topic (chapter/section) Lab Assignment Comments/Quizzes
W-1 Sept 1
L1 Introduction to course and therapeutics, definitions,
Definitions, Abbreviations, Patients Data/Components of Clinical Case History SOAP notes
Parts of prescriptions (review)
L2 Prescriptions and responsibilities of Prescriber(2)
W-2 Sept 8
L3 Factors affecting response and effects of drugs (2)
Patients Data/Components of Clinical Case History SOAP notes Clinical Case
List of drugs contraindicated in pregnancy, liver kidney and Heart disease
L4 Factors affecting response and effects of drugs (1)
Lab tests and their Interpretation (1)
W-3 Sept 15
L5 Lab tests and their Interpretation (2)
Clinical case for abnormal lab values, Calculation of IBW and Creatinine Clearance
Guidelines for treatment of Hyperkalemia
Quiz Lab Tests
L6 Lab tests and their Interpretation (2)
W-4 Sept 22
L7 Hypertension and its treatment (2) Clinical case of Hypertension, SOAP for the case, points for patient counselling
Assignment on Updates on antihypertensive drugs: BB. ACEI, ARB, CCB
L8 Hypertension and its treatment(2)
W-5 Sept 29
L9 Hypertension and its treatment (2)
Clinical case of Hypertension, SOAP for the case, points for patient counselling
Anti anginal Drugs
Quiz Hypertension
L10 Coronary Artery Disease (2)
W-6 Oct 6-9) (4 days)
L11 Coronary Artery Disease (2) Clinical Case for Angina, ACS, Acute MI
Opioid Analgesics and thrombolytic
Quiz on CAD
L12
Coronary Artery Disease (2)
W-7 Oct 13
W-8 Oct-20 (1 day)
HAJJ VACATIONS
6
W-8 Oct 21
(4 days)
L14 Cardiac Arrhythmias & Treatment (2)
Clinical case for AF, V Tech, Torsade de pointes, AV Blocks
Classification and main Pharmacologic features of Antiarrhythmic agents
W-9 Oct 27
L15 Cardiac Arrhythmias & Treatment (2)
Clinical case on Acute LVF Main Pharmacologic features of Drugs used in HF
L16 Heart Failure: Acute and Chronic (2)
W-10 Nov 3
L17 Heart Failure: Acute and Chronic (2)
Clinical case on Chronic HF, with different Classes and disease combinations
Guidelines on Classification and T/m of HF
Tentative Mid Term
L18 Heart Failure: Acute and Chronic (2)
W-11 Nov 10
L19 Pharmacotherapy of shock: use of various IV fluids and inotropes (2)
Clinical case on various types of Shock and its management
Parenteral inotropes and IV fluids
Quiz Heart Failure
L20 Pharmacotherapy of shock: use of various IV fluids and inotropes (1) Venous Thromboembolism (1)
W-12 Nov 17
L21 Venous Thromboembolism (2) Clinical case studies on VTE
Pharmacologic features of Anticoagulants, anti-platelets and thrombolytics
L22 Venous thromboembolism (1) Stroke and its management (1)
W-13 Nov 24
L23 Stroke and its management (1) Dyslipidaemias and treatment (1)
Clinical case of thrombotic and hemmorrhagic stroke, TIA
Review of antidyslipedemic
Quiz on VTE
L24 Dyslipidaemias and treatment (2)
W-14 Dec 1
L25 Dyslipidaemia and its treatment (1) Peripheral Arterial Disease (1)
Clinical case on dyslipidemia
Pharmacology of Iron therapy
L26 Peripheral Arterial Disease (1) Anemias: Investigation and treatment (1)
W-15 Dec 15
L27 Anemias: Investigation and treatment (1) Sickle Cell Disease: Complications and their treatment (1)
Clinical case on Anemia, Calculation for parenteral Iron therapy
Articles related with Incidence of SCD
Quiz on SCD
7
L28 Sickle Cell Disease: Complications and their treatment (2)
W-16 Dec 22
L29 Sickle Cell Disease: Complications and their treatment (1) Cardiovascular testing (1)
Clinical case study on SCD
L30 Revision/left over topics
W-17 Dec-29
L31 Revision/left over topics/Practical
W-18 Jan 5 Final Exams
Course for MidTerm: Upto/including cardiac Arrhythmias: cered upto lecture 15, week 9 above
8
D. Class Format:
1. Class will consist of interactive lectures/discussions 2. Students are required to come prepared in the class for the topic to be discussed. 3. Students may have brief unannounced quiz, from the material discussed in the previous class 4. Student will be responsible for all material in reading assignments regardless of whether or not the
material is discussed in class. Exams and quizzes will cover all the material, PP presentations, assignment and book
5. Generally the lecture format when a disease will be discussed, will be as under: o Clinical vignette followed by questions o ILO o Introduction
Definitions, Epidemiology Pathophysiology, Clinical Presentations & Diagnosis Signs Symptoms Lab investigations for the disease state under discussion
o Therapeutic objectives o Treatment:
General: Non Pharmacological Pharmacological Therapeutic aspect of Main Drugs: Drug related problems: Drug interactions/adverse
effects and contraindications o Therapeutics Outcomes and Follow up evaluation
6. Practical Session will consist of
a. ILO for the sessions, constructed mutually by the instructor and the students b. Clinical case discussion in Small Groups, as per above schedule followed by answer to the
questions c. Writing and presenting the case in SOAP format by each group. Students are required to keep
the record d. Maintaining clinical case portfolio
E. Library Assignments Students will be assigned to collect material from web resources regarding updates on therapy of various diseases which will be announced with the lecture presentations F. Service learning: Students will be required to participate in one or two sessions of service learning activity already planned, like, patients education, patients’ counselling, applicable during. E. Examinations and Assessment:
1. Quizzes: In addition to unannounced quizzes (which may be on daily basis), there will be announced classroom quizzes, as shown in the schedule above, however minimum number of quizzes will be as shown below in assessment schedule. These quizzes include topics from the lectures that are covered before the quiz. The quizzes worth 10% of the final grade in the course. The quizzes may consist of MCQ’s, SEQ’s or clinical histories followed by questions.
9
2. Mid Term and Final: For the theoretical section of this course, there will be 2 examinations, Midterm (25) , and Final exam (40). The total outcome of these exams will represent 65% of the final grade in the course. Exam will generally consist of MCQ’s with Single Best Response, however, SEQ may also be included.
3. Practical Exam will carry 25 marks distributed as under: a. Portfolio and class performance/assignments during practical sessions 10 marks b. Final Practical Exam with three clinical cases: 5 points for each: 15 marks
4. Schedules for Midterm and Final exams will be announced by the Committee for Academic affairs in consultation with relevant students’ committee
5. Schedule of Assessment:
Schedule of Assessment (tentative) Assessment
Assessment task (eg. essay, test, group project, examination etc.)
Week due Proportion of Final Assessment
1
Quiz #1 3rd
2.5 %
2
Quiz #2 5th
2.5 %
3
Quiz #3 11th
2.5 %
Quiz #4 13 2.5%
6
Library/Home Assignment/Portfolio Continuous 10 %
7
Mid Term Exam (Final Schedule will be issued by Academic Affairs committee)
8/9th
25 %
8
Practical Exam With the
final exam 15 %
9 Final Exam End of
semester 40 %
Total 100%
F. Attendance: I expect you to be at every class. I often give information in class that is not found in the textbook. Attendance is one of the most important work ethics in this profession. If you miss 25% of the total classes during the semester, you will be dropped from the final exam. COMING IN LATE While it is mandatory to come on time in every class, I do realize that some logical circumstances may prevent you from getting to class on time. Please show respect if you come in late. G. Academic Dishonesty and misconduct: It includes all of the following:
1. Cheating in exams, quizzes, lab/small group sessions, from any source, like fellow student, notes, electronic sources.
2. Plagiarism: presenting work, words, ideas, presentations, assignments of others, in whole or in part, in assignments, presentations or projects
3. Falsifying tempering records of attendance, false excuses for absence 4. Disrespect to instructors, administration and colleagues 5. Non adherence to instructions regarding class discipline, dress code etc,
10
Students found to commit any of the above will be subject to disciplinary actions according to University Rules and Regulations, mentioned in COCP Students’ Handbook
11
12
Kingdom of Saudi Arabia Ministry of Higher Education
King Faisal University College of Clinical Pharmacy
DEPARTMENT OF…………….
Course Plan
A: General Information
Course Coordinator/Instructor: Dr Tamer Shehata
Instructors:
Contacts:
1. Office No. 1059 2. Office hours: Sunday 10:30-11:20, Monday 8:30-10:20, Thursday 8:30-9:20. 3. Email and office contacts: tamershehataa@yahoo.com, Tel: 035899904
College/Department: COCF/ Pharmaceutical Sciences
Course title and code: Biopharmaceutics / 2010314
Year and Semester: 3rd year 1st smester
Credit hours: 3 (2+1) hours
Pre-requisite: None
Schedule: Male: Lecture: Sunday 7:30-9:20 Practical: Thursday 11:30-1:35 Female: Lecture: Wednesday 7:30-9:20 Practical: : Wednesday 11:30-1:35
B: Course Description & Objectives
1. Aims of the Course
This course is aiming to introduces students to the concept and principles of biopharmaceutics.
Physicochemical and dosage form factors influencing bioavailability. During this course,
students will learn how to assess and measure key biopharmaceutical properties,
bioequivalence, biopharmaceutical classification scheme (BCS). Influence of dosage regimens
on the plasma concentration-time profile of a drug in the body, elementary compartmental
modeling design and the factors involved in steady-state plasma concentration of a drug..
2. Briefly describe any course development objectives that are being implemented.
13
The expected development of the current course is the use of computer software to simulate and
calculate different cases parameter we are discussing during lectures or practical labs.
3. Course Objectives:
After successful completion of the course, the student will be able to: After successful completion of the course, the student will be able to:
A-Upon successful completion of this course, students will be able to explain the key concept of
biopharmaceutics and pharmacokinetics
B- Interpret the relationship between the drug, its dosage form, and route of administration,
C- Evaluate the biological, physiological and physicochemical factors influencing bioavailability of a
drug,
D- Predict the concept of bioavailability and bioequivalence and explain the relationship between drug
delivery optimization and therapeutic outcome. Topics to be covered till Mid Term
Basics of Pharmacokinetics
B: Learning Resources
1. Required Textbook(s) : Basic Pharmacokinetics, Second Edition. Mohsen Hedaya, 2012, CRC Press.
2. Additional References :
Biopharmaceutics and Clinical Pharmacokinetics an introduction, Robert E Notari, Marcel Dekker
Inc, New York.
Biopharmaceutics and Drug Interactions, D.E. Cadwallader, U.S.A.,Rache.
Drug Interactions: A source Book of Adverse Interactions, their Mechanisms, Clinical Importance
and Management, Ivan H. Stockley, London: Pharmaceutical Press.
Therapeutic Drug Monitoring, G.E. Schumacher, Appleton and Lange
3.Electronic Materials, Web Sites, etc. Excel sheets
5- Other learning material such as computer-based programs/CD, professional standards/regulations: Kinetica Software
14
C: Course Weekly Activities
Week Lecture
Topic (chapter/section) Intended Learning Outcomes
Lab Assignment/projects
W-1 Sept 1
L1 Introduction to biopharmaceutics and Pharmacokinetics, Pharmacokinetic models
1. Define biopharmaceutics and pharmacokinetics 2. Describe general approaches utilized in pharmacokinetic modelling
Problems on
reaction rates
L2
W-2 Sept 8
L3 One compartment I.V bolus administration
1. calculate the appropriate IV dose required to achieve a specific drug concentration 2. estimate VD after a single IV
Problems on
one
compartment
L4
W-3 Sept 15
L5 Multicompartment 1. calculate the appropriate IV dose required to achieve a specific drug concentration following two compartment 2. estimate VD after a single IV
Problems on
one
compartment
L6
W-4 Sept 22
L7 Drug pharmacokinetics following single oral dose
1. calculate drug absorption and drug elimination rates following oral absorption 2. recognise flip flop phenomena
Problems on
one
compartment
L8
W-5 Sept 29
L9 Quiz
Steady state principles
1. calculate drug concentration at steady state 2. describe factors affecting drug concentration at steady state
Problems on
two
compartments
L10
W-6 Oct 6-9) (4 days)
L11 Dose regimen design Multiple drug administration and loading dose
1. define CPmax ss, Cp min ss 2 define factors affecting time to achieve steady state during multidrug administration.
Problems on
two
compartments
Collect
information
about
pharmacoki
netics for
certain
drugs
L12
W-7 Oct 13 Hajj Vacations
W-8 Oct-20 (1 day)
15
W-8 Oct 21
(4 days)
L14 Drug Absorption
following oral
administration
1- Biological Factors
1. describe the basic structure of cell membrane 2. describe different anatomical barriers in GIT and biological factors affecting absorption.
Problems on
oral drug
absorption
W-9 Oct 27
L15 Drug Absorption
following oral
administration
2- Physiological Factors
1. describe different
Physiological Factors affecting drug absorption
2. differentiate between the general mechanisms of drug absorption
Problems on
oral drug
absorption
L16
W-10 Nov 3
L17 Drug Absorption
following oral
administration
3- Physicochemical Factors
1. describe different
Physicochemical Factors affecting drug absorption
Problems on
dose regimen
L18
W-11 Nov 10
L19 Drug distribution Quiz
1. Describe different factors affecting drug distribution
Problems on
loading dose
L20
W-12 Nov 17
L21 Biotransformation
Phase I
1. Describe different factors affecting drug biotransformation 2- describe different mechanisms of biotransformation
Case study on
drug
distribution
L22
W-13 Nov 24
L23
Biotransformation
Phase II
1. Describe different factors affecting drug biotransformation 2- describe different mechanisms of biotransformation
Case study on
Phase I
L24
W-14 Dec 1
L25 Elimination 1. Describe factors affecting drug elimination 2. describe the drug elimination through different body organs
Case study on
Phase II
L26
W-15 Dec 15
L27
Bioavailability
And
Bioequivalence
1. define bioavailability 1. define bioequivalence 2. discuss the situation when bioequivalence is required. 3. discuss the situation when bioequivalence can be waived.
Case study on
elemination Collect
information
about
bioavilabili
ty for
certain
drugs
L28
W-16 L29 Bioavailability 1-different method for Problems on
16
Dec 22 L30 And
Bioequivalence
determining bioequivalence 2. discuss the situation when bioequivalence can be waived.
Bioequivelance
W-17 Dec-29
L31 Application on
Biopharmaceutics
1. review the pharmacokinetic parameters on certain selected drug products
Application on
Biopharmaceu
tics
W-18 Jan 5
Final Exams
Class Format: Class will consist of lectures and in some instances class discussion of problems or other assignments. In addition, student will be responsible for all material in reading assignments regardless of whether or not the material is discussed in class. Since these reading assignments are provided before class, it is expected that students will read assignments before coming to class. It should be anticipated that class discussion may require knowledge of the reading material and student who are not prepared may find class discussion difficult to follow. E. Library Assignments Collect information about pharmacokinetics and bioavilability for certain drugs
F. Service learning/Interprofessional Education:(if applicable) NO E. Examinations and Assessment: During the semester, there will be announced classroom quizzes in advance. These quizzes include topics from
the lectures that are covered before the quiz. The quizzes worth 10% of the final grade in the course.
For the theoretical section of this course, there will be 2 examinations, Midterm , and Final exam. The outcome
of these exams will represent 65% of the final grade in the course.
Overall, the course will be graded as follows:
Schedules for Midterm and Final exams will be announced by the Committee for Academic affairs in
consultation with relevant students’ committee
Grading Scheme Assessment
Assessment task (eg. essay, test, group project, examination etc.)
Week due Proportion of Final Assessment
1
Quiz #1 5th
5 %
2
Quiz #2 7th
5 %
3
Mid Term Exam 8th
25 %
4
Lab Exam 15th 20 %
17
5 assignment and attendance 14th 5%
6 Final Exam End of
semester 40 %
Total 100%
F. Attendance: I expect you to be at every class. I often give information in class that is not found in the textbook. Attendance
is one of the most important work ethics in this profession. If you miss 25% of the total classes during the
semester, you will be dropped from the final exam.
COMING IN LATE
While it is mandatory to come on time in every class, I do realize that some logical circumstances may prevent
you from getting to class on time. Please show respect if you come in late.
G. Academic Dishonesty and misconduct: It includes all of the following:
6. Cheating in exams, quizzes, lab/small group sessions, from any source, like fellow student, notes, electronic sources.
7. Plagiarism: presenting work, words, ideas, presentations, assignments of others, in whole or in part, in assignments, presentations or projects
8. Falsifying tempering records of attendance, false excuses for absence 9. Disrespect to instructors, administration and colleagues 10. Non adherence to instructions regarding class discipline, dress code etc,
Students found to commit any of the above will be subject to disciplinary actions according to University Rules and Regulations, mentioned in COCP Students’ Handbook
18
19
AKingdom of Saudi Arabia Ministry of Higher Education
King Faisal University College of Clinical Pharmacy
DEPARTMENT OF…………….
Course Plan
A: General Information
Course Coordinator/Instructor: Dr. Mohammed Abdou
Instructors: Dr. Mohammed Abdou
Contacts:
4. Office No. 5. Office hours: 10.30am- 11.30 am every day
6. Email and office contacts: mmohammed@kfu.edu.sa
College/Department: College of clinical pharmacy, department of pharmaceutical sciences
Course title and code: Medicinal chemistry 3. Course code: PS-15
Year and Semester: 1st Semester, 3
rd year
Credit hours: 2+0
Pre-requisite: 2010212
Schedule: Male: Lecture: Tuesday , Practical: No practical Female: Lecture: Monday and Wednesday Practical: No practical
B:Course Description &Objectives
1. Aims of the Course
This course enables the student to know the chemistry and mode of action of drugs acting as antibacterials, antivirals, antifungals, antiparasitics and antineoplastics. The following topics will be addressed: Chemistry of antibiotics (Bata lactams, tetracyclines, macrolides, rifamycins, chloramphenicol, aminoglycosides, antifungal and polypeptide), antibacterials, antimycobacterials, antivirals, antifungals, antimalarials, anthelmientics, antiscabious, antipedicular agents, antiprotozoal, antibilharazial agents and antineoplastics. Drug design for related drugs
20
2. Briefly describe any course development objectives that are being implemented. (eg increased use of IT or web based reference material, changes in content as a result of new research in the field or feedback from peers and students)
The Active learning method will be used for teaching the course and the students will
be asked to summarize the lectures at the end of each lecture.
Some topics will be covered such as the recent drugs from each class in the syllabus.
3. Course Objectives:
After successful completion of the course, the student will be able to: A. Demonstrate an understanding of the concept of chemotherapy and selective toxicity. B. Identify the different classification schemes for antibiotics along with knowledge of the history,
chemical structures, and pharmacokinetic and pharmacodynamic properties of selected natural and synthetic antimicrobial agents belonging to various classes.
C. Relate the chemical structure of various classes of antimicrobial agents to their biological activity.
D. Classify anticancer agent and describe pharmacodynamic and pharmacokinetic properties of various classes of anticancer agents.
Topics to be covered till Mid Term: Introduction to medicinal chemistry, topical antibacterials, urinar tract antiseptics, sulfonamides, antibiotics, beta lactams, cephalosporins, tetracyclines, macrolides, aminoglycosides.
B: Learning Resources
1.Required Textbook(s) : Principles of Medicinal Chemistry, T. L. Lemke, W.O. Foye, David A Williams, Victoria F Roche, S.
William Zito, Wolters Kluwer, Publisher; Lippincott Williams and Wilkins, Ed. 6th
2008
2. Additional References : An Introduction to Medicinal Chemistry, Graham L. Patrick, Publisher; Oxford University Press Inc,
New York, Ed. 4th
2009
3.Electronic Materials, Web Sites, etc. www.kfu.edu.sa/digitallibrary
5- Other learning material such as computer-based programs/CD, professional standards/regulations:
Some websites will be used for teaching them the mode of action of drugs
Some softwares will be used to learn them the structure activity relationship
21
C:Course Weekly Activities
Week Lec
ture
Topic (chapter/section) Intended Learning Outcomes Lab Assignment/projects
W-1 Sept 1
L1 Introduction to Medicinal
Chemistry 3 Description of the medicinal chemistry 3 and its role
in drug discovery
List all the course contents with grading system
Identify biochemical differences between the human
cell and invading organisms such as bacteria, fungi,
viruses and parasites
There is no lab
Will be assigned at the end of each lecture
L2 Topical Antibacterial
(Antiseptics and disinfectants) Identify the concept of chemotherapy and selective
toxicity.
Identify the different classes for topical antibacterial
Relate the chemical structure of various classes of
antimicrobial agents to their biological activity
Discuss the Pharmacodynamic properties of
antibacterial drugs
W-2 Sept 8
L3 Urinary antiseptics List the main clinical uses of urinary antiseptics
Identify the different chemical classes of drugs used
as urinary antiseptics
Discuss the structure activity relationship of urinary
antiseptics
Explain the mode of action of different urinary
antiseptics
There is no lab
Will be assigned at the end of each lecture
L4 Sulfonamides: mode of action and
different uses Demonstrate the importance of sulfonamides for
treatment of varieties of diseases Identify the chemistry of different examples of
sulfonamides with different uses Discuss the main structure features of sulfonamides Describe the mode of action of some sulfonamides
W-3 Sept 15
L5 Introduction to Antibiotics List all types of antibiotics
Define ‘’Antibiotic’’ Demonstrate an understanding of the biochemical
differences between the human cell and invading
organisms such as bacteria, fungi, viruses and
parasites
There is no lab
Will be assigned at the end of each lecture
L6 Antibiotics: A-β lactams
Identify the chemical modification for getting broad
spectrum, stable long acting penicillins
Discuss the structure activity relationship of β
lactams
Describe the mechanism of action for β lactams in
bacteria
W-4 Sept 22
L7 Quiz 1
There is no lab
Will be assigned at the end of each lecture
L8 Antibiotics: Cephalosporins List the main differences between β lactams and
Cephalosporins
Demonstrate the different generations of
Cephalosporins.
Discuss the structure activity relationship of
Cephalosporins
Describe the mode of action of cephalosporins
W-5 Sept 29
L9 Antibiotics: Aminoglycosides -Discuss the aminoglycosides structure features, and uses
=List different examples of Aminoglycoside
=Discuss the structure activity relationship of
Aminoglycosides
=Illustrate the Pharmacodynamic properties of
aminoglycosides
There is no lab
Will be assigned at the end of each lecture
22
L10
Antibiotics: Tetracyclines =Explain the chemical features of tetracyclines,
nomenclature.
=Discuss the chemical classes of tetracyclines
=Discuss the structure activity relationship of
Tetracyclines
=Describe the mode of action of Tetracyclines
W-6 Oct 6-9) (4 days)
L11
Antibiotics: Macrolides =Discuss the chemistry of macrolides as a class of
antibiotics
=List different examples of macrolides
=Discuss the structure activity relationship of Macrolides
=Explain the pharmacokinetics and Pharmacodynamic
properties of macrolides
There is no lab
Will be assigned at the end of each lecture
L12
Antibiotics: Chloramphenicol Discuss the stereochemistry of Chloramphenicol
List all uses and features of Chloramphenicol
Discuss the structure activity relationship of
Chloramphenicol
Explain the pharmacokinetics and Pharmacodynamic
properties of Chloramphenicol
W-7 Oct 13 Hajj Vacations
W-8 Oct-20 (1
day)
W-8 Oct 21
(4 days)
L14
Midterm exam
.
There is no lab
W-9 Oct 27
L15
Antimycobacterial drugs
Explain the meaning of ‘’Antimycobacterial drugs’’
Discuss different examples of Antimycobacterial
drugs; structure, name, synthesis
Discuss the structure activity relationship of
Antimycobacterial drugs
Illustrate the mode of action of Antimycobacterial
drugs
There is no lab
Will be assigned at the end of each lecture
L16
Antifungal drugs Demonstrate the features of fungal infection and
antifungal drugs.
Discuss different examples of Antifungal Drugs
drugs; structure, name, synthesis
Discuss the structure activity relationship of
Antifungal Drugs
Explain the Pharmacodynamic properties of
antifungal drugs W-10 Nov 3
L17
Antiviral Drugs part 1 Identify the main differences between bacteria and
viruses.
Discuss different examples of Antiviral Drugs drugs;
structure, name, uses
There is no lab
Will be assigned at the end of each lecture
L18
Case studies Case studies of some antiviral drugs and how it was discovered
W-11 Nov 10
L19
Antiviral Drugs part 2 Correlate the chemical structure of antiviral drugs to
their biological activities
Describe the different mechanisms by which antiviral
drugs could act
There is no lab
Will be assigned at the end of each lecture
L20
Anticancer drugs part1 Discuss Cancer etiology, types, methods of design of
different anticancer drugs
W-12 L2 Quiz 2 Ther
23
Nov 17 1 e is no lab
L22
Anticancer drugs part 2 Identify different classes of anticancer drugs;
structure, name, synthesis
Correlate the chemical structure of anticancer drugs
to their biological activities
W-13 Nov 24
L23
Anticancer drugs part 3 Describe the different mechanisms of anticancer drugs There is no lab
Will be assigned at the end of each lecture
L24
Case studies Case studies of some anticancer drugs and how it was discovered
W-14 Dec 1
L25
Ant scabies drugs Explain scabies, etiology, main causes, and treatmet
Explain the medicinal chemistry of different
Antiscabious drug
Correlate the chemical structure of Antiscabious
drugs to their biological activities.
Discuss the mode of action of Antiscabious drugs
There is no lab
Will be assigned at the end of each lecture
L26
discussion of assignments
W-15 Dec 15
L27
Antileprotic drugs =Discuss leprosy, its etiology, main symptoms, and
methods of treatment
=Discuss the medicinal chemistry of some examples of
antileprotic drug
=Correlate the chemical structure of Antileprotic drugs to
their biological activities.
There is no lab
Will be assigned at the end of each lecture
L28
Quiz 3
W-16 Dec 22
L29
Antiparasitic drugs =Identify the classification of parasitic drugs and the
chemistry of these classes.
=Correlate the chemical structure of Antiparasitic drugs to
their biological activities.
=Discuss the mode of action of different ant parasitic
drugs
There is no lab
Will be assigned at the end of each lecture
L30
Revision and discussion of assignments
W-17 Dec-29
L31
Revision and discussion of assignments
There is no lab
Will be assigned at the end of each lecture
W-18 Jan 5
Final Exams
24
D. Class Format: Class will consist of lectures and in some instances class discussion of problems or other assignments. In addition, student will be responsible for all material in reading assignments regardless of whether or not the material is discussed in class. Since these reading assignments are provided before class, it is expected that students will read assignments before coming to class. It should be anticipated that class discussion may require knowledge of the reading material and student who are not prepared may find class discussion difficult to follow. E. Library Assignments
The students will be given some assignment about
‘’Difference between antibiotics drugs’’
‘’Viral diseases’’
‘’Anticancer drugs’’ F. Service learning/Interprofessional Education:(if applicable) E. Examinations and Assessment: During the semester, there will be announced classroom quizzes in advance. These quizzes include topics from the lectures that are covered before the quiz. The quizzes worth 10% of the final grade in the course. For the theoretical section of this course, there will be 2 examinations, Midterm , and Final exam. The outcome of these exams will represent 65% of the final grade in the course. Overall, the course will be graded as follows: Schedules for Midterm and Final exams will be announced by the Committee for Academic affairs in consultation with relevant students’ committee
Grading Scheme Assessment Assessment task (eg. essay, test, group project, examination
etc.) Week due Proportion
of Final Assessment
1
Quiz #1 Week 4 5%
2
Quiz #2 Week 12 5%
3
Quiz #3 Week 15 5%
4
Service Learning (if applicable).
5
Classactivities, participation, attendance 5%
6
Library/Home Assignment 10%
7
Mid Term Exam Week 8 30%
8
Lab Exam …
9 Final Exam End of
semester 40%
25
Total 100%
F.Attendance: I expect you to be at every class. I often give information in class that is not found in the textbook. Attendance is one of the most important work ethics in this profession. If you miss 25% of the total classes during the semester, you will be dropped from the final exam. COMING IN LATE While it is mandatory to come on time in every class, I do realize that some logical circumstances may prevent you from getting to class on time. Please show respect if you come in late. G. Academic Dishonesty and misconduct: It includes all of the following:
11. Cheating in exams, quizzes, lab/small group sessions, from any source, like fellow student, notes, electronic sources.
12. Plagiarism: presenting work, words, ideas, presentations, assignments of others, in whole or in part, in assignments, presentations or projects
13. Falsifying tempering records of attendance, false excuses for absence 14. Disrespect to instructors, administration and colleagues 15. Non adherence to instructions regarding class discipline, dress code etc,
Students found to commit any of the above will be subject to disciplinary actions according to University Rules and Regulations, mentioned in COCP Students’ Handbook
Course Coordinator Dr. Mohammed Abdou
26
27
Kingdom of Saudi Arabia Ministry of Higher Education
King Faisal University
College of Clinical Pharmacy DEPARTMENT OF PHARMACEUTICAL SCIENCES
Course Outline
A: General Information
Course Coordinator/Instructor: Dr. Anroop Nair/ Dr. Arshia Shariff
Contacts:
7. Office No. 1084
8. Office hours: 7.30 AM - 2.30 PM
9. Email and office contacts: arshiashariff@yahoo.com Tel: 035899825
College/Department: Clinical Pharmacy/Pharmaceutical Sciences
Course title and code: Pharmaceutical Delivery Systems, 2010312
Year and Semester: Third Year, Fifth semester
Credit hours: 2+0 per week (2 office hours per week)
Pre-requisite: Pharmaceutical Dosage Forms (2010223)
B: Course Description & Objectives
1. Aims of the Course
The aim of this course is to provide the student a comprehensive knowledge & basics of
pharmaceutical drug delivery systems for efficient drug delivery into human body that are
therapeutically effective, bioavailable, safe and elegant.
2. Briefly describe any course development objectives that are being implemented. (eg
increased use of IT or web based reference material, changes in content as a result of new
research in the field or feedback from peers and students)
Update the recent advances in drug delivery systems with the aid of web material
Teaching aid includes videos and other interactive learning materials.
Involve students in research projects and home assignments.
3. Course Objectives:
After successful completion of the course, the student will be able to:
A. Explain the concept of drug delivery systems
B. Understand the fundamentals of Sustain/Controlled/Targeted drug delivery systems
C. Describe drug carriers and their common applications
D. Appreciate the importance of drug carriers with respect to drug delivery
E. Discuss the rationale use of Novel carrier systems such as Liposomes, Niosomes,
Microspheres, Nanoparticles.
28
B: Learning Resources
1. Required Textbook(s) :
1. Targeted and Controlled Drug Delivery: Novel Carrier Systems: Vyas S.P, Khar RK,
Publisher; CBS Publishers & Distributors. 2010
2. Drug Delivery Systems, Vasant VR and Mannfred AH, Publisher; CRS press, Ed. 2nd
2003.
2. Additional References :
1. Pharmaceutics: the Science of Dosage Form Design, Michael E. Aulton, Publisher;
Churchill Livingstone, Ed. 2nd
2002.
2. The Science and Practice of Pharmacy. Pharmaceutical Sciences, Gennaro A.R,
Remington, Publisher; Lippincott Williams & Wilkins, Ed. 21st 2005.
3. Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems, Ansel H.C. Allen,
L.V, Popovich N, Publisher; Williams and Wilkins, Ed. 9th
2010
3. Electronic Materials, Web Sites, etc.
1. www.emedicine.com
2. www.sciencedirect.com
3. www.pubmed.com
4. Other learning material such as computer-based programs/CD, professional
standards/regulations:
CD for British Pharmacopeia (B.P.), and United States Pharmacopeia (U.S.P). British
Pharmaceutical Codex (B.P.C). Martindale (extra pharmacopeia).
C: Course Weekly Activities
Week Topic (chapter/section) Lab Assignment Notes
1
Sept 1
L1
L2
Fundamentals of sustained release dosage
forms
- √
2
Sept 8
L3
L4
Physiological and biological factors
influencing design and performance of
controlled release products
- √
3
Sept
15
L5
L6
Liposomes - - √
4
Sept
22
L7 Liposomes - 1 √
L8 Niosomes
5
Sept
29
L9 Niosomes - 2 √
L10 Microspheres
6
Oct 6
7
Oct 13
8
Oct 20
L11 Microspheres - 3 √
L12 Nanoparticles
Hajj Vacation
Hajj Vacation
7
Oct 27
L13 Nanoparticles - 4 √
L14 Parenteral or Sterile Preparation
29
10
Nov 3
L15 Parenteral or Sterile Preparations -
L16 Parenteral or Sterile Preparations
11
Nov
10
L17 Parenteral or Sterile Preparations - 5 √
L18 Calculation related to Osmolarity &
Isotonicity
12
Nov
17
L19 Calculation related to Osmolarity &
Isotonicity
- 6 √
L20 Ocular drug delivery
13
Nov
24
L21 Ocular drug delivery - √
L22 Ocular drug delivery
14
Dec 1
L23 Ocular drug delivery - 7 √
L24 Pulmonary drug delivery
15
Dec 8
L25 Pulmonary drug delivery - 8 √
L26 Pulmonary drug delivery
16
Dec
15
L27 Radiopharmaceuticals - 9 √
L28 Radiopharmaceuticals
17
Dec
22
L29 Radiopharmaceuticals - √
L30 Radiopharmaceuticals
18
Dec29
19
Jan 5
L31
L32
Revision
Revision
Final Exam
D. Class Format:
Class will consist of lectures and in some instances class discussion of problems or other assignments. In addition,
student will be responsible for all material in reading assignments regardless of whether or not the material is discussed in
class. Since these reading assignments are provided before class, it is expected that students will read assignments before
coming to class. It should be anticipated that class discussion may require knowledge of the reading material and student
who are not prepared may find class discussion difficult to follow.
E. Library Assignments
Assignments on Liposomes, Niosomes, Microspheres, Nanoparticles, Parenteral or Sterile Preparations, Ocular
drug delivery systems, calculation related to Osmolarity & Isotonicity, pulmonary drug delivery and
Radiopharmaceuticals.
F. Service learning: (if applicable)
E. Examinations and Assessment:
30
During the semester, there will be announced classroom quizzes in advance. These quizzes include topics from the
lectures that are covered before the quiz. The quizzes worth 10% of the final grade in the course.
For the theoretical section of this course, there will be 2 examinations, Midterm , and Final exam. The outcome of these
exams will represent 65% of the final grade in the course.
Overall, the course will be graded as follows:
Schedules for Midterm and Final exams will be announced by the Committee for Academic affairs in consultation with
relevant students’ committee
F.
Attendance:
I expect you to be at every class. I often give information in class that is not found in the textbook. Attendance is one of
the most important work ethics in this profession. If you miss 25% of the total classes during the semester, you will be
dropped from the final exam.
COMING IN LATE
While it is mandatory to come on time in every class, I do realize that some logical circumstances may prevent you from
getting to class on time. Please show respect if you come in late.
G. Academic Dishonesty and misconduct:
It includes all of the following:
16. Cheating in exams, quizzes, lab/small group sessions, from any source, like fellow student, notes,
electronic sources.
17. Plagiarism: presenting work, words, ideas, presentations, assignments of others, in whole or in part, in
assignments, presentations or projects
18. Falsifying tempering records of attendance, false excuses for absence
19. Disrespect to instructors, administration and colleagues
20. Non adherence to instructions regarding class discipline, dress code etc,
Students found to commit any of the above will be subject to disciplinary actions according to University Rules and
Regulations, mentioned in COCP Students’ Handbook
Grading Scheme Assessment Assessment task (eg. essay, test, group project,
examination etc.) Week due Proportion
of Final Assessment
1
First quiz exam 5th 05%
2
Midterm exam 8th 30%
3
Second quiz exam 11th 05%
4
Library/Home Assignment 12th 10%
Final exam End of semester
50%
Total 100%
31
32
Kingdom of Saudi Arabia Ministry of Higher Education
King Faisal University
College of Clinical Pharmacy DEPARTMENT OF PHARMACEUTICAL SCIENCES
Course Outline
A: General Information
1. Course title and code: Pharmaceutical Care 2, 2030312
2. Credit hours 3 (2+1)
3. Program(s) in which the course is offered.
Pharm D Program
4. Name of faculty member responsible for the course Dr Sabah Akrawi
5. Level/year at which this course is offered 1st level, 3
rd year
6. Pre-requisites for this course (if any) Pharmaceutical Care 1, 2030221
7. Co-requisites for this course (if any) None
8. Location if not on main campus Main Campus
Objectives
1. Summary of the main learning outcomes for students enrolled in the course.
Upon successful completion of the course students will be able to:
(a) Have a clear understanding of the concept of the pharmaceutical care and medication
therapy management.
(b) Brief review of patient data collection, history taking, important lab. data
interpretation, communication skills in patient counseling.
(c) Perform basic physical patient assessments of human organ systems.
(d) Describe, Interpret and record positive findings in physical assessment required for
proper pharmaceutical care plan.
(e) Interpret the lab reports of the patient for Individualized Therapeutics plan and
follow up evaluation.
2. Briefly describe any plans for developing and improving the course that are being implemented. (eg increased use
33
of IT or web based reference material, changes in content as a result of new research in the field)
1) Constructive and focused review of the course content to ensure alignment with )
current development in the study areas
(2) Extensive use of problem-based assignments to deepen students’ critical thinking skills
(3) Increased learners’ interactions with the university library, recommended textbooks and
internet-based resources through regular assignment of guided readings
(4) Fast-track the democratization of the learning space for students during lecture periods to
facilitate constructive, deep and transformative learning
C. Course Description (Note: General description in the form to be used for the Bulletin or Handbook should be attached)
1 Topics to be Covered
List of Topics No of
Weeks
Contact hours
Introduction to Pharmaceutical care 0.5 1
Pharmacotherapy planning 1 2
Patient interview and history taking 1.5 3
Patient counselling 0.5 1
Barriers to effective communication 1 2
Ethical considerations in Pharmaceutical Care Practice 1 2
Interpreting laboratory values 2.5 5
Vital signs assessment and their interpretation 1 2
Medication therapy management 1.5 3
Inventory clinical examination of individual organ system 1 2
Interpretation of findings in diagnosis and prognosis during pharmacotherapy 0.5 1
Total 14 28
Exams 2 3.5 hours Final:2 hrs, MidTerm:1 hr, Quizes:30 minutes
2 Course components (total contact hours per semester):
Lecture: 31 Tutorial: SGS
During
lectures
Laboratory: 42 Practical/Field
work/Internship Other: None
2. Additional private study/learning hours expected for students per week. (This should be an average
:for the semester not a specific requirement in each week):
34
Students are expected to devote at least 3 hours /week for self study at home
Students will be motivated to apply the principles of Pharmaceutical care and physical assessment during clinical clerkship and practical sessions
4. Development of Learning Outcomes in Domains of Learning
For each of the domains of learning shown below indicate:
A brief summary of the knowledge or skill the course is intended to develop;
A description of the teaching strategies to be used in the course to develop that knowledge or skill;
The methods of student assessment to be used in the course to evaluate learning outcomes in the
domain concerned.
a. Knowledge
(i) Description of the knowledge to be acquired:
On successful completion of this course, students shall be able to: 1. Describe the roles of Pharmacists within the context of pharmaceutical care practice 2. Define various terms used in pharmaceutical Care Practice 3. Describe and identify various drug Therapy problems 4. Describe the various components of Pharmaceutical Care Practice 5. Demonstrate knowledge and skills required for an effective pharmaceutical care practice 6. Demonstrate the knowledge of ethical principles necessary for pharmaceutical care practitioner
(ii) Teaching strategies to be used to develop that knowledge:
Interactive Lectures where students act as central partner in learning.
Effective use of audiovisual equipment and PowerPoint presentations for class discussions
Encouraging independent study among students using books and relevant websites
Motivate the students to apply the knowledge during Clinical Rotations and Therapeutic practical
(iii) Methods of assessment of knowledge acquired:
Question and answer sessions in the class room (formative)
Written Short essay questions in Quizzes, Midterm exams and final semester exam
b. Cognitive Skills
(i) Description of cognitive skills to be developed:
On successful completion of this course, the students shall be able to: i. Identify the drug therapy problems in clinical cases (actual and potential) ii. Organize the data retrieved from patient and hospital record in a professional manner iii. Develop, implement and monitor pharmaceutical care plan with a view to resolving drug therapy
problems
(ii) Teaching strategies to be used to develop these cognitive skills:
Regular attendance and active participation of students during the grand rounds in hospital to understand the therapeutic approaches of disease management
35
Interactive discussion on the pharmaceutical care aspects of selected case in the hospital
Completion of therapeutic Log book with identifying patients problem
(iv) Methods of assessment of students cognitive skills :
Written SEQ, problem identifying and problem solving, questions in MidTerm and Final Exams
c. Interpersonal Skills and Responsibility
(i) Description of the interpersonal skills and capacity to carry responsibility to be developed :
Regularity and punctuality in academic schedules
Demonstrate of professional honesty, compassion and respect for patients and colleagues, while working as a team
Obtain, organize and analyze necessary information from the patients’ file/hospital data base
Observing all the ethics of Pharmaceutical Care Practice
Maintain patients confidentiality and trust all the time
Communication with the health care staff, like, Physicians, nurses, and the patients
(ii) Teaching strategies to be used to develop these skills and abilities:
Motivation and Encouragement of students to participate in class room and Clinical case discussions
Instruction and role modeling on ethics of team work, patient-pharmacist relationship, selflessness, during clinical activities
Clinical case discussions, followed by presentations by the students
Problem based learning
Each student has to maintain a log book of 4 therapeutic case histories in the semester
(iii) Methods of assessment of students interpersonal skills and capacity to carry responsibility:
Direct observation by the faculty
Written ( (problem solving), short essay questions in Quizzes, Midterm exams and final semester exam
d. Communication, Information Technology and Numerical Skills
(i) Description of the skills to be developed in this domain.
(ii) Teaching strategies to be used to develop these skills
(iii) Methods of assessment of students numerical and communication skills
e. Psychomotor Skills (if applicable) NA
5. Schedule of Assessment Tasks for Students During the Semester Assessment Assessment task (eg. essay, test, group project, examination Week due Proportion of
36
etc.) Final Assessment
Quiz 1
Written: SEQ's 5 5%
Quiz 2
Written: SEQ's 9 5%
Mid-Term Exam
Written: MCQ's, SEQ's 7 25%
Practical
Participation and Attendance Throughout the semester
25%
Final Exam
Written: SEQ's 16 40%
Total
100%
D. Student Support
1. Arrangements for availability of teaching staff for individual student consultations and academic advice.
(include amount of time teaching staff are expected to be available each week)
Office Hours: 3 hrs
Available on email, University Students' Forum
E Learning Resources
1. Required Text(s):
1. A Practical Guide to Pharmaceutical Care, John P. Rovers, Jay D. Currie, Harry P. Hagel,
Randy P. McDonough, Jenelle L. Sobotka
2. Pharmaceutical Care Practice., 2nd Ed. 2004, Robert J. Cipolle, Linda M. Strand, Peter C. Morley.
McGraw-Hill's.
2. Essential References
3- Recommended Books and Reference Material (Journals, Reports, etc) (Attach List)
4-.Electronic Materials, Web Sites etc:
www.medscape.com/pharmacist
5- Other learning material such as computer-based programs/CD, professional standards/regulations:
- Other learning material such as computer-based programs/CD, professional standards/regulations
F. Facilities Required
Indicate requirements for the course including size of classrooms and laboratories (ie number of seats in
classrooms and laboratories, extent of computer access etc.)
1. Accommodation (Lecture rooms, laboratories, etc.)
2. Lecture hall for 60 students (for future)
37
3. Computing resources: Well equipped computer lab, connected to internet
4. Other resources (specify --eg. If specific laboratory equipment is required, list requirements or attach
list) :
1. College Library with all the texts and reference materials mentioned
2. University Hospital for planned clinical training of the students with clinical pharmacist in each unit
G Course Evaluation and Improvement Processes
1 Strategies for Obtaining Student Feedback on Effectiveness of Teaching:
Students anonymous evaluation in each semester
Feedbacks during class discussions with students
Students’ reflection through e-mails 2 Other Strategies for Evaluation of Teaching by the Instructor or by the Department:
Self evaluation
Individual feedback from students
3 Processes for Improvement of Teaching: Studying reports
Lectures and Workshops on various aspects of academic development including teaching methodology and learning techniques are conducted frequently by national and international experts throughout the academic year.
Regular reflection on teaching and assessment practices based students' feedback, students’
results and personal self-assessment with a view to identifying points intervention for improvement.
Sponsored grants for research and innovation in teaching and learning are frequently offered. Instructions by the Departmental Coordinators and the Dean on areas requiring
improvement.
3. Processes for Verifying Standards of Student Achievement (eg. check marking by an independent
member teaching staff of a sample of student work, periodic exchange and remarking of tests or a
sample of assignments with staff at another institution):
Evaluation by external reviewers
5 Describe the planning arrangements for periodically reviewing course effectiveness and planning for
improvement.:
Collecting all reports and evaluations at the end of the semester for a reviewing purpose
Curriculum review by the Curriculum Committee based on the recommendations of the Departments
Attendance:
I expect you to be at every class. I often give information in class that is not found in the textbook. Attendance is one of
the most important work ethics in this profession. If you miss 25% of the total classes during the semester, you will be
dropped from the final exam.
COMING IN LATE
While it is mandatory to come on time in every class, I do realize that some logical circumstances may prevent you from
getting to class on time. Please show respect if you come in late.
G. Academic Dishonesty and misconduct:
It includes all of the following:
38
1. Cheating in exams, quizzes, lab/small group sessions, from any source, like fellow student, notes, electronic
sources.
2. Plagiarism: presenting work, words, ideas, presentations, assignments of others, in whole or in part, in
assignments, presentations or projects
3. Falsifying tempering records of attendance, false excuses for absence
4. Disrespect to instructors, administration and colleagues
5. Non adherence to instructions regarding class discipline, dress code etc,
Students found to commit any of the above will be subject to disciplinary actions according to University Rules and
Regulations, mentioned in COCP Students’ Handbook
39
40
Kingdom of Saudi Arabia Ministry of Higher Education
King Faisal University College of Clinical Pharmacy
DEPARTMENT OF Pharmaceutical Sciences
Course Plan
A: General Information
Course Coordinator/Instructor: Dr. Ibrahim Alhaider and Dr. Promise Emeka
Instructors: Dr. Promise Emeka
Contacts: 10. Office No. 1003 11. Office hours: 4-6 hours
12. Email and office contacts: pemeka@kfu.edu.sa, emekapm@yahoo.co.uk
College/Department: Pharmaceutical Sciences, College of Clinical Pharmacy
Course title and code: Pharmacology 4 P-S13
Year and Semester: 2013/2014, 1st
semester
Credit hours: 6 credit hours
Pre-requisite: 2020121
Schedule: Male: Lecture: Tuesday and Thursday. Practical: days & time: NA Female: Lecture: Monday and Thursday Practical: NA
B: Course Description & Objectives
Aims of the Course: To equip the students with the knowledge of chemotherapy, their use and application in pharmacy practice and patient care. To identify adverse drug reactions and resistance that might accompany the use of chemotherapeutic agents. Also for them to be able to advice patients and their relatives for better treatment outcome and report side effects and misuse.
2. Briefly describe any course development objectives that are being implemented. (eg increased use of IT or web based reference material, changes in content as a result of new research in the field or feedback from peers and students).
The use of Blackboard for the lectures and supportive material will be undertaken.
41
Students will also be encouraged to ask questions and initiate discussions during the lecture to carry out interactive learning, where student's interest in the subject can be enhanced.
Case study scenarios will be used to bring out the clinical aspects and applications.
Students will be given assignments to take away in order to improve their reading habits and use of library in other to encourage self-study/learning.
3. Course Objectives:
After successful completion of the course, the student will be able to: A. Describe the pharmacodynamics and pharmacokinetics of a) antimicrobial drugs, b) anticancer drugs c) drugs acting on immune system. B. Apply this knowledge in the specific clinical situations in identifying the problem C. The students will be able to analyse a related clinical problem and suggest a solution for it. D. Describe the genetic basis of individualized response to drugs. Topics to be covered till Mid Term
B: Learning Resources
Required Textbook(s) : Basic and Clinical Pharmacology, Bertram Katzung, Susan Masters, Anthony Trevor, Publisher; Lange
Basic Science, Ed. 12th 2012.
Additional References : 1. Rang & Dale's Pharmacology, Humphrey P. Rang, Maureen M. Dale, Publisher; Churchill
Livingstone, Revised Ed. 7th 2011.
2. Clinical Pharmacology, P. N. Bennett, Morris J. Brown, Publisher; Churchill
Livingstone/Elsevier, Ed.10th 2008. 3. Goodman and Gilman's: The Pharmacological Basis of Therapeutics, Laurence Brunton, Bruce
Chabner, Bjorn Knollman, Publisher; McGraw-Hill, Ed. 12th 2010.
3.Electronic Materials, Web Sites, etc.: http://aac.asm.org/cgi/content/abstract/43/6/1379
http://www.mayoclinicproceedings.com/content/86/3/250.full
http://aac.asm.org/cgi/reprint/10/4/736
http://www.cancer.org/Treatment/TreatmentsandSideEffects/
http://www.chemotherapytreatments.org/articles/types-of-chemotherapy-drugs.htm
http://www.ema.europa.eu/docs/en_GB/document_library/Other/2009/11/WC500015452.pdf
http://www.nice.org.uk/cg069
5- Other learning material such as computer-based programs/CD, professional standards/regulations: On-line text books, multimedia associated reference materials and the relevant websites learning
addresses on chemotherapy will be provided.
42
C: Course Weekly Activities
Week Topic (chapter/section) Intended Learning
OUTCOMES
Lab Assignment/
projects
Remark
1
Sept 1
L1 Introduction to the course
and expectations.
1. Define course objectives. Outline
course outcome, assessment, and
mode of course delivery, and
student’s responsibilities.
NA Comments on
Course Plan
study.
L2 Basic principles of
chemotherapy
1. Cognize the concept of selective
toxicity, what it is and how it may
be achieved and how these
mechanisms relate to selective
toxicity.
2. Be acquainted with the
definitions of chemotherapeutic
spectrum and chemotherapeutic index and
how they relate to selective toxicity
3. Understand the role of the host in
chemotherapy.
4. Identify the multiple sites of
inhibition by antibacterial agents.
NA 1. Spectrum of
Activity of
Antimicrobial
agents
Library
search
L3 Mode of Action of
antibacterial drugs.
Microbial resistance, drug
combinations rationale
,Principles of clinical use of
antibacterial drugs
1. Define and describe the general
and specific pharmacokinetic
barriers to effective chemotherapy.
2. Understand the difference
between bacteriostatic and
bactericidal, and how this relates
to drug choice and dosage intervals.
3. Comprehend the general
mechanisms of actions of
antibacterial agents and resistance
to chemotherapeutic drugs, and
cognize how the use of these drugs
selects for resistant populations.
4. Pinpoint the indications for
combination chemotherapy.
5 Discern the rationale behind
chemoprophylaxis.
6. Comprehend the appropriate and
inappropriate uses of
chemotherapeutic drugs.
NA 2. . Bactreiostic vs
bacteriocidal Library
search
43
2
Sept 8
L4 Sulphonimides and
Trimethoprim
1. Describe the mechanism of
action of sulfonamides.
2. Cognize the concept of
"antimetabolite".
3. Appreciate the role of
pharmacokinetics in the action and
uses of sulfonamides.
4. Identify the pharmacokinetic and
pharmacodynamic differences
among various sulfonamides.
5. To know the adverse effects of
sulfonamides 6. 6. 6. Understand
the rationale of combined
sulfonamide-trimethoprim
chemotherapy.
7. Know the clinical uses and
adverse effects associated with
trimethoprim.
NA 3. Drug allergies
in chemotherapy. Library
search
L5 Penicillins. 1. Define the significance of the
beta-lactam ring.
2. Explain the role of penicillin
binding proteins (PBP) in their
MOA.
3. Enumerate the chemotherapeutic
spectrum of penicillins.
4. Classify and identify different
types of penicillins.
5. Describe the mechanisms of
resistance — beta-lactamases and
cross-resistance.
6. Describe fully their adverse
reactions — hypersensitivity
NA 4.Hypersensitivity
reactions with the
use of antibiotics
Library
search
L6 Cephalosporins and Case
study Discussion
1. Identify the similarities to and
differences from penicillins.
2. Describe the changes in
pharmacokinetics and
chemotherapeutic spectrum of first-,
second-, and third-generation
cephalosporins
3. Undertake the classification of
cephalosporins and their clinical
uses.
NA 5. Relationship
btw
Cephalosporins
and penicillins
Library
search
3
Sept
15
L7 Tetracyclines 1. Describe their mechanisms of
action.
2. Understand and describe their
spectrum of activity and clinical
uses.
3. Understand the dependency of
therapeutic and toxic effects on
pharmacokinetics.
4. Understand why their use is
relatively limited (i.e. specific
indications for use).
NA 6. Drug
interaction with
antibiotics.
Library
search
L8 Chloramphenicol 1. Describe their mechanisms of
action.
2. Understand and describe their
spectrum of activity and clinical
uses.
3. Understand the dependency of
therapeutic and toxic effects on
pharmacokinetics.
4. Understand why their use is
relatively limited (i.e. specific
indications for use).
NA 7. Safe use of
antibiotics in
pregnancy
Library
search
44
L9 Aminoglycosides and Case
study Discussion
1. Understand the mechanisms of
action for aminoglycosides.
2. Identify spectrum of activity and
clinical uses.
3. Be acquainted with
pharmacokinetics — routes of
administration, excretion.
4. Know the classic adverse effects
of aminoglycosides.
5. Understand the dependency of
therapeutic and toxic effects on
pharmacokinetics.
6. Understand development of
resistance to aminoglycosides.
7. Role in combination
chemotherapy.
NA 8.Toxicity of
aminoglycosides Library
search
4
Sept
22
L10 Quiz 1 Anti-mycobacterial
Drugs: Tuberculosis
1. Describe and understand the
consequences of the mycobacterial
life cycle in regard to
chemotherapy.
2. Understand the mechanisms of
action for antimycobacterial drugs.
3. Distinguish between "first-line"
and "second-line" anti-TB drugs.
4. Know the pharmacogenetics of
isoniazid metabolism.
5. Understand and identify the
appropriate use of drug
combinations in antimycobacterial
chemotherapy.
NA 9. Rational for
combination
therapy
Library
search
L11 Anti-mycobacterial Drugs:
Leprosy
L12 Macrolides 1. Describe their mechanisms of
action.
2. Understand and describe their
spectrum of activity and clinical
uses.
3. Understand the dependency of
therapeutic and toxic effects on
pharmacokinetics.
4. Understand why their use is
relatively limited (i.e. specific
indications for use).
NA 10. Drug
interactions with
Microlides
Library
search
5
Sept
29
L13 Quinolones and
Fluoroquinolones
1. Understand the function of DNA
gyrases, and the effects of their
inhibition.
2. Identify the clinical uses of
quinolones and fluoroquinolones.
3. Describe and enumerate their
classes.
4. Know the adverse effects and
potential drug-drug interaction for
quinolones.
NA
11. Safety of
Quinolones in
children
Library
search
L14 Clindamycin, Linezolid and
Case study Discussion
1. Describe their mechanisms of
action.
2. Understand and describe their
spectrum of activity and clinical
uses.
3. Understand the dependency of
therapeutic and toxic effects on
pharmacokinetics.
4. Understand why their use is
relatively limited (i.e. specific
indications for use).
Library
search
45
L15 Streptogramins and
Cycloserine
. Describe their mechanisms of
action.
2. Understand and describe their
spectrum of activity and clinical
uses.
3. Understand the dependency of
therapeutic and toxic effects on
pharmacokinetics.
4. Understand why their use is
relatively limited (i.e. specific
indications for use).
12. Synergistic
action in
chemotherapy
Library
search
6
Oct 6
L16 Vancomycin and other Beta
lactam agents
. Describe their mechanisms of
action.
2. Understand and describe their
spectrum of activity and clinical
uses.
3. Understand the dependency of
therapeutic and toxic effects on
pharmacokinetics.
4. Understand why their use is
relatively limited (i.e. specific
indications for use).
NA
13. Treatment of
acquired
infections
Library
search
L17 Anti-viral Drugs 1. Understand the viral life cycle
and its' implications for
chemotherapy.
2. Explain and describe the
mechanisms of action antiviral
drugs.
3. Classify antiviral agents.
NA 14. Rationale for
drug
combinations in
viral infections
Library
search
L18 Anti-viral Drugs
7
Oct 13 Hajji Holiday
8
Oct 20
L 19
NA
Library search
L20 Anti-viral Drugs 4. Enumerate their clinical uses and
adverse reactions.
5. Identify resistance development
in their use and the rational for
combination therapy.
L21 Anti-fungal Drugs 1. Understand why selective
toxicity against fungal pathogens is
more difficult to achieve than is
antibacterial.
2. Know the mechanisms of action,
pharmacokinetics, and clinical uses
of the antifungal drugs.
3. Know the adverse effects of
antifungal drugs.
4. Describe different classes of
antifungal agents.
5. Drug interactions associated their
use.
NA
15. Drug- drug
interactions in the
use of antifungal
agents
Library
search 9
Oct 27
L22 Anti-fungal Drugs
L23 Anti-fungal Drugs
L24 Anti-protozoal Drugs 1. Understand the general
approaches to antiparasitic
NA
10 L25 Anti-protozoal Drugs
46
Nov 3 L26 OVERVIEWS chemotherapy
2. Descibe and enumerate the
general strategies and relevant
drugs used to treat the following
protozoal infections: a) Malaria, b)
Amebiasis, c) trypanosomiasis, d)
Cryptosporidiosis, e) Leshmaniasis
and f) Toxoplasmosis
3. Understand the principal
indications, mechanism of action,
adverse effects and
contraindications for the major
drugs used in the treatment of
protozoal infections.
L27 Anthelmintics 1. Know the distinction between
protozoal and helminth infections
2. Understand the general strategies
and relevant drugs used to treat the
major Helminth Infections.
3. Know the principal indications,
mechanism of action, adverse
effects and contraindications for the
major drugs used in the treatment of
helminth infections.
16. Broad
spectrum agents
in helmintic
therapy.
Library
search 11
Nov 10
L28 Anthelmintics
L29 Anthelmintics
L30 Quiz-2 Case study
Discussion
12
Nov 17
L31 Anticancer Drugs 1. Define the characteristics of
cancer cells and the principles of
cell kill and tumour growth
characteristics, and their relevance
to chemotherapy.
2. Describe the terms “cell cycle
specific” & “cell cycle nonspecific”
as it applies to anticancer drugs.
3. Understand the acute and chronic
toxic/ side-effects of the anticancer
drugs.
4. Understand the problems of drug
resistance and possible mechanisms
in cancer chemotherapy.
5. Enumerate and identify the major
classes of anticancer drugs
according to their mechanism of
action and their clinical uses.
6. Understand the rationale for
selecting combinations of
anticancer drugs.
NA
17. Selective
toxicity in cancer
chemotherapy
Library
search
L32 Anticancer Drugs
L33 Anticancer Drugs
13
Nov 24
L34 Anticancer Drugs
L35 Anticancer Drugs
L36 Anticancer Drugs and Case
study Discussion
14
Dec 1
L37 Immunopharmacology 1. Understand the concept that
interference with immune responses
has the potential to increase the risk
of disease.
2. Understand the rationales for
diagnosis and treatment of
opportunistic pathogens in patients
treated with immunomodulators.
3. Understand the indications,
mechanism of action and potential
adverse effects of the major classes
of immunomodulatory drugs.
NA
Library
search L38 Immunopharmacology
L39 Immunopharmacology
15
Dec 8
L40 Pharmacogenetics 1. Define pharmacogenetic and
enumerate the concept of variability
NA
18. Genetic
induced drug Library
search L41 Pharmacogenetics
47
L42 Pharmacogenetics in drug responses among the
general population.
2. Describe the role of phase I and
II isozymes associated with adverse
drug reactions.
3. Identify the role of
polymorphisms in drug
metabolizing enzymes and their
relationship in drug actions and the
patient response to drugs.
4. The application of
Pharmacogenetics in clinical
practice as it applies to
individualized therapy.
reactions
16
Dec 15
L43 Case study Discussion Immunopharmacology and
Pharmacogenetics
NA
-
L44 Overview NA
L45 Class Assignment Assigned Research topics NA
17
Dec 22
L46 Revisions
NA
11 Submission of
research topics
L47 Review of class assignment NA Submission of
research topics Library
search
L48 Examinations NA
D: Class Format: (You can modify it according to your course)
Class will consist of lectures and in some instances class discussion of problems or other assignments. In
addition, student will be responsible for all material in reading assignments regardless of whether or not the
material is discussed in class. Since these reading assignments are provided before class, it is expected that
students will read assignments before coming to class. It should be anticipated that class discussion may require
knowledge of the reading material and student who are not prepared may find class discussion difficult to
follow. Students are required to have a course portfolio; this should consist of explanations of lectures
during class discussion and will be taken into account when considering border-line cases.
E: Library Assignments
Please add topics and description for library assignments: Topics:-
Mechanism of Drug resistance in chemotherapy
Adverse drug reactions in cancer treatment
Chemotherapy of immuno-compromised patients
Rationale for drug combination in chemotherapy
Contraindications of chemotherapeutic agents in pregnancy
Safe use of antibiotics in children
F: Service learning/ Interprofessional Education :(if applicable)
Please add the topics and strategy for service learning module of your course, if applicable
This semester, students will go on education campaign on the rational use of antibiotics at Al Ahsa mall/Al
Othaim Mall. Hand bills will be distributed in both Arabic and English explaining the proper use of antibiotics
to avoid drug resistance within the community.
G: Examinations and Assessment:
48
During the semester, there will be an announced classroom quizzes in advance. These quizzes include topics
from the lectures that are covered before the quiz. The quizzes are worth 10% of the final grade in the
course. For the theoretical section of this course, there will be 2 examinations, Mid-term, and Final exam. The
outcome of these exams will represent 80 % of the final grade in the course.
Overall, the course will be graded as follows: (Please see grade distribution of your course and arrange
accordingly)
Schedules for Midterm and Final exams will be announced by the Committee for Academic affairs in
consultation with relevant students’ committee
Grading Scheme (Please refer to grade distribution of your course and adjust the grading accordingly) Assessment
Assessment task (eg. essay, test, group project, examination etc.)
Week due Proportion of Final Assessment
1
Quiz #1 4th
5 %
2
Quiz #2 12th
5 %
3
Quiz #3 ( if applicable) - -
4
Service Learning (if applicable). 13th
-
5
Class activities ( to assist border-line cases) 6th
-
6
Library/Home Assignment 12th
10%
7
Mid Term Exam (Final Schedule will be issued by Academic Affairs committee)
8th
30 %
8
Lab Exam - -
9 Final Exam End of
semester 50 %
Total 100%
H: Attendance:
I expect you to be at every class. I often give information in class that is not in the presentation or found in the
textbook. Attendance is one of the most important work ethics in this profession. If you miss 25% of the total
classes during the semester, you will be dropped from the final exam.
COMING IN LATE
While it is mandatory to come on time in every class, I do realize that some logical circumstances may prevent
you from getting to class on time. Chronic late comers will not be allowed into the class during lecture. Please
show respect if you come in late, stay outside.
I: Academic Dishonesty and misconduct:
49
It includes all of the following:
21. Cheating in exams, quizzes, small group sessions, from any source like fellow student, notes,
electronic sources.
22. Plagiarism: presenting work, words, ideas, presentations, assignments of others in whole or in
part, in assignments, presentations or projects
23. Falsifying tempering records of attendance, false excuses for absence
24. Disrespect to instructors, administration and colleagues
25. Non adherence to instructions regarding class discipline, dress code etc,
Students found to commit any of the above will be subject to disciplinary actions according to University Rules
and Regulations, mentioned in COCP Students’ Handbook
Recommended