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7/16/2019 SISTEM REPRODUKSI WANITAc.pdf
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SISTEM REPRODUKSI WANITA
Happy H
FKG UNEJ
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TO REVIEW THE COMPONENTS OF THEFEMALE REPRODUCTIVE SYSTEM
TO UNDERSTAND THE HORMONAL
REGULATION OF OOGENESIS, OVULATION,AND THE UTERINE CYCLE
TO IDENTIFY THE HISTOLOGY OF THE
REPRODUCTIVE TRACT
TO CHARACTERIZE THE GENERAL
ORGANIZATION OF THE OVARIES
FEMALE REPRODUCTIVE SYSTEM
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OVARIES
OVIDUCT
(UTERINE
TUBES)
UTERUS
VAGINA
FEMALE REPRODUCTIVE SYSTEM
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FEMALE REPRODUCTIVE SYSTEM
OVIDUCT (UTERINE TUBES)
UTERUS ;
INFUNDIBULUM, AMPULLA, ISTHMUS, UTERINE
FUNDUS, BODY (CORPUS), CERVIX
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FEMALE REPRODUCTIVE SYSTEM
OVARY
- thin connective tissue capsule
underlying germinal epithelium
TUNICA ALBUGINEA
GERMINAL EPITHELIUM
CORTEX
- surrounds the medulla and
contains maturing follicles
MEDULLA
- central connective tissue
containing vascular supply and
nervous innervation
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FEMALE REPRODUCTIVE SYSTEM
OVARY
3 to 5 million OOGONIA differentiate into
PRIMARY OOCYTES during early development
OOCYTES becomes surrounded by squamous
(follicular) cells to become PRIMORDIAL FOLLICLES
most PRIMORDIAL FOLLICLES undergoatresia leaving 400,000 at birth
oocytes at birth arrested at
Meiosis I (prophase)
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FEMALE REPRODUCTIVE SYSTEM
OVARY
THREE STAGES OF OVARIAN FOLLICLES CAN
BE IDENTIFIED FOLLOWING PUBERTY:
(each follicle contains one oocyte)
(1) PRIMORDIAL FOLLICLES
- very prevalent; located in theperiphery of the cortex
- a single layer of squamous follicular
cells surround the oocyte
(2) GROWING FOLLICLES
- three recognizable stages:
(a) early primary follicle
(b) late primary follicle
(c) secondary (antral) follicle
(3) MATURE (GRAAFIAN) FOLLICLES
- follicle reaches maximum size
OOG
ENESIS
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FEMALE REPRODUCTIVE SYSTEM
OVARIAN FOLLICLES
(1) PRIMORDIAL FOLLICLES
(2) GROWING FOLLICLES
(a) early primary follicle
- follicular cells still unilaminarbut now are cuboidal in appearance
- oocyte begins to enlarge
(b) late primary follicle
- multilaminarfollicular layer; cells now termed granulosa cells
- zona pellucida appears; gel-like substance rich in GAGs
- surrounding stromal cells differentiate into
theca interna and theca externa
(b) secondary (antral) follicle
- cavities appear between granulosa cells forming an antrum
- follicle continues to grow
- formation ofcumulus oophorus and corona radiata
(3) MATURE (GRAAFIAN) FOLLICLES
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FEMALE REPRODUCTIVE SYSTEM
OVARIAN FOLLICLES
late primary follicle
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FEMALE REPRODUCTIVE SYSTEM
OVARIAN FOLLICLES
GRANULOSA (FOLLICULAR) CELLS
ZONA PELLUCIDA
OOCYTE
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FEMALE REPRODUCTIVE SYSTEM
OVARY
CORPUS LUTEUM
CORTEX
MEDULLA
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FEMALE REPRODUCTIVE SYSTEM
OVARY
GERMINALEPITHE
LIUM
T
UNICAALBUGINEA
CORTE
X
PRIMORDIAL
FOLLICLES
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FEMALE REPRODUCTIVE SYSTEM
OVARY
G
ERMINALEPITHELIUM
TUNICAALBUGINEA
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FEMALE REPRODUCTIVE SYSTEM
OVARYOVARY H&E
PRIMORDIAL
FOLLICLES
EARLY 1
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FEMALE REPRODUCTIVE SYSTEM
OVARY OVARY H&E
CORPUS
ALBICANS
EARLY PRIMARY
FOLLICLES
OVARY
PRIMORDIAL
FOLLICLE
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FEMALE REPRODUCTIVE SYSTEM
OVARY
LATE PRIMARY FOLLICLE
multilaminar
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FEMALE REPRODUCTIVE SYSTEM
OVARY
MATURE (GRAAFIAN) FOLLICLE
cumulus oophorus
corona radiata
theca interna and externa
zona pellucida
theca interna cells begin to
produce androgens that are
converted to estrogens
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FEMALE REPRODUCTIVE SYSTEM
HORMONAL REGULATION OF
OOGENSIS AND OVULATION
HYPOTHALAMUS release of GnRF which
stimulates release of LH and FSH from the
adenohypophysis (ANTERIOR PITUITARY)
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FEMALE REPRODUCTIVE SYSTEM
HORMONAL REGULATION OF OOGENSIS AND OVULATION
FOLLICULAR PHASE LUTEAL PHASEOVULATION
10-20 primordial follicles begin to develop
in response to FSH and LH levels
FSH and LH stimulate theca and granulosa
production of estrogen and progesterone
surge of LH induces ovulation
theca and granulosa cells transform into the corpus
luteum and secrete large amounts of progesterone
if fertilization does not occur, corpus luteum
degenerates ... if fertilization does occur, HCGreleased from the embryo maintains corpus luteum
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FEMALE REPRODUCTIVE SYSTEM
HORMONAL REGULATION OF OOGENSIS AND OVULATION
OVULATION:
sharp surge in LH
with simulataneous
increase in FSH
Meiosis I resumes;
oocyte and surrounding
cumulus break away and
are extruded
oocyte passes intooviduct
ECTOPIC
IMPLANTATIONS
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FEMALE REPRODUCTIVE SYSTEM
CORPUS LUTEUM
FORMED FROM FOLLICLE WALL WHICH
REMAINS FOLLOWING OVULATION
(1) GRANULOSA LUTEIN CELLS
- large, light cells derived from
granulosa cells
TRANSFORMED CELLS SECRETE
ESTROGENS AND PROGESTERONE:
(2) THECA LUTEIN CELLS
- strands of small cells derived from
theca interna
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FEMALE REPRODUCTIVE SYSTEM
CORPUS LUTEUM
(1) GRANULOSA LUTEIN CELLS
(2) THECA LUTEIN CELLS
CORPUS LUTEUM H&E
(1)
(2)
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FEMALE REPRODUCTIVE SYSTEM
OVIDUCT
SITE OF FERTILIZATION
TRANSMITS OVA FROM
OVARY TO UTERUS
MUCOSA
EPITHELIUM AND LAMINA PROPRIA
MUSCULARIS
INNER CIRCULAR; OUTER LONGITUDINAL
INCREASES AS APPROACH UTERUS
SEROSA
MEIOSIS II IN PROGRESS AND ULTIMATELY
ARRESTS UNLESS FERTILIZED
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FEMALE REPRODUCTIVE SYSTEM
OVIDUCT
SIMPLE COLUMNAR EPITHELIUM
TWO CELL TYPES:
(1) CILIATED
(2) PEG CELLS (NONCILIATED)
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FEMALE REPRODUCTIVE SYSTEM
UTERUS
PERIMETRIUM, MYOMETRIUM, ENDOMETRIUM
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FEMALE REPRODUCTIVE SYSTEM
UTERUS
ENDOMETRIUM
TWO LAYERS:
undergoes cyclic changes which prepare
it for implantation of a fertilized ovum
(1) FUNCTIONAL LAYER (stratum functionalis)
(2) BASAL LAYER (stratum basale)
- BORDERS UTERINE LUMEN
- SLOUGHED OFF AT MENSTRATION
- RETAINED AT MENSTRATION
- SOURCE OF CELLS FOR REGENERATION OF
FUNCTIONAL LAYER
- CONTAINS UTERINE GLANDS
STRAIGHT AND SPIRAL ARTERIES
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FEMALE REPRODUCTIVE SYSTEM
HORMONAL REGULATION OF UTERINE CYCLE
(1) PROLIFERATIVE PHASE concurrent with follicular maturation and influenced by estrogens
(2) SECRETORY PHASE concurrent with luteal phase and influenced by progesterone
(3) MENSTRUAL PHASE commences as hormone production by corpus luteum declines
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FEMALE REPRODUCTIVE SYSTEM
UTERUS
PROLIFERATIVE PHASE
cells in basal layer begin to
proliferate to regenerate
functional layer
spiral arteries begin to lengthen
and revascularize developing layer
functional layer becomes thicker
than basal layer during late
proliferative phase
developing uterine glands are
tubular in arrangement
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FEMALE REPRODUCTIVE SYSTEM
UTERUS
PROLIFERATIVE PHASE
tubular uterine glands
simple columnar lining
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FEMALE REPRODUCTIVE SYSTEM
UTERUS
PROLIFERATIVE PHASE
tubular uterine glands
simple columnar lining
UTERUS H&E
UTERINE
GLANDS
PROLIFERATIVE PHASE
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FEMALE REPRODUCTIVE SYSTEM
UTERUS
SECRETORY PHASE
functional layer thickens
glands become coiled and
accumulate large quantities of
secretory product
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FEMALE REPRODUCTIVE SYSTEM
UTERUS
SECRETORY PHASE
functional layer thickens
glands coiled
UTERUS H&E
COILED
UTERINE
GLANDS
SECRETORY PHASE
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FEMALE REPRODUCTIVE SYSTEM
UTERUS
SECRETORY PHASE
functional layer thickens
glands become coiled and
accumulate large quantities of
secretory product
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FEMALE REPRODUCTIVE SYSTEM
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FEMALE REPRODUCTIVE SYSTEM
VAGINA
STRATIFIED SQUAMOUS EPITHELIUM
LAMINA PROPRIA
---------------- no glands ----------------
MUSCULARIS
INNER CIRCULAR
OUTER LONGITUDINAL
ADVENTITIA
MUCOSA
FEMALE REPRODUCTIVE SYSTEM
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FEMALE REPRODUCTIVE SYSTEM
LABIA MINORUM
LABIA MINORUM H&E
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MATURNUWUN, MUGI KASIL
Tq, Met blajar
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