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Specific Mutation Induced by Triplex-Forming Oligouncleotides in Mice. Karen M. Vasquez, Latha Narayanan, Peter M. Glazer. 20 October 2000 Science Date: 2001 4/25 Speaker: 劉育男. Introduction:. ~Aptamer. ~SELEX. - PowerPoint PPT Presentation
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Specific Mutation Induced by Triplex-Forming Oligouncleotides in Mice
Karen M. Vasquez, Latha Narayanan, Peter M. Glazer
20 October 2000 Science
Date: 2001 4/25
Speaker: 劉育男
Introduction:
~Aptamer
~SELEX
Triplex-Forming Oligonucleotide
(TFOs)
TFO 發展面臨的問題
1.Cell uptake
2.Stability of TFO
3.Specific targeting site or potential site
4.New DNA damage agent
5.Triplex-binding code
Conclusion:
These studies established that small DNA molecule can be administered by i.p. or intravenous injection and gain access to tissue and to cell nuclei
Chromosomal DNA throughout the somatic tissues of an animal can be targeted by nucleic acid aptamers
Aptamers 的應用
~ 取代 antibodies
作為更專一性的結合 ligand
Medical usage, Lab usage
~ 調控 Cell bioactivities
Drug design
The End
Thank you
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