Enzymes.pptx v1 2019 · 2019-04-11 · RATES OF REACTION AND THEIR DEPENDENCE ON ACTIVATION ENERGY...

Enzymes

2nd yearBiologydepartment

غسق جبار .د.مزھراء سالم . د.أنجالء قاسم . د.م

Locationofenzymes

Zn+2,Mg+2Flavin,heme,Niacin

Cofactors:

The enzyme with its cofactor called Holoenzyme .

The protein portion of the holoenzyme is calledApoenzyme.

In the absence of the appropriate cofactor, theapoenzyme typically does not show biologic activity.

A prosthetic group is a tightly bound coenzyme thatdoes not dissociate from the enzyme

Co-factor=Zn+2

Holoenzyme=Zn+2+theenzyme

Apoenzyme=Onlytheprotein

Carbonicanhydraseenzyme

The EC number : is a unique identifier for each enzymeclassified according to this system. The EC number consists of4 digits. The first digit represents the class of enzyme, thesecond digit strands for the subclass, the third digit representsthe sub-subclass or subgroup and the fourth digit provides theparticular enzyme

E.C.1.1.1.4EnzymeCode

Reactiontype

SubclassSub-Subclass

Thespecificenzymename

Theenzymecodenumber

E.C.2.71.1EnzymeCode

Transferase

TransferofphosphatePhosphateaccepter

Hexokinasephosphotransferase

Substrate binding

Michaelis-Menten plot

Competitive Non-Competitive Un-Competitive