YUAN-YUN LIN_ISOMRM

Yuan-Yun Lin , Ling Chao*, Kevin C.-W. Wu* Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan

Discussions

Objective

Acknowledgements

Characterization

SEM of MCNs

E-mail ：lingchao@ntu.edu.tw and kevinwu@ntu.edu.tw

Synthesis of A Novel Phospholipid Layer/Mesoporous Carbon Nanoparticles (MCNs) Core/Shell Structure as An Anticancer Drug Nanovehicle

for Efficient Drug Loading

Synthesis of a Novel Phospholipid Layer/MCNs

Experimental

Doxorubicin

Hydrophobic Drug Loading

Lipid coating

MCNs

Vial DOPC@CCl4

Remove organic solvent under N2

Mix well

Add solution

Drug Loading Testing

centrifugation Optical Microscope Fluorescence Photometer

Analysis

TEM of MCNs

50 nm

BET of MCNs

Relative Pressure (p/p0)

Volu

me

Abs

orbe

d (c

m3 g

-1)

Pore Diameter (nm) V

P

0

50

100

150

200

250

300

350

0 0.2 0.4 0.6 0.8 1 1.2

0 0.05

0.1 0.15

0.2 0.25

0.3 0.35

0.4 0.45

0.5

0 50 100 150 200

Drug Loading

0

20

40

60

80

100

Load

ing(

%)

Results

Because of their high surface area and the hydrophobicity, mesoporous carbon nanoparticles (MCN) were successfully synthesized and utilized as a potential drug nanocarrier. In addition, a phospholipid layer was applied as a gate-keeper to control the load/release behavior of drugs. The MCN/phospholipid core/shell structure here provides a new alternative for next-generation bio-medical applications.

The research was supported by the National Taiwan University.

Synthesis of a Novel Phospholipid Layer/Mesoporous Carbon Nanoparticles for Intracellular Drug Delivery.

MCNs

Drug loading Lipids mixing

!

Cell Culture

(a) (b) drug

100 nm

5 µm

MCN+doxo.: 16.23 µmole/ doxo./g MCN MCN+doxo.+lipid: 8.76 µmole/ doxo./g MCN

MCN+doxo. MCN+doxo.+lipid

Texas Red @DHPE

MCN

fluorescence