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Mapping of complex traits
Jei Kim, MD
2010. 4. 9
(Adopted from Dr. T. A. Manolio’s slides)
(Atherosclerosis 2009;207:144-149)
(BMC Med Genet 2007;8(suppl 1): S11)
(BMC Med Genet 2007;8(suppl 1): S17)
GWAS in stroke fields
1. Single-gene disorders
2. Disorders having complex inher-itance - complex interaction between 1) genotype at one or more loci 2) a variety of environmental expo-sures
Inherited dis-eases
Mendelian disorders vs. Common disor-ders (ref. 2)1. Mendelian disorders
- rare and highly heritable- variation in single gene is both necessary and sufficient to cause disease
2. Common disorders- influenced by several genetic and environmental factors (ref. 2, 3)- cluster in families (ref. 3)
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