Figure 1: . 1-5nm (University of Arkansas, USA).
4.....................................3 Figure 2: (Johns Hopkins
University, USA). 12......................................3 1.
.................................4In vitro
..........................................................4 In vivo
..........................................................6
.........................................................6
2. ...8
.........................................................8
........................12
............................................13
3. .............................15
.........................................................15
........................................16
2
Intellectum 04/ 08
.......................................................16
Figure 1: . 1-5nm (University of Arkansas,
USA).........................................5 Figure 2: (Johns
Hopkins University,
USA)..........................................12
3
M . , . ( ) . ( ) (.. , ) (.. , ).
1. , . , .
In vitro in vitro . , , . ` . , , , , , , , , , . (chip), , DNA
.
4
Intellectum 04/ 08
Figure 1: . 1-5nm (University of Arkansas, USA).
ex vivo , . , in vitro (biochips). , , , . : . . . , , , ( ) ( )
. () , ,
.
5
.
, .
In vivo in vivo (.. ), . (.. ). , , . in vivo , , ,
(theranostics). in vivo :
.
. .
.
, , - , (, , ) , , (.. , , ).
AIDS. , / ,
6
Intellectum 04/ 08
. : ( ) . - / . / . . - . . .
.
7
2. - . , . , , , , . , / (/) , . , . / , . . , , , , ( ) ., . ,
: , , , , , , .
- (10100 nm) . 8
Intellectum 04/ 08
. in vivo . , / . (.. , RGD, , , ..) . . / . ( ) , (PEG). (.. )
PEG. . , . , , . - - -. ( - ) (.. PEG ). . - ( ) . ( ) , 10-1000
nm. . , - . . 9
. - (PLGA) / . PLGA (.., PVA-gPLGA, SB-PVAg-PLGA DEAPA-PVAg
PLGA) PLGA , , .. CO2 . . , . in vivo. , , . / . / . . , / (.. , ).
- / , , . . . . . . [.. , , ( ) ..] . , ,
10
Intellectum 04/ 08
. pH, , , , , . (.. pH ). . - . , . , ( ). : , , , , , . . . (..
, / ..). -SH . SH . / . , , . , 11
, . . . (.. ). , :
. . . .
.
Figure 2: (Johns Hopkins University, USA).
, . . , . - (.. , , , ..) (MEMS) ( ) . , (stents), , 12
Intellectum 04/ 08
. . , , - . - (micro-chips) : (.. , ) (.. , ) .
: , , : . . . . , . . . , , 13
, , . , , - . : . in vitro . . in vivo . in vivo in vitro .
14
Intellectum 04/ 08
3. . , . , , . . / , , . . , . , , . . / , (biomimesis) . : , -
.
, , . (.. pH, , , ) . - (.. ) . :
15
. . . . . . , . - .
.
(.. , , ) . : - .
, , . , , . , . . 16
Intellectum 04/ 08
: , , .
17
