Pharmacokinetics disposition (absorption) (distribution) (metabolism) (excretion)

1 2 3 4

pKapH

active transport1 2 3 4

(absorption) (per os) (sublingual) (per rectum)

(first pass elimination)

() (intravenous injection,iv) (intravenous infusion,iv in drop) (intramuscular injection,im) (subcutaneous injection,sc)

5 m 10 m

(distribution) D + P DP 99% 1% 98% 2% +

131

pH pH7.4 pH7.0

biotransformation; drug metabolism : ,

P450cytochrome P450 enzymatic system : + + +

(excretion)

1. 2.pH 3. (

1. 2.pH

. Cmax) (Tpeak) (latent period) (persistent period)

-

F=AUC 100%AUC

F=AUC100 %AUC

.. FAUCTpeakCmax

MTCMEC

. CL LKg-1 h-1

Vd c A A (mg) Vd = C0 (mg L-1)

(half-life time t1/2)

. . . .

..

t1/2=0.693/k

5t1/2

. t1/2=C0/2k0