258
#  # ################>### #### #### ### #### ## ########### #### ### # ### ### ### ### ### ### ### ### ��� ��������������������������������������������������������������������������������������� ���������������������������������������������������������������������������������� ���������������������������������������������������������������������������������� ���������������������������������������������������������������������������������� #n# <1###b @ ��� ����������� ��� ����� �������������� ��� ������������ ��� ����� ����������� ##rq Ztx PNG �� # ###IHDR### ###n#####

170112 - Purin Synthesis

Embed Size (px)

Citation preview

  • 7/25/2019 170112 - Purin Synthesis

    1/258

    ## ################>###

    ################# ########### #### #### ### ### ### ### ### ### ### ###

    #n#

  • 7/25/2019 170112 - Purin Synthesis

    2/258

    \j####sRGB# # ##0 IDATx^ # ,)n ! " $###%& $ ,# ' P## ###### # x ( * #@## H + -- . ## *### / ## % ## ## # ## # #G # ## ## #@ 2 ## # (

    #3@##@###### #

    #4Z##4#####G N# G ## * 5 6. 5 $ 7# -4 #' # n 1## A83 4 90 #: ; # ^ 3 ## # 8 '

    =xb ) I^ #A ?B # # ##& # &/ =#.P# C # 7ECF =r # #J q# # b ! I #"bDG x jK# L #: M#

  • 7/25/2019 170112 - Purin Synthesis

    3/258

    * #OE I # Q # #6 qn #4# Sq: # ##+ Z#9# A !#\ , , ,,,,,,,,,, UI

  • 7/25/2019 170112 - Purin Synthesis

    4/258

    Z# G*FV # \ H#/# 9'#9 < 0 GL Z Z# 4>4 2S I W VM A0 I+ ^5 T L 3 9X S =# ' # 6# Y , sq 6 . ACb C ##8###T#N F x [ b P# 2 0 t #Z> #J 96 I]#M## \ #6# % #F J >_3#

    R

    #M

    C 4 ! L `/ R# # : # # ## V

    t 6 t ! r 3 . # ###a# #6 # N R B $ J #X# q3 2 "# # cEN % # d # _ # # # # 5# # , . ##j6 7# \ ### ] #1 #1 R )

    5)## # ( s >e f# Cd `#?#

  • 7/25/2019 170112 - Purin Synthesis

    5/258

    #G $/ b B #E @# _\ 0#V 5 #:# #JGj V#7 d #7#:# [$g X #j O

    P

  • 7/25/2019 170112 - Purin Synthesis

    6/258

    UIS # 0 #5 # Pn # h> ( a ##" % D ! U : ## `St #q# + L

    9 #9 #] (H .M ##@ # >' S ) x # # 9G^ ###^ G GGGGGGGGGG r(#f #9M* ##(C # qi 8 8(t / I # @##' 4 N& 3 ) # +Q I#U 5

  • 7/25/2019 170112 - Purin Synthesis

    7/258

    0q ) ##>B ##:@## M @ x# 14 P#4# d# 8\#UN9 I)04ZN

  • 7/25/2019 170112 - Purin Synthesis

    8/258

    5 C i L _ t[- # (4E### ## # tF# 4JU i4 @ # *# @^Rt> ##f #nP ## n 8( # [ . 2 6,0f

    # #5 # # b#' # # a #VSQI BEQ

    Q#]### #Im' M _E *# [ #s# #Et ## * ********** R C # ? ) # _# #T 9 M# # 9 #) ji 9G # # # P# t E#

    #XZs ^ # #6G,#O ### # R

    B # @### # # # #^qU3 'S? 9 # PR 5 T # A QU#: # q # # % #

  • 7/25/2019 170112 - Purin Synthesis

    9/258

    L - " @--fA `1fD #0 U# )2#

  • 7/25/2019 170112 - Purin Synthesis

    10/258

    V # B ## # jA O#s=t S C # X * n 5V A (#n # f ALC Q b # t# ## #x , #& D@q nQ ^ i ## #" @2#HR t # ># Bq\# ^ U Ma$#

    Z d # #4E ## #t rG B# t=

    " &4 5@#H % ### #X9 E# # #[ . H#It PJ $ # > OS3i ##` 8 >SI44U @s #7 # NSiq ` # ##a # #4 P i B #'`R ##5 ! % G D ` # [U , H j4 ! bE O H @# TEq# j f##[ LG #U ( dS B 1 ( = # Q EG`r _ - s D(j4 # E #

  • 7/25/2019 170112 - Purin Synthesis

    11/258

    Vj 7E#J O #j *#Z > A #t \ # #5t #Q` #S s d iXs## O 3

    SQ# 1J =jP% 8 5# < -? L T & &&&&&&&&&&

  • 7/25/2019 170112 - Purin Synthesis

    12/258

    # [ d # = #M X## uO# j Si r # d q ## # I %# [ q $bG# [q# #

  • 7/25/2019 170112 - Purin Synthesis

    13/258

    -[d# [vr ) G (5) # Z s# G j - 17 ## 9 # _ ( ] -#[s s##L X0 s"#5 F t# 7j Z a # ? b # / Q # " # r4 #f * # V bE i na U DM * .F # 4 "# R# #f#

    # ` '/1#]6 # 3 :r4 F / $ t# # X aq +# 7U8 ` #(d# *

    #TRb## A#C6 8

  • 7/25/2019 170112 - Purin Synthesis

    14/258

    ##D # #)# E+ ( r M 8##V %# #U# _ # 7 , j# C $G# I t [ O# @C \#_ ! " H##b#Q + &

    #i q*## = #3.5##VC#& # '# ? A E *_

  • 7/25/2019 170112 - Purin Synthesis

    15/258

    ^ D . , rG r @ a X#a#x @ X UP ## #d # #qF:@###@# #X , # d ## 0 % %%%%%%%%%% #

    < `#[#UE# f . ## +H##?]Pd] 2]# F_8n## @## # ## U!_] X # &w # ## *f## @###C# >< *##@ ^## L. ###N##?x# ># X# ####O ## # ?## L @ 5!## *O## # ## # @ #=

  • 7/25/2019 170112 - Purin Synthesis

    16/258

    #@ *## #x =V %O## # I# ## # ## ##Z A##@### !2 ###O > SV x J "RQy##?! _# ##@ +# # %UZ > ##E# ' #######%4 B x #>#4# # @1 #> Z / % PS# X # #& ?[# # q L\# #8'

    #Q %Jxj#V #% ( # #####

    M

    \ %# ) % # ( i:J r #: ### iI j &rl[ #ir # # M ## # F ## .# X#t # @ X

    #< D # \G## ### #j # #28# i 5# 1 3#

    d " #N N##?j ) F: 3Q 53 N#q

    #A##?D NR )9 &L * U##H##?8 :N_ n `### X# L [ # 1## #x @ HC #`@##V* @ Q %L L>BjC V (N #J d- #>#

  • 7/25/2019 170112 - Purin Synthesis

    17/258

    f U6 #Q + S N#6& U # 9 Q% \ ) (Q 7 $tT T #s ##A =t "# JT jz #:7 r( > Q E J T{ P | < N=# Z +

    =,+ # # /# s 5#4((-# #7#G

  • 7/25/2019 170112 - Purin Synthesis

    18/258

    ) sM ^#' ## &* @ I# V 6 2_ ## %M# #taq ( F # 4# # # # #471 A # 9D G U @

  • 7/25/2019 170112 - Purin Synthesis

    19/258

    # #t

  • 7/25/2019 170112 - Purin Synthesis

    20/258

    ^ OS#*

    #,=@ @ QL 1b. D

    P9

  • 7/25/2019 170112 - Purin Synthesis

    21/258

    $ [ ##O6 F [ # j ^ 5# = # N# As 1 2 # n% #9# n ] F@ #M =(N = # V

    43O " ,

  • 7/25/2019 170112 - Purin Synthesis

    22/258

    9# #T\B # `#T QRq US6 # ,# ## # #E# 4 " `91### ? 1/ Q[1a n# 4 5 :Z b # /S _ ( rG[ >#X#[ C nA> #5+% # G# n # #' a[ 6 7

  • 7/25/2019 170112 - Purin Synthesis

    23/258

    4 _ n]E #[ : bJ " + # H1 @_ #[# T JH Q &^Q$ # B6_ (bU Z ,f# ) P ZGQ#p dZ# 3 1` # ##\ #/6(^ < 5 8 X# @ MQ/R # L #C ## 5LC #fC `$ 8 #) ##In.( 0 A-D #5## LA# *4Z(? s$ #d !(t #Q . # D###1 -_ZXq b # # 2! # >A T C a $ = B 3# # F9#U ( ( 4 #?& # d # # 1 2 R* QT +d# b .+ +S# ##$>

  • 7/25/2019 170112 - Purin Synthesis

    24/258

    B $ F 5_U S##

    b M# 611n # # d$ _2 S B##5 !V , ` "

  • 7/25/2019 170112 - Purin Synthesis

    25/258

    ) , M5 QV^ F N T /& b G3 t / G #^# " b" # . 9\ $ % i ^ #AM\7X A

    ?# 4U T >9 2#q U# #*.# >L0 # ]$' ,S!##X 7 F# [ /0 # #i? H Q 6> S# # ##> 7xnq[ B B [n? q###E# L # FV#AQ b # 0

    3#S,^N :

  • 7/25/2019 170112 - Purin Synthesis

    26/258

    #

    # @ # 'V _ B s#(< ] M# G # # I.# I ##I$ M C #' # V " #5 ]& 7 ^ BN % O # 0# E TG#!#S f># #D %#Z # ' It_Dn #Z s @75#a \ "+# ] D DDDDDDDDDD a% M t

  • 7/25/2019 170112 - Purin Synthesis

    27/258

    # U# \# X## a F 5 G# @ ## E bO M C- # - ? F . ## P## # # #: E N ##?j L ' ## # D" b = L# 8 @@ # # x ` # O_E 2U F

    # # x< N E# =] ##

  • 7/25/2019 170112 - Purin Synthesis

    28/258

  • 7/25/2019 170112 - Purin Synthesis

    29/258

    TT j /x # * @ O# [#@ 7q d#(9 #0i# ### # _ 2 G #.### ## S I nn =## 0##X5b# # #? aSP& 5 : H9 # ## . x# H #`#`8 #### # N t# G## D##? d@ br # @+#b##@ T## J## A## C# > # )# `#3 ##\##? ? < F 1# ## > ^ ###A##?D ! H & #>* +G +I 4## @8 @ ^ ? +M 2 0 # #$ t9 V # # I 4 # +# F E ?B # #\8 @CF" 1 " ## J# ! : # # ## # 4

    Z >##'##=# #UXF 3 FqjI 5 # C -BF 5C ##J V /# B^# #i 4# " * ( * 6 0##a# `S 3 R ]B #F 5 ##=#Z - @ # ! R @QR 2r

  • 7/25/2019 170112 - Purin Synthesis

    30/258

  • 7/25/2019 170112 - Purin Synthesis

    31/258

    # & = # ## # ##UZD ## ## ## ## ##A @ ##n ## ###7##@ ### x@ .5x## ### # J: U # >U( ## [ .9 GS /6#f#< ## ##^, G G % A#C # # # 6n # t - # ## # # #E ' [ _# # 7 : N #%n # # #U[ d # b

  • 7/25/2019 170112 - Purin Synthesis

    32/258

    6? 34# @ -CL #Q# # {I@X# s ? #: O#& S Q # [#!# 7 Q:nI+- # j9 G S 7 SR -\4

    ## ## % # t X # D2q HD ` " O [ H D #+ $7# 4E / J I /I, s# U 8 TnG #s . s ! $#a# MNF P ` 9, s6aGJ # # 7#M #j % < C " S # 4F1 V Z 1 C`# #D TR =# j # G x #P# S [ 9 ` # 9: i !# s A ? T S%# @C < Q # O: ` ' #D #M 7^##4 NEq H ## #SQM ` USG#t# S D 8) 7 $ 7#_ N $ 1# # # Z U Z # U- [ #1: V ;# t d# 1! #I .+ 7 $ #:j =

  • 7/25/2019 170112 - Purin Synthesis

    33/258

    J( I # /da . # Z 2 d & #9. 9X V #/11 r #`#E # # /* " S & ` s "L L T* 46_Z &V _ W ># : s9 -(( = N 6 ?#iV #X @

  • 7/25/2019 170112 - Purin Synthesis

    34/258

    "## 9 ` a t#_ # # T2 jiF >#L # '#R A : > / 2 #j< X A " " a# Z 6 j^t B # : ( q

  • 7/25/2019 170112 - Purin Synthesis

    35/258

  • 7/25/2019 170112 - Purin Synthesis

    36/258

  • 7/25/2019 170112 - Purin Synthesis

    37/258

    x ? . C#DU #?J Q J R H?%&. : I #S EM#q ?\ Ed sr *EMA # N 9+ ? ' #H JO B f# , a#I2 - JM # QXq ##9#x r t* 6 # ] 2

  • 7/25/2019 170112 - Purin Synthesis

    38/258

    0 0# #@ S#$ r "2 : ) ## "## " ###f\ # > J ## ##Es# # V: @ ( 1 #2Z` #I%$ _ # f #9 '8## ?#J# # b JM##G ## A## F ## ##(#P ^ !%D # # #6 2# t7 ##### >,8*##@ X# _! # *# # O# # ## # bN ###@ xb g #### @+###@##@##@##@##@##@## #1 i ####IND B8 #n# ## # / B 1 P# PNG ####IHDR###a######### ####sRGB# # ##RIDATx^ #P * # J #Q # bq# # # AX > # V5f $## @ @ -

    R#$2#####x## #### ##]t # ###

  • 7/25/2019 170112 - Purin Synthesis

    39/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    40/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    41/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    42/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    43/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    44/258

    # @ @ n # @@# ##### ## $### ## 7# ### ## n # @ Z#A ###

    *#Ax 9 # i # !#9 # #T #i

    #

    &! 9\S x 6 # Ii #

    = J#> I( 3`# 7n \ ###\ # ' XL #n $

  • 7/25/2019 170112 - Purin Synthesis

    45/258

    ## n@ 2 * iJ( C# ## L @ G5 )af Kj #N+ _. O \# 9 ? j \@#^ + : ,\ U#= V##H \@# # # #,# V # 4k C#a #

    L#b8)7 B# # U d # J: r # -# # Q # #^7+ Z 2 & # # D N C# ^_

    6 + 1 "D 0##= !] 8 # ## #]f # # # LJT _* Q #J[ #L ' 8 5 r C fC #f # L4# #5 #' # # 1 r#A [ # ##I 7# = 8D@## ## F _ ,q 5 af ## #?R#Ax Df # : . 5 ? # X #

    #B *^ ##- + # B Xt D # V = # # 6# M #, # V4# # & N% - # # 6## 8 (##8 M##AO # #SL O # #A f # 2M #Z #n a I?C ##] #\ U# >:/ # ? G#2 r MC*# #: m - \ xo : \ N

  • 7/25/2019 170112 - Purin Synthesis

    46/258

    5 ## V#N J 1Fq# ###C WB#A # n2#O ## X# !# # # #_ rGt#" XG+6 ## BZ s 2 qb " D #a ## Y< ) # * & # Pt

  • 7/25/2019 170112 - Purin Synthesis

    47/258

    # # J ]#b@8##A .N#O I : ## # i#[#O # # a##[A V! NP ! L :6 Z' L :7#+F Z# ^ 2[ (_TS#a #"' #\M #b

  • 7/25/2019 170112 - Purin Synthesis

    48/258

    #= + n0 6 : # G# M# ?. R !6F TQ #*s # A2 #[ ## . # , %#7 q L # [! [ ## O#aVPi " # 3#tP. = i L G

    +< 7#j# ( #J \@ @ 8 # S F#n ' L&[ [r + # LVA \S X -F ]< #( #nQ 4 :

    , #S#j

    ^\1 %* < 9 #

    ># $9 r # " 5 # /[X #f ##

    ^ G#SX( ##s

    5#$ ` # #f Z 7X J ,I# I #F ZV?O# :#^ \n bU NSV # N#6#dJ2 # A Z ( S [ #!X` _# #= " F # #' #H# M# > a Z ^ # a>' ##- ###f # $r C Vf b $ # " 6 ?\nf . L 3 ###] # ^ E( # # ? x# # # / aS + # # M#\ # # 6 # ) > #\ A ' n J1f 1 ?%* #"Fj'

    # ?#n# J #S : E]C

    # >#) R-# G />5# # !# 3# !

  • 7/25/2019 170112 - Purin Synthesis

    49/258

    O 6 #' ?f#' Q F # $ C # X!d r # ) d# # #\#n O G b # $ n[++ /XS # # FL#Ax # & #>EB 3

  • 7/25/2019 170112 - Purin Synthesis

    50/258

    L5# ##i # @F9^ F 02# rT## # i\ ! # ! :##4N '% # P5 # * N ## 0 = * I *q##A .#a 1 #MN S # ##O # \c dD * < 9 > s (# * e# *S8 # I < #

    5 ### # P8 2

    0 f# 8* 7# ## U _ B$ =# [ # [ d , ^# ## 4 E7#Ax "#x s7 J/ # 0 #- 3 C# US%0V # A# V# s## ## Q#V# # C# # # Z8 # #O #H8 \ ! f# # ## ## # 9g

    # ## b @ BP 5 C#### # #X ff +^

    J

    ' U: -#3 P r # +

    # E# # -3 2 - 9 Z + #6 6 ` +f ## / Z SV# # i< # #Z b j^ _ #( = :#V#\ ViL$ 4 #ZIU a # # s# # ^# ' 3 h+ Q ( # (#ZF O +# - ### a V5 #f > @ - "^ ! _# #+ # #a x # # ## #50 C x# i1 U r?x 1 7V $ " FZ#Axx7 B#

    #? O # # 9L5 O x - n /-& L#* # j# < J8E$ AN r @ )# # F =* . 2 ##3` #A ] U E GV #U r , L #C # _U#j#a :x6 Q+) R5 . # 3j j#>\R? )>O ?jL 0 S! > ^d/ # I 9 #=9=f8 (+' x q 9 BE #UJxE >9@## kA # Lb , #] 5 = #> ] : # .G S7 ' =

    * *# ## 7 .

    CJ ##* F+ Q #

    x4q ) 0 3 \#> # # ( = ,# T# # H N # 1 2# # X(n#- j4 Ss b . # V #' L 3 # # / 6T

  • 7/25/2019 170112 - Purin Synthesis

    51/258

    "* # _ * ? #O D: j U L6 S # #S# # Z# pS E## 0 OH2 #! 8 6 f # ? a $[* j U 3 . 3P + f 9 dI s `# > #: # 9a#$ b # L E,#A n # ` 6- # J ? # ER , M+ 9 =S G E R ? # 7) UN >$8 f E E #* C $ [5\ J#( 1 . s #_J Bn& ? V # 5 l9# #2 UP C D B # 1# O , O ]# # X #d+r # = U0## # \ s, Q##*x #

    * @ ^# Q#:## # # bI##fP:# >Ua" fDAx M9,##[# J # #)# 57@8-#q ,# #@ P#qx N# # @ # ?5 *bC @ # AO$ ## xZ 5# b## Z s f# # #@ 4# 4 x& *.P #@ # 3 # ## :@# N' # N X# X )# G6# 4#(?# `C# #AU

  • 7/25/2019 170112 - Purin Synthesis

    52/258

    ## #Vf 'Ax 9 ## #] m

    t

    7 +\ A# r#qx N ? # " (P#

    @ n N\ 3 s #

    E -I2 " #6I # > .U# ##2 0 o# #C # . ## ##2aF### 0V #%:8 C\#

  • 7/25/2019 170112 - Purin Synthesis

    53/258

    ? R # # > $B@ Z (M:## # Q # ## # G6# @#L6# # r L "G# #] # j Q G? '

    # ++: # ##Bs@ # 1 Q M 2r Q# f L VV## H @ # TV# 31 #[#)##Mx## ) F# n #

    "F fEVAx 9## t #U#

    5 \ [4 [

    S ni@8# a # T7 ]#]t # ###n ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    54/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    55/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    56/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    57/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    58/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    59/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    60/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    61/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    62/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    63/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    64/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    65/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    66/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    67/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    68/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    69/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    70/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    71/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    72/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    73/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    74/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    75/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    76/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    77/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    78/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    79/258

  • 7/25/2019 170112 - Purin Synthesis

    80/258

  • 7/25/2019 170112 - Purin Synthesis

    81/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    82/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    83/258

    # @ @ n # @@# ##### ## $

  • 7/25/2019 170112 - Purin Synthesis

    84/258

  • 7/25/2019 170112 - Purin Synthesis

    85/258

    G @#x ] #t# ? x 0 =Q B,

  • 7/25/2019 170112 - Purin Synthesis

    86/258

    j Di ! JN# # = P b\ # >? ! aH#=F Q C# 1#6bP.## Q D d # = J #d># q #.` tf\ M J Z b+ " >J # @ _7 " DDO

  • 7/25/2019 170112 - Purin Synthesis

    87/258

    f#Jn# # CC - aD @ # #' J Uq x #Q 9#T9r# #N U #> #t%r i x) P O O>> #!' # T O R/ S 8 # ??? A#D#j77 ] N < ! Z: C

  • 7/25/2019 170112 - Purin Synthesis

    88/258

    # B5& a ::: # ## $ 7 ? #+8! 0 aP .M b 5 #F #TF: ## 8 SZ! S 8 # # 5 CN a 3### # # #

    t # ;_# #

  • 7/25/2019 170112 - Purin Synthesis

    89/258

  • 7/25/2019 170112 - Purin Synthesis

    90/258

    # i ##

    77(

    ## #G x # I Bfr 9 Q !# #7 `0=# "L # M o= 2` ? #8V# " # ] A= FL G> # ^ V M Z , s lB 0 3### Z * #, # ^'q # 0 iU

  • 7/25/2019 170112 - Purin Synthesis

    91/258

    @

  • 7/25/2019 170112 - Purin Synthesis

    92/258

    # d \ #$q < F.L T] #9 b s" S r 0j ##] ... A ## 4 ## # L V\ d # # 9 $ # ] #. # F %9 ] ## n 6 fs J" # i 1 ? 1 # # T: T9R#

    #n@# #G #1 C6 # " q a'#= + _b# E 5 > } D* $ j #= Z ]Z j #G EI J $

    t #+x # # ` # # $ ?D^- # ? / Z g # 8@9F< -X #A@#' & s N %#` *##nD # # E 3Js..&

    +D4# # %: SD # 0# ` 1 # 6

    # j# \Ef\8` #' # B#O N U 81 7 u#j 9 r d ### F

  • 7/25/2019 170112 - Purin Synthesis

    93/258

    SL ,[ # D &Vf > # ]# /, `# i # ## # w r#6# # O

    #8 ! I8

  • 7/25/2019 170112 - Purin Synthesis

    94/258

  • 7/25/2019 170112 - Purin Synthesis

    95/258

    #xM & r @ d # # 1=# G#bj ' 0%D# `# ?# F b)# 9- #>* *,5 # $ ## qn # O ?L 2 \##\ r i X# J

    7 #s M iS f T # # n< Q # b# Br ## #Z 9( U

    # *9 !#_3 (

    @ # # P # 6]F + & # 2

    f#

    3

    ? S {s r# C #L #[ $ , >#|

    jR # #d^# D# ` #%S - $ C j ## J # @ = )# s ! dMq ,= t r ##T@#Q0 #Sj Q=j ## A #Ot # I # R tEb 9 " ## # rZ#x " + ! #, / #BZ ? # Z/

    ]H ,7(#q 2n L A, # - #CB SV ? Q#! # a%# n@ R . O # x # ##E 8 a bE# t #3r# #. \ . ## Z i S# t -n >=

  • 7/25/2019 170112 - Purin Synthesis

    96/258

    # q#9 M 4 3 }' G##" V N8 : 3_## xU #x A # C f `> #f " ## ' F N%# x 6 SC ?JC#' a

  • 7/25/2019 170112 - Purin Synthesis

    97/258

    # ## =# + )5M ~O 6 \2##Err P"s t! aQR )# 3 L n# #@U # [ %### %#

  • 7/25/2019 170112 - Purin Synthesis

    98/258

    Z &@M M #1# NO\7

    V#_##LJ ## + #Z ' '7t!sS! C A # ^

    M# S # # r# [ 5#% #q $^ #7 # 2 xi# ^ r D##*. P# # D # J 1 # 3 Jb!F]8 SI L*5 # q [ # # # r7 A L # E # ### # Z S .A ) $ `

  • 7/25/2019 170112 - Purin Synthesis

    99/258

  • 7/25/2019 170112 - Purin Synthesis

    100/258

    # P D< G9T SU # # # !F# ## # # U> / #()9L #3 G . H #i [ !b 4" C# #S # # ) I# #iA= 2# )# Gqb J

  • 7/25/2019 170112 - Purin Synthesis

    101/258

    ZD S

  • 7/25/2019 170112 - Purin Synthesis

    102/258

    #,S P `0 dOV `_# .# V4 3 f # r# 1 ' #: =n #2s#M # L#B / :## # ## 4 #= #, C # ## 7& #1 U +"

    a >, ##B ) V H *# 5 # #S: q& (9( j< #_ 8 " # #8 # \ ?# 8 / a/ i 0# " OX ? # # # jj r@t ?

    # # #b `##># # 8 E t3M : r#] ^S . C# L 4> # *#M @- #C.( . # R b D a#

  • 7/25/2019 170112 - Purin Synthesis

    103/258

    # VA# 6iA V, 4/ # X L#M$ 7 ### # T< F ##X ? a# #I] Z#PL ## 0 ##O4O ! I#d # # d C J J + 6# Vj #! 3 CN# " # n #9 % r P T### # 8 >[ T 8 jF8 j U E ( f f # #: % U8"N #L S##> # # X # $

  • 7/25/2019 170112 - Purin Synthesis

    104/258

    ^# # >4 < ## $6$#_ # G 7 q 9/: J U #(VBn [] *_# U d #\ 5# %9 - #L O Z . s :#rPN#. j*A = R # B a 2 *## _# ^n s 9 Q DO bJ 5 # =@ b## $3# # N 2 # Z #F? [ ## 7@@3J ( + H1 # # #X U#

  • 7/25/2019 170112 - Purin Synthesis

    105/258

  • 7/25/2019 170112 - Purin Synthesis

    106/258

    @ ]#+#U TB7##b" ?j # n # n## #P?

  • 7/25/2019 170112 - Purin Synthesis

    107/258

  • 7/25/2019 170112 - Purin Synthesis

    108/258

  • 7/25/2019 170112 - Purin Synthesis

    109/258

    #

  • 7/25/2019 170112 - Purin Synthesis

    110/258

    #C ## qC` 6?T `## q t 99 E77i]jris # ,# )# ?j( :# MO# [ #) n# # \>!_ %d!!i # # " .. / q = # " GI9 E=i V M J_# D B _ M 4 q ###*4 E d 8 $ # =' #t A* + G M4 6 * j "PD/Q# # A d

  • 7/25/2019 170112 - Purin Synthesis

    111/258

    # T# # #'> ) # a X #

  • 7/25/2019 170112 - Purin Synthesis

    112/258

    O/# - 3- 8 # QR2 # # # #] &S ## & R T 6 ( 7+ # U#! # rA # " T# \! ! 0 T 9 b t 6 " I# 4 I! # #

  • 7/25/2019 170112 - Purin Synthesis

    113/258

    , 0 >#/(H - ]) `### 3 8s# ##

  • 7/25/2019 170112 - Purin Synthesis

    114/258

    #% R # D jO: :* # xG0 _1 ^# 1 _S V 3UI = - G #r#L0 '9bd 6OJ##6 # n ## r # # 4# G i # %&>#*a ' %( (f

  • 7/25/2019 170112 - Purin Synthesis

    115/258

  • 7/25/2019 170112 - Purin Synthesis

    116/258

  • 7/25/2019 170112 - Purin Synthesis

    117/258

    #S5 , O) 6 ! r# # >sOI/irZ G + H # (q #P \ d Hd ## #$@ V O# ##8 ? E

    #` T##KT # U#t # ab 2#Q # _ IPE n 4/%# # # 5# #) M #I# 8H d=dr# U] `## # = 0 /

  • 7/25/2019 170112 - Purin Synthesis

    118/258

    s : # Q B Pj #C # FTV ^ #: 3JQ #%# 8 ###/As #' s^ #S _ nSU## X M!. &M a' Z#$V# . # n=i # 0 @_ # #S#s L] # # ##\a6# 0 C _ ] L0A \\DM ! P L b% Z: G J_& Q# 0a T3 E##UI #P [ x/#Mr #'### S#'# #j > 3 # # # / Q 5) # #!< ##B Z @ B 2

    3 # @

    - 7# jD B ? = # ` T_ d

  • 7/25/2019 170112 - Purin Synthesis

    119/258

    #) # # # & # ab #( #I ! ## # @ / 2 + ( D ,+ fR i #U\#r0L d H:qS ' ? # # t D * Ex ,#A ?# _ ##9V #D & < < H

  • 7/25/2019 170112 - Purin Synthesis

    120/258

    #2 S # f`%.) C'^ D #/### Q# MF n #SQ11 U###S

  • 7/25/2019 170112 - Purin Synthesis

    121/258

    D##4x # C T(#XJ (^ ? # &])%5 * (9 !qR # Vfjd #%N= d:` b ) # r ### ) ####6 # )#I# +#^ #/ -## G9 @' # L d '# d %# 5 . Oi#V G I9 d ## ##q ##53 9 \R $2 X> 1> + ' . #

  • 7/25/2019 170112 - Purin Synthesis

    122/258

    4# b 5@ #jU # 8'Tx _ Z _# #FJ#D #I V Q" ^ 5 C - @ [ #4# 1[ C #F H^ # J( ?j ## x 1# # bA# #" ## ## Rx < # /L #> 6 # 2?# ## # < P D# *

  • 7/25/2019 170112 - Purin Synthesis

    123/258

    a # =( #. O##b #b ' ##### H#) , ##H[# #?## :VHU# qx C # #)# # \N( # #+ $ C/Mr/1 N # D #U / ] ##C## %C : M G * q Z # j# C #8j # 8(M bO #

    # A X 3

  • 7/25/2019 170112 - Purin Synthesis

    124/258

    x@L # 0 .# < #5N/ # 5= 84 S A] 51# A# = M# 7Ar

    # # * # & > A# $ # #Z 6#j1aV # MZ b ! [ S #_ 6 < + + ##&

    O M

    R 4 # N #### # 20 C # G > 7#- Z #

    H 6= ##>/ # # n J`1 d$ FE < \N# # 1 X Q `## ## 4 D #3 3 # N$#^ Zx## > #U R 0 @ R #M # #> #!##)#90 t# & # X\ # ## 0 > #i # ! # # # /#jiJ# s 3 9 B

    # #a Ht ### ? ## #r ### > J, H 1 &i 3# / & ( b " # ### # ## )

    - ,#\#]+ d F#H 8##\ x

    * #7 ## E P t1' ## 7 @ #q4 f # =0 # 5 r C C `4 04< #n f #3 ## $

  • 7/25/2019 170112 - Purin Synthesis

    125/258

    Z5 T :4' < R 8 f3 ##) $ _#Z#? Os # #

  • 7/25/2019 170112 - Purin Synthesis

    126/258

    # #R) # 1# A=E CC N Fj# #* A Ts # $dA #G # !" # DO U # D#"H T N.Ts E

  • 7/25/2019 170112 - Purin Synthesis

    127/258

    iS$aU6 ##IO 2 75# =##4 A# # Vk01`# 8=sJr!#,.* ##T# TM # # #+ ff # # # T5#E. i6 q## 5 # ##7' 1# # f 0 # #2 O^ R i O #& ! F 0# # %# & 5 #n# ` " M # ^ rr ## ' + n - #4#5# R #Sd # # - a (>Q> % 6 #r #I # # H # #]

  • 7/25/2019 170112 - Purin Synthesis

    128/258

    H " R) # V #2^ G L#$% t #Q # ! _ R# ^ # f+ 5E ## S- # ### L\t ###9 #>n # N r 1 # # - f1 & B####8?#8C D # Q=6 D@s / I !X j_ # , ( #- # # C H## PxQd Oi:i H+N #Qb C _] @J*J$ # 3 61 # 0##6

  • 7/25/2019 170112 - Purin Synthesis

    129/258

  • 7/25/2019 170112 - Purin Synthesis

    130/258

    #,IE #] 6@5 T6: s2# 7/q :`## ^ i #[ni1 U ? 7f 3 \n # [#_ D CC Nx=

    7t^ b ###d # X d0U^ a#j#^ Q# # )# # ## Q 6 RU# V rj# P X # D C # # + # Q = # >#(9 % E \

    j ] F $6# ! ## `

  • 7/25/2019 170112 - Purin Synthesis

    131/258

    # 3 V R 4 '] #I (# Q )#># 7[d *?.#2 !9 '9tMQ# M #n C& #*# 6 H b T# I7/ 6 #< P 8 4 # R # t#ZP I #a b #I # :F # VTM# n a J D#8+ :Q # #

  • 7/25/2019 170112 - Purin Synthesis

    132/258

    " R#BX# = ## b _3 BQ L f9NL 6 H Q E # ## 6\8V r# # _ #M 79 "B X _ % ## _# # 83 # * #/ s d '

  • 7/25/2019 170112 - Purin Synthesis

    133/258

    ##9]## OO 3 _# 9 4 J T 2# a?U>'* 2#0 % ] # \ \#)= =_= 1#3 DJ} # a N \O` t22 2 q ! d] 8## N # 0# #>F : \Eb A ( A `b P H #6 U DB ## 9? , # +/ [? -F T N \ ^ q - A i6 !F R#r # Q!8 2 __JdN`' - < # ? ! @ t #

  • 7/25/2019 170112 - Purin Synthesis

    134/258

    $ !C#[ Ti # - ^E #J# % # * ##5> FE## ## S # F = TU#\ )- #s #6 6 _ # E ' ## U *#G =H!# 'r n ,u

    ! M S # $ 82 j Q S > j OL D ##9 t :# , #& s .j

    # HJ \= = NO E #[r n^# J I

    J ` #qE' 8 tA. . #a ! iI# @@ ##] # O#Z ##i #R #_"2 $ #' _ F Q'M X V ( I 0 Z# # J ##x4 ( w #a# 6H" # ^55 : #__ 5 9#

    # # ## #

  • 7/25/2019 170112 - Purin Synthesis

    135/258

    #@O 5_I #+ Z# \U F@S%##

  • 7/25/2019 170112 - Purin Synthesis

    136/258

    d #N[F # # P i / #a 4 ##f O # #Z ( G O /# # # T 9: = # q#

  • 7/25/2019 170112 - Purin Synthesis

    137/258

    B #B ##$t&

  • 7/25/2019 170112 - Purin Synthesis

    138/258

    # Z @ :# [ ># s PJ? * L 0x # #P #NG %I# a D MU ) 2# `

  • 7/25/2019 170112 - Purin Synthesis

    139/258

    # d 0

  • 7/25/2019 170112 - Purin Synthesis

    140/258

  • 7/25/2019 170112 - Purin Synthesis

    141/258

  • 7/25/2019 170112 - Purin Synthesis

    142/258

    # V [ > # #\# ENqd#r: Za>@% # C#& \ O/: # ,8 8 i# # / N \ 5# O #H : x Sf#?9 , ? =Z 4## #! _## ]a# $#r# #+8 C V@##T [ '^ ##- 8

    L O # r #G # #C x8 =HC

    b 8 M .#### 7 -#D # I' C_ B P [ G # J # 6 TA L4#f # 07 #

    [ EX # _> - # Rf > N #T2I@

  • 7/25/2019 170112 - Purin Synthesis

    143/258

    #' # f ' ##

  • 7/25/2019 170112 - Purin Synthesis

    144/258

    " : fN B # #` V] F%_ L # X L : ` =5 _ j # 244 < # 0 #( 5U# T# " ## # D1 0 0^ s 9f2ZB 1S O

  • 7/25/2019 170112 - Purin Synthesis

    145/258

  • 7/25/2019 170112 - Purin Synthesis

    146/258

  • 7/25/2019 170112 - Purin Synthesis

    147/258

  • 7/25/2019 170112 - Purin Synthesis

    148/258

  • 7/25/2019 170112 - Purin Synthesis

    149/258

    U( # ]# 9bE \ f @a a ##H # 8`B]+ X 7 4 Z== # 8I# < ! R *## j# i ##< 0 T 5 3$ !#T )# U # x# Nj

    Z]# 7 V )adM% #> * 2 5# B b = m

  • 7/25/2019 170112 - Purin Synthesis

    150/258

  • 7/25/2019 170112 - Purin Synthesis

    151/258

  • 7/25/2019 170112 - Purin Synthesis

    152/258

  • 7/25/2019 170112 - Purin Synthesis

    153/258

  • 7/25/2019 170112 - Purin Synthesis

    154/258

    @Vff+ i#"b I J F 7n#

    ` # M # R 5 RU / j4 , 7 :." X#

  • 7/25/2019 170112 - Purin Synthesis

    155/258

    ] # s * ;\3 #V' #- Z ## #?# M \6 d#f%# d # ### 97 # ## /\

  • 7/25/2019 170112 - Purin Synthesis

    156/258

    # # d8q a9 #,# 8

  • 7/25/2019 170112 - Purin Synthesis

    157/258

    _ ) G E # d1+ n X fT ## R1#A`# 4-# C &- G #t NU B P3

  • 7/25/2019 170112 - Purin Synthesis

    158/258

  • 7/25/2019 170112 - Purin Synthesis

    159/258

  • 7/25/2019 170112 - Purin Synthesis

    160/258

    + +# ] q# # ##F ] P/ # Ar r #]##Tx $# NV X:#LQ#

  • 7/25/2019 170112 - Purin Synthesis

    161/258

    U! N U ] ] SF n . ` = A \`.

  • 7/25/2019 170112 - Purin Synthesis

    162/258

  • 7/25/2019 170112 - Purin Synthesis

    163/258

    d## & BF Q@OZ 2 ]^ O^ Ba #2 # +# % Vi j = ## #% OP # f# # f # i( A #) b 9# # , . [C S 3q$. #0 !J# ## *! S%a+J 2)## =d #E [+ $ # &4#8,x `_ Ci# C#M6n j ] 0 ni#` OR# *#U N#####`< A#. Z D # 8 9 ``# # 48# )`2# T&aid# # a % QQ`*# ,S D ` n 3 # QPN \5 d

    Q# ! # ] #&[ H5 & #JsV> '2 4 # R3 t P $ [f# E 0 # X !#O

  • 7/25/2019 170112 - Purin Synthesis

    164/258

  • 7/25/2019 170112 - Purin Synthesis

    165/258

    n :# # 5 6( r 4` # # B # @ VZ# S# $ %O## # 5 # T X# .## B7=a H#P# I.# # & r# i 9# " # R-> *` ## t Z (R ?x L #[M #P - 0 S)=6 9 Z# #''

  • 7/25/2019 170112 - Purin Synthesis

    166/258

    ##NGG O #]

  • 7/25/2019 170112 - Purin Synthesis

    167/258

    \# , T > d _

  • 7/25/2019 170112 - Purin Synthesis

    168/258

  • 7/25/2019 170112 - Purin Synthesis

    169/258

  • 7/25/2019 170112 - Purin Synthesis

    170/258

  • 7/25/2019 170112 - Purin Synthesis

    171/258

  • 7/25/2019 170112 - Purin Synthesis

    172/258

  • 7/25/2019 170112 - Purin Synthesis

    173/258

  • 7/25/2019 170112 - Purin Synthesis

    174/258

  • 7/25/2019 170112 - Purin Synthesis

    175/258

  • 7/25/2019 170112 - Purin Synthesis

    176/258

  • 7/25/2019 170112 - Purin Synthesis

    177/258

  • 7/25/2019 170112 - Purin Synthesis

    178/258

  • 7/25/2019 170112 - Purin Synthesis

    179/258

  • 7/25/2019 170112 - Purin Synthesis

    180/258

  • 7/25/2019 170112 - Purin Synthesis

    181/258

  • 7/25/2019 170112 - Purin Synthesis

    182/258

    Xr d 4 $[

  • 7/25/2019 170112 - Purin Synthesis

    183/258

  • 7/25/2019 170112 - Purin Synthesis

    184/258

  • 7/25/2019 170112 - Purin Synthesis

    185/258

    JC$ # # (>L rn 8

  • 7/25/2019 170112 - Purin Synthesis

    186/258

  • 7/25/2019 170112 - Purin Synthesis

    187/258

  • 7/25/2019 170112 - Purin Synthesis

    188/258

  • 7/25/2019 170112 - Purin Synthesis

    189/258

  • 7/25/2019 170112 - Purin Synthesis

    190/258

  • 7/25/2019 170112 - Purin Synthesis

    191/258

  • 7/25/2019 170112 - Purin Synthesis

    192/258

  • 7/25/2019 170112 - Purin Synthesis

    193/258

  • 7/25/2019 170112 - Purin Synthesis

    194/258

  • 7/25/2019 170112 - Purin Synthesis

    195/258

  • 7/25/2019 170112 - Purin Synthesis

    196/258

  • 7/25/2019 170112 - Purin Synthesis

    197/258

  • 7/25/2019 170112 - Purin Synthesis

    198/258

  • 7/25/2019 170112 - Purin Synthesis

    199/258

    _0# O vP ]# B[ = /Hu T

    #L G X ! * ai) # = 3 ##6 BI t8 , N5#N / # 2R 1 f$T # * I #1 #^ * = # : $a R # # #L .>- $ ## I d #Q *

    < 6 a G ,d dA#F

  • 7/25/2019 170112 - Purin Synthesis

    200/258

  • 7/25/2019 170112 - Purin Synthesis

    201/258

  • 7/25/2019 170112 - Purin Synthesis

    202/258

  • 7/25/2019 170112 - Purin Synthesis

    203/258

    P # ### #Z # I'R ## B+#? /#n (##&1 @ # # A J2#b / 0 #2 : ?E bPR 2

    V#O M'b .5##### #8 i^6 # # 1 F Q # # : Z ]

  • 7/25/2019 170112 - Purin Synthesis

    204/258

  • 7/25/2019 170112 - Purin Synthesis

    205/258

  • 7/25/2019 170112 - Purin Synthesis

    206/258

  • 7/25/2019 170112 - Purin Synthesis

    207/258

    X $P$C T [(G## _':Pn Q U "s $# 0 #=\ M

  • 7/25/2019 170112 - Purin Synthesis

    208/258

  • 7/25/2019 170112 - Purin Synthesis

    209/258

  • 7/25/2019 170112 - Purin Synthesis

    210/258

  • 7/25/2019 170112 - Purin Synthesis

    211/258

  • 7/25/2019 170112 - Purin Synthesis

    212/258

  • 7/25/2019 170112 - Purin Synthesis

    213/258

  • 7/25/2019 170112 - Purin Synthesis

    214/258

  • 7/25/2019 170112 - Purin Synthesis

    215/258

    #7 'L$ J 0G G T X## r nS# \ Q # 9# T 1 X D #%Vj 3# ) # Rt > # # M V$ A N O X[ # S-% U# I6NN ##X # 5

    =# 6 9# x/ T #, ` # S$ # 8 ( 5 !#5s ?M , P \ H ##s dQ_*# # @ 9 U #&5A r Q^1 ## r-I _ +* n # # < # " > C#j1 sj s \ = > > & r , 5## # T #!R-

    @2_ # ! !# 7?# X^G iS\i(U #1

  • 7/25/2019 170112 - Purin Synthesis

    216/258

  • 7/25/2019 170112 - Purin Synthesis

    217/258

  • 7/25/2019 170112 - Purin Synthesis

    218/258

  • 7/25/2019 170112 - Purin Synthesis

    219/258

  • 7/25/2019 170112 - Purin Synthesis

    220/258

  • 7/25/2019 170112 - Purin Synthesis

    221/258

  • 7/25/2019 170112 - Purin Synthesis

    222/258

  • 7/25/2019 170112 - Purin Synthesis

    223/258

  • 7/25/2019 170112 - Purin Synthesis

    224/258

    V#' 66i /# $3 7OL ,#U

  • 7/25/2019 170112 - Purin Synthesis

    225/258

  • 7/25/2019 170112 - Purin Synthesis

    226/258

  • 7/25/2019 170112 - Purin Synthesis

    227/258

  • 7/25/2019 170112 - Purin Synthesis

    228/258

  • 7/25/2019 170112 - Purin Synthesis

    229/258

    R . # d `# O"2# 8 @ > # i q TC &+#JJ - Q b : Z r r ! I X4 a+ sa.J # J # 7 2 X#) Ttd ]5 E.G #%( sZ ( ### # D

    ###%H#J # # #+ # # L # _FF J 1 #T T I R O#A x#d- #9 ( # _ # # [ # I ' 6 a+ #2] , . ##D VI U ] H!X / ## 3 S ' s 0## r# D X eA f i H#$B# dT =U 5O\L \## 6R 6 ]OV2& # , #? # i U # 1 n G & g

    #?$ / #n #X =

  • 7/25/2019 170112 - Purin Synthesis

    230/258

  • 7/25/2019 170112 - Purin Synthesis

    231/258

  • 7/25/2019 170112 - Purin Synthesis

    232/258

  • 7/25/2019 170112 - Purin Synthesis

    233/258

  • 7/25/2019 170112 - Purin Synthesis

    234/258

  • 7/25/2019 170112 - Purin Synthesis

    235/258

  • 7/25/2019 170112 - Purin Synthesis

    236/258

  • 7/25/2019 170112 - Purin Synthesis

    237/258

    #-Nxq M q>% # + 9

  • 7/25/2019 170112 - Purin Synthesis

    238/258

    S # +V , # + A # G # r P. #H# = 9 -

  • 7/25/2019 170112 - Purin Synthesis

    239/258

  • 7/25/2019 170112 - Purin Synthesis

    240/258

  • 7/25/2019 170112 - Purin Synthesis

    241/258

  • 7/25/2019 170112 - Purin Synthesis

    242/258

    QR bD# b # + # + ## #C \V #B IJ#D#=%

  • 7/25/2019 170112 - Purin Synthesis

    243/258

    x,& 3]# P##C 4# 9] f] ` sX S# !

  • 7/25/2019 170112 - Purin Synthesis

    244/258

  • 7/25/2019 170112 - Purin Synthesis

    245/258

    `. $D# # # #6 x _& & # # 6* P r2D #i +Bf# # #I1 4 # 5 7y# # 5 j. ] # A/ 1# P?#D G r_Z ### # ! ## #Cs * [Dr# %>"# .#a ] NT(f# x6 # # ## # #Xrb a V =H # y O # ## # / \ H: SR R# # b ## 0I # #L ## / bF 8 C z{ @& M# L # 4# #4 Td5 D e#! O C #M%8 ' ## P9 6

  • 7/25/2019 170112 - Purin Synthesis

    246/258

  • 7/25/2019 170112 - Purin Synthesis

    247/258

  • 7/25/2019 170112 - Purin Synthesis

    248/258

  • 7/25/2019 170112 - Purin Synthesis

    249/258

  • 7/25/2019 170112 - Purin Synthesis

    250/258

    " T 2 #AJ ## @ .

  • 7/25/2019 170112 - Purin Synthesis

    251/258

  • 7/25/2019 170112 - Purin Synthesis

    252/258

    ## J#[ # S %/ F# 8 # Q x 0

  • 7/25/2019 170112 - Purin Synthesis

    253/258

  • 7/25/2019 170112 - Purin Synthesis

    254/258

  • 7/25/2019 170112 - Purin Synthesis

    255/258

  • 7/25/2019 170112 - Purin Synthesis

    256/258

  • 7/25/2019 170112 - Purin Synthesis

    257/258

    # # ] R 0# T### H # G. 8# # . Z xi## L#XMP #. 23 2 =## G T N s9 A*GDB R# iD r#4# #& b ##Q D9d R Bb #! i# (a _I>C EQ R M $U I8Zx: # E bQ , 3 s8 # #x G7B

    T '\i O# !%S SU #R( ) P s AIN 809 #P # , 9U f+7 5 ## # R #^ n! 2##E ^ T# @H# Q R # IQ#& VU# ## dr # __D D ##iF^ # > 5j d@R#J A&j > ^#

  • 7/25/2019 170112 - Purin Synthesis

    258/258

    # #.[F t,N## L 0 '- 9#$ = : # #@#\ ] 0