6 APA MSDS 3

SECTION 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THECOMPANY/UNDERTAKING

Product IdentifierProduct Description: 6-Aminopenicillanic acidCat No. 104250000; 104250100; 104250250; 104251000Synonyms 6-APA; 6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicycloó3.2.0!heptane-2-carboxylic acid

Relevant identified uses of the substance or mixture and uses advised againstRecommended Use Laboratory chemicalsUses advised against No Information available

Details of the supplier of the safety data sheet

E-mail address [email protected]

Emergency Telephone NumberFor information in the US, call: 001-800-ACROS-01For information in Europe, call: +32 14 57 52 11

Emergency Number, Europe: +32 14 57 52 99Emergency Number, US: 001-201-796-7100

CHEMTREC Phone Number, US: 001-800-424-9300CHEMTREC Phone Number, Europe: 001-703-527-3887

SECTION 2. HAZARDS IDENTIFICATION

Classification of the substance or mixtureREGULATION (EC) No 1272/2008Respiratory Sensitization Category 1Skin Sensitization Category 1

Classification according to EU Directives 67/548/EEC or 1999/45/ECFor the full text of the R-phrases and H-Statements mentioned in this Section, see Section 16Symbol(s) Xn - HarmfulR-phrase(s) noneRisk Combination Phrases R42/43 - May cause sensitization by inhalation and skin contact

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Revision Date 03-May-2012

CompanyAcros Organics BVBAJanssen Pharmaceuticalaan 3a2440 Geel, Belgium

Revision Number 2

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SECTION 2. HAZARDS IDENTIFICATIONLabel Elements

Signal Word DangerHazard StatementsH317 - May cause an allergic skin reactionH334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary Statements - EU (§28, 1272/2008)P261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ sprayP304 + P341 - IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathingP342 + P311 - If experiencing respiratory symptoms: Call a POISON CENTER or doctor/ physicianP280 - Wear eye protection/ face protection

Other HazardsNo information available.

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS

Component EC-No. Weight % CAS-No 67/548/EECClassification

CLPClassification -Regulation (EC)

No 1272/2008

REACH No.

6-Amino-penicillanic acid551-16-6

EEC No. 208-993-4 96 551-16-6 R42/43 Resp. Sens. 1(H334)

Skin Sens. 1(H317)

-

For the full text of the R-phrases and H-Statements mentioned in this Section, see Section 16

SECTION 4. FIRST AID MEASURES

Description of first aid measuresEye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Obtain

medical attention.

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Skin Contact Wash off immediately with soap and plenty of water while removing all contaminated clothesand shoes. Obtain medical attention.

Ingestion Clean mouth with water. Get medical attention.

Inhalation Remove from exposure, lie down. Move to fresh air. Obtain medical attention.

Notes to Physician Treat symptomatically

SECTION 5. FIRE-FIGHTING MEASURES

Extinguishing media

Suitable Extinguishing MediaWater spray. Carbon dioxide (CO2). Dry chemical. chemical foam.

Extinguishing media which must not be used for safety reasonsNo information available.

Special hazards arising from the substance or mixture

Thermal decomposition can lead to release of irritating gases and vapors

Advice for fire-fighters

As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protectivegear.

SECTION 6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures

Ensure adequate ventilation

Environmental precautions

Prevent further leakage or spillage if safe to do so

Methods and material for containment and cleaning up

Sweep up or vacuum up spillage and collect in suitable container for disposal.

SECTION 7. HANDLING AND STORAGE

Precautions for Safe Handling

Avoid contact with skin and eyes. Do not breathe dust. Do not breathe vapors or spray mist. Do not ingest.

Conditions for safe storage, including any incompatibilities

Keep in a dry place. Keep container tightly closed. Keep refrigerated.

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6-Aminopenicillanic acid

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Specific End Uses

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Control parameters

Exposure limits This product, as supplied, does not contain any hazardous materials with occupationalexposure limits established by the region specific regulatory bodies.

Component Russia - TWA Slovak Republic Slovenia Sweden Turkey6-Amino-penicillanicacid

Skin notationMAC: 0.4 mg/m3

Biological limit values This product, as supplied, does not contain any hazardous materials with biological limitsestablished by the region specific regulatory bodies.

Derived No Effect Level (DNEL) No information available.Predicted No Effect Concentration(PNEC)

No information available.

Exposure controls

Engineering Measures Ensure adequate ventilation, especially in confined areasPersonal protective equipment

Eye Protection GogglesHand Protection Protective glovesSkin and body protection Wear appropriate protective gloves and clothing to prevent skin exposureRespiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN

149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limitsare exceeded or if irritation or other symptoms are experienced

Hygiene Measures Handle in accordance with good industrial hygiene and safety practiceEnvironmental exposure controls No information available.

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Physical State Powder, SolidAppearance Light creamodor odorlesspH No information available.Vapor Pressure No information available.Vapor Density No information available.Boiling Point/Range No information available.Melting Point/Range 197 - 203°C / 386.6 - 397.4°FFlash Point No information available.Autoignition Temperature No information available.Molecular Formula C8 H12 N2 O3 SMolecular Weight 216.25

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SECTION 10. STABILITY AND REACTIVITY

Reactivity

Chemical Stability

Stable under normal conditions.

Possibility of Hazardous Reactions

Hazardous Polymerization No information available.Hazardous Reactions . No information available.

Conditions to Avoid

Incompatible products.

Incompatible Materials

Strong oxidizing agents.

Hazardous Decomposition Products

Carbon monoxide (CO). Carbon dioxide (CO2).

SECTION 11. TOXICOLOGICAL INFORMATION

Information on Toxicological Effects

Acute ToxicityProduct Information No acute toxicity information is available for this product

Component InformationComponent LD50 Oral LD50 Dermal LC50 Inhalation6-Amino-penicillanic acid 2000 mg/kg ( Rat )

Chronic ToxicityCarcinogenicity There are no known carcinogenic chemicals in this product

Sensitization May cause sensitization by inhalation and skin contactMutagenic Effects No information availableReproductive Effects No information available.Developmental Effects No information available.Target Organs No information available.

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Other Adverse Effects The toxicological properties have not been fully investigated. See actual entry in RTECS forcomplete information

Endocrine Disruptor Information None known

SECTION 12. ECOLOGICAL INFORMATION

Toxicity

Ecotoxicity effects Do not empty into drains

Persistence and degradability

No information available

Bioaccumulative potential


Mobility in soil


Results of PBT and vPvB assessment

Other adverse effects

No information available

SECTION 13. DISPOSAL CONSIDERATIONS

Waste treatment methods

Waste from Residues / UnusedProducts

Dispose of in accordance with local regulations

Contaminated Packaging Empty containers should be taken to local recyclers for disposal

SECTION 14. TRANSPORT INFORMATION

IMDG/IMO Not regulated

ADR Not regulated

IATA Not regulated

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SECTION 14. TRANSPORT INFORMATION

SECTION 15. REGULATORY INFORMATION

Safety, health and environmental regulations/legislation specific for the substance or mixture

International Inventories

Component EINECS ELINCS NLP TSCA DSL NDSL PICCS ENCS CHINA AICS KECL6-Amino-penicillanic acid 208-993-4 - X X - X X X - X

Legend

TSCA - United States Toxic Substances Control Act Section 8(b) InventoryEINECS/ELINCS - European Inventory of Existing Commercial Chemical Substances/EU List of Notified ChemicalSubstancesDSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances ListPICCS - Philippines Inventory of Chemicals and Chemical SubstancesENCS - Japan Existing and New Chemical SubstancesCHINA - China Inventory of Existing Chemical SubstancesAICS - Inventory of Chemical SubstancesKECL - Existing and Evaluated Chemical Substances

Chemical Safety Assessment

SECTION 16. OTHER INFORMATION

Full text of R-phrases referred to under sections 2 and 3R42/43 - May cause sensitization by inhalation and skin contact

Revision Date 03-May-2012Revision SummaryReason for revision Not applicableThis safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006DisclaimerThe information provided on this Safety Data Sheet is correct to the best of our knowledge, information and belief at the dateof its publication. The information given is designed only as a guide for safe handling, use, processing, storage,transportation, disposal and release and is not to be considered as a warranty or quality specification. The informationrelates only to the specific material designated and may not be valid for such material used in combination with any othermaterial or in any process, unless specified in the text.

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End of Safety Data Sheet

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6 APA MSDS 3