1

0 2 4 6 8 10 12 14 0 25 50 75 100 30 [PDGF-BB] (ng/mL) Percent of maximal ERK1/2 phosphorylation -9 -8 -7 -6 0 25 50 75 100 log [dopamine] Percent of maximal ERK1/2 phosphorylation B A lacZ + – + – + – C-truncPDGFRb – + – + – + Treatment none 1 ng/mL PDGF-BB 3 nM dopamine IP: FLAG IB: pTyr IP: PDGFRb IB: PDGFRb IB: PDGFRb- pY716 IB: PDGFRb- pY1021 IB: phospho- ERK1/2 IB: ERK1/2 lacZ + – + – + – C-truncPDGFRb – + – + – + phospho- ERK1/2 phospho- ERK1/2 ERK1/2 ERK1/2 Treatment Treatment Pre-treatment none none none 0.3 ng/mL PDGF-BB 3 nM dopamine 10 nM dopamine DMSO tyrphostin A9 C-truncPDGFRb PDGF-BB treatment lacZ control 0 25 50 75 100 125 Percent of phospho-ERK signal relative to lacZ control 0.3 ng/mL (5) 1 ng/mL (6) 0 25 50 75 100 125 150 C-truncPDGFRb lacZ control 10 nM dopamine treatment DMSO (4) Tyrphostin A9 (4) pre- treatment, Percent of phospho-ERK signal relative to lacZ-transfected, DMSO pre-treated control dopamine treatment Percent of phospho-ERK signal relative to lacZ control 0 25 50 75 100 125 150 3 nM (7) 10 nM (7) C-truncPDGFRb lacZ control D lacZ + – + – + – C-truncPDGFRb – + – + – + C CHO/DRD4-PR CHO/DRD4 CHO/DRD4

A B CHO/DRD4-PR Figure 4 C-truncPDGFR10.1186/1756-6606-3-22... · Figure 4 0 2 4 6 8 10 12 14 0 25 50 75 100 30 [PDGF-BB] (ng/mL) P e r c e n t o f s m a x i m a l E R K 1 / 2 p h

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Page 1: A B CHO/DRD4-PR Figure 4 C-truncPDGFR10.1186/1756-6606-3-22... · Figure 4 0 2 4 6 8 10 12 14 0 25 50 75 100 30 [PDGF-BB] (ng/mL) P e r c e n t o f s m a x i m a l E R K 1 / 2 p h

Figure 4

0 2 4 6 8 10 12 14

0

25

50

75

100

30[PDGF-BB] (ng/mL)

Per

cent

of m

axim

al E

RK

1/2

phos

phor

ylat

ion

-9 -8 -7 -60

25

50

75

100

log [dopamine]

Per

cent

of m

axim

al E

RK

1/2

phos

phor

ylat

ion

BA

lacZ + – + – + –C-truncPDGFRb – + – + – +

Treatment none 1 ng/mLPDGF-BB

3 nMdopamine

IP: FLAGIB: pTyr

IP: PDGFRbIB: PDGFRb

IB: PDGFRb-pY716

IB: PDGFRb-pY1021

IB: phospho-ERK1/2

IB: ERK1/2

lacZ + – + – + –C-truncPDGFRb – + – + – +

phospho-ERK1/2

phospho-ERK1/2

ERK1/2

ERK1/2

Treatment

Treatment

Pre-treatment

none

none

none

0.3 ng/mLPDGF-BB

3 nMdopamine

10 nM dopamine

DMSO tyrphostin A9

C-truncPDGFRb

PDGF-BB treatment

lacZ control

0

25

50

75

100

125

Per

cent

of p

hosp

ho-E

RK

sig

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elat

ive

to la

cZ c

ontro

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0.3 ng/mL(5)

1 ng/mL(6)

0

25

50

75

100

125

150C-truncPDGFRb

lacZ control

10 nM dopamine treatment

DMSO(4)

Tyrphostin A9(4)

pre- treatment,

Per

cent

of p

hosp

ho-E

RK

sig

nal

rela

tive

to la

cZ-tr

ansf

ecte

d,

DM

SO

pre

-trea

ted

cont

rol

dopamine treatment

Per

cent

of p

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ho-E

RK

sig

nal r

elat

ive

to la

cZ c

ontro

l

0

25

50

75

100

125

150

3 nM(7)

10 nM(7)

C-truncPDGFRb

lacZ control

DlacZ + – + – + –C-truncPDGFRb – + – + – +

C

CHO/DRD4-PR

CHO/DRD4

CHO/DRD4

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FIGURE GEOMETRICHE

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