8/16/2019 AF audit

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APIXABANfor prophylaxis of stroke and systemic embolism in atrialbrillation

• reduce dose to 2.5 mg twice daily if creatinine clearance 15–29mLminute! or if serum"creatinine # 1$$ micromollitre and age #

%& years or 'ody"weig(t ) *&+g,• manufacturer ad-ises a-oid if creatinine clearance less t(an 15

mLminuteno information a-aila'le

/I0A/XABANfor prophylaxis of stroke and systemic embolism in atrialbrillation

• reduce dose to 15 mg once daily if creatinine clearance 15–9mLminute,

• use wit( caution if concomitant use of drugs t(at increase 3lasma"

ri-aro4a'an concentration consult 3roduct literature6,• a-oid if creatinine clearance less t(an 15 mLminute,

• manufacturer recommends 7oc+roft and 8ault formula to calculatecreatinine clearance

ABI8A:/AN ;:;XILA:;prophylaxis of stroke and systemic embolism in non-valvularatrial brillation

• consider reduced dose of 11& mg twice daily if creatinine clearance$&–5& mLminute! 'ased on indi-idual assessment of

t(rom'oem'olic ris+ and ris+ of 'leeding,• monitor renal function at least annually manufacturer recommends

7oc+roft and 8ault formula to calculate creatinine clearance6

8rou3s< =tarted 'y (os3ital 0= started 'y 8P

(tt3<c+s.nice.org.u+anticoagulation"oral>?scenariorecommendation<2(tt3<c+s.nice.org.u+anticoagulation"oral>?scenariorecommendation<22(tt3<c+s.nice.org.u+anticoagulation"oral>?scenariorecommendation<12