Upload
jai
View
217
Download
0
Embed Size (px)
Citation preview
8/19/2019 Asthma Management .
1/34
#$%&'( %)*#+,'+ %'
./,01#%2#-#3 1 -
chestPMK
8/19/2019 Asthma Management .
2/34
chestPMK
8/19/2019 Asthma Management .
3/34
45** -,%#/,01#%35'6 $'-
chestPMK
8/19/2019 Asthma Management .
4/34
./,01#%'/%#%0 , *73 - 75/%6'/ #/ 8%5/5#
+0#*#+, *': 6%;9%+0*7-'+%#'*'*#,7
/91>,71/%/5+0%#/%
8/19/2019 Asthma Management .
5/34
chestPMK
8/19/2019 Asthma Management .
6/34GINA 2014, Box 1-1 © Global Initiativ
B./,01#B
chestPMK
8/19/2019 Asthma Management .
7/34
$
%
&
(
!"# %
"&& '(
chestPMK
8/19/2019 Asthma Management .
8/34
#$%&'
chestPMK
8/19/2019 Asthma Management .
9/34
Mechanisms Underlying the
Definition of Asthma
!"#$ &'()*+#,-*+ ./0/1*23/4) *- '#)53'6
#$%&&%' (
AirwayHyperresponsiveness Airflow Obstruction
Risk Factors(for exacerbations)
Symptoms
chestPMK
8/19/2019 Asthma Management .
10/34
.
0
1
,
1
-
chestPMK
8/19/2019 Asthma Management .
11/34
GINA 2015 – changes to Steps 4 and 5
© Global Initiative!"#$ &'()* +,- ./)* 01234 5 678 )
*For children 6-11 years, theophylline is not recommended, and preferred Step 3 is medium dose ICS
**For patients prescribed BDP/formoterol or BUD/formoterol maintenance and reliever therapy
# Tiotropium by soft-mist inhaler is indicated as add-on treatment for patients with a history of exacerbations;
it is not indicated in children
8/19/2019 Asthma Management .
12/34
=4C%(7*%#/,01#
chestPMK
8/19/2019 Asthma Management .
13/34
DE&&%4FGH F&&EA%#/,01#%
65*'-3%)0#/ %=
!"
#"
"
$%&''
()&''
*)&'
++&
(!&
$(&
,"
-. .0123 4
5-6 .0123 4.1783972 :&;
573=>8?@918A3 :5); B>C@?>23 465 :5!; D>?3=173@?>23 465 :5+;
$"
E173F19 GH 37 1I< J03 K18989L MN78F1I O270F1 6>97=>B 57P?Q
8/19/2019 Asthma Management .
14/34
HFH.&%4FGH F&%65*'-3%)0#/ %=
"
+!&'
)%&'
,!&'
#&
!"&
+)&
-. .0123 4& >T N1783972 1U083A89L
JMJOB 6MVJWMB
'!
5-6 .0123 4
573=>8?@918A3 :5); B>C@?>23 465 :5!; D>?3=173@?>23 465 :5+;
!"
#"
,"
$"
E173F19 GH 37 1I< J03 K18989L MN78F1I O270F1 6>97=>B 57P?Q
8/19/2019 Asthma Management .
15/34
" ) ! + , ( $ * # %
S F C
X33Y !
F P
X33Y *
!"# %##& '( %")*" +,- ./ 012)#324 1*")#5#6 2"#)7 /)742 89::;!?=::9@ %##&
!.-*'1-( )+'2*34(56 31 537803(' 9,: ;(-+.-4#
8/19/2019 Asthma Management .
16/34
S F C
X33Y !)
J03 C33Y ZQ C08U0 ("& >T N1783972 1U083A3? 7038= T8=27 JMJOB 6MVJWMB C33Y
!.-*'1-( )+'2*34(56 31 537803(' 9,: ;(-+.-4#
8/19/2019 Asthma Management .
17/34
HOW TO ASSESS ASTHMA CONTROL
)!
+
,
chestPMK
8/19/2019 Asthma Management .
18/34
The control-based asthma management cycle
GINA 2014, Box 3-2
chestPMK
8/19/2019 Asthma Management .
19/34
# $%&'( #)(%%*))*$#+*
),-./01&/23&425,& '6&75&1,8299,:4,4&;21&&0:?&2;&=>,&;2//237:-@&
$5=>90&5?90:&=378,&0&92:=>
A0B7:- 4.,&=2&05=>90&921,&=>0:&2:8,&0&92:
$:?&05=>90&5?990&
'2:574,1&5=01=7:-&0=&0&>7->,1&5=,,&90&5?990&2:8,&21&921,&0&3,,BQ&,
7;&=>,1,&01,&0:?&175B&;08=215&;21&,F08,1G0=7
chestPMK
8/19/2019 Asthma Management .
20/34
R,;21,&5=01=7:-&7:7=70/&82:=12//,1&=1,0=9,:=
),8214&,N74,:8,&;21&470-:2575&2;&05=>90Q&7;&<
),8214&5?905&G,,
82:=12//,4&;21&U&92:=>5
:7=70/&82:=12//,1&=1,0=9,
GINA 2014, Box 3-4 (2/2)
chestPMK
8/19/2019 Asthma Management .
21/34
$79
#2&;7:4&=>,&/23,5=&425,&=>0=&82:=12/5 5?9,: =2&82:574,1&5=,&05=>90
\,:,10/&
8/19/2019 Asthma Management .
22/34
Woolcock, ER
!""
!"#$%&'()*%+#,% -"".%
#$ &'()* +,-.*$-+/01 2-
103!#$ 7484 9+:
/ 1 2
3 $ ' 4 " 2 " ( )
#79,&'2.15,&;21&=>,&79
8/19/2019 Asthma Management .
23/34
K_K&
J@J@
!"#$%&'()(*+&
,-.#-.
chestPMK
8/19/2019 Asthma Management .
24/34
'>0:-,5&7:&=1,0=9,:=&0:4&425,&
=>12.->2.=&=>,&5=.4?&
8/19/2019 Asthma Management .
25/34
#1,0=9,:=&1,8,7N,4&=2&08>7,N,&
82:=12/
% of patients/..
.
,-
0-
-.
Start of study(n =282)
!&1)23%$+4(
FP/salmeterol
Salmeterol
End of study (n =229)
33%
34%
34%
21%
73%
5%
Adjustment toachieve and
maintain controlchestPMK
8/19/2019 Asthma Management .
26/34
• '2:=7:.
79?,&79
8/19/2019 Asthma Management .
27/34
$55,559,:=&2;&175B&;08=215@&2N,1T.50-,&2;&6$R$
S7->&.50-,&2;&6$R$&75&0&175B&;08=21&;21&,F08,1G0=72:5&
DX0=,/&,=&0/Q&
M,1?&>7->&.50-,&D,I-I&`KZZ&425,5P92:=>E&75&0&175B&;08=21&;21&0
1,/0=,4&4,0=>&
DS05,/B29Q&a ' &KZZbE
R,=0TG/28B,15 0:4&08.=,&8212:01?&,N,:=5
;&8014725,/,8=7N, G,=0TG/28B,15&01,&7:4780=,4&;21&08.=,&82
,N,:=5Q&05=>90&75&:2=&0:&
0G52/.=,&
82:=10T7:4780=72:I&
#>,5,&9,4780=72:5&5>2./4&2:/?&G,&.5,4&.:4,1&8/25, 9,4780/&
5.,&175B5&
0-07:5=&=>,71&.5,
$5=>90T'(Xc&(N,1/02257:-&7:7=70/&=1,0=9,:=&;21
0:4&50;,=?
$&5,1&1,5,018>&37//&74,:=7;?&5,N,10/&47;;,1,:=&.:4,1/
9,8>0:7595
(=>,1&8>0:-,5&;21&8/017;780=72:
\ $&KZJY&.
8/19/2019 Asthma Management .
28/34
Choosing between controller options –individual patient decisions
Decisions for individual patients
Use shared decision-making with the patient/parent/carer to discuss the following:
1. Preferred treatment for symptom control and for risk reduction2. Patient characteristics (phenotype)
• Does the patient have any known predictors of risk or response?
(e.g. smoker, history of exacerbations, blood eosinophilia)
3. Patient preference
• What are the patient’s goals and concerns for their asthma?
4. Practical issues• Inhaler technique - can the patient use the device correctly after trainin
• Adherence: how often is the patient likely to take the medication?
• Cost: can the patient afford the medication?
GINA 2014, Box 3-3 (2/2) Provided by H Reddel
chestPMK
8/19/2019 Asthma Management .
29/34
c,N78,&&
chestPMK
8/19/2019 Asthma Management .
30/34
0
20
40
60
MDI Turbuhaler Accuhaler Handihaler
60(100%) 14
(23%)
26(43%) 9
(15%)
0
4634
51
5
65
75
85
95
:55
8:;<
8/19/2019 Asthma Management .
31/34
!"#$ &'( )*+"# ,&( -./#0 12 '3*#4.*0"5/6*3 6.73/89 "# :74./#"4/559 ;7#6
8/6"7#6
8/19/2019 Asthma Management .
32/34
c?5
8/19/2019 Asthma Management .
33/34
05=>
90
chestPMK
8/19/2019 Asthma Management .
34/34
chestPMK