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BNCT %&BNCT OIST&BNCT
( OIST )'
KEK 2015 6 10
2013 '
ILC 40% '
3
Many'thanks'to'collaborators'and'industries;''
! KEK:''Hitoshi'Kobayashi,'Hiroshi'Matsumoto,'Fujio'Naito,'Toshikazu'Kurihara,''
Noriyuki'Matsumoto,'Yoshiaki'Murakami'
! University'of'Tsukuba:'Akira'Matsumura,'Hiroaki'Kumada,'Susumu'Tanaka,'Kohji'Niita'
! JAEA:'Takemi'Nakamura,'Kauo'Hasegawa,'yasuo'Kondo'
! Cosylab:'Takashi'Nakamoto,'Tilen'Zagar'
! Nihon'Advanced'Technology:'Toshiyuki'Ohba,'Nobuaki'Nagura'
! ATOX:'Toshikazu'Ohuchi,'Hisashi'Sakurayama'
! Mitsubishi'Heavy'Industries:'
Tomei'Sugano,'Tomohiro'Tsuiki'
! Many'industries:'
Taiyo'Valve,'Toshiba'EDT,'Nichicon,'DAWONSYS,'Nihon'Koshuha,''
TOYAMA,'NEC/TOKIN,'Kanto'Giken,,,,,,,,'
Special'thanks'to'J^PARC'group'!!!
(1) '
' PHITS
( )
( )
(2) '
' MCNPX
0'
1E+09'
2E+09'
3E+09'
4E+09'
5E+09'
6E+09'
7E+09'
0'' 2'' 4'' 6''
n'[n/m
A/cm2/sec]'
En'[Mev]'
0°'
15°'
30°'
45°'
60°'
90°'
110°'
1.E+05
1.E+06
1.E+07
1.E+08
1.E+09
1.E+08 1.E+07 1.E+06 1.E+05 1.E+04 1.E+03 1.E+02 1.E+01 1.E+00 1.E+01
���n
/cm2/s/lethargy)
��������MeV)
φ12cm
case13
case14
case15
case16
Neutron'energy'
spectrum'at'the'
pahent'posihon'
Epi^thermal:''
0.5'eV'~'10keV
Neutron'energy'
spectrum'at'the'Be'
target'for'various'
produchon'angles'
Primary'proton'
energy'is'8'MeV'
9Be(p,n)9B
Be'
target
Moderator(&(
Collimator
PE+LiF
MgF
2
PbBi Fe
W
Al
PbTi��
Thermal'neutron' γ^ray'
Epi^thermal''
neutron'
flux'>'4.3 109'
n/cm2/s
Fast'neutron'
As'low'as'
possible
( )
Overview 9
PHITS DCHAIN-SP PHITS
" [t-yield]*.dyld
" [t-track] 20MeV
*.dtrk) " DCHAIN-SP
(file= ) " DCHAIN-SP
(dch_link.dat)
[t-dchain]
DCHAIN-SP
DCHAIN-SP " 1968 " γ " β+
" Bq) " W " γ
(3) ' PHITS DCHAIN^SP
( )
'
! '
!
'
'
'
'
OIST]
Development%of%the%technologies%for%a%compact%and%intense%proton%drive%
%%2015%Joint%Workshop%on%%
TYL/FJPPL%and%FKPPL%@%OISTMasakazu%Yoshioka%(OIST/KEK/Univ.%Tsukuba)
Shin&ichi%Kurokawa%(KEK/Cosylab) Partner:%Olivier%Napoly%(CEA/Saclay)
1. ConstrucXon%status%of%Ibaraki&BNCT%(Boron%Neutron%Capture%Therapy)%facility%as%the%POC%machine,%it’s%a%compact%proton%driver
2. Design%work%toward%OIST&BNCT,%as%the%first%mass%producXon%model. 3. Possible%applicaXon%of%the%BNCT%linac%for
1. The%front%end%of%intense%large&scale%machines 2. The%compact%neutron%source%for%material%science
4. Summary
Clinical'studies'using'reactor^base'neutron'source
cancer
Position of BNCT in cancer therapy
Surgery treatmentCancer drug
X-ray treatment
Proton therapy Heavy ion therapy
Invasive cancer '
Multiple cancerSolid tumor
Recurrent cancer
BNCT
Coverage of BNCT! Brain malignancy ! Head neck cancer ! Malignant melanoma ! Lung cancer ! Multiple liver cancer ! Mesothelial cancer
(asbestos exposure victim) ! Recurrent breast cancer ! Various recurrent cancer
Neutron Source: Replace the Research Reactor with Accelerator # Accelerate Drug development
Basic%configuraXon%of%proton%linac%for%BNCT
16(
Ion(
Source
H+(50(keV
RFQ DTL
Beam(
Transport(&(
Expander
3(MeV 8(MeV
1.2(MW(
Klystron(
324(MHz
Be'
target
Moderator(&(
Collimator
80(kW
Peak'current Max.(50(mA
Pulse'width Max.(1(ms
Pulse'repehhon Max.(200(pps
Duty 20%
Beam'power 80(kW
Klystron
DTL
RFQ
Waveguide
Beam(Transport
Target(
Moderator(
Collimator(
>(109n/cm2/s(
epiVthermal(neutron(
Beam(Expander
0'
1E+09'
2E+09'
3E+09'
4E+09'
5E+09'
6E+09'
7E+09'
0'' 2'' 4'' 6''
n'[n/m
A/cm2/sec]'
En'[Mev]'
0°'
15°'
30°'
45°'
60°'
90°'
110°'
1.E+05
1.E+06
1.E+07
1.E+08
1.E+09
1.E+08 1.E+07 1.E+06 1.E+05 1.E+04 1.E+03 1.E+02 1.E+01 1.E+00 1.E+01
���n
/cm2/s/lethargy)
��������MeV)
φ12cm
case13
case14
case15
case16
Neutron'energy'
spectrum'at'the'
pahent'posihon'
Epi^thermal:''
0.5'eV'~'10keV
Neutron'energy'
spectrum'at'the'Be'
target'for'various'
produchon'angles'
Primary'proton'
energy'is'8'MeV'
9Be(p,n)9B
Be'
target
Moderator(&(
Collimator
PE+LiF
MgF
2
PbBi Fe
W
Al
PbTi��
Thermal'neutron γ^ray
Epi^thermal''
neutron'
flux'>'4.5 109'
n/cm2/s
Fast'neutron
As'low'as'
possible
Neutron'flux'requirement
InstallaXon%of%RF%system%and%beam%transport%by%2014
Modulator1.2'MW'Klystron Beam'transport'&'expander
RF Conditioning
First%beam%commissioning%was%completed%in%December%2014
20(
(Preliminary)(
Ion(Source
RFQ
DTL
Fluorescent'screen'on'
target'
Very'low'peak'current:'~'1'uA'
Project%Xmeline%in%near%future:%1.%InstallaXon%of%TMCS%is%going%on%2.%Neutron%beam%commissioning%#%summer%~%3.%Cell%and%animal%level%study%#%end%of%this%year%~%4.%Clinical%trial%#%JFY%2016~
• Target,(Moderator,(Collimator(and(Shield(
• Installa\on(was(completed(except(shield.(
1. ConstrucXon%status%of%Ibaraki&BNCT%(Boron%Neutron%Capture%Therapy)%facility%as%the%POC%machine,%it’s%a%compact%proton%driver
2. Design%work%toward%OIST&BNCT,%as%the%first%mass%producXon%model.
3. Possible(applica\on(of(the(BNCT(linac(for(
1. The(front(end(of(intense(largeVscale(machines(
2. The(compact(neutron(source(for(material(science(
4. Summary
IbarakiVBNCT((
# POC(machine(based(on(JVPARC(RF(design(
# Installed(in(an(exis\ng(building((acer(remodeling),((
# not(necessarily(op\mized(for(BNCT
The(purpose(of(the(OISTVBNCT((
#(establish(the(first(mass(produc\on(model(
Its(design(should(be(op\mized(for(BNCT,(based(on(IbarakiVexperiences(
Sugawara'Unit'is'aiming'to'study'
! BNCT'! Cancer'Stem'Cell'
! Drug'delivery'system'
! Imaging'technology
The'design'team'(Parameter'Board)''
was'created'last'weak,'on'May'14'''
! Project'leader:'Hirotaka'Sugawara'(OIST)'! Parameter'board'chair:'Kazuo'Hasegawa'(JAEA)'
! Scienhfic'secretary:''' 'Masakazu'Yoshioka'&'Yasuo'Higashi'(OIST)'
! Secretary:'Fumiko'Suzuki'(OIST)''
! Members:'
$ OIST:'H.'Sugawara,'M.'Yoshioka,'Y.'Higashi'
$ KEK:'F.'Naito,'S.'Kurokawa,'H.'Matsumoto'
$ JAEA:'K.'Hasegawa,'Y.'Kondo'$ Univ.'Tsukuba:'H.'Kumada'
'
! Ad'Hoc'meehngs'with'industries'will'be'held.
'
Common'parts'and'concept'of'OIST^BNCT'with'Ibaraki^BNCT'
! Linac'configurahon:''“50'kV'ECR'ion'source'+'RFQ'+'DTL”''with'duty'factor'of'20%'! Careful'design'by'considering'space'charge'effect'(loss'issue),'beam'ophcs'and'
beam'emiwance'matching'between'subsystems'
! Use'of'solid'beryllium'target''
'Ibaraki 'OIST'(Tentahve) comments'for'OIST^BNCT
RF'frequency 324'MHz J^PARC'freq.' 'EU'Freq.
Beam'Energy 8'MeV Higher'beam'energy'
Lower'beam'powerBeam'Power 80'kW
Epi^thermal''
Neutron'Flux4.5' '109'n/cm2/s
irradiahon'hme'for'pahent'
~15'min.
Peak'current 50'mAenough'margin'for'
50'kV'ECR'ion'source'operahon
Pulse'width 1'msMarx'circuit'for'main'circuit'or'
droop'compensahon'circuit
Repehhon'rate 200'Hz
RFQ'energy'gain 3'MeVLower'vane'hp'surface'electric'
field'for'stable'operahon
DTL'energy'gain 5'MeV
Klystron 1 1.2MW'SBK 3 0.5MW'MBKSBK:'Single'beam'klystron'
MBK:'Mulh'beam'klystron
ITEM' VALUE'
BEAM'ENERGY'[MeV]:' )
BEAM'ENERGY'JITTER'[%]:' <±0.5'
PEAK'BEAM'CURRENT'[mA]:' 50'
AVERAGE'BEAM'CURRENT'[mA]:' 10.5'
BEAM'POWER'[kW]:' (B @3 D72A6.4 A A FKMG % NL
MAX.'REP.'RATE'[Hz]:' 60'
ITEM' VALUE'
3 8 KHO F:DG % %
C3 KHO F DG %) (
C A 53 KHO F CG % (1B 3 A KHO F G +
B @3 D72A6.4 A A FKMG % NL )RISE'&'FALL'TIME'(0'to'100%)'
[ms]:'<0.1'
FLATNESS'@TOP'(RMS):'
STABILITY'@TOP'(RMS):'
REP.'RATE'[Hz]:'single'&'1'to'60'
MODULATOR'
FALL'
^ possible'configurahon 2' case'design'
We'will'add'one'more'MBK'to'DTL'and'increase'energy'gain
ITEM' VALUE'
4 3 B3 1E F:6PG )Q %
BA BA 4 D3 KHOF DG
03 : C A 53 KHO F CG % R (
03 : 1B 3 A KHO F G R +
5 7 FI0GS .
D3447173 1E A @ AB A7
F GS))
Circu
lator
Circu
lator
1.'Accelerator'room'
! ECR'Ion'Source'! RFQ'and'DTL'! Circulator'! Mulh^beam'klystron
2.'Irradiahon'room'
! Beam'transport'and'beam'size'expansion'
! Target,'Moderator'and'Collimator'
! Bed'for'pahent
3.'Power'supply'room'
! Klystron'Modulator'power'
supply'
! Low'level'RF'circuits'! Magnet'power'supply'
! Vacuum'control
5.'Uhlity'room'
! Cooling'water'systems'
! Air'venhlahon'and'condihon'! Electric'power'distribuhon
4.'Roof'top'
! Cooling'tower'! Water'chilling'unit
6.'Control'room'
! Main'control'system'
! Personal'protechon'&'radiahon'safety'system'
! Machine'protechon'system'
! Timing'system
Solenoid'
Collector'
Electron'gun':'6'beams'
Cavity'
TOSHIBA'Mulh^Beam'Klystron'
(MBK)'E3736'for'ILC'&'XFEL(SRF)'
i^BNCT'Klystron'system'E37619'
Single'beam,'1.2'MW,'^90kV,'33A
OIST^BNCT'Klystron'system:'6'beams,'600'kW,'^31kV,'33A'
Advantage'of'MBK'by'comparing'with'SBK:''
! higher'AC'to'RF'power'conv.'eff.'(61/54'%)'! lower'modulator'power'supply'voltage'(31/91'kV)'''
#'compact'and'reliable'modulator'power'supply'
! Longer'cathode'life'due'to'lower'cathode'loading
MBK:'mulh'beam''Klystron'
One'of'the'key'technologies
! We are almost reaching at the starting line of the OIST-BNCT.
! The preliminary design work has been already started. ! Timeline of the project (depends on the budget profile)
$ 2015 # Make a full design work and TDR $ OIST/KEK/Tsukuba Univ./JAEA collaboration is crucial $ Effective outsourcing (Cosylab/NAT/ATOX) is necessary
$ 2015~2016 # ECR ion-source construction and test $ 2016~2018 # manufacturing of the linac $ 2017~2019 # manufacturing of the target, moderator,
collimator and irradiation system $ 2019 # installation and commissioning
30(
Ridge(waveguide
2(solenoids(for(ECR(condi\on((874(gauss)
3(electrodes
An%example%of%collaboraXon%between%%%BNCT%and%CEA/Saclay
ECR'Ione'source''
for'Ibaraki^BNCT
LEBT
31(
Beam(reducer
Differen\al(evacua\on
Solenoid(focus
Beam(dump(to(remove(
unnecessary(ions(H2+(and(H3
+(
+(Emigance(Monitor(
Chopper
1. ConstrucXon%status%of%Ibaraki&BNCT%(Boron%Neutron%Capture%Therapy)%facility%as%the%POC%machine,%it’s%a%compact%proton%driver
2. Design%work%toward%OIST&BNCT,%as%the%first%mass%producXon%model.
3. Possible'applicahon'of'the'BNCT'linac'for'1. The'front'end'of'intense'large^scale'machines'
2. The'compact'neutron'source'for'material'science'
4. Summary
ECR'ion'source'
! High'current'! Easy'to'maintenance
High'current'RFQ
MBKsKey'elements'for''
high'current'and''
High'duty'linac
ESS
Many'common'technical'requirements'for''
the'BNCT'and'the'front^end'of'ESS'!!
Large'scale'neutron'source'
High'flux,'but'
Limited'machine'hme
Small'scale'neutron'source'
Low'flux,'but'
Taylor^made'studies
! HUNS:'Hokkaido'
University'
Neutron'
Source'
! 45MeV'Electron'linac
! RANS:'Riken'
Accelerator^driven'
Neutron''
Source'
! 7MeV,'600W'proton'Linac
We'need'
both'!!
compact'neutron'source'for'material'and'life'science'
and'Industrial'applicahons'
If Michi can show a good market, I will establish a venture
35MV/m Electron linac
BNCT RFQ
2 UCANS '
# Dreams'will'come'true!!
1. ConstrucXon%status%of%Ibaraki&BNCT%(Boron%Neutron%Capture%Therapy)%facility%as%the%POC%machine,%it’s%a%compact%proton%driver
2. Design%work%toward%OIST&BNCT,%as%the%first%mass%producXon%model. 3. Possible(applica\on(of(the(BNCT(linac(for(
1. The(front(end(of(intense(largeVscale(machines(
2. The(compact(neutron(source(for(material(science(
4. Summary
ECR'ion'source'
! High'current'! Easy'to'maintenance
High'current'RFQ
MBKs
! Our'first'and'second'compact'proton'driver'construchon'
'#'Ibaraki'BNCT,'full'commissioning'will'be'very'soon'(POC'machine)'
'#'OIST^BNCT'five'year'construchon'program'has'been'just'started'
'''''''The'role'is'to'establish'the'first'mass'produchon'model'
! Experiences'of'CEA/Saclay'on'this'field'is'very'important'
! Technologies'for'BNCT'are'common'with'front^end'of'the'large'scale'machine'
! BNCT'linac'can'be'applied'as'a'compact'neutron'source'for'material/life'science'
''''''and'industrial'applicahons''