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HORMON V CC CHT LIN QUANPhan Th Nh Qunh, MSc.B mn Ha DcKhoa Dc, HYD HuI CNGHORMONnh ngha:Hormon l nhng cht c tit ra bi cc t bo c hiu v tc dng ln cc receptor c hiuc im:Tc dng vi liu lng rt thpTc dng c hiuCc tuyn lin h vi nhau thnh h thng ni tit Lin h cht ch vi h thng TK3HORMONBn cht ha hc:Cu trc steroid: Hormon v thng thn, hormon sinh dcCha nhn cyclopentanoperhydrophenanthren

Cu trc acid amin:Hormon tuyn gip, hormon ty thng thnCu trc peptid, polypeptidHormon tuyn yn

HORMONC ch tc ng:nh hng n hot ng gene v s tng hp protein:Hormon tan/lipidPhc hp hormon-receptor gn vo ADNTc dng thng qua cc repetor ph thuc G-proteinHormon cu trc peptidLm thay i lng cAMPHot ng thng qua protein kinaseHormon polypeptidiu ha s tng trng, bit haHORMONiu ha bi tit hormon:Vng di i l trung tm iu ha ca h thng ni tit:Yu t gii phng (RF: releasing fator)Yu t c ch (IF: inhibiting factor)Tuyn yn:Sn xut hormon chi phi hot ng ca cc tuyn khcChu s kim sot ca vng di i

HORMONCc loi hormonHormon vng di iHormon tuyn ynHormon tuyn gipHormon tuyn tyHormon v thng thnHormon sinh dc

HORMON VNG DI IHormonTn y Chc nngp dng tr liuGHRHGrowth Hormon Releasing Hormon Gy phng thch GHChn on nguyn nhn thiu GHLm tng chiu cao TE thiu GHSomatostatin (SRIH)Somatotropin Realease Inhibiting Hormonc ch phng thch GH, TSH, glucagon, insulin v gastrin, c ch bi tit d dy-rutChng to ccU ty, u t trng, u t bo tit glucagonTRHThyrotropin Releasing HormonKch thch bi tit TSH v prolactinChn on bnh tuyn gipCRHCorticotropin Releasing HormonKch thch bi tit ACTH v beta-endorphinChn on kh nng tit ACTH ca tuyn ynGnRHGonadotropin Releasing HormonKch thch/c ch tit gonadotropinThiu gonadotrpin gy gim chc nng tuyn sinh dcDy th sm, ung th tuyn tin lit, ung th v ph thuc estrogenDopamin (PIH)Prolactin Inhibiting Hormonc ch tit prolactinKim sot tng prolactin huyt10HORMON TUYN YNHormon tuyn ynHormon tin ynHormon hu ynGH (somatotropin)TSH (Thyroid-Stimulating Hormon)ACTH (Adrenocorticotropin)GonadotropinProlactinOxytoxcinVasopressin (Antidiuretic Hormon, ADH)GHL peptid gm 191 acid aminc bi tit nh GHRH v c ch bi tit bi somatostatinC ch tc dng:Trc tip: hormon gn vo receptor t bo chGin tip: kch thch sn xut IGF gan v cc m khc. IGF lm tng sinh sn, xng, m mm, tng s lng t bo

13GHTc dng:Kch thch tng trng c th tr emiu ha chuyn ha t bo ngi ln v tr emp dng tr liu:Tr thiu GH cho tr emSomatrem v Somatotropin ti t hp ADNTSHC ch tc dng:Kch thch adenyl cyclase t bo tuyn gip tng bt gi iod v sn xut hormon gipp dng:Chn on phn bit gim nng tuyn gip nguyn pht v th phtDng BN ung th tuyn gip di cnACTHThnh lp t proopiomelanocortinc tit vo ban ngy, cao nht lc sng smp dng:Lm tng bi tit hormon v thng thnChn on sn xut corticosteroid bt thngGonadotropinL tn chung ca 3 hormon tc dng trn t bo sinh dc:LH (luteinizing hormon): hormon to hong thFSH (follicle stimulating hormon): hormon kch thch to nang trnghCG (human chorionic gonadotropin): gonadotropin nhau thaiGonadotropinTc dng:Sinh bo t v sn xut steroid sinh dcFSH: Pht trin nang trng Kch thch sinh tinh trngLH: Tng hp progesteron th vng v tng hp androgen bung trngKch thch tng hp testosteron

Gonadotropinp dng:Tr v sinh cho ph n v nam giiTrnh thaiTr tinh hon n trc dy thChn on c thaiChn on ngy rng trngChn on cc bnh ca h sinh dc nam v nProlactinC ch ngn tit l ch yu: cht ch vn c ch tit, cht i khng tng tit prolactinKhng kch thch tng hp v bi tit m ch nn khng c c ch feed backTc dng:Cng cc hormon khc kch thch tuyn v pht trin trong thi gian mang thai v duy tr s sinh snTng prolactin huyt: c ch trc di i-tuyn yn-sinh dc gy bt lc, chy sa, v kinh, v sinhOxytoxinc tng hp vng di i, tch tr thy sau tuyn ynTc dng:Kch thch co tht t cung tng chuyn d, gy sy thai trong iu trGy co tht c trn tuyn v kch thch tit saVasopressinc tng hp vng di i v bi tit thy sau tuyn ynTc dng:Trn receptor V1: gy co c trnTrn recepor V2: tng tnh thm t bo ng thn tng ti hp thu nc li tiuThucTc ngCh nhCh thchSomatremGHSuy tuyn ynGH cha methionin N tn cng, ti t hp ADNOctreotidTng t somatostatinChng bi tit nhiu tuynTc dng di hn somatostatin thin nhinCosyntropinTng t ACTH, kch thch v thng thnThay th corticosteroid trong chn onCha 24 aa u c hot tnh ca ACTHLeuprolid, goserelin, nafarelin Tng t GnRHV sinh, ung thKch thch tuyn sinh dc nu dng theo nhp sinh l, c ch nu dng lin tcUrofollitropinGing FSHV sinhLy trch t nc tiu ngihCGGing LHV sinhLy trch t nc tiu ngiMenotropinHot tnh FSH & LHV sinhLy trch t nc tiu ngiBromocriptin c ch phng thch prolactinNgn tit sa, c ch u tuyn ynAlcaloid ergot, cht ch vn dopamin mnhDesmopressin Tng t ADHi tho nht do tuyn ynCh vn receptor V2, tc dng di hn ADH Tm tt cht tng t hormon vng di i v tuyn yn c s dng trong tr liuTHANK YOU!