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  • 2008 pp291-308

  • _2.12.mpg

  • _.pps_.pps

  • (Toxicity)

    LD50LC50

  • (Lethal Concentration 50%, LC50)

    (Lethal Dosage 50%, LD50)

  • Classification of toxic agents

    *based on their target organ: liver, kidney, hematopoietic

    system

    *based on their use: pesticide, solvent, food additive

    *based on their source: animal, plant, synthetic

    *based on their effects: cancer, mutation

    *based on their physical state: gas, liquid, particle

    *based on their labeling requirements: explosive, flammable

    *based on their chemistry: aromatic amine, halogenated

    hydrocarbon

    *based on their poisoning potential: extremely toxic, very toxic

    *based on their biochemical mechanism of action: sulfhydryl

    inhibitor, methemoglobin producer

    *based on the source of exposure or legislative purposes: air

    pollutants, water pollutants, occupation-related agents

  • Characteristics of exposure

    route and site of exposure: ingestion (gastrointestinal

    tract), inhalation (lungs), topical/dermal (skin)

    duration and frequency of exposure

    _515_flv.flv_515_flv.flv 2010.doc _1.13.avi

  • Spectrum of undesired effects

    1. allergic reactions

    2. idiosyncratic reactions

    3. immediate vs. delayed toxicity

    4. reversible vs. irreversible toxic effects

    5. local vs. systemic toxicity

    2012.doc

  • (Acute Toxicity) (24 - 48)()

    (Chronic Toxicity)

  • Interaction of chemicals

    1. additive effect

    2. synergistic effect

    3. potentiation

    4. antagonism

    .doc

  • (Toxic Chemical Substance)

  • (Broad distribution) (Environmental accumulation)

  • (Bioconcentration) (Bioaccumulation) (Biomagnification)

  • Grasshopper Effect

    Future_Conditional__The_Grasshopper_Effect__Toxic_Pollution_in_the_Arctic.mp4

  • (Operation)

  • ()

  • (

    )()()()

    ()

  • ()

    1.

    (1)5

    (2)180

    (3)180

    2.

    (1)(BCF)500

    (2)-(log Kow)3

  • ()

    1.(IARC)12

    1

    2.1

    3.()

    12

  • (IARCWHO) (US EPA) (a)(b)

    IARC US EPA

    1 A

    2A

    B1 ()

    B2 ()

    a.b.

    2B C a.b.

    DDT

    3 D

    4 E (C6-H11-NO)

  • (EC)

    1

    2

    3

  • ()

    1.

    (1)(LD50)25

    (2)(LD50)50

    (3)(LC50)250

    2.

    (1)(LC50)1

    (2)(EC50)1

  • ()

    1.(IARC)2B

    2.2

    3.2

    4.

    5.

  • 26 26

    .

  • _.pps_.pps

  • 0.1%w/w

    1000PPM900 PPM

    50PPM

  • Allyl butyrate

    CAS No. : 2051-78-7

    LD 50 : 250 mg/kg

    (Rat, Oral)

    Harmful Harmful Harmful Non-toxic Toxic Toxic Toxic Moderately Toxic Hazardous

  • 1992

    Globally Harmonized System of Classification and

    Labelling of Chemicals (GHS)

  • UNCED)

    IFCS

    1992

    OECD

    UNCETDG

    ILO

    GHS

    GHS

    GHS

    200212

    20062

    200610

    20071019

    G

    HS

  • GHS ILO SAFEWORK

    -Safe Chemicals Use

    ILO

    MSDS/SDS

    GHS

    Strategic

    Approach to

    International

    Chemicals

    Management

    (SAICM) 2020

    National Chemical

    Management

    GHS Guidance Document, UNITAR, 2005/OSHA, USA

    GHS

    ()

    International Labor Organization

  • X =

    (Hazard Communication)

  • GHS Hazard Classification

    Labelling

    Material Safety Data Sheet, MSDS/SDS

    Classification Categories

  • GHS

    (UNCETDG)

    (OECD)

  • GHS

    +

    + CNS6864UNTDG

    +

    + MSDS16

    GHS + 27

    + CNS1503027CNS15030-127

    +

    + MSDSSDSSDS16

  • GHS 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

    UN

    1. GHS 2.45

    A: B: 1%0.1-0.3% 1 20.1 3CNS15030

    2015

    12/1

    12/1 5/31 11/30

    A

    B

    1

    2

    3

  • CNS 15030

  • AB

    AB

  • /1

    /1

  • 13

  • 1~2

  • 4

    /2

    /2

    3

  • GHS

    9

    G

    H

    S

    8 5.2 5.1 5.1 4.3 4.2 4.2 4.2 4.1 4.1 3 2.2 5.1 2.1 2.1 1

  • GHS

    9

    G

    H

    S

    ~

    /

    /

    8 8 6.1

  • GHS

    (w/w)

  • (Material safety data sheet MSDS/SDS)

  • MSDS (Material Safety Data Sheet) ()

    SDS (Safety Data Sheet) (GHS)

    SDS

  • MSDS GHS SDS

  • MSDS GHS SDS

  • _.pps_.pps