Other bioactive productsU 1300 DOI: 10.1002/chin.201243203

Ethyl 2,4,6-Trihydroxybenzoate Is an Agonistic Ligand for Liver X Receptor that Induces Cholesterol Efflux from Macrophages Without Affecting Lipid Accumu-lation in HepG2 Cells. — Ester (I), isolated from C.biondii, displays LXR agonist ac-tivity. This compound is a direct ligand of LXR-α and LXR-β and regulates the expres-sion of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells. — (HOANG, M.-H.; JIA, Y.; JUN, H.-J.; LEE, J.-H.; LEE, D.-H.; HWANG, B.-Y.; KIM, W.-J.; LEE, H.-J.; LEE*, S.-J.; Bioorg. Med. Chem. Lett. 22 (2012) 12, 4094-4099, http://dx.doi.org/10.1016/j.bmcl.2012.04.071 ; Div. Biotechnol., Coll. Life Sci. Biotechnol., Korea Univ., Seoul 136-713, S. Korea; Eng.) — H. Hoennerscheid

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ChemInform 2012, 43, issue 01 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim