Clase Endocrinoooooo

8/17/2019 Clase Endocrinoooooo

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CCKACh

Gαs AC Gαi

LeucineGlucose

GLUT2 transporter

b Cellcytosol

H2O

IP3

CO2

Citricacidcycle

Mitochondrion

Pyruvate

Depolarization

Extracellular

space

[Ca2+]Ca2+

Voltage-gatedCa2+ channel

KATP channel

[Ca2+]

Glucose-6-phosphate

Glucokinase

Glycolysis

ATP

ATP

ATP

ER

PKC

Proteinkinase C

Secretorygranules

Insulin

PKA

cAMP

PLC

Gq

DAG

PIP2

Glucagonβ-adrenergicagonists

Somatostatingalaninα-adrenergic

agonists

Glucose enters the cellvia a GLUT2 transporter,which mediatesfacilitated diffusion ofglucose into the cell.

The increased glucose influxstimulates glucose metabolism,leading to an increase in[ATP]i or in [ATP]i/[ADP]i.

The increased [ATP]i and/or[ATP]i/[ADP]i inhibits an ATP

-

sensitive K+ channel.

Inhibition of this K+ channelcauses Vm to become morepositive (depolarization).

The depolarization activates avoltage-gated Ca2+ channel inthe plasma membrane.

The activation of this Ca2+ channel promotes Ca2+ influx,

and thus increases [Ca2+],which also evokes Ca2+-induced Ca2+ release.

The elevated [Ca2+] leads toexocytosis and release into theblood of insulin containedwithin the secretory granules.

Other modulators of secretionact via the adenylyl cyclase-cAMP protein kinase A pathwayand the phospholipase and thephospholipase C–phosphoinositidepathway.


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Calcioplasmático

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200 mg excreción renal

Dieta

(1000 mg)

800 mg excreción heces

Remodelación ósea

Absorción

(350 mg)

excreción

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Amino terminal poseeactividad biológica


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Plasma calcium

Parathyroid glandsPTH secretion

Phosphatereabsorption

Calciumreabsorption

Urinary excretionof calcium

Release of calciuminto plasma

Urinary excretionof phosphate

Plasma phosphate

1,25-(OH)2 D3formation

Plasma1,25-(OH)2 D3

Boneresorption

IntestineCalcium absorption

Plasma PTH

Kidneys

Plasma calcium


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Plasma phosphate

reabsorptionCalcium

of calciumUrinary excretion

Kidneys

Plasma

Plasma calcium

Phosphatereabsorption

of phosphate

1,25-(OH)2 D3

1,25-(OH)2 D3 formation

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Plasma PTH

absorptionCalcium

Intestine

Phosphateabsorption

Bone

promotes PTHaction

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Parafollicular cells

Phosphate

releaseCalciumUrinary excretion

Plasma phosphate

reabsorption

Urinary excretion

Calcium

CT secretion

Boneresorption

of calcium

Kidneys

Plasma CT

Plasma calcium

reabsorption

of phosphate


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Anterior pituitarygland

Vein

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gland

Mamillary body

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Epididymis

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Clase Endocrinoooooo