DAFTAR ISI Halaman Lembar persetujuan ................................ i Kata pengantar .................................... ii Daftar isi ……………………………………………………………………….............iv BAB I PENDAHULUAN.................................. 1 A. Latar Belakang ............................... 1 B. Perumusan Masalah ............................ 3 C. Tujuan Penelitian ............................ 3 D. Manfaat Penelitian............................ 3 BAB II TINJAUAN PUSTAKA............................ 5 A. Amilum ....................................... 5 B. Amilum Pregelatinasi ......................... 6 C. Amilum Pregelatinasi Suksinat ................ 8 D. Tablet ....................................... 8 E. Bahan Pengisi ................................ 11 F. Diltiazem HCl ................................ 12 G. Evaluasi ..................................... 12 1. Evaluasi amilum ........................... 12 2. Evaluasi sifat fisik granul ............... 12 a. Waktu alir .............................. 13 b. Sudut baring ............................ 13 c. Distribusi ukuran granul ................ 13 d. Kerapuhan granul ........................ 14 e. Uji kompresibilitas ..................... 14 3. Evaluasi tablet yang dihasilkan ........... 15 a. Uji keseragaman bobot ................... 15 b. Uji kekerasan tablet .................... 15 c. Uji kerapuhan tablet .................... 15 iv
