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DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand, Sami Dridi, Nagaraj Kerur, Younghee Kim, Won Gil Cho, Hiroki Kaneko, Benjamin J. Fowler, Sasha Bogdanovich, Romulo J.C. Albuquerque, William W. Hauswirth, Vince A. Chiodo, Jennifer F. Kugel, James A. Goodrich, Steven L. Ponicsan, Gautam Chaudhuri, Michael P. Murphy, Joshua L. Dunaief, Balamurali K. Ambati, Yuichiro Ogura, Jae Wook Yoo, Dong-ki Lee, Patrick Provost, David R. Hinton, Gabriel Núñez, Judit Z. Baffi, Mark E. Kleinman, Jayakrishna Ambati Cell Volume 149, Issue 4, Pages 847-859 (May 2012) DOI: 10.1016/j.cell.2012.03.036 Copyright © 2012 Elsevier Inc. Terms and Conditions

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

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Page 1: DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 

Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand, Sami Dridi, Nagaraj Kerur, Younghee Kim, Won Gil Cho, Hiroki Kaneko, Benjamin J. Fowler, Sasha Bogdanovich, Romulo J.C. Albuquerque, William W. Hauswirth, Vince A. Chiodo, Jennifer F. Kugel, James A. Goodrich, Steven L. Ponicsan, Gautam Chaudhuri, Michael P. Murphy, Joshua L. Dunaief, Balamurali K. Ambati, Yuichiro Ogura, Jae Wook Yoo,

Dong-ki Lee, Patrick Provost, David R. Hinton, Gabriel Núñez, Judit Z. Baffi, Mark E. Kleinman, Jayakrishna Ambati  

Cell Volume 149, Issue 4, Pages 847-859 (May 2012)

DOI: 10.1016/j.cell.2012.03.036

Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 2: DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

Figure 1

Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 3: DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

Figure 2

Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 4: DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

Figure 3

Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 5: DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

Figure 4

Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 6: DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

Figure 5

Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 7: DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

Figure 6

Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 8: DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

Figure 7

Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 9: DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

Figure S1

Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 10: DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

Figure S2

Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 11: DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

Figure S3

Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 12: DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

Figure S4

Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 13: DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

Figure S5

Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 14: DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

Figure S6

Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 15: DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

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