Upload
nhuynguyengoc
View
29
Download
2
Embed Size (px)
DESCRIPTION
Dược liệu
Citation preview
1
DC LIU CHA ANTHRANOID
2
PHAN T
Tn khoa hc: PTD la hep Senna angustifolia Mill. = Cassia angustifolia Vahl., Phn h Ceasalpinioidae, H Fabaceae PTD la nhn Senna acutifolia (Del.) = Cassia acutifolia Del. Phn h Ceasalpinioidae, H Fabaceae Nhiu tac gia xem hai loi nay la mt: Senna angustifolia Mill.
3
4
C. angustifolia C. acutifolia
5
6
7
PHAN T
- B phn dng: l cht (Folium Sennae).
- Cn dng ht
8
THNH PHN HA HC
Anthranoid chim 2 - 3 %.
-Dng t do: rhein, aloe emodin, chrysophanol
-Dng glycosid:
R1 = R2 = H cc sennidin
- R3 = COOH, trans : Sennidin A
- R3 = COOH, cis : Sennidin B
- R3 = CH2OH, trans : Sennidin C
- R3 = CH2OH, cis : Sennidin D
R1 = R2 = Glu cc Sennosid tng ng
OH
COOH
R3
OHOR1
OR2
O
O
HH
9
THNH PHN HA HC
-Cc flavonoid: kaempferol, isorhamnetin.
-Cht nha !!!!
Kaempferol
OH O
CH3
CH3
Glu
OH
Tinnevellin glucosid
INH TINH (SKLM) AG: n-propanol EA nc (4:40:30) AQ: benzen acid acetic (80:20)
11
NH LNG - Dch chit (nc) loi tp chuyn sang dng
oxy ha thy phn thu dch anthraquinon/KOH UV 500 nm
- Cht chun: 1,8-dihydroxyanthraquinon
- Hm lng tnh theo sennosid
1 mg 1,8-dihydroxyanthraquinon = 1.797 mg sennosid
12
TC DNG - CNG DNG
- Ngi Rp dng t TK IX, sau nhp sang Chu u, hin nay rt ph bin
- Liu dng:
- 2 g: tr tiu ha
- 3 - 4 g: nhun trng
- 5 - 7 g: ty x
13
MUNG TRU
Tn khc: Mung lc, cy lc,
Tn khoa hc: Senna alata (L.) Roxb., Fabaceae
= Cassia alata L.,
BPD: L (Folium Cassiae), ht (Semen Cassiae)
14
15
THNH PHN HA HC Trong l, qua, r u c anthranoid:
L
AQ
chrysophanol, aloe emodin, rhein,
emodin.
AG
Rhein-8-glucosid, physcion-8-glucosid
Aloe-emodin-8-glucosid
Flavo Kaempferol
O
O
OH
COOH
OGlu
Rhein-8-glucosid
16
Qua
AQ
chrysophanol, aloe emodin, rhein,
emodin.
AG
Rhein-8-glucosid, Aloe-emodin-8-
glucosid
Flavo Kaempferol
17
TC DNG - CNG DNG
- Dng cha lc: gi nt p ln ch nhim
- Cha to bn: dng 4 - 5 g l dng thuc sc
- Cha giun a: phi hp vi ht Trm bu
18
Dc in Vit Nam IV qui nh:
Rheum palmatum L., Polygonaceae
Rheum officinale Baillon, Polygonaceae
Hoc ging lai ca 2 loi trn.
palmatum: hnh bn tay
officinale: dc dng
I HONG
19
Cy thao ln (2m).
L hnh tim to (30-40cm), c b cha (Polygonaceae)
R. palmatum c thy su hn R. officinale.
Sau 3-4 nm mc 1 ngn thn hnh chy mang nhiu hoa.
Cy a m, mt. Mc cao >1000m. Tt nht 2200-4000m.
C ngun gc t Trung Quc. Vit Nam cn phai nhp.
I HONG
M T THC VT
20 20
Rheum sp
21 21 Rheum palmatum
22 22 Rheum palmatum
23 23
Rheum palmatum
24 24
B phn dng: thn r Rhizoma Rhei
Thn r nhng cy t 3-4 nm tui.
Ma thu, khi cy tn li
Ct b r, thn r gt b v ngoi.
Phi hay sy kh
Ct gi 1 nm mi dng.
Mt s ni cn dng cung l lm bnh.
I HONG
THU HI CH BIN
25 25
I HONG
M T DC LIU
DVN III
Ming hnh da, tr hay ovan
10cm
Mt ngoi mu vng nu, i khi c nhng am en nht
DVN IV
Hnh tr, hnh non, dng cu hay meo mo khng u hay nhng phin mng
= 3-10cm
Mt ngoi mu nu vng hay nu , i khi c nhng m en nht. Phin c th c nhng sc en
Vt b c mu cam
Mi c trng
V ng cht
26 26
Rhizoma Rhei
27 27
1. manh ban 2. manh mo mem
3. si
4. calci oxalat
hnh cau gai
5. hat tinh bot
Soi bt
28 28
Anthranoid 3-5%
Tannin 5-12%, PC (khng thy phn) > PG
V c: Calci oxalat
Tinh bt, pectin, nha
Tannin coi nh tp cht khi nghin cu anthranoid, d tan trong nc, cn (dung mi thng dng chit xut Anthranoid)
I HONG
THNH PHN HA HC
29 29
AQ t do 1-2 gm: chrysophanol, emodin, physcion, aloe
emodin v rhein.
AG chim 60-70% anthranoid ton phn.
AG ca cc dn cht kh (lu kho 1 nm)
Cc dianthron: cac rheidin, cac palmidin,
I HONG THNH PHN HA HC
OH O
O
OH
OH OH
COOH
COOH
OH O
O
OH
OH OH
COOH
OH CH3
Dirhein Rheidin A
30 30
Phan ng Borntrager:
0.10g bt + 5ml H2SO4 (BM).
Lc
Lc vi Benzen, Ether (DVN III), cloroform (DVN
IV), dicloromethan (PTN DLiu)
c mu vng.
Ly lp dung mi hu c, lc vi KOH 0.1N, amoniac
10% (DVN). lp kim c mu .
I HONG
NH TNH
31 31
Sc k lp mng:
Pha tnh: silica gel G hot ha 105oC (DVN III), silica gel F 254 (DVN IV, PTN Dliu).
Pha ng: EP-EA-acid formic (75:25:1) (DVN), Bz-EA-a. formic (75:24:1) (PTN Dliu).
Dung dch th:
Chit bng nc acid. Lc
Lc vi ether ethylic, c n cn
Ha li trong ether
Chm sc k
I HONG
NH TNH
32 32
I HONG
Sc k lp mng:
Dung dch i chiu: emodin/ether ethylic nng 1mg/ml hoc dch chit bt H chun.
Chm trn cng ban mng.
Quan st di UV 365nm.
H ban mng trong hi amoniac.
I HONG
NH TNH
33 33
Pht hin bng SKLM.
Pha tnh: Silica gel F254 Pha ng: EA-MeOH-H2O (100:3.5:10)
Dung dch th: chit bng ethnol, BM. Lc, chm ln ban mng 10L.
Quan st UV 365nm.
Khng c c vt pht hunh quang tm xanh khoang Rf 0.4-0.6 (vt ca rhaponticosid)
I HONG
TP CHT (DVN IV)
34 34
Rhaponticosid xut hin khi co ln tp cac loai: R. rhaponticum hay R. undulatum.
Rhaponticosid phat hunh quang UV 365.
Co th kim tra bng SKLM vi h n-butanol-a.acetic-nc (4:1:5).
I HONG TP CHT
hRf = 50 55 70 80 95
C
T
mau th T a b lan rhaponticosid
35 35
6.1. Phng phap Auterhoff
- thuy phan trc tiep vi AcOH bang, un soi 15 phut
- e nguoi, tach aglycon bang ether soi.
- aglycon cho phan ng vi (NaOH + NH3)
- tach lp kiem (mau o), em o quang (515 nm)
- So sanh vi dung dch CoCl2
- (A cua d.dch CoCl2 1% # A cua d.dch istizin 3,6 ppm)
ai hoang phai cha 2,5% anthranoid, tnh theo Istizin
NH LNG
36 36
- chiet m (g) mau bang nc nong cach thuy.
- e nguoi, them Na bicarbonat, lac, loc lay dch
- Oxy hoa bang FeCl3 2% nong, thuy phan (HCl nong)
- chiet aglycon bang ether, can ether + Mg acetat / MeOH
- o o hap thu A 515 nm (khong dung chuan)
- ket qua c tnh trc tiep X% = 64A / 100m
ai hoang phai cha 2,2% anthranoid (tnh theo rhein)
Thc chat : nh lng cac anthranoid acid
6.2. Phng phap DVN IV
NH LNG
37 37
I HONG
Tng tit dch: tng thai nc, Na v K
Tc dng ln h c trn
Lm tng nhu ng rut nhun, ty.
Tng nhu ng bng quang, t cung PNCT, b vim bng quang khng nn dng.
Gy sung huyt CC ngi b tr.
Cha nhiu dng kh khng dng DL ti.
Nhiu Calci oxalat thn trng/si thn.
Ung c tc dng chm: 8-12 gi.
I HONG
TC DNG
38 38
I HONG
Tc dng mnh dn theo liu lng:
0.05-0.1g : b, kch thch tiu ha.
0.1-0.15g : nhun trng.
0.5-2g : x.
I HONG
TC DNG
39
NHU
Tn khac: nhau nui, cy ngao, cy mt quy , Giu
Tn khoa hoc: Morinda citrifolia L., Rubiaceae
BPD: Toan cy (r, vo thn, la va qua), nhng chu yu la
r.
Qua cng ang c lu y nhiu.
Cng dung:
Cha cao huyt ap, au lng nhc mi.
40 40
NHAU
Ten khac: Cay ngao, Nhau nui, Mat quy
Ten khoa hoc: Morinda citrifolia L.
Ho ca phe (Rubiaceae)
Mo ta thc vat
Cay cao khoang 6-8 met.
La moc oi, phien la to, hnh bau duc, tren bong lang.
Qua phc. Qua co v chua hi khai, an c.
41
42
Nhau nc: Morinda persicaefolia Ham., Rubiaceae
43
Damnacanthal Nor-damnacanthal
Cac cht co tac dng khang khi u trong r Nhau nui
44
H TH
Tn khoa hc: Fallopia multiflora Haraldson
(Polygonum multiforum Thunb.), Polygonaceae
M ta:
Dy leo, la n hinh tim,
R c mau nu o to va nc
B phn dung: r c (Radix Poligoni multiflori)
Thu hai ch bin: ao c vao mua ng, cu chng cu sai
Cng dng:
Lam thuc b mau, cha ru toc bc sm
Cha suy nhc thn kinh, mt ngu hay qun.
45 45
46
L HI - Tn khac: Tng am, h thit, Nha am
- Tn khoa hc: Aloe sp., Asphodelaceae (Liliaceae, Aloeaceae)
Hai loai thng dung: Aloe vera L. va Aloe ferox Mill.
- Aloe ferox Mill. cao t 2 - 5m, l mc thnh hoa th dy, di 15 -50cm, rng 10cm gc, c gai mt di l v mp l. Hoa mu . Ch yu c nam Phi, cho l hi x Cape
- Aloe vera L. (= vulgaris Lam.) thn ngn 30 - 50cm. L ch c gai 2 mp. Hoa mu vng. Cy ngun gc bc Phi, cho l hi Barbade.
- BPD: La dung ti hay ly nha th
47
Aloe ferox Mill.
Aloe vera L.
48
Aloe ferox Mill.
49
50
51
Cac anthranoid co trong mt s loai Aloe
52
53
54
Cac C-Glycosid
55
TC DNG - CNG DNG
- Kich thich tiu hoa ty x tuy liu lng
- Cht nhy dung tr bng, dung trong my phm
56
HT