1

【著書又は訳書】

1. 藤田 剛，柴 秀樹，栗原英見（和泉雄一，木下淳博，沼部幸博，山本松男編集）

ザ・ぺリオドントロジー第 2 版

第 2 章 歯周病のリスクファクター 3. 環境因子: 44-45， 4. 宿主因子 (3)全身的因

子:57-58， 永末書店，2014.

2. 栗原英見，藤田 剛（全国歯科衛生士教育協議会監修）

歯科衛生士教本 歯周病学第 2 版

I編 3 章 ③ペリオドンタルメディシン(歯周医学): 37-38，医歯薬出版，2015.

3. 吉江弘正，藤田 剛，應原一久（日本歯周病学会編集）

歯周病と全身の健康

第 2 部 5）歯周炎が関節リウマチ（RA）の発症，増悪との関係において想定されるメ

カニズム: 104-106，医歯薬出版，2016.

4. 藤田 剛，柴 秀樹，栗原英見（沼部幸博，梅田 誠，齋藤 淳，山本松男編集）

ザ・ぺリオドントロジー第 3 版

第 2 章 歯周病のリスクファクター 4. リスクファクターの各論 2. 環境因子: 42-44，

3. 宿主因子 2) 全身的因子:52-54， 永末書店，2019.

【総説 英語】

1. Fujita T., Shiba H., Kurihara H. Irsogladine maleate regulates gingival

epithelial barrier function and intercellular communication in gingival epithelial

cells. Inflammation and Regeneration. 32 (3):107-111, 2012.

2. Fujita T., Shiba H., Kurihara H. Irsogladine maleate regulates barrier function

and neutrophil accumulation in gingival epithelium. J Oral Biosci. 54(2): 79-82,

2012.

3. Fujita T., Yoshimoto T., Kajiya M., Ouhara K., Matsuda S., Takemura T.,

Akutagawa K., Takeda K., Mizuno N., Kurihara H. Regulation of defensive

function on gingival epithelial cells can prevent periodontal disease. Japanese

Dental Science Review 54:66-75, 2018.

2

【総説 日本語】

1. 柴 秀樹，藤田 剛，内田雄士，栗原英見 歯肉上皮細胞の機能制御による歯周炎予

防法開発の基礎研究 日歯周誌. 第 54巻第 4号:315-322, 2012.

2. 藤田 剛 歯肉上皮の機能制御に着目した新規歯周病予防法の基礎研究 日歯周誌.

第 55巻第 4号: 287-293, 2013.

3. 武田克浩，加治屋幹人，松田真司，柏井 桂，佐々木慎也，水野智仁，藤田 剛，栗

原英見 脳由来神経栄養因子 (BDNF)を用いた新しい歯周炎治療の開発 日歯周

誌．第 58巻第 3号: 91-97, 2014.

4. 栗原英見，藤田 剛 歯周組織の慢性炎症制御からセンテナリアン到達へ 日歯保

存誌 第 61巻第 6号：327-332, 2018

【原著 英語】

1. Shiba H., Fujita T., Doi N., Nakamura S., Nakanishi K., Takemoto T., Hino T.,

Noshiro M., Kawamoto T., Kurihara H., Kato Y. (1998) Differential effects of

various growth factors and cytokines on the syntheses of DNA, type I collagen,

laminin, fibronectin, osteonectin/secreted protein, acidic and rich in cysteine

(SPARC), and alkaline phosphatase by human pulp cells in culture. J Cell Physiol.

174(2): 194-205.

2. Sakata M., Shiba H., Komatsuzawa H., Fujita T., Ohta K., Sugai M., Suginaka H.,

Kurihara H. (1999) Expression of osteopretegerin (osteoclastogenesis inhibitory

factor) in cultures of human dental mesenchymal cells and epithelial cells. J Bone

Miner Res. 14(9): 1486-1492.

3. Shiba H., Nakanishi K., Sakata M., Fujita T., Uchida Y., Kurihara H. (2000) Effects

of ageing on proliferative ability, and the expressions of secreted protein, acidic and

rich in cysteine (SPARC) and osteopretegerin (osteoclastogenesis inhibitory factor)

in cultures of human periodontal ligament cells. Mech Ageing Dev. 117(1-3): 69-

77.

3

4. Uchida Y., Shiba H., Komatsuzawa H., Takemoto T., Sakata M., Fujita T.,

Kawaguchi H., Sugai M., Kurihara H. (2001) Expression of IL-1 and IL-8 by

human gingival epithelial cells in response to Actinobacillus

actiomycetemcomitans. Cytokine. 14(3): 152-161.

5. Shiba H., Uchida Y., Kamihagi K., Sakata M., Fujita T., Nakamura S., Takemoto

T., Kato Y., Kurihara H. (2001) Transforming growth factor-1 and basic

fibroblast growth factor modulate osteocalcin and osteonectin/SPARC syntheses in

vitamin D-activated pulp cells. J Dent Res. 80(7):1653-1659.

6. Fujita T., Shiba H., Sakata M., Uchida Y., Nakamura S., Kurihara H. (2002)

SPARC stimulates the synthesis of OPG/OCIF, MMP-2 and DNA in human

periodontal ligament cells. J Oral Pathol Med. 31(6): 345-352.

7. Sakata M., Shiba H., Komatsuzawa H, Fujita T., Uchida Y., Yoshino H., Ogawa T.,

Kawaguch H., Kurihara H. (2002) Osteoprotegerin levels increased by

interleukin-1 in human periodontal ligament cells are suppressed through

prostaglandin E2 synthesized de novo. Cytokine. 18(3): 133-139.

8. Fujita T., Shiba H., Sakata M., Uchida Y., Ogawa T., Kurihara H. (2002) Effects

of transforming growth factor-1 and fibronectin on SPARC expression in cultures

of human periodontal ligament cells. Cell Biol Int. 26(12): 1065-1072.

9. Rashid F., Shiba H., Mizuno N., Mouri Y., Fujita T., Shinohara H., Ogawa T.,

Kawagucti H., Kurihara H. (2003) The effect of extracellular calcium ion on gene

expression of bone-related proteins in human pulp cells. J Endod. 29(2): 104-

107.

10. Fujita T., Shiba H., Van Dyke TE., Kurihara H. (2004) Differential effects of

growth factors and cytokines on the synthesis of SPARC, DNA, fibronectin and

alkaline phosphatase activity in human periodontal ligament cells. Cell Biol Int.

28(4): 281-286.

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11. Fujita T., Zawawi KH., Kurihara H., Van Dyke TE. (2005) CD38 cleavage in

fMLP- and IL-8 induced chemotaxis is dependent on p38 MAP kinase but

independent of p44/42 MAP kinase. Cell Signal. 17(2): 167-175.

12. Fujita T., Kantarci A., Warbington ML., Zawawi KH., Hasturk H., Kurihara H.,

Van Dyke TE. (2005) CD38 expression in neutrophils from patients with

localized aggressive periodontitis. J Periodontol. 76(11): 1960-1965.

13. Uchida Y., Shiba H., Komatsuzawa H., Hirono C., Ashikaga A., Fujita T.,

Kawaguchi H., Sugai M., Shiba Y., Kurihara H. (2005) Irsogladine maleate

influences the response of gap junctional intercellular communication and IL-8 of

human gingival epithelial cells following periodontopathogenic bacterial challenge.

Biochem Biophys Res Commun. 333(2): 502-507.

14. Fujita T., Ashikaga A., Shiba H., Uchida Y., Hirono C., Iwata T., Takeda K.,

Kishimoto A., Hirata R., Kawaguchi H., Shiba Y., Kurihara H. (2006) Regulation

of IL-8 by Irsogladine maleate is involved in abolishment of Actinobacillus

actinomycetemcomitans-induced reduction of gap-junctional intercellular

communication. Cytokine. 34(5-6): 271-277.

15. Fujita T., Iwata T., Shiba H., Igarashi A., Hirata R., Takeda K., Mizuno N., Tsuji

K., Kawaguchi H., Kato Y., Kurihara H. (2007) Identification of marker genes

distinguishing human periodontal ligament cells from human mesenchymal stem

cells and human gingival fibroblasts. J Periodontal Res. 42(3): 283-286.

16. Mizuno N., Shiba H., Xu WP., Inui T., Fujita T., Kajiya M., Takeda K., Hasegawa

N., Kawaguchi H., Kurihara H. (2007) Effect of neurotrophins on differentiation,

calcification and proliferation in cultures of human pulp cells. Cell Biol Int.

31(12):1462-1469.

17. Fujita T., Ashikaga A., Shiba H., Kajiya M., Kishimoto A., Hirata R., Tsunekuni

N., Hirono C., Kawaguchi H., Shiba Y., Kurihara H. (2008) Irsogladine maleate

counters the interleukin-1-induced suppression in gap-junctional intercellular

communication but does not affect the interleukin-1-induced zonula occludens

protein-1 levels in human gingival epithelial cells. J Periodontal Res. 43(1):96-

102.

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18. Kajiya M., Shiba H., Fujita T., Ouhara K., Takeda K., Mizuno N., Kawaguchi H.,

Kitagawa M., Takata T., Tsuji K., Kurihara H. (2008) Brain-derived neurotrophic

factor stimulates bone/cementum-related protein gene expression in

cementoblasts. J Biol Chem. 283(23): 16259-16267.

19. Kishimoto A., Fujita T., Shiba H., Komatsuzawa H., Takeda K., Kajiya M.,

Hayashida K., Kawaguchi H., Kurihara H. (2008) Irsogladine maleate abolishes

the icrease in interleukin-8 levels caused by outer membrane protein 29 from

Aggregatibacter (Actinobacillus) actinomycetemcomitans through the ERK

pathway in human gingival epithelial cells. J Periodontal Res. 43(5): 508-513.

20. Shiba H., Tsuda H., Kajiya M., Fujita T., Takeda K., Hino T., Kawaguchi H.,

Kurihara H. (2009) Neodymium-doped Yttrium-Aluminium-Garnet laser

irradiation abolishes the increase in interleukin-6 levels caused by peptidoglycan

through the p38 mitogen-activated protein kinase pathway in human pulp cells.

J Endod. 35(3):373-376.

21. Tsunematsu T., Kudo Y., Iizuka S., Ogawa I., Fujita T., Kurihara H., Abiko Y.,

Takata T. (2009) RUNX3 has an oncogenic role in head and neck cancer. PLoS

ONE. 4(6): e5892.

22. Kajiya M., Shiba H., Fujita T., Takeda K., Uchida Y., Kawaguchi H., Kitagawa M.,

Takata T., Kurihara H. (2009) Brain-derived neurotrophic factor protects

cementoblasts from serum starvation-induced cell death. J Cell Physiol.

221(3):696-706.

23. Fujita T., Hayashida K., Shiba H., Kishimoto A., Matsuda S., Takeda K.,

Kawaguchi H., Kurihara H. (2010) The expressions of claudin-1 and E-cadherin

in junctional epithelium. J Periodontal Res. 45(4):579-582.

24. Fujita T., Kishimoto A., Shiba H., Hayashida K., Kajiya M., Uchida Y., Matsuda S.,

Takeda K., Ouhara K., Kawaguchi H., Abiko Y., Kurihara H. (2010) Irsogladine

maleate regulates neutrophil migration and E-cadherin expression in gingival

epithelium stimulated by Aggregatibacter actinomycetemcomitans. Biochem

Pharmacol. 79(10):1496-1505.

6

25. Kajiya M., Shiba H., Komatsuzawa H., Ouhara K., Fujita T., Takeda K., Uchida Y.,

Mizuno N., Kawaguchi H., Kurihara H. (2010) The antimicrobial peptide LL37

induces the migration of human pulp cells: a possible adjunct for regenerative

endodontics. J Endod. 36(6):1009-1013.

26. Zawawi KH., Kantarci A., Schulze-Spate U., Fujita T., Batista EL Jr., Amar S.,

Van Dyke TE. (2010) Moesin-induced signaling in response to lipopolysaccharide

in macrophages. J Periodontal Res. 45(5):589-601.

27. Takeda K., Sakai N., Shiba H., Nagahara T., Fujita T., Kajiya M., Iwata T.,

Matsuda S., Kawahara K., Kawaguchi H., Kurihara H. (2011) Characteristics of

high-molecular-weight hyaluronic acid as brain-derived neurotrophic factor

scaffold in periodontal tissue regeneration. Tissue Eng Part A. 17(7-8):955-967.

28. Matsuda S., Fujita T., Kajiya M., Takeda K., Shiba H., Kawaguchi H., Kurihara H.

(2012) Brain-derived neurotrophic factor induces migration of endothelial cells

through a TrkB-ERK-integrin (V)(3)-FAK cascade. J Cell Physiol. 227(5):2123-

2129.

29. Fujita T., Yumoto H., Shiba H., Ouhara K., Miyagawa T., Nagahara T., Matsuda

S., Kawaguchi H., Matsuo T., Murakami S., Kurihara H. (2012) Irsogladine

maleate regulates epithelial barrier function in tumor necrosis factor--stimulated

human gingival epithelial cells. J Periodontal Res. 47(1):55-61.

30. Fujita T., Firth JD., Kittaka M., Ekuni D., Kurihara H., Putnins EE. (2012) Loss

of caludin-1 in lipopolysaccharide-treated periodontal epithelium. J Periodontal

Res. 47(2):222-227.

31. Ouhara K., Kawai T., Silva MJ., Fujita T., Hayashida K., Karimbux NY., Kajiya

M., Shiba H., Kawaguchi H., Kurihara H. (2012) Expression levels of novel

cytokine IL-32 in periodontitis and its role in the suppression of IL-8 production

by human gingival fibroblasts stimulated with Porphyromonas gingivalis. J Oral

Microbiol. 4.

7

32. Fujita T., Alotaibi M., Kitase Y., Kota Y., Ouhara K., Kurihara H., Shuler CF.

(2012) Smad2 is involved in the apoptosis of murine gingival junctional

epithelium associated with inhibition of Bcl-2. Arch Oral Biol. 57(11):1567-1573.

33. Kittaka M., Shiba H., Kajiya M., Ouhara K., Takeda K., Kanbara K., Fujita T.,

Kawaguchi H., Komatsuzawa H., Kurihara H. (2013) Antimicrobial peptide

LL37 promotes vascular endothelial growth factor-A expression in human

periodontal ligament cells. J Periodontal Res. 48(2): 228-234.

34. Miyagawa T., Fujita T., Ouhara K., Matsuda S., Kajiya M., Hayashida K., Imai H.,

Yoshimoto T., Iwata T., Shiba H., Abiko Y., Kurihara H. (2013) Irsogladine

maleate regulates the inflammatory related genes in human gingival epithelial

cells stimulated by Aggregatibacter actinomycetemcomitans. Int

Immunopharmacol. 15(2):340-347.

35. Kittaka M., Shiba H., Kajiya M., Fujita T., Iwata T., Rathvisal K., Ouhara K.,

Takeda K., Fujita T., Komatsuzawa H., Kurihara H. (2013) The antimicrobial

peptide LL37 promotes bone regeneration in a rat calvarial bone defect. Peptides.

46:136-142.

36. Ouhara K., Savitri IJ., Fujita T., Kittaka M., Kajiya M., Iwata T., Miyagawa T.,

Yamakawa M., Shiba H., Kurihara H. (2014) miR-584 expressed in human

gingival epithelial cells is induced by Porphyromonas gingivalis stimulation and

regulates interleukin-8 production via lactoferrin receptor. J Periodontol. 85(6):

198-204.

37. Kajiya M., Takeshita K., Kittaka M., Matsuda S., Ouhara K., Takeda K., Takata

T., Kitagawa M., Fujita T., Shiba H., Kurihara H. (2014) BDNF mimetic

compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt

signaling cascade. Int Immunopharmacol. 19(2): 245-252.

38. Imai H., Fujita T., Kajiya M., Ouhara K., Miyagawa T., Matsuda S., Shiba H.,

Kurihara H. (2014) Amphotericin B down-regulates Aggregatibacter

actinomycetemcomitans-induced production of IL-8 and IL-6 in human gingival

epithelial cells. Cell Immunol. 290(2): 201-208.

8

39. Yoshimoto T., Fujita T., Ouhara K., Kajiya M., Imai H., Shiba H., Kurihara H.

(2014) Smad2 is involved in Aggregatibacter actinomycetemcomitans-induced

apoptosis. J Dent Res. 93(11): 1148-1154.

40. Kabir MA., Fujita T., Ouhara K., Kajiya M., Matsuda S., Shiba H., Kurihara H.

(2015) Houttunia Cordata suppressed the Aggregatibacter

actinomycetemcomitans-induced increase of inflammatory-related genes in

cultured human gingival epithelial cells. J Dent Sci. 10:88-94.

41. Nagahara T., Yoshimatsu S., Shiba H., Kawaguchi H., Takeda K., Iwata T., Mizuno

N., Fujita T., Kurihara H. (2015) Introduction of a mixture of -tricalcium

phosphate into a complex of bone marrow mesenchymal stem cells and type I

collagen can augment the volume of alveolar bone without impairing cementum

regeneration. J Periodontol. 86(3): 456-464.

42. Savitri IJ., Ouhara K., Fujita T., Kajiya M., Miyagawa T., Kittaka M., Yamakawa

M., Shiba H., Kurihara H. (2015) Irsogladine maleate inhibits Porphyromonas

gingivalis-mediated expression of toll-like receptor 2 and interleukin-8 in human

gingival epithelial cells. J Periodontal Res. 50(4):486-493.

43. Matsuda S., Fujita T., Kajiya M., Kashiwai K., Takeda K., Shiba H., Kurihara H.

(2015) Brain-derived neurotrophic factor prevents the endothelial barrier

dysfunction induced by interleukin-1 and tumor necrosis factor-. J Periodontal

Res. 50(4): 444-451.

44. Khung R., Shiba H., Kajiya M., Kittaka M., Ouhara K., Takeda K., Mizuno N.,

Fujita T., Komatsuzawa H., Kurihara H. (2015) LL37 induces VEGF expression

in dental pulp cells through ERK signaling. Int Endod J. 48(7):673-679.

45. Fujita T., Yoshimoto T., Matsuda S., Kajiya M., Kittaka M., Imai H., Iwata T.,

Uchida Y., Shiba H., Kurihara H. (2015) Interleukin-8 induces DNA synthesis,

migration and down-regulation of cleaved caspase-3 in cultured human gingival

epithelial cells. J Periodontal Res. 50(4):479-485.

46. Kittaka M., Kajiya M., Shiba H., Takewaki M., Takeshita K., Khung R., Fujita T.,

Iwata T., Nguyen TQ., Ouhara K., Takeda K., Fujita T., Kurihara H. (2015)

9

Clumps of a mesenchymal stromal cell/extracellular matrix complex can be a novel

tissue engineering therapy for bone regeneration. Cytotherapy. 17(7):860-873.

47. Ouhara K., Iwasaki Y., Kajiya M., Savitri I., Kitagawa M., Tokunaga N., Shintani

T., Ogawa I., Hino T., Fujita T., Shiba H., Kurihara H. (2015) The differential

expression of mgl mRNA by P. gingivalis affects the production of methyl

mercaptan. Oral Dis. 21(5):626-633.

48. Yoshimoto T., Fujita T., Kajiya M., Matsuda S., Ouhara K., Shiba H., Kurihara H.

(2015) Involvement of smad2 and Erk/Akt cascade in TGF-1-induced apoptosis

in human gingival epithelial cells. Cytokine. 75(1):165-173.

49. Kashiwai K., Kajiya M., Matsuda S., Ouhara K., Takeda K., Takata T., Kitagawa

M., Fujita T., Shiba H., Kurihara H. (2016) Distinction between cell proliferation

and apoptosis signals regulated by brain derived neurotrophic factor in human

periodontal ligament cells and gingival epithelial cells. J Cell Biochem.

117(7):1543-1555.

50. Miyagawa T., Fujita T., Yumoto H., Yoshimoto T., Kajiya M., Ouhara K., Matsuda

S., Shiba H., Matsuo T., Kurihara H. (2016) Azithromycin recovers reductions in

barrier function in human gingival epithelial cells stimulated with tumor necrosis

factor-. Arch Oral Biol. 62:64-69.

51. Konishi A., Takeda K., Fujita T., Kajiya M., Matsuda S., Kittaka M., Shiba H.,

Kurihara H. (2016) Sequential process in brain-derived neurotrophic factor-

induced functional periodontal tissue regeneration. European Journal of Oral

Sciences. 124:141-150.

52. Yoshimoto T., Fujita T., Kajiya M., Ouhara K., Matsuda S., Komatsuzawa H.,

Shiba H., Kurihara H. (2016) Aggregatibacter actinomycetemcomitans outer

membrane protein 29 (Omp29) induces TGF--regulated apoptosis signal in

human gingival epithelial cells via fibronectin/integrinβ1/FAK cascade. Cell.

Microbial. 18:1723-1738.

53. Takeda K., Obinata Y., Konishi A., Kajiya M., Matsuda S., Mizuno N., Sasaki S.,

Fujita T., Kurihara H. (2016) Brain-derived neurotrophic factor inhibits

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intercellular adhesion molecule-1 expression in interleukin-1-treated endothelial

cells. Cell Biochem Biophys. 74:399-406.

54. Yamakawa M., Ouhara K., Kajiya M., Munenaga S., Kittaka M., Yamasaki S.,

Takeda K., Takeshita K., Mizuno N., Fujita T., Sugiyama E., Kurihara H. (2016)

Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis

in SKG mice. Clin. Exp. Immunol. 186:177-189.

55. Imai H., Fujita T., Kajiya M., Ouhara K., Yoshimoto T., Matsuda S., Takeda K.,

Kurihara H. (2016) Mobilization of TLR4 into lipid rafts by Aggregatibacter

actinomycetemcomitans in gingival epithelial cells. Cell. Physiol. Biochem.

39:1777-1786.

56. Takeda K., Tokunaga N., Aida Y., Kajiya M., Ouhara K., Sasaki S., Mizuno N.,

Fujita T., Kurihara H. (2017) Brain-derived neurotrophic factor inhibits

peptidoglycan-induced inflammatory cytokine expression in human dental pulp

cells. Inflammation. 40:240-247.

57. Okanobu A., Matsuda S., Kajiya M., Fujita T., Kittaka M., Shiba H., Kurihara H.

(2017) A novel gingival overgrowth mouse model induced by the combination of

CsA and ligature-induced inflammation. J. Immunol. Methods. 445:31-36.

58. Takeshita K., Motoike S., Kajiya M., Komatsu N., Takewaki M., Ouhara K., Iwata

T., Takeda K., Mizuno N., Fujita T., Kurihara H. (2017) Xenotransplantation of

interferon-gamma-pretreated clumps of a human mesenchymal stem

cell/extracellular matrix complex induces mouse calvarial bone regeneration.

Stem Cell Research & Therapy. 8:101.

59. Takewaki M., Kajiya M., Takeda K., Sasaki S., Motoike S., Komatsu N., Matsuda

S., Ouhara K., Mizuno N., Fujita T., Kurihara H. (2017) MSC/ECM Cellular

Complexes Induce Periodontal Tissue Regeneration. J. Dent. Res. 96: 984-991.

60. Kido JI., Murakami S., Kitamura M., Yanagita M., Tabeta K., Yamazaki K., Yoshie

H., Watanabe H., Izumi Y., Suda R., Yamamoto M., Shiba H., Fujita T., Kurihara

H., Mizuno M., Mishima A., Kawahara N., Hashimoto K., Naruishi K., Nagata T.

(2018) Useful Immunochromatographic Assay of Calprotectin in Gingival

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Crevicular Fluid for Diagnosis of Diseased Sites in Patients with Periodontal

Diseases. J. Periodontology. 89: 67-75.

61. Ouhara K., Munenaga S., Kajiya M., Takeda K., Matsuda S., Sato Y., Hamamoto

Y., Iwata T., Yamasaki S., Akutagawa K., Mizuno N., Fujita T., Sugiyama E.,

Kurihara H. (2018) The induced RNA-binding protein, HuR targets 3'-UTR

region of IL-6 mRNA and enhances its stabilization in periodontitis. Clin. Exp.

Immunol. 192:325-336.

62. Motoike S., Kajiya M., Komatsu N., Takewaki M., Horikoshi S., Matsuda S.,

Ouhara K., Iwata T., Takeda K., Fujita T., Kurihara H. (2018) Cryopreserved

clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic

capacity and induce bone regeneration. Stem Cell Research & Therapy. 9:73.

63. Sasaki S., Takeda K., Takewaki M., Ouhara K., Kajiya M., Mizuno N., Fujita T.,

Kurihara H. (2019) BDNF/HMW-HA complex as an adjunct to non-surgical

periodontal treatment of ligature-induced periodontitis in dogs. J. Periodontology.

90: 98-109.

64. Munenaga S., Ouhara K., Hamamoto Y., Kajiya M., Takeda K., Yamasaki S.,

Kawai T., Mizuno N., Fujita T., Sugiyama E., Kurihara H. (2018) The involvement

of C5a in the progression of experimental arthritis with Porphyromonas gingivalis

infection in SKG mice. Arthritis Research & Therapy 20:247

65. Komatsu N., Kajiya M., Motoike S., Takewaki M., Horikoshi S., Iwata T., Ouhara

K., Takeda K., Matsuda S., Fujita T., Kurihara H. (2018) Type I collagen

deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture

clumps of mesenchymal stem cell/extracellular matrix complexes. Stem Cell

Research & Therapy. 9:342.

66. Akutagawa K., Fujita T., Ouhara K., Takemura T., Tari M., Kajiya M., Matsuda S.,

Kuramitsu S., Mizuno N., Shiba H., Kurihara H. (2019) Glycyrrhizic acid

suppresses inflammation and reduces the increased glucose levels induced by the

combination of Porphyromonas gulae and ligature placement in diabetic model

mice. Int Immunopharmacol. 68: 30-38.

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67. Matsuda S., Okanobu A., Hatano S., Kajiya M., Sasaki S., Hamamoto Y., Iwata T.,

Ouhara K., Takeda K., Mizuno N., Fujita T., Kurihara H. (2019) Relationship

between periodontal inflammation and calcium channel blockers induced gingival

overgrowth-a cross-sectional study in a Japanese population. Clinical Oral

Investigations. 23(11): 4099-4105.

68. Motoike S., Kajiya M., Komatsu N., Horikoshi S., Ogawa T., Sone H., Matsuda S.,

Ouhara K., Iwata T., Mizuno N., Fujita T., Ikeya M., Kurihara H. (2019) Clumps

of mesenchymal stem cell/extracellular matrix complexes generated with xeno-free

conditions facilitate bone regeneration via direct and indirect osteogenesis. Int J

Mol Sci. 20 (16): 3970.

69. Memida T., Matsuda S., Kajiya M., Mizuno N., Ouhara K., Fujita T., Hirata S.,

Yoshida Y., Sugimoto T., Nishi H., Kawaguchi H., Sugiyama E., Kurihara H. (2019)

Multiple external root resorption of teeth as a new manifestation of systemic

sclerosis-a cross-sectional study in Japan. J Clin Med. 8(10):1628.

70. Kaneda-Ikeda E., Iwata T., Mizuno N., Nagahara T., Kajiya M., Takeda K., Hirata

R., Ishida S., Yoshioka M., Fujita T., Kawaguchi H., Kurihara H. (2020)

Periodontal ligament cells regulate osteogenesis via miR-299-5p in mesenchymal

stem cells. Differentiation. 112:47-57.

71. Mizuno N., Iwata T., Ohsawa R., Ouhara K., Matsuda S., Kajiya M., Matsuda Y.,

Kume K., Tada Y., Morino H., Yoshimoto T., Ueki Y., Mihara K., Sotomaru Y.,

Takeda K., Munenaga S., Fujita T., Kawaguchi H., Shiba H., Kawakami H.,

Kurihara H. (2020) Optineurin regulates osteoblastogenesis through STAT1.

Biochem Biophys Res Commun. 14;525(4): 889-894.

72. Mizuno N., Kume K., Nagatani Y., Matsuda S., Iwata T., Ouhara K., Kajiya M.,

Takeda K., Matsuda Y., Tada Y., Ohsawa R., Morino H., Mihara K., Fujita T.,

Kawaguchi H., Shiba H., Kawakami H., Kurihara H. (2020) Aggressive

periodontitis and NOD2 variants. J Hum Genet. (in press)

13

【原著 日本語】

1. 柴 秀樹，武田克浩，應原一久，加治屋幹人，藤田 剛，水野智仁，日野孝宗，河口

浩之，栗原英見 抗菌ペプチド LL37 によるヒト歯髄細胞の炎症性サイトカイン発

現制御 日歯内療誌. 第 29巻第 3号:147-154, 2008.

【症例報告 英語】

1. Matsuda S., Memida T., Mizuno N., Ogawa I., Ouhara K., Kajiya M., Fujita T.,

Sugiyama E., Kurihara H. (2018) Reparative bone-like tissue formation in the

tooth of a systemic sclerosis patient. Int. Endod. J. 51: 1059-1066.

【症例報告 日本語】

1. 小島将督，加来真人，久保隆靖，藤田 剛，小野重弘，永安慎太郎，小島俊逸，角 明

美，四方花佳，山本多栄子，本川雅英，谷本幸太郎 多数歯欠損を伴う叢生症例に対

して歯の移植を適応した一治験例 広島大学歯学雑誌. 第 46 巻第 2 号:156-161,

2014.

【その他】

1. 藤田 剛 特集 天然歯周組織とインプラント周囲組織：歯肉上皮細胞の機能制

御による歯周病予防法の開発 歯界展望. 第 123巻第 2号:264-270, 2014.

2. 河口浩之，林 秀昭，水野智仁，藤田 剛，長谷川直彦，柴 秀樹，中村茂夫，日野

孝宗，吉野 宏，栗原英見，田中英夫，木村昭郎，辻紘一郎，加藤幸夫 歯周組織

の細胞移植療法 骨髄間葉系幹細胞を用いた歯周組織再生療法 Clinical Calcium.

第 15巻 7号: 99-104, 2005.

3. 河口浩之，林 秀昭，水野智仁，藤岡大助，内田雄士，平地昭雄，毛利吉宏，岩田倫

幸，足利 新，藤田 剛，長谷川直彦，日野孝宗，吉野 宏，辻紘一郎，加藤幸夫，

栗原英見 自家骨髄間葉系幹細胞移植による歯周組織再生療法の開発 再生医

療 2. 第 4巻 1号:69-77, 2005.

14

【特許】

特許出願，多孔金属薄膜，土井一矢，小畠玲子，藤田 剛，久保隆靖，梅原華子，井上

拓，千葉茂樹， 特願 2019-129101

5) 主な国際学会発表

1. Fujita T., Shiba H., Sakata M., Uchida Y., Kurihara H. Expression manner of

SPARC in human periodontal ligament derived cells. 77th The International

Association for Dental Research (Vancouver), 1999. (Meeting program, p100)

2. Fujita T., Shiba H., Sakata M., Uchida Y., Nakamura S., Shinohara H., Yoshino H.,

Kurihara H. The effect of fibronectin on SPARC expression in periodontal

ligament derived cells. 78th The International Association for Dental Research

(Washington, DC), 2000. (Meeting program, p96)

3. Fujita T., Kantarci A., Lund F., Van Dyke TE. MAP kinase in CD38 expression

and chemotaxis in neutrophils. 82nd The International Association for Dental

Research (Honolulu), 2004. (Program book, p71)

4. Ashikaga A., Fujita T., Uchida Y., Shiba H., Kawaguchi H., Kurihara H.

Irsogladine maleate recovered the reduction of IL-8-associated intercellular

communication: 83th General session and Exhibition of the international

association for dental research (Baltimore), 2005. (Program book, p117)

5. Fujita T., Takeda K., Shiba H., Mizuno N., Kawaguchi H., Abiko Y., Kurihara H.

Irsogladine maleate regulates CXC-chemokine expression in human gingival

epithelial cells. 85th General session and Exhibition of the international

association for dental research (New Orleans), 2007. (Program book, p66)

6. Hirata R., Fujita T., Iwata T., Kishimoto A., Kajiya M., Shiba H., Kawaguchi H.,

Tsuji K., Kurihara H. Role of mesenchymal stem cells in gingival epithelial cell

function. 85th General session and Exhibition of the international association for

dental research (New Orleans), 2007. (Program book, p140)

7. Kajiya M., Shiba H., Fujita T., Takeda K., Ouhara K., Kawaguchi H., Kitagawa M.,

Takata T., Tsuji K., Kurihara H. Effects of brain-derived neurotrophic factor in

15

cementoblast-like cells. 85th General session and Exhibition of the international

association for dental research (New Orleans), 2007. (Program book, p140)

8. Fujita T., Kishimoto A., Shiba H., Kajiya M., Takeda K., Hayashida K., Uchida Y.,

Matsuda S., Kawaguchi H., Kurihara H.: Irsogladine maleate abolishes IL-8

production through ERK in human epithelial cells: 87th General session and

Exhibition of the international association for dental research (Miami), 2009.

(Program book, p168)

9. Kishimoto A., Fujita T., Shiba H., Hayashida K., Uchida Y., Kawaguchi H.,

Kurihara H.: Preventive effect of Irsogladine maleate for periodontal disease: 87th

General session and Exhibition of the international association for dental research

(Miami), 2009.

10. Matsuda S., Fujita T., Kajiya M., Takeda K., Shiba H., Kawaguchi H., Kurihara

H.: Brain-derived neurotrophic factor (BDNF) enhances endothelial cell migration.

87th General session and Exhibition of the international association for dental

research (Miami), 2009.

11. Takeda K., Sakai N., Shiba H., Kajiya M., Fujita T., Kawaguchi H., Kurihara H.:

BDNF/Hyaluronic acid complex enhances periodontal tissue regeneration. : 87th

General session and Exhibition of the international association for dental research

(Miami), 2009.

12. Fujita T., Yumoto H., Ouhara K., Miyagawa T., Shiba H., Matsuda S., Kawaguchi

H., Matsuo T., Kurihara H. Irsogladine maleate regulates gingival epithelial

barrier functions in inflammatory condition. 89th General session and Exhibition

of the international association for dental research (San Diego), 2011. (Program

book, p92)

13. Matsuda S., Fujita T., Shiba H., Kurihara H.: Brain-derived neurotrophic factor

(BDNF) enhances endothelial cell migration. 89th General session and Exhibition

of the international association for dental research (San Diego), 2011. (Program

book, p143)

14. Imai H., Fujita T., Ouhara K., Uchida Y., Kajiya M., Shiba H., Kurihara H. The

16

anti-inflammatory effect of amphotericin B in gingival epithelium. 91st General

session and Exhibition of the international association for dental research (Seattle),

2013. (program book, p131)

15. Kaneda E., Iwata T., Fujita T., Ishida S., Takahashi K., Shiba H., Kurihara H.

Regulation of osteogenesis in mesenchymal stem cells by periodontal tissue. 91st

General session and Exhibition of the international association for dental

research (Seattle), 2013. (program book, p205)

16. Kajiya M., Shiba H., Fujita T., Ouhara K., Takeda K., Kittaka M., Takata T.,

Kitagawa M., Kurihara H. Small molecule BDNF mimetic regulates

cementoblast differentiation via TrkB signaling. 91st General session and

Exhibition of the international association for dental research (Seattle), 2013.

(program book, p88)

17. Yoshimoto T., Fujita T., Kajiya M., Shiba H., Kurihara H. TGF-1 induce

mitochondria-dependent apoptosis in human gingival epithelial cells. 92nd

General session and Exhibition of the international association for dental

research (Cape town, South Africa), 2014.