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Evidence Based Botanicals in the Treatment of Inflammation
Eugene R. Zampieron, ND,AHG
Sponsored by Restorative Formulations(Non-CME presentation)
DrZ teaching at the University of Bridgeport College of Naturopathic Medicine, CT
• Licensed Naturopathic physician– Connecticut since 1990
• Dr. Friedman’s mentor• Registered Professional,
Herbalist, AHG• Author/Radio host• Academic and clinical faculty
member and Founding Presidential advisors Board Member – University of Bridgeport College
of Naturopathic Medicine,Connecticut
• Caribbean Ethnobotany researcher– EcoToursforCures.com
Why do I choose/use Enfla-Mend Px & T-Cell balance Px & other RF products??
Our topic and objectives…• Inflammation is a primary factor in heart
disease, arthritic disease, digestive disorders, respiratory inflammation, diabetes, cancer and aging in general.
• Some botanical agents are shown to have broad acting anti-inflammatory effects for all these complaints
• I use the term INFLAM-aging with patients
https://www.google.com/search?hl=en&site=imghp&tbm=isch&source=hp&biw=1034&bih=615&q=nfk+beta&oq=NFkbet&gs_l=img.1.0.0i10i24k1.1273.7507.0.10216.11.10.1.0.0.0.137.917.0j8.8.0.foo%2Cnso-enfk%3D1%2Cnso-usnt%3D1%2Cnso-qnt-npqp%3D0-21%2Cnso-qnt-
npdq%3D0-57%2Cnso-qnt-npt%3D0-16%2Cnso-qnt-ndc%3D400%2Ccspa-dspm-nm-mnp%3D0-08%2Ccspa-dspm-nm-mxp%3D0-2%2Cnso-unt-npqp%3D0-21%2Cnso-unt-npdq%3D0-35%2Cnso-unt-npt%3D0-1%2Cnso-unt-ndc%3D400%2Ccspa-uipm-nm-mnp%3D0-0125%2Ccspa-
uipm-nm-mxp%3D0-0875%2Ccfro%3D1...0...1.1.64.img..2.6.678.0..0j35i39k1j0i10k1.zmV0Hd13B9I#hl=en&tbm=isch&q=nfk+beta+pathway&imgrc=WXo2oRzHp3
bVaM:
Boswellia serrata(Salai/Salai guggul)
• Boswellia serrata (Salai/Salai guggul), is a moderate to large sized branching tree of family Burseraceae (Genus Boswellia), grows in dry mountainous regions of India, Northern Africa and Middle East.
http://i.telegraph.co.uk/multimedia/archive/02433/Frankinsense1_2433367b.jpg
http://www.nature.com/nature/journal/v444/n7121/images/444529a-i1.0.jpg
Boswellia serrata(Salai/Salai guggul)
• The oleo gum-resins contain 30-60% resin, 5-10% essential oils, which are soluble in the organic solvents, and the rest is made up of polysaccharides.
Boswellia serrata(Salai/Salai guggul)
• The resinous part of Boswellia serrata possesses monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids and four major pentacyclic triterpenic acids i.e. β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid, responsible for inhibition of pro-inflammatory enzymes.
Penta{5} cyclic ringsSteroidal in nature
Fractions of Boswellic acid and inhibition of NFkB
Fractions of boswelliic acids
Effects of Boswellia triterpenoids
Boswellia is not inferior to
NSAID mesalazine
Some had complete remission with
Boswellia
Boswellia blocks
Smad7 and thus
restores Smad 3 &
TGFB, which
Acts to down
regulate the immune
system in colitis
Boswellia helps SMAD3
http://c431376.r76.cf2.rackcdn.com/18172/fimmu-03-00020-HTML/image_m/fimmu-03-00020-g003.jpg
IL17
Better for
autoimmunity
TgfBIL-2 Treg
IL-4Th2
Boswellia modulates
c3 into C3a & C3b
Stops NFkB
Your Cartilage & Collagen doesn't stand a chance when these pathways are activated!
B
Boswellia was as effective
as allopathic drugs for UC
and Crohn’s
AKBA from Boswellia Prevented Intestinal Polyposis better
than aspirin
Boswellia induces
apoptosis in the polyps
http://www.molecular-cancer.com/content/figures/1476-4598-2-41-3-l.jpg
Curcuma
prevents this
Boswellia may inhibit ulcers; this is critical in treating rheumatic dz,
as NSAIDS can cause ulcers & Leaky gut
Boswellia blocks
Leukotrienes and may
increase protective
prostaglandins
Eschscholzia is a fast acting herb in EnFlamend known to reduce pain and anxiety
• California Poppy (Eschscholziacalifornica) is the official state flower of California.
• The plant grows to 60 cm, has feathery foliage and velvety, golden-orange flower petals.
• It is a member of the Papaveraceae.
Ethnobotany of Eschscholzia
• Western coastal Indians used the seed as a general pain killer, especially as a toothache remedy
• Also used externally for its antimicrobial properties as a poultice for sores and other skin disorders, its extract has been shown to be a very effective antispasmodic aiding in muscle spasms, cramps, convulsions and chronic coughs, which are a type of spasm
History of Eschscholzia
• California Poppy was a commonly used herb in native American and Hispanic societies, and gained considerable interest from medical practitioners in the lat 1800’s, when it was added to the Park-Davis drug catalog as “an excellent soporific and analgesic, above all harmless.”
The Eclectics on California Poppy….
• Eschscholzia was stated to be an “…analgesic and soporific without the dangers attending opiates, quieting pain and producing (a) calm sleep” (1893).
• Externally, the various Poppies can be used to treat pain and arrest local inflammation, used as a lotion, liniment, or plaster
Eschscholzia Constituents• Like the Opium Poppy,
California Poppy contains a variety of isoquinolinealkaloids including very small amounts of morphine and codeine.
• Large varieties of other isoquinolines, including: californidine, californinechelerythrine, chelilutin chelirubine, coptisine,cryptocavine,cryptopine,escholidine, escholine, scholinine, eschscholtzidine, protopine and sanguinarine.
Clinical Studies
• California Poppy (CP) extract inhibits degradation of catecholamines and synthesis of epinephrine (adrenaline) in vitro.
• Preserving catecholamines may explain the Pain relieving and endorphin activity of CP.
• Alkaloids from CP enhance (GABA) binding to receptors, which may indicate a benzodiazapine-like activity.
Pain cycle broken by EnFlamend and its herb Eschscholzia….
Eschscholtia
Benzodiazepine receptors
Eschscholzia binds to GABA Receptors
Enfla-mend Px has 375 Mg of Eschscholtzia per 3 caps, in the range recommended by the worlds leading phytotherapists
• Dosage for pain:
• 1:2, 3-6 ml
(Mills and Bone 2005)
• 1:5, 1-4 ml, 25% ethanol (Hoffmann 2003)
• 200- 800 g dried equivalent, per day
Enfla-Mend Px has used the cutting edge technologies to provide practitioners with the best curcumin delivery
systems…..
Curcuma longa
• Curcumin (diferuloylmethane; 1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione)
• Curcumin is the major bioactive component of turmeric or Curcuma longa L., a widely used natural food product in curry powder and food coloring (mustard).
Curcuma and its multi-effects down-stream of NfKB
New mechanism of action of curcuma in Cardiovascular disease
Curcuma lowered
oxyLDL
Upregulated
ABCA1What the heck is this??
How does it work??
ATP binding
Cassette transporter?
Curcumin
causes efflux
ejection of
cholesterol from
foam cells which
is
picked up by
HDL & ApoA1ABCA1 is ATP-
Binding cassette
transporter A1
A deficiency in
ABCA1 may
cause
increased
atherosclerosis
Smooth muscle migration is
essential in the sequence &
pathogenesis of
atherosclerosis
MMP’s
Degrading
the
extracellular
matrix
STOP
Curcuma spp.
Stopped this
migration of smooth
muscle cells into the
plaque
Curcumin is Poorly Absorbed
• Traditionally people have prepared curcumin in fat – heating with butter or oil– creates “liposomes” of a sort: little spheres of fat that carry the curcumin across the intestinal wall.
Meriva TM
Phosphatidyl
Complex is a
Patented and
Evidence-based
Whole intact
Curcuma
Wholistic, balanced
with Meriva TM
Volatile oils intact
Bromelain acts
As another
Absorption
synergist, and is a
powerful botanical agent
By it’s own right…
Piperine for
ASSIMILATION
Quercetin & resveratrol, powerful anti-inflammatory
Agents by themselves….
synergizes absorption kinetics with Meriva
Bromelain,piperine & the volatile oils
Meriva
showing better
absorption of
curcuminoids
Adding Piperine…The science• Curcumin bioavailability has been improved by co-
administering it with piperine.• Piperine is a piperidine alkaloid found in the fruit of the
black pepper (Piper nigrum), and is responsible for the pungency of black pepper spice.
Piperine’s Effect on Curcumin
• Piperine improves Curcumin’s bioavailability by inhibiting Hepatic phase II glucuronidation
• Piperine also improves intestinal absorption by inhibiting P-glycoprotein-1, a broad-acting xenobiotic efflux transporter).
Piperine inhibits liver
degradation of the
curcuma, supporting
tissue saturation
Graph of curcuma plus synergists, not even taking into account EnFlamend uses Meriva, which is superior to
regular curcuma
Quercetin and Resveratrol also offer powerful anti-inflammatory effects
Quercetin
Quercetin stops
leaky gut
Resveratrol in Enfla-mend
Resveratrol has its own
effects on oxidative stress
by blocking TNF alpha
INHIBITION of
TNF alpha
BromelainProteolytic Enzyme From Pineapple
Bromelain
Bromelain modulates cytokines
Bromelain blocks bradykinin,VCAM-1 and Cox 2
Bromelain modulated
VCAM-1 and stops
atherosclerosis
Bromelain versus NSAIDS: an effective and healthier choicehttp://www.tbyil.com/BromelainT4.jpg
Osteoarthritis and Sports Medicine References for Bromelain