Final measle 30 07-11

1. MEASLE Preface 1-4.indd 1 7/30/2011 6:55:44 PM

2. ( 13 2554) : ISBN : 978-616-11-0778-9 : 0 2590 3196-9 0 2965 9152 E-mail: [email protected] : : 25,000 MEASLE Preface 1-4.indd 2 7/30/2011 6:55:44 PM

3. 1 1 2 7 3 13 4 25 5 37MEASLE Preface 1-4.indd 3 7/30/2011 6:55:44 PM

4. MEASLE Preface 1-4.indd 4 7/30/2011 6:55:44 PM

5. : 1 1 MEASLE Content 1-48.indd 1 7/30/2011 6:53:40 PM

6. 1 : 2 MEASLE Content 1-48.indd 2 7/30/2011 6:53:40 PM

7. 1 : (Measles Elimination) ..2537 ..2545 99 250,000 ..2533 105 ..2546 (Import-related measles) (Eastern Mediterranean region) (European region) ..2553 (Western Pacific Region) ..2555 ..2563 11 63 ..2553 ..2563 ..2551 78 ..2543 3 MEASLE Content 1-48.indd 3 7/30/2011 6:53:40 PM

8. 1 : 2563 (Measles elimination) (Endemic measles case) 12 (Measles eradication) ..2552 1 4 MEASLE Content 1-48.indd 4 7/30/2011 6:53:40 PM

9. 1 : 1 1. EPI program EPI program 95 (Supplementary immunization activity: SIA) 2. (outbreak size) 10 80 3. 1 (imported case) 4. 12 9 .. 2527 1 .. 2539 96 91 4,000 - 7,000 5 MEASLE Content 1-48.indd 5 7/30/2011 6:53:41 PM

10. 1 : 5 (2554-2558) 1. 95 2. 3. 80 4. 6 MEASLE Content 1-48.indd 6 7/30/2011 6:53:41 PM

13. 2 : (Exanthematous fever) Measles Paramyxovirus RNA (air borne) 1-2 (3 5 ) 4 8-12 14 () 3 4 maculo-papular 2-3 9 MEASLE Content 1-48.indd 9 7/30/2011 6:53:41 PM

14. 2 : 5-6 2 1-2 Kopliks spots 3-4 (Malnutrition) corneal ulcer encephalitis 1. 4 Kopliks spots 10 MEASLE Content 1-48.indd 10 7/30/2011 6:53:41 PM

15. 2 : 2. IgM antibody measles ELISA 4-30 throat swab nasal swab 1-5 1. 2. 3. UNICEF 1% 4 2 9-12 (MMR) 1 11 MEASLE Content 1-48.indd 11 7/30/2011 6:53:41 PM

16. 2 : 72 MMR 72 6 Immunoglobulin (IG) IG 0.25 ./. IG 1 12 MEASLE Content 1-48.indd 12 7/30/2011 6:53:41 PM

19. 3 : 2 15 MEASLE Content 1-48.indd 15 7/30/2011 6:53:41 PM

20. 3 : 2 1. 1.1 2 1.2 1 2. measles IgM 80 ( ) 3. 80 4. 48 80 16 MEASLE Content 1-48.indd 16 7/30/2011 6:53:42 PM

21. 3 : ICD-10-TM B05 Measles Includes: morbilli Excludes: subacute sclerosing panencephalitis B05.0+ Measles complicated by encephalitis Postmeasles encephalitis B05.1+ Measles complicated by meningitis Postmeasles meningitis B05.2+ Measles complicated by pneumonia Postmeasles pneumonia B05.3+ Measles complicated by otitis media Postmeasles otitis media B05.4 Measles with intestinal complications B05.8 Measles with other complications Measles keratitis and keratoconjunctivitis B05.9 Measles without complication Measles NOS (not otherwise specific) *** German measles /Rubella ( ICD-10 B06) 17 MEASLE Content 1-48.indd 17 7/30/2011 6:53:42 PM

22. 3 : 1. (Clinical Criteria) > 38 C (Cough) (Coryza) (Conjunctivitis) Kopliks spot 1-2 2. (Laboratory Criteria) ( 1 18) 2.1. Serology test : Measles IgM 2.2. Viral isolation : Throat swab culture Nasal swab culture (Case Classification) 1. (Suspected case) 2. (Probable case) 3. (Confirmed case) - - 18 MEASLE Content 1-48.indd 18 7/30/2011 6:53:42 PM

23. 3 : - 7 (Reporting criteria) 1. (Individual case investigation) Measles IgM 2. (Outbreak Investigation) (ME1 form) (ME2 form) Measles IgM 10 20 19 MEASLE Content 1-48.indd 19 7/30/2011 6:53:42 PM

24. 3 : Throat / Nasal swab 5 Genotype PCR ( Throat/Nasal swab ) 1. 2. Index case 3. Index case Measles IgM 4. Index case Measles MMR - Measles MMR 1 95 1 - 2 ( index case) - MMR 2 95 1 6 20 MEASLE Content 1-48.indd 20 7/30/2011 6:53:42 PM

25. 3 : 1. / / ICD10 OPD card / Lab ( ) www.boe.moph.go.th . . . / www.boe.moph.go.th 21 MEASLE Content 1-48.indd 21 7/30/2011 6:53:42 PM

26. 3 : 2. Index case SRRT / / / () measles IgM 10 20 (ME 1 form) Throat/ Nasal swab Genotype 5 (ME 2 form) www.boe.moph.go.th . . . / www.boe.moph.go.th 22 MEASLE Content 1-48.indd 22 7/30/2011 6:53:42 PM

27. 3 : ME 1 form ID ______ ( running number ) 1. ........................................ 2. ......................................... 3. ...... ......... (// ..../...../.....) 4. [ ] [ ] 5. [ ] [ ] // [ ] [ ] [ ] [ ] [ ] [ ] ........... 6. ( ) ( ) ( ) , ( ) ( ) ( ) ( ) , ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) 7. .................................................................................................................... 8. / ......................... / / ................. / ..................... 9. __/__/____ (dd/mm/yyyy) __/__/____ (dd/mm/yyyy) 10. __/__/____ (dd/mm/yyyy) 11. __/__/____ (dd/mm/yyyy) ..................... . ......................... 12. [ ] [ ] [ ] 13. [ ] [ ] __/__/____ [ ] [ ] 14. [ ] [ ] [ ] [ ] [ ] / [ ] [ ] [ ] [ ] .......................................... 15. -- [ ] 1 [ ] 2 [ ] [ ] [ ] / 1 __/__/____ 2 __/__/____ (dd/mm/yyyy) 16. [ ] 2 ...................... 17. [ ] / 2 ...................................... ........................... 18. ..................... .................. 19. / ..................... .................. 20. __/__/____ __/__/____ .................. 21. Throat/ Nasal swab __/__/____ __/__/____ ........ 22. [ ] [ ] [ ] 23 MEASLE Content 1-48.indd 23 7/30/2011 6:53:42 PM

28. ME 2 form ................................................ 24 ID / / Lab MEASLE Content 1-48.indd 24 M MMR throat/nasal swab 1 dd/mm/yyyy 1 dd/mm/yyyy dd/mm/yyyy 1 OPD 1 2 2 2 IPD 2 3 3 Active 3 case 4 finding 5 3 : 7/30/2011 6:53:42 PM

31. 4 : 1 .. 2563 1) 2) 3) 2 3 (Measles Regional Reference Laboratory in SEAR) 11 27 MEASLE Content 1-48.indd 27 7/30/2011 6:53:42 PM

32. 4 : .. 2563 (genotype) 28 MEASLE Content 1-48.indd 28 7/30/2011 6:53:43 PM

33. 4 : 12 3 14 3 / 1. IgM 48 / ELISA 90 2. 1 / 90 1) IgM ELISA 2) 29 MEASLE Content 1-48.indd 29 7/30/2011 6:53:43 PM

34. 4 : IgM 1 1 IgM 30 MEASLE Content 1-48.indd 30 7/30/2011 6:53:43 PM

35. 4 : 1. ELISA IgM Serum : 4-30 3-5 . Serum ( Serum) - - - 2. (Genotype) 2.1 Throat swab : 1-5 swab posterior pharynx swab viral transport media swab 2.2 Nasal swab : 1-5 swab palate 2-3 swab swab viral transport media swab : 1. throat swab nasal swab 2. Viral transport media / 3. swab 31 MEASLE Content 1-48.indd 31 7/30/2011 6:53:43 PM

36. 4 : (ME 1 form) Line listing form (ME 2 form) Serum : serum 2-8 o. 3 3 2-8 o. Throat swab / Nasal swab : 2-8 o. 24 : 1. Positive / Negative / Equivocal OD. cut-off 2. (Genotype) / 1. 2. 32 MEASLE Content 1-48.indd 32 7/30/2011 6:53:43 PM

37. 4 : 1. ELISA IgM - hemolyse, 2. (Genotype) - 3. 33 MEASLE Content 1-48.indd 33 7/30/2011 6:53:43 PM

38. 4 : 1. Laboratory diagnosis of Measles, influenza and others Respiratory Virus infection, Center for Diseases Control and prevention (CDC). US. Department of Health and Human services, Public Health service. 1995. 2. Guideline for Collection and Shipment of Blood and Urine Samples for Measles Antibody and Virus Assays. Course manual for WHO Inter-regional training workshop on Laboratory Diagnosis of Measles Infection, July 20-24 1998. NIV, Johannesberg, South Africa. 3. World Health Organization, Manual for the laboratory diagnosis of measles and rubella virus infection, Second edition. WHO/IVB/07.01. 4. Measles elimination field guide, 2nd edition. Pan American Health Organization. 2005 5. Griffin, D. E., Measles virus. In Fields Virology, 5th edn, pp. 155111585. Edited by D. M. Knipe, P. M. Howley, D. E. Griffin, R. A. Lamb, M. A. Martin, B. Roizman & S. E. Straus. Philadelphia: Lippincott Williams & Wilkins. 2007 34 MEASLE Content 1-48.indd 34 7/30/2011 6:53:43 PM

39. 4 : 1. : 88/7 4 . . . 11000 : 02-5890022 99312, 98362 . : 02-5915449 2. () 153 4 . 075-213105 7 075-215675 . . 92000 54 .1 .- 042-207364 6 042-207367 . . . 41330 59/2 3 . . 038-455200, 038-455165 . . . 038-784006 7, 20000 038-455235, 038-455379 136 4 . 034-720668 71 034-720540 . . . 75000 - 044-346005 17 044-346018 7.5 . . . 30000 35 MEASLE Content 1-48.indd 35 7/30/2011 6:53:44 PM

40. 4 : () 400/2 . 043-240800 043-240845 . . 40000 82 . . 045-312230 3 045-312230 104 . . 34000 2 4 . 056-267423, 056-267329 . . 056-267428 60130 055-247581 2 055-247581 2 5 . 121 . . 65000 191 8 . 053-112188 90 053-112194 . . 50180 102 . . 077-355301 6 077-355300 . 84100 616/1 2 . 074-447024 8 074-333809 . . 90100 148 3 . . 053-176225 6 053-176224 . 57100 141 4 . 076-352041 2 076-352044 . . 83110 36 MEASLE Content 1-48.indd 36 7/30/2011 6:53:44 PM

43. 5 : herd immunity 93-95 (homogeneous) 39 MEASLE Content 1-48.indd 39 7/30/2011 6:53:44 PM

44. 5 : 1. MMR ( 95) (routine immunization) -- (MMR) 2 9-12 1 ( 1 ) 1 95 1 95 MMR 1.1 1 MMR 1 1.2 1 1 40 MEASLE Content 1-48.indd 40 7/30/2011 6:53:44 PM

45. 5 : 2. -- ( 7 ) ( 7 ) 2.1 MMR 1 MMR MMR 1 2.2 7 1 2.2.1 MMR 9 MMR 1 1 2.2.2 MMR 1 9 MMR 1 2.3 .1 .6 (.3) 41 MEASLE Content 1-48.indd 41 7/30/2011 6:53:44 PM

46. 5 : 2.3.1 MMR MMR 1 MMR 1 2.3.2 MMR MMR 1 MMR 1 2.3.3 MMR MMR 1 MMR 2.4 2.1 - 2.3 MMR MMR 6 MMR 1 3. MMR MMR 3.1 3.2 42 MEASLE Content 1-48.indd 42 7/30/2011 6:53:44 PM

47. 5 : 3.3 ( ) 1 (8-12 ) 2 ( 2 ) herd immunity 1. ( 7 ) MMR 9 7 1 MMR MMR 2 72 9 MMR 43 MEASLE Content 1-48.indd 43 7/30/2011 6:53:44 PM

48. 5 : 2. MMR 1 MMR MMR 2 72 MMR MMR - 1 MMR MMR 1 3. MMR 1 MMR MMR 1 4. MMR 7 1 - 6 44 MEASLE Content 1-48.indd 44 7/30/2011 6:53:44 PM

49. 5 : MMR MMR MMR MMR 1. 7 1 6 MMR . MMR 2. . MMR MMR 45 MEASLE Content 1-48.indd 45 7/30/2011 6:53:44 PM

50. 5 : 2 MMR 0-2590-3222 0-2590-3365 0-2591-7716 [email protected] 46 MEASLE Content 1-48.indd 46 7/30/2011 6:53:44 PM

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Final measle 30 07-11