Interaksi Obat Sistem Kardiovaskular - Copy

8/18/2019 Interaksi Obat Sistem Kardiovaskular - Copy

1/13

JURNAL PRAKTIKUM

FARMAKOLOGI

INTERAKSI OBAT

(BLOK KARDIOVASKULAR)

DISUSUN OLEH:

ESANIKARUPPIAH : 080100413 NAANTHINI DILLY KANAN : 080100

FRANKLIN OSWALD : 080100

PERDANA SIDAURUK : 080100

SULOCHANA MOHAN : 080100

KELOMPOK : A1

MEJA : 10

FAKULTAS KEDOKTERAN UNIVERSITAS

SUMATERA UTARA 010


2/13

PENDAHULUAN

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3/13

PEMBAHASAN INTERAKSI OBAT

OBAT 1

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5/13

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6/13

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7/13

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8/13

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9/13

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11/13

PENDEKATAN ANALISA INTERAKSI OBAT

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2a%!" !ra(si! *aa$ "s"s T.! A.! T.! A.! T.! A.!

P#r"ba0a( ,ora "s"s T.! A.! T.! A.! T.! A.!

E,#% !o%sis pa*a sa"ra(

c#r(a

T.! A.! T.! A.! T.! A.!

DISTRIBUSI Oba! 1 / Oba! & Oba! 1 / Oba!

.

Oba! & / Oba! .

I%a!a( oba! *#(-a( pro!#i(

pas$a

A.!

Norvas%:3

T#(or$i(:

@1@

A.!

Norvas%:3

Esi-a(:

3

A.!

T#(or$i(:@1@

Esi-a(:

3

Da3a i%a!a( !#r0a*ap +ari(-a(

!"b"0

A.!

T#(or$i(: 2*!%!,.,-!, *$/%* 2%!

Ti*a% a*a A.!

T#(or$i(: 2*!%!,.,-!, *$/%* 2%! 1


12/13

1 !.*,*- (%*.!/!%

/!.! /!.! !,%&,-)

!.*,*- (%*.!/!% /!.

/!.! !,%&,-)

METABOLISME Oba! 1 / Oba! & Oba! 1 / Oba!

.

Oba! & / Oba! .

M#ra(sa(- #(4i$ $i%roso$0a!i oba! ai(

T.! A.! T.! A.! Esi-a(:dibantu oleh sitokrom P4!"($P#"&

M#(-0a$ba! #(4i$ $i%roso$

0a!i oba! ai(

T.! A.! T.! A.! Esi-a(:inhibitor monoamine oksida

P#r"ba0a( aira( *ara0 %#

0#par

Norvas% :90% ditukarkan kepadametobolit 'aninakti)melaluimetabolismehepar

T#(or$i( :%.! ,-!"!

%!2"$ ",%!$

/*%!!

Norvas% :90% ditukarkankepada metobolit'an inakti) melaluimetabolisme hepar dimetabolit di hepar

Esi-a(: dimetabolit di hepar

T#(or$i( :%.! ,-!"!%!2"$ ",%!$ /*%!

Esi-a(: dimetabolit di hepa

EKSKRESI Oba! 1 / Oba! & Oba! 1 / Oba! . Oba! & / Oba

Oba! 3a(- *i%#"ar%a( $#a"i

0#$p#*":

• Ha$ba!a( *aa$ s#%r#si oba!

%# *aa$ 0#$p#*"

• Ga(--"a( 5r#"p!a%#6 oba! *ari

sa"ra( c#r(a %# si%"s 0#pa!i%

'si%"s #(!#ro0#pa!i%)

T.! A.!

T.! A.!

T.! A.!

T.! A.!

T.! A.!

T.! A.!

Oba! 3a(- *i%#"ar%a( $#a"i

-i(+a:

• Fi!rasi -i(+a

• S#%r#si !"b""s -i(+a

• P#r"ba0a( pH "ri(

Norvas% :

@0 %2"% .$*$

.!"! &*,5

T#(or$i(:

.$*$!, $7!*! &%

"!"& -,!"

Norvas% :

@0 %2"%

.$*$ .!"!

&*,5

Esi-a(:

$%!;"!

.$*$ "!"&&*,

T#(or$i(:

.$*$!,$7!*! &%

"!"& -,!"

Esi-a(:

$%!;"!

.$*$"!"& &*,

A(aisa : T!.! *!$ !,%!*! 2!% N*9!$ (A"./,!)6T,*, (A%,"") !&/&, E$"-!,

(B,;.!;/,)5


13/13

Far$a%o*i(a$i%

I(!#ra%si Oba! 1 / Oba!

&

Oba! 1 / Oba!

.

Oba! & / Oba! .

Sis!#$ r#s#p!or 3a(- sa$a T.! A.! T.! A.! T.! A.!

Sis!#$ ,isioo-is 3a(- sa$a T.! A.! T.! A.! T.! A.!

P#r"ba0a( *aa$ %#s#i$ba(-a(caira( ##%!roi!

T.! A.! T.! A.! T.! A.!

Ga(--"a( $#%a(is$# a$bia( a$i(#

*i 0"+"(- sara, a*r#(#r-i%

T.! A.! T.! A.! T.! A.!

I(!#ra%si *#(-a( p#(-0a$ba! MAO T.! A.! T.! A.! T.! A.!

K#si$p"a( : T!.! *!$ !,%!*! 2!% N*9!$ (A"./,!)6T,*, (A%,"") !&/&,

E$"-!, (B,;.!;/,)5

Daftar pustaka

1) F!*!"- .!, T*!/ E.$ ? D/!*%, F!*!"- .!, T*!/&% FK UI (&!$&*!%

46100 .!, 34@)

) 5P&2.57

3) 5.*&-"257
http://www.pubmed.com/http://www.pubmed.com/

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