KP dr.Yuziani.pptx

7/24/2019 KP dr.Yuziani.pptx

http://slidepdf.com/reader/full/kp-dryuzianipptx 1/18

OBAT–OBAT YANG BEKERJA

PADA DARAH

( ANTIANEMIA, ANTIKOAGULAN, ANTITROMBOSIT )



Menurunnya jumlah hemoglobin dalam seldarah merah sehingga oksigenasi ke

jaringan dan organ terganggu.Kadar Hb dipengaruhi umur, jenis kelamin,geofras dan metode pemeriksaan.



PENYEBAB TERJADINYA ANEMIA :

1. TER!"# $E%"!R!H!% "&M 'M&!H (!%)!K*. $EM'+%!H!% !(%RM!& +E& "!R!H-. !%'!% $!"! !R#%!% HEM$ET#K /. K'R!%%)! 0!KTR $EM(EK'!% "!R!H

KEKURANGAN ZAT BESI ANEMIA HIPOKROM / FERIPRIVE

KEKURANGAN VIT B 12 &

ASAM FOLATANEMIA HIPERKROM /

MEGALOBLASTER .



NTI NEMI

HEM!T#%#K! !"!&!H (!T (!T )!% (ER#+# (!H!% (!H!%$EM(E%T'K!% "!R!H "!% "#'%!K!% '%T'K$E%"ER#T! !%EM#! K!RE%! KEK'R!%!%'%+'R $EM(E%T'K "!% K!T!&#+!TR .

+E& "!R!H MER!H "#(E%T'K "!&!M +'M +'M T'&!% , "#!%T!R!%)! $!"! E$#$H)+#+ T'&!% $!%!% , +'M +'M T'&!% $#$#H "!%+'M +'M T'&!% $E%"EK .

"!&!M $R+E+ $EM(E%T'K!%%)! "#$ER&'K!% 0e 2 3!T (E+# 4 5#T (1* !+!M 0&!T



BAHAN BAHAN HEMATINIKA

1. ZAT BESI ( Fe

MERUPAKAN UNSUR INTI DALAM PEMBENTUKAN HAEM , IKATAN HAEM DENGAN PROTEIN

BERPRAN SEBAGAI PENYALUR ZAT ASAM DARI Hb DAN

MENDORONG SUM SUM TULANG UNTUK MENGHASILKAN

SEL SEL DARAH .

ABSORBSI AKAN MENINGKAT DALAM SUASANA ASAM ( VIT C )

DAN AKAN MENURUN BILA PEMBERIAN BERSAMA ANTASIDA ,

TETRASIKLIN DAN MAKANAN .

HAEMOGLOBIN .

2. VITAMIN B12 & ASAM FOLAT .

UNTUK SINTESA DNA DEFISIENSI SALAH SATU VITAMIN DIATAS

PRODUKSI DAN MATURASI ERITROSITGANGGUAN

ANEMIA MEGA !

LOBLASTER .



ANTIKOAGULAN " ANTITROMBOSIT "

TROMBOLITIK DAN HEMOSTATIK

MER'$!K!% (!T (!T '%T'K ME%6E!H "!%$E%(!T!% TRM(EM(&# +ERT! '%T'K ME

ME%!T!+# $E%"!R!H!% .

KE"'! KE!"!!% T+( TER!"# K!RE%! TER!%'%)! $R+E+ HEM+T!+#+ , KH'+'+%)! 0'%+# TRM(+#T "!% $R+E+ $EM(EK'!% "!R!H .

KE&!#%!% TRM(EM(&# +ER#% ME%)ERT!# $E%)!K#T&!#% +E$ERT# !!& !%T'% , "#!(ETE+ ME&#T'+ ,

5!R#+E+ 5E%! "!% KER'+!K!% !RTER# .

(!T (!T )!% "#'%!K!% '%T'K $E%6E!H!% "!%$E%(!T!% TRM(EM(&# #!&!H !%T#K!'&!% ,

!%T#TRM(+#T "!% TRM(&#T#K "!% (!T '%T'K ME%!T!+# $E%"!R!H!% TERM!+'K HEM+T!T#K .



HEMOSTASIS

MER'$!K!% $R+E+ $E%HE%T#!% $E%"!R!H!% $!"!

$EM('&'H "!R!H )!% 6E"ER! .

"!&!M $R+E+ T+( (ER$ER!% 0!KTR 0!KTR :

PEMBULUH DARAH

TROMBOSIT PEMBEKUAN DARAH

VASO KONTRIKSI

BERAGGREGASISUMBAT TROMBOSIT

TAHAP TAHAP PEMBEKUAN DARAH :

1. !KT#5!+# TRM($&!+T#%*. $EM(E%T'K!% TRM(#% "!R# $RTRM(#%

-. $EM(E%T'K!% 0#(R#% "!R# 0#(R#%E%

"!&!M $R+E+ #%# "#$ER&'K!% 0!KTR 0!KTR$EM(EK'!% "!R!H .



HEMOSTATIK :

!"!&!H 3!T 7 (!T '%T'K ME%HE%T#K!%

$E%"!R!H!% .

"#'%!K!% '%T'K ME%!T!+# $E%"!R!H!% )!%ME&#$'T#

"!ER!H )!% &'!+ .

$R+E+ TER!"#%)! $EM(EK'!% "!R!H (#&! TER!"# KER'+!K!% !R#%!% M!K!

!K!% TER!"# KER'+!K!% TRM(+#T "!% !K!%

ME%E&'!RK!%

THRM($&!+T#%E%!+E )!% !K!% ME%!KT#0K!% THRM($&!+T#%E% THRM($&!+T#% .

"E%!% (!%T'!% 5#T K H!T# $RTRM(#% . THRM($&!+T#% !K!% MER(!H $RTRM(#%

THRM(#% ."E%!% (!%T'!% 6!&+#'M THRM(#% !K!% MER(!H



PENDARAHAN DAPAT JUGA DIHENTIKAN DENGAN :

) MEMBERIKAN OBAT YANG DAPAT MENINGKATKAN

FAKTOR FAKTOR PEMBEKUAN DARAH MISAL VIT K

2) MENGHAMBAT MEKANISME FIBRINOLITIKMISAL ! ASAM AMINOKAPROAT

! ASAM TRANEKSAMAT .

#ARA KERJA HEMOSTATIK :

1. HEMOSTATIK LOKAL :(EKER! "E%!% 6!R! MEM(E%T'K $ERM'K!!% !+#%$!"! $EM('&'H "!R!H )!% $E6!H .

THRM(+#T !K!% $E6!H !$!(#&! (ER+E%T'H!% "E%!%

$ERM'K!!% !+#% T+( "!% ME%E&'!RK!% 3!T 3!T!T!' 0!KTR $EM(EK' "!R!H , 6%TH 8 E&!T#% +$%

8 9)6E& 8 H'M!%

0#(R#%

+$%E .



Cara kerja hemostatik ........lanjutan

*. !"+TR#%E%+

ME%)E(!(K!% $E%E%"!$!% $RTE#% "!R!H "!%$E%KER'T!% +E&!$'T &E%"#R $EM('&'H "!R!H

+EH#%! TER!"# $E%HE%T#!% $E%"!R!H!% . 6%TH $ER!K %#TR!T "!% 0ER# K&R#"! .

-. K!'&!%+#! (EKER! "E%!% 6!R! MEM$ER6E$!T $ER'(!H!%$RTHRM(#% ME%!"# THRM(#% "!%ME&!%+'%K!%

$E%'M$!&!% 0#(R#%E% . 6%TH EK+TR!K $RTHRM(#% , THRM(#% .

/. (!T (!T 5!+K%+TR#KTR !"RE%!&#% "!% %R !"RE%!&#% MEM$'%)!# E0EK

+#M$!TM#MET#K +EH#%! ME%)E(!(K!%5!+K%+TR#K+# ,

+EH#%! $E%"!R!H!% (ERHE%T# .



. HEMOSTATIK SISTEMIK :

1. $EM(ER#!% TRANS!SI "ARAH , $!+#E% ME%ER#M! +E&'R'H

0!KTR )!% "#$ER&'K!% '%T'K $EM(EK'!% "!R!H "!% TER!"# $ER(!#K!% +#RK'&!+# . #T$

*. $EM(ER#!!% %IT K '%T'K MER!%+!% $EM(E%T'K!%$RTHRM(#% . #%$

-. $EM(ER#!% KOA&!LAN )!#T' $RE$!R!T )!% "#('!T "!R#+!$# "!% "#H!R!$K!% ME&E%K!$# 0!KTR 0!KTR $EM <

(EK'!% "!R!H )!% K'R!% . #K$

/. $EM(ER#!% KAR'A(OKROM ME%HE%T#K!% $E%"!R!H!%"E%!% MEM$ER(!#K# $ERME!(#&#T!+ K!$#&ER .

6%TH +E"#!!% !"%! , TE%+#"%! "!% !%!R9)& . #K$

=. $EM(ER#!% ASAM AMINOKA)ROAT "AN ASAM TRANEKSAMAT : MER'$!K!% $E%H!M(!T (ER+!#% "!R# !KT#5!TR $&!+8 M#%E% "!% $&!+M#% )!% (ER$R!% ME%H!%6'RK!%

0#(R#%E% ,0#(R#% "!% 0!KTR $EM(EK'!% "!R!H .

6%TH +E"#!!% K!&%E9 > TR!%+!M#% . #A$



ANTIKOAGULAN

"#'%!K!% '%T'K ME%6E!H $EM(EK'!% "!R!H "E%!%

!&!% ME%H!M(!T $EM(E%T'K!% !T!' ME%H!M(!T 0'%+# (E(ER!$! 0!KTR $EM(EK'!% "!R!H . "#$ER&'K!% '%T'K ME%6E!H TER(E%T'K "!% ME&'!+%)! TRM('+ "!% EM(&# , M!'$'% '%T'K ME%6E!H (EK'%)! "!R!H #%5#TR $!"! $EMER#K+!!% &!(R!TR#'M "!%

TR!%+0'+# .

!%T#K!'&!% R!& "!% HE$!R#% ME%H!M(!T $EM(E% < (E%T'K!% 0#(R#% "!% "#'%!K!% +E6!R! $R0#&!KT#K

'%T'K ME%'R!%# #%+#"E%+ TRM(&# TER'T!M! $" 5E%!

!%T#K!'&!% "!$!T "#(!# !T!+ T#! KE&M$K

1. HE$!R#%*. !%T#K!'&!% R!& 2 K'M!R#% > ?!R0!R#% 4-. !%T#K!'&!% )!% (EKER! ME%#K!T K!&+#'M .



1. HEPARIN :

"#(ER#K!% +E6!R! $!RE%TER!& =::: < *:.::: '%#T

"#'%!K!% '%T'K $E%)!K#T !K#(!T THRM(EM(&#

M#+!& 8 $!+K! #%0!RK 8 $E%"!R!H!% $!R' $!R'

8 $E%"!R!H!% T!K .

(EKER! "E%!% 6!R! !%T#THRM($&!+T#% )!#T'

"E%!% ME%#K!T !%T#THRM(#% MEM(E%T'KKM$&EK

+EH#%! $EM(E%T'K!% THRM(#% "!R#$RTHRM(#%

TER!%' .

+E&!#% #T' '! (EKER! "E%!% 6!R!!%T#THRM(#% .



2. KUMARIN DAN $ARFARIN :

"#(ER#K!% $ER R!&

(EKER! "E%!% ME%H!M(!T 0!KTR$EM(EK'!%

"!R!H )!% MEMER&'K!% 5#T K .

(EKER! KM$ET#T#0 !%T!%#+ 5#T K "!% T#"!K TER(E%T'K $RTHRM(#% .

E0EK +!M$#% 8 M'!&8 M'%T!H

8 'RT#K!R#! .



*. )EN&IKAT ION KALSI!M

1. %!TR#'M +#TR!T #N4

"!&!M "!R!H !K!% ME%#K!T K!&+#'M ME%!"#KM$&EK+ K!&+#'M +#TR!T ."#$ER'%!K!% "!&!M "!R!H '%T'K TR!%+0'+#K!RE%! T#"!K TK+#K , KE6'!&# K!&!' "+#+ T#%#

!K!% ME%)E(!(K!% "E$RE+# !%T'% .

*. !+!M K+!&!T "!% +E%)!?! K+!&!T &!#%%)! #A$ "#'%!K!% '%T'K !%T#K!'&!% #% 5#TR , +E(!( TER&!&' TK+#K '%T'K #% 5#5 . -. %!TR#'M E"ET!T #N$

ME%#K!T K!&+#'M ME%!"# +'!T' KM$&EK+ "!%(ER+#0!T +( !%T#K!'&!% .



ANTITROMBOSIT

!"!&!H (!T8(!T )!% "!$!T ME%H!M(!T !RE!+# TRM(+#T +EH#%! TERH!M(!T%)! $EM(EK'!% TRM('+ )!% TER'T!M! +ER#% "#TEM'K!% $!"! !RTER# . (!T (!T )!% TERM!+'K &%!% #%#

!+$#R#% "#$#R#"!M& +'&0#%$#R!3% "EK+TR!% $R+T!+#K&#% 2 $& * 4 T#K&$#"#% .



SPIRIN .

ME%H!M(!T +#%TE+! TRM(+!% !* 2 T9 !* 4 "!&!M

TRM(+#T "!% $R+T!+#K&#% 2 $&* 4 "# $EM('&'H"!R!H "E%!% ME%H!M(!T +E6!R! #RE5ER+#(E& E%3)M+#K& K+#E%!+E, !K#(!T%)! TER!"# $E%'R!%!%!RE!+# TRM(+#T .

(ERM!%0!!T $!"! #%0!RK M#K!R" !K'T !!R T#"!KK!M('H 0!T!& .

$E%'%!!% !%K! $!%!% '%T'K ME%'R!%#KEK!M('H!% T#! 7 +TRKE K!RE%! $E%)'M(!T!%

$EM('&'H "!R!H .

E0EK +!M$#% 8 #R#T!+# &!M('% 2 !%'!% 8$E%6ER%!!% 4

8 $E%"!R!H!% +!&'R!% $E%6ER%!!% .



"I)IRI"AMOL :

ME%H!M(!T !M(#&!% "!% MET!(&#+ME !"E%+#% &EH ER#TR+#T "!% +E& E%"TE& $EM('&'H "!R!H

ME%#%K!TK!% K!"!R%)! "!&!M $&!+M! . !"E%+#% ME%H!M(!T 0'%+# TRM(+#T .

$EM!K!#!% +ER#% "#KM(#%!+#K!% "E%!% !+$#R#% +(

TER!$# #%0!RK M#K!R" > +TRKE . E0EK+!M$#% 8 +!K#T KE$!&!

8 !%'!% +!&'R!% $E%6ER%!!% .

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KP dr.Yuziani.pptx