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BB2530Micro- an nanotechnology for

BiologyVT 2014

Aman Russom, Ph.D

Associate ProfessorKTH Royal Institute of TechnologySchool of Biotechnology,Div of Proteomics and Nanobiotechnology

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Lecturers

Invited guest Assoc. Prof Martin Wiklund 1L. Microuidic accoustics

1 Lab Harisha , Asim, Mary

Dr. Håkan Jönsson / Staffan Sjöström 1L. Droplet microuidics

Prof. Helene Andersson-Svahn

1L. Microdevices for biological application

(DNA + cells)

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Course outline

• Aim- To give a broad introduction to the interdisciplinary

field of micro- and nanotechnology and will highlightbasic concepts of microfluidics with emphasis on “Lab-on-a-chip” systems for biological applications.

• After the course, you will be able to:- Describe the concept of “ Lab-on-a-chip ”- Describe the main microfabrication technologies

used to microfabricate microchips and chose the

appropriate material and design of micro- andnanostructures for a given biological problem- Explain potential and limits of microfluidics and

suggest strategies to handle challenges.- Participate in scientific discussions & Identify future

trends in this field.

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Course outline

• Aim- To give a broad introduction to the interdisciplinary

field of micro- and nanotechnology and will highlightbasic concepts of microfluidics with emphasis on “Lab-

on-a-chip” systems for biological applications.• After the course, you will be able to:

- Describe the concept of “ Lab-on-a-chip ”- Describe the main microfabrication technologies

used to microfabricate microchips and chose the

appropriate material and design of micro- andnanostructures for a given biological problem- Explain potential and limits of microfluidics and

suggest strategies to handle challenges.- Participate in scientific discussions & Identify future

trends in this field.

Explain what microuidics is Explain why and when it can be used

! Get a feeling for the technology behind !

Be creative and have fun doing it

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Example: Lesson about microfluidics

DiscussionDanielTorXin YiSiriJamesRezan

DavidFideleEmmaCamillaJennyVidhya

JuliaKristinKimQuentinYangLovisa

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First…Movie from youtube

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A: the red (bigger) particles will come out first (Right arm up)

B: the green (smaller) particles will come out first (Left arm up)C: Both particles will come out at the same time (stand up)

1 minute to think ! discuss with each other

Question: which of the particles willcome out first?

Flow

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Green

particles flow faster through the channel and are detected first

Laminar flow " parabolic flowprofile " Particles flowingat the center are

traveling fastercompared to theparticles close tothe walls

Particles are affected different byb an external field

Question: which of the particles willcome out first?

Flow

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Course outline

• Lectures- Three blocks

• Microfab (+ study visit) & microfluidics• Applications part1 (invited speakers• Applications part 2 /Discussion forum / reflexion

• Lab- Hands-on experience with microfluidic chips

• Project

- presentation (Creativity & fun)

• Home assignments

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Course outline

Time 25 march 20 April 13 May

L1 – L3IntroductionMicrofabrication

L4 – 6µ fluidicspart 1&2

Study visitLab

L7-9

Applications

L10-11

Reflexion +projectpresentation

Exam: June 2

Block 1

Block 2

Block 3

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Course outline

• Examination:- Written exam ( A – F), 4 p- Lab, 1p- Project, 1p

- 3 Home assignments - mandatory• Bonus points for each correct one• Bonus points

– for > 80% presence & discussions• Intelligent questions• Good presentation

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Study visit

• The electrum lab in Kista, Tue 29 apr at 14:00• Adress: Isafjorsgatan 22, Kista• www.electrumlaboratoriet.se

• Meeting point:- Just inside the entrance at Isafjordsgatan 22 (in front

of the lunch restaurant)- Aman mobile: 070-950 9486

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Next Lectures

• L2 (27 March): Microfabrication part 1• L3 (1 April): Microfabrication part 2

• To read:- Book: chapter 1 ”How do we make small things”- Review article: Hierleman et al ” Microfabrication

Techniques for Chemical/Biosensors” Part I –III

• Practical – you will start with the project coursestarting from next lecture…