Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

No Wnt signaling

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

ß-catenin recruitment and phosphorylation

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

ß-Trcp binding and ß-catenin degradation

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

Downstream gene expression inhibited

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

Wnt signaling

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

Activation of Disheveled and inhibition of ß-catenin degradation

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

Formation of LEF/TCF transcriptional complex

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

Downstream gene expression activated

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

Crosstalk between Wnts and other pathways