MONOGRAFIA UNIFRANZ

8/17/2019 MONOGRAFIA UNIFRANZ

1/17

UNIVERSIDAD MAYOR DE SAN ANDRESFACULTAD DE CIENCIAS FARMACEUTICAS Y BIOQUIMICAS

INSTITUTO DE SERVICIOS DE LABORATORIO DE DIAGNOSTICO EINVESTIGACION EN SALUD

LABORATORIO DE ENDOCRINOLOGÍA Y BIOMARCADORES

COMPARACIÓN DE LOS NIVELES SÉRICOS DE LA25 HIDROXIVITAMINA D EN PACIENTES CON

ENFERMEDAD RENAL CRÓNICA Y SU RELACIÓNCON EL HIPERPARATIROIDISMO SECUNDARIO

PROTOCOLO DE TESIS PARA OPTAR EL TITULO DE ESPECIALIDAD ENDIAGNOSTICO DE LABORATORIO EN SALUD

POR: SILVIA GIOVANA NAO COPANA

LA PAZ – BOLIVIA

2015


2/17

TABLA DE CONTENIDODEDICATORIA....................................................................................................... 2

I. INTRODUCCIÓN........................................................................... .............. .... 3

II. OBJETIVOS..................................................................................................... 5

1. Objeti ! "e#e$%&......................................................................................... .... 52. Objeti !' e'(e)*+i)!'.......................................................................... ............. 5

III. ,ARCO TEÓRICO....................................................................... .............. ... 6

IV. CONCLUSIONES........................................................................... ............. 13

V. RECO,ENDACIONES............................................................................. ....... 14

VI. BIBIOGRA-IA............................................................................................ 15


3/17


4/17

DEDICATORIA


5/17

I. INTRODUCCIÓNL% e#+e$ e/%/ $e#%& )$ #i)% ERC e' 3# ($!b&e % e e$"e#te /e '%&3/ (4b&i)% %)e$)% /e& 106 /e &% (!b&%)i # 3#/i%& O,S 2015 . N3e %' e i/e#)i%' #!' '3"ie$e# &% ($!"$e'i # /e &% ERC 8 3)9%' /e &%' )! (&i)%)i!#e' (3e/e# e't%$ $e&%)i!#%/%' /e+i)ie#)i% /e &% it% i#% D. L!' (%)ie#te' )!# ERC tie#e# 3#% t%'% e:)e()i!#%& e%&t% /e /e+i)ie#)i% "$% e /e it% i#% D 73e 'e %"$% % %4# ;' (!$ &% /i' i#3)i)%(%)i/%/ (%$% )!# e$ti$ 25< 9i/$!:i – it% i#% D e# &% +!$ % %)ti % &% 1 2

it% i#% D =i'% > ,%$ti# 200? .

L!' #i e&e' b%j!' #i e&e' '@$i)!' /e 25 9i/$!:i < it% i#% '!# %&t% e#te ($e %&e#te e#t$ (%)ie#te' )!# e#+e$ e/%/ $e#%& )$ #i)% e# t!/! e& 3#/!. L!' (%)ie#te' e# ($!)e'! /e

/i;&i'i' 8 (%)ie#te' t$%'(&%#t%/!' #! '!# 3#% e:)e()i # /%/! 73e &!' #i e&e'i#%/e)3%/% e#te /e 25< 9i/$!:i – it% i#% D 'e 9%# e#)!#t$%/! e# 9%'t% 3# 6 e (!b&%)i!#e' e3$!(e%' C! !&i#! G%&&ie#i B$%#)%))i! A$)i/i%)!#! Bi%#)9i >200 . Si# e b%$"! e' #e)e'%$i! /e't%)%$ 73e e'te ti(! /e e't3/i!' &!' 9%# $e%&i %/! e&3"%$e' /!#/e &%' )!#/i)i!#e' % bie#t%&e' '!# /i+e$e#te' 8 '!b$e t!/! /!#/e e& *#/i)e /e&3 3&t$% i!&et% 8 )!#'i/e$%#/! 73e e'te +%)t!$ j3e"% 3# (%(e& i (!$t%#te e# e& et%/e &% it% i#% D.

L% it% i#% D e' 3#% 9!$ !#% i (!$t%#te (%$% &% 9! e!'t%'i' i#e$%& 8 &% %+!$ %)i # 8 %#te#i ie#t! /e &!' 93e'!'. A/e ;' &% it% i#% D tie#e +3#)i!#e' ;'% (&i%' e# e& )3e$(! 73e % (&*e '3 (%(e& t$%/i)i!#%& e#te )!#!)i/! e# e73i&ib$i! i#

,%#'!!$ %bib G9%#i -%t i B%/$3//i# > ,%#'!!$ 2010 . E# &% i#'3+i)ie#)i%)$ #i)% /e+i)ie#)i% /e )%&)it$i!& )!#t$ib38e %& /e'%$$!&&! 8 &% ($!"$e9i(e$(%$%ti$!i/i' ! 'e)3#/%$i! t$%'t!$#!' /e &!' 93e'!' 8 e& et%b!&i' ! i#e$%& %&te$

C! !&i#! G%&&ie#i B$%#)%))i! A$)i/i%)!#! Bi%#)9i > Ve !&i 200 .

L%' i#'tit3)i!#e' e# '%&3/ #%)i!#%&e' /e(%$t% e#t%&e' $e"i!#%&e' 8 3#i e$'it%$i&&% %/!' % 3#i$'e % &!' e'+3e$ !' i#te#'i+i)%/!' (%$% /i+3#/i$ 8 %(&i)%$ &%' /i$e$e)! e#/%)i!#e' %)t3%&i %/%' (%$% /ete#e$ &% )$e)ie#te e(i/e i% /e /e+i)ie#)i% /e it%D e# (%)ie#te' $e#%&e' 8 '3' )!#'e)3e#)i%' )! ! 9i(e$(%$%ti$!i/i' ! 'e)3#/%$i! (!$ &!


6/17

t%#t! e& ($e'e#te e't3/i! tie#e )! ! !bjeti ! ($i#)i(%& )! (%$%$ &!' #i e&e' '@$i)!' /e &25 9i/$!:i – it% i#% D e# (%)ie#te' )!# e#+e$ e/%/ $e#%& )$ #i)% e# /i+e$e#te' et%$e#%&e' e# /i;&i'i' (%)ie#te' e# ($!)e'! /e /i;&i'i' 8 (%)ie#te' (!'t


7/17

II. OBJETIVOS

. O!"#$%&' (#)#*+,

2. O!"#$%&'- #- #/01%/'-


8/17

III. MARCO TEÓRICOL% it% i#% D %3#73e (!$ t$%/i)i # 'e %#tie#e e& #! b$e /e it% i#% '3't%#)i% !$/e !$i"e# e: "e#! 73e e' #e)e'%$i% (%$% &%' +3#)i!#e' it%&e' e# $e%&i/%/ &% it3# )! (&ej! 9!$ !#%& /e '*#te'i' %8!$it%$i% e#te e#/ "e#%. E& 'i'te % 9!$ !#%& /e

it% i#% D e't; +!$ %/! (!$ /i+e$e#te' et%b!&it!' 73e i#)&38e# /e'/e ($e)3$'!$e' !et%b!&it!' /e !$i"e# /iet@ti)! % 3#% &%$"% &i't% /e et%b!&it!' /e &% )%/e#% /e '

e#/ "e#% 9%'t% e& et%b!&it! ;' %)ti ! e& 1


9/17

9*"%/! 4')3&!' 8 "$%'%. L%' (e$'!#%' 73e 'e e:(!#e# (!)! %& '!& &%' /e (ie& !')3$% 8 !be'!' tie#e# %8!$ ($!b%bi&i/%/ /e '3+$i$ 9i(! it% i#!'i' D.E& $e)e(t!$ /e it% i#% D VDR 8 &% 1


10/17

1. C!#t$!& /e +%)t!$e' /e $ie'"! (%$% &% %&b3 i#3$i% Si'te % Re#i#% A#"i!te#'i#% A&/!'te$!#% SRAA L% it% i#% D (%$ti)i(%

$e"3&%)i # /e& SRAA.S3($i e &% t$%#')$i()i # /e &% $e#i#% /i' i#38e#/! &!' #i e&e' /e %#"i!te#'i#%)i$)3&%#te.

E+e)t! %#ti($!&i+e$%ti ! L% it% i#% D i#te$ ie#e /e +!$ % /i$e)t% e# &% ($!&/i+e$e#)i%)i # /e &!' (!/!)it!'. A/e ;' /i' i#38e '3 %(!(t!'i'. P!$ t!/! e&&! 'e '%be 73e ($e ie#e &% "&! e$3&!e')&e$!'i' 8 /i' i#38e &% %&b3 i#3$i%. T% bi@# 'e 9% /e')$ (!'ee )%(%)i/%/ %#ti($!&i+e$%ti % % #i e& /e& i!)%$/i!.

A)t3%)i # '!b$e &% )@&3&% b (%#)$e;ti)% ej!$%#/! '3 +3#)i!#% ie#t! 8 %3 e#tt!&e$%#)i% (e$i+@$i)% % &% i#'3&i#%.

2. -ib$!'i' I#te$'ti)i%& L% it% i#% D i#te$ ie#e e# e& /e'%$$!&&! /e &% +ib$!'i' i#t (!$ /i'ti#t%' *%'

Di' i#38e#/! &% e:($e'i # /e& TG-


11/17

ERC e# 9e !/i;&i'i' ! /i;&i'i' (e$it!#e%& 73e (3e/e )!#t$ib3i$ %4# ;' % &% /i' i#3)i #/e &!' #i e&e' /e )%&)it$i!&.

L% it% i#% D e' 'i#teti %/% e# &% (ie& +i"3$% 1. (!$ &% )!# e$'i # +!t!&*t/e9i/$!)!&e'te$!& e# ($! it% i#% DF &% )3%& (!$ i'! e$i %)i # te$ %& 'e )!# i

it% i#% DF 73e e' t$%#'(!$t%/% (!$ ($!te*#%' (&%' ;ti)%' DBP Vit% i# D Bi#P$!tei# 9%'t% e& 9*"%/! /!#/e )!# &% (%$ti)i(%)i # /e& )it!)$! ! C P2R1 'e ($!/3)e25


12/17

e:t$%$$e#%&e' )! ! % % (ie& ($ 't%t% # /3&!' &i#+;ti)!' )!&!# (;#)$e%'e'(i#%& )e$eb$! ! (&%)e#t% 9%8 %)ti i/%/ /e& e# i % 1<


13/17


14/17

IV. CONCLUSIONESU#% e $e)!&e)t%/% t!/% &% i#+!$ %)i # #e)e'%$i% (%$% $e%&i %$ e& ($e'e#9e !' $e%&i %/! &%' 'i"3ie#te' ($e"3#t%' /e i# e'ti"%)i #

• YC3;&e' '!# &!' #i e&e' /e &% 25 9i/$!:i – it% i#% D e# (%)ie#te' )!# i#'3+i)ie#)i

$e#%& )$ #i)% e/i/%' e# /i+e$e#te' (e$i!/!'W ($e9e !/i;&i'i' 9e !/i;&i'i' 8 (!'tt$%#'(&%#te $e#%&

• Y[3@ $e&%)i # tie#e &!' #i e&e' '@$i)!' /e &% 25 9i/$!:i – it% i#% D /e (%)i

$e#%&e' )!# e& 9i(e$(%$%ti$!i/i' ! 'e)3#/%$i!


15/17

V. RECOMENDACIONESL% 9i( te'i' (&%#te%/% e# e& ($e'e#te e't3/i! e' &% 'i"3ie#te

• E:i'te 3#% %$i%)i # /e &!' #i e&e' '@$i)!' /e &% 25 9i/$!:i – it% i#% D

(%)ie#te' )!# i#'3+i)ie#)i% $e#%& )$ #i)% e/i/%' e# /i+e$e#te' (e$i!/!'W ($e9e !/i;&i'i' 9e !/i;&i'i' 8 (!'tt$%#'(&%#te $e#%&.

• L% /i' i#3)i # /e &!' #i e&e' '@$i)!' /e &% 25 9i/$!:i – it% i#% D )!# &&e %

(%)ie#te' )!# e#+e$ e/%/ $e#%& )$ #i)% % 3#% %&t% ($e/i'(!'i)i # /e "e#e$%9i(e$(%$%ti$!i/i' ! 'e)3#/%$i! 8 !t$%' %&te$%)i!#e' et%b &i)%'.


16/17

VI. BIBIOGRAFIA

1. B%#/% ,. 2010 .“PREVALENC A !E " PERPARA# R$ ! %&$ %EC'N!AR $ EN PAC EN#E% %$&E# !$% A "E&$! (L % %) CEN#R$ !E ! AL % % “!R

CARL$% EL *AL!E &$N#EVER!E). +'AYA,' L 2 - 2 /. G3%8%73i& .E)3%/!$ U#i e$'i/%/ /e G3%8%73i&.

2. C! !&i#! ,. G%&&ie#i ,. B$%#)%))i! D. A$)i/i%)!#! T. Bi%#)9iVe !&i G. 200 . Vit% i# D $et%i#' %# i (!$t%#t $!&e i# t9e (%t9!"e#e'i'

%#%"e e#t !+ 'e)!#/%$8 98(e$(%$%t98$!i/i' i# )9$!#i) $e#%& +%i&3$e 0 NEP"R$L 5


17/17

?. R% !' R. A&); %$ R. Ote$! A. De -$%#)i')! A. > De& Pi#! ,. I (%)t! e)!# i)! /e& t$%t% ie#t! )!# it% i#% D e# (%)ie#te' )!# e#+e$ e/%/$e#%& )$ #i)%. Nefrolo a 52?

Documents

MONOGRAFIA UNIFRANZ