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Factori de risc pentru cu germeni multi-rezisten i n HAP, HCAP VAP
Folosirea antibioticelor n antecedente - p la 90 de zile Durata episodului curent de spitalizare n= Frecven a crescut a rezisten ei la antibiotice n comunitate sau n unitatea n care este internat
pacientul Prezen a factorilor de risc pentru HCAP:
- spitaliz = n antecedente (pn la 90 de zile) - d - pacien i cu spitaliz ri prelungite frecvente - pacien i din centre de ngrijire - terapii n ambulator (incluznd antibiotice) - membri de familie cu germeni multi-rezisten i
Patologii sau terapii imunosupresoare
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infiltrate = 0 puncte Infiltrate difuz = 1 punct Infiltrat localizat = 2 puncte
Progresia radiografiei pulmonare A
pulmonar) = 2 puncte AD
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Suspiciune de HAP, VAP sau HCAP
Obtinerea secretiilor de la nivelul tractului respirator pentrudiagnosticul microbiologic: culturi (cantitativ si semicantitativ) si microscopie
Initierea terapiei antibiotice empirice conform algoritmului si datelormicrobiologice locale (terapia NU va fi initiata daca suspiciunea de pneumonie
este minora SI microscopia este negativa)
Ziua 2&3: analiza raspunsului microbiologic & clinic(temperatura, leucocite, RX toracica, sputa, modificari hemodinamice, SO2)
Evolutie favorabila la 48-72 ore
Nu Da
Culturi - Culturi + Culturi - Culturi +
Investigatii pentru altipatogeni, complicatii, alt
diagnostic saualta localizare a infectiei
Modificarea schemei atbInvestigatii pentru alti
patogeni, complicatii, altdiagnostic sau
alta localizare a infectiei
Considera stopareaterapiei atb
DeescaladareTratament atb 7-8 z
Reevaluare
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Nu Da
Antibiotice cu spectru limitatMonoterapie
(tabel 3)
Antibiotice cu spectru largPoliterapie(tabel 4si 5)
Terapie antibiotica empiricaSuspiciune de HAP, VAP sau HCAP
Debut tardiv (> 5 zile) sauFactori de risc pentru GMR prezenti
Antibiotic recomandat
Streptococcus Pneumonie Haemophillus influenzae MSSA Bacili gram-negativ sensibili E.coli K. pneumonie Enterobacter spp. Proteus spp. Seratia
Ceftriaxona sau Levofloxacina, moxifloxacina sau ciprofloxacina sau Ampicilina/sulbactam sau Ertapenem
4*/C090//5:*:3
4*/C0:90C%0/*35:3
Germeni poten iali Schema terapeutic recomandat
Cefalosporine antipseudomonas (cefepime, ceftazidime) sau Carbapenemi antipseudomonas (imipenem, meropenem) sau
-% -lactamaze (piperacilin-tazobactam)
PLUS
Fluoroquinolone antipseudomonas (ciprofloxacina sau levofloxacina) sau Aminoglicozide (amikacina, gentamicina)
PLUS
Streptococcus Pneumonie Haemophillus influenzae MSSA Bacili gram-negativ sensibili E. coli K. pneumonie Enterobacter spp. Proteus spp. Seratia Germeni multirezistenti Pseudomonas aeruginosa Klebsiella pn. (ESBL +) Acinetobacter spp MRSA Legionella pneumophilla
Linezolid sau vancomicina
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-+ Piperacillintazobactam 4.5g / 6 h
Aminoglicozide
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Quinolone antipseudomonas
Levofloxacin 750 mg / zi Ciprofloxacin 400 mg / 8 h Vancomicina 15 mg / kg / 12 h Linezolid 600mg / 12h
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