日中合同シンポジウム―FAOPS2019 に向けて―...formation in various cell types. In addition, many cell biological phenomena, such as vesicular transport, cytoskeletal

第 95 回日本生理学会大会

54

企画シンポジウム 1 第 1 会場／Planned Symposium 1 Hall 1

大会 1 日目：3 月 28 日（水）／March 28 (Wed) 9:00～10:50

日中合同シンポジウム―FAOPS2019 に向けて―

China-Japan Joint Symposium (-Towards FAOPS2019-)

From Neuronal Circuits to Behavior

オーガナイザー・Organizer

渡部文子（東京慈恵会医科大学臨床医学研究所）

Watabe Ayako M.（Jikei Univ School of Medicine, Institute of Clinical Medicine and Research）

Minmin Luo（National Institute of Biological Sciences, Beijing and School of Life Sciences, Tsinghua University）

1PS-01AM-1 Reward processing by the dorsal raphe

Luo Minmin

National Institute of Biological Sciences, Beijing and Tsinghua University

1PS-01AM-2 情動行動を制御する扁桃体神経回路基盤

〇渡部文子

慈恵医大・医・臨床医学研

Neuronal circuits underlying the regulation of aversive valence in mice.

Watabe M Ayako

Jikei Univ. Sch Med, Chiba, Japan

1PS-01AM-3 アクティブゾーン・タンパク質の機能制御から捉える報酬行動の神経回路機構

〇大塚稔久, 萩原明

山梨大学・院医・生化学

Possible roles of the active zone proteins in neural circuits underlying reward activity in

mice

Ohtsuka Toshihisa, Hagiwara Akari

Dept Biochem, Grad Sch Med, University of Yamanashi, Yamanashi, Japan

The 95th Annual Meeting of the Physiological Society Meeting

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1PS-01AM-4 認知活動を制御する Ca2+シグナリング

〇尾藤晴彦, 金亮, 井上昌俊, 井ノ口霞, 横山達士, 酒井一輝, 宮澤優介, 石井雄

一郎, 岡村理子, ギャモンニコラス, 小針成敬, 近藤弥生, 坂本雅行, 藤井哉

東京大・院医・神経生化

Deciphering Ca2+-dependent signaling pathways underlying cognitive processes

Bito Haruhiko, Kim Ryang, Inoue Masatoshi, Inokuchi Kasumi, Yokoyama Tatsushi, Sakai

Kazuki, Miyazawa Yusuke, Ishii Yuichiro, Okamura Michiko, Gammon Nicholas, Kobari

Shigetaka, Kondo Yayoi, Sakamoto Masayuki, Fujii Hajime

Dept. Neurochem., Grad. Sch. Med., The Univ. of Tokyo, Japan

Aim and Scope

An essential function of the neural circuits is to generate optimal behaviors in response to diverse

environmental stimuli. A wide range of behavioral and physiological traits, including learning and memory,

motivation, reward, and emotion, can be regulated by various kinds of neurotransmitters and neuromodulators

at specific neuronal circuits. Dysfunction of these neuronal circuit underlies brain disorders such as depression,

drug addiction, and anhedonia. In the past decade, technological advances have enabled us to achieve high

resolution studies, including optogenetics, chemogenetics, and microendoscopic imaging, which will be

presented by the following four speakers in the present symposium. Therefore, I believe this symposium will

shed light on the fundamental roles of neuronal circuits in various aspects of behavioral control.


56



平滑筋生理学から病態生理学へのトランスレーション

Translation of smooth muscle physiology to pathophysiology


小林誠（山口大学大学院医学系研究科分子細胞生理学講座）

Kobayashi Sei（Department of Molecular and Cellular Physiology, Yamaguchi University, Graduate School of Medicine）

平野勝也（香川大学医学部自律機能生理学）

Hirano Katsuya（Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University）

1PS-02AM-1 遺伝子改変動物を用いた正常血圧維持におけるリン酸化 CPI-17-Thr38 の重要性の証明

〇堀正敏

東大・院農生研・獣医薬理

Proof of importance of phospho-CPI-17 at Thr38 in maintenance of normotensive pressure

using genetically modified mice

Hori Masatoshi

Dept. Vet. Pharmacol., Grad. Sch. Agri. & Life Sci., The Univ. of Tokyo, Tokyo, Japan

1PS-02AM-2 肺循環系におけるトロンビン受容体の生理学・病態生理学

〇平野勝也

香川大・医・自律機能生理

Physiology and pathophysiology of thrombin receptor in pulmonary circulation

Hirano Katsuya

Dept Cardiovasc Physiol, Fac Med, Kagawa Univ, Kagawa, Japan

1PS-02AM-3 消化管平滑筋収縮を調節する新しい分子機構の検討

〇江藤真澄, 北澤俊雄

トマスジェファソン大・医・生理

Novel elements that regulate Ca2+ sensitization force in GI smooth muscles

Eto Masumi, Kitazawa Toshio

Dept Mol Physiol & Biophys, Sidney Kimmel Medical College at Thomas Jefferson University,

Philadelphia, USA


57

1PS-02AM-4 血管攣縮と細胞遊走の両方を制御するシグナル経路の病態生理学

〇小林誠

山口大・院医・分子細胞生理学

Phathophysiology of the common signaling pathway regulating vasospasm and cell migration

Kobayashi Sei

Dept. Mol. Cell. Physiol., Yamaguchi Univ Grad. Sch. Med, Ube, Japan

Aim and Scope

The Ca2+-dependent reversible phosphorylation of 20 kDa myosin light chain was found to be a fundamental

mechanism of contraction of smooth muscle in mid 70s. Later, the critical role of the myofilament Ca2+

sensitivity in the regulation of smooth muscle contraction was recognized in late 80s, and the underlying

mechanisms were clarified in 90s. The inhibition of myosin phosphatase by the Rho kinase- or PKC-mediated

phosphorylation of CPI-17 or MYPT1, regulators of myosin phosphatase, plays a major role in regulating the

myofilament Ca2+ sensitivity. Now, a whole picture of the regulatory mechanisms of physiological contraction

of smooth muscle becomes clearer. These mechanisms could also be applicable to contraction and migration

of non-muscle cells. This symposium discuss further advancement in understanding the mechanisms of

smooth muscle contraction and recent progress in the translational research related to smooth muscle

contraction and cell migration. Eto discuss novel elements regulating the gastrointestinal smooth muscle

contraction. Hori discuss a role of CPI-17 in normotension. Hirano discuss a unique contractile property of

pulmonary artery and its role in pulmonary hypertension. Kobayashi discuss common mechanisms regulating

vasospasm and cell migration. This symposium will help audiences to overview current situation of research in

smooth muscle physiology and pathophysiology.


58



日本解剖学会連携シンポジウム細胞極性形成の分子機構

Joint Symposium with the Japanese Association of Anatomists

Molecular mechanisms of cell polarity formation


古瀬幹夫（生理学研究所細胞構造研究部門）

Furuse Mikio（Division of Cell Structure, National Institute for Physiological Sciences）

原田彰宏（大阪大学大学院医学研究科細胞生物学）

Harada Akihiro（Department of Cell Biology, Graduate School of Medicine, Osaka University）

1PS-03AM-1 哺乳類の上皮細胞極性における極性輸送の役割

〇原田彰宏

大阪大・院医・細胞生物

The role of polarized transport in the cell polarity of mammalian epithelial cells.

Harada Akihiro

Dept Cell Biol, Grad Sch Med, Osaka Univ, Suita, Japan

1PS-03AM-2 ショウジョウバエ視細胞における極性輸送の分子機構

〇佐藤明子

広島大・院総科・行動

Polarized transport in Drosophila photoreceptors

Satoh Kono Akiko

Grad. Sch Integ. Arts and Sci., Hiroshima Univ., Higashi-Hiroshima, Japan

1PS-03AM-3 上皮細胞極性における密着結合の裏打ちタンパク質 ZO-1 と ZO-2 の役割

〇古瀬幹夫 1,2, 大谷哲久 1,2

1:生理研・細胞構造, 2:総研大・生理科学

The role of tight junction-associated plaque proteins ZO-1 and ZO-2 in epithelial

polarity

Furuse Mikio1,2, Otani Tetsuhisa1,2

1:Div Cell Structure, NIPS, Okazaki, Japan, 2:Dept Physiol Sci, Sch Life Sci, SOKENDAI,

Okazaki, Japan


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1PS-03AM-4 微小管束化・架橋因子 MTCL1 による細胞極性制御機構

〇鈴木厚, 佐竹智子

横浜市大・院生命医・分子細胞

Cell polarity regulation by the microtubule crosslinking and stabilization factor, MTCL1

Suzuki Atsushi, Satake Tomoko

Mol Cell Biol Lab, Grad Sch Med Life Sci, Yokohama City Univ, Yokohama, Japan

Aim and Scope

Cell polarity plays fundamental roles in physiological functions of many organs, which include the polarized

distribution of membrane transporters in epithelial cells and the formation of axons and dendrites in neurons.

A signal transduction system containing atypical protein kinase C is known to be involved in cell polarity

formation in various cell types. In addition, many cell biological phenomena, such as vesicular transport,

cytoskeletal organization and cell adhesion, need to be properly regulated to complete functionally polarized

cells. However, the detailed molecular mechanisms behind these processes are still unclear. In this symposium,

the speakers will present their recent studies on cell polarity formation in epithelial and neural cells. The

symposium will help better understand molecular mechanisms of cell polarity, which forms the bases for

physiological functions of many organs.


60



全日本鍼灸学会連携シンポジウム東洋医学の科学的理解―筋性疼痛・運動障害の鍼治療メカニズムに主眼をおいて

Joint Symposium with the Japan Society of Acupuncture and Moxibustion

Scientific basis of the oriental medicine: acupuncture mechanism on muscle pain and motor

dysfunction


内田さえ（東京都健康長寿医療センター研究所自律神経機能研究室）

Uchida Sae（Department of Autonomic Neuroscience, Tokyo Metropolitan Institute of Gerontology）

野口栄太郎（筑波技術大学大学院技術科学研究科保健科学専攻鍼灸学コース）

Noguchi Eitaro（Graduate School of Technology & Science, Tsukuba University of Technology）

1PS-04AM-1 整形外科や運動疾患における鍼灸の適応疾患

〇近藤哲哉

関西医療大学・保医

Indication of acupuncture and moxibustion in musculoskeletal or motor disorders

Kondo Tetsuya

Faculty of Health Sciences, Kansai University of Health Sciences

1PS-04AM-2 遅発性筋痛モデルにおける筋性疼痛/痛覚過敏の筋性および神経性機構

〇水村和枝

中部大・生命健康・理学療法

Muscular and neural mechanisms of muscular pain/hyperalgesia in a rat model of

delayed onset muscle soreness (DOMS)

Mizumura Kazue

Dept Phys Ther, Coll Life Health Sci, Chubu Univ, Kasugai, Japan

1PS-04AM-3 筋膜痛の末梢神経・脊髄機構

〇田口徹

新潟医福大・理学療法

Peripheral and spinal mechanisms of pain in the muscle fascia

Taguchi Toru

Dept Phys Ther, Niigata Univ Health Walfare, Niigata, Japan


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1PS-04AM-4 鍼，漢方治療による鎮痛作用とそのメカニズム

〇砂川正隆

昭和大・医・生理・生体制御学

The analgesic effects and the mechanisms of acupuncture and Kampo medicine

Sunagawa Masataka

Dept. Physiol., Sch. Med., Showa Univ., Tokyo, Japan

1PS-04AM-5 体性運動反射に対する鍼の効果―振動誘発指屈曲反射を指標として

〇高倉伸有

東京有明医療大・鍼灸

Effect of acupuncture on vibration-induced finger flexion reflex in humans

Takakura Nobuari

Dept Acupunct, Tokyo Ariake Univ, Tokyo, Japan

Aim and Scope

"Acupuncture, a key component of “Oriental medicine” has been commonly used to ameliorate

musculoskeletal pain, movement disorders, etc. In recent years, many clinical trials about the evidence of

acupuncture therapy are conducted in many countries. Physiological basis about the acupuncture mechanism

on muscle pain and on motor dysfunctions have also been greatly progressed and accumulated.

The objective of this symposium is to understand the efficacy of acupuncture therapy by recent clinical trials,

and discuss about the latest basic research that explain the mechanism of clinical effects of acupuncture, by

inviting the leading scientists in this field. This symposium will focus to motor system disorders, such as

musculoskeletal pain, joint inflammation, movement disorders among the important clinical effects of

acupuncture.

From the field of physiology, newest findings about the mechanism of delayed onset muscle soreness

(DOMS) and myofascial pain, and physiological mechanism of oriental medicine including acupuncture and

kampo therapy, will be introduced. From the field of acupuncture, latest knowledge about the clinical efficacy

of acupuncture therapy, acupuncture effects on somato-motor reflex, and the issue of placebo needle, will be

introduced."


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脳機能改善を目指す運動療法の分子メカニズム

The understanding of molecular mechanisms underlying exercise therapy for the future of

neurorehabilitation


田中潤也（愛媛大学医学部分子細胞生理学）

Tanaka Junya（Dept Mol Cell Physiol, Grad Sch Med, Ehime Univ）

宮本修（川崎医科大学生理学２）

Miyamoto Osamu（Dept Physiol 2, Kawasaki Med Sch）

1PS-06AM-1 持久力、認知、意欲を高める運動効果

〇征矢英昭

筑波大・体育・運動生化学

Exercise regimen that enhances endurance, cognition and motivation

Soya Hideaki

Labo of Exercise Biochemistry, Faculty of Health and Sport Sciences, Univ of Tsukuba,

Tsukuba, Japan

1PS-06AM-2 ラットの軽度水泳ストレスによる不安・抑うつ様行動はトレッドミル運動により改善す

る

〇石田和人, 小池航平, 丸山彰子, 上西祐貴, 若山聡夢, 杉山佳隆

名古屋大・院医・リハビリ療法学

Anxiety/depressive-like behaviors by mild stress can be improved by treadmill exercise in

rats without the change of HPA axis.

Ishida Kazuto, Koike Kohei, Maruyama Akiko, Uenishi Yuki, Wakayama Satomu, Sugiyama

Yoshitaka

Dept Phys and Occup Ther, Grad Sch, Nagoya Univ, Nagoya, Japan

1PS-06AM-3 脳梗塞後リハビリテーションによる神経回路再編：リハビリテーション治療の可能性と

限界

〇岡部直彦, 中村恵美, 氷見直之, 宮本修

川崎医科大学・生理学２

Neural network remodeling induced by rehabilitative training after stroke: Effectiveness

and Limitations

Okabe Naohiko, Nakamura Emi, Himi Naoyuki, Miyamoto Osamu

2nd Dept Physiol, Kawasaki Med Sch, Okayama, Japan


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1PS-06AM-4 急性期運動療法の有効性と危険性の分子メカニズム：ラット脳梗塞・脳損傷モデルを用

いた研究

〇田中潤也, 阿部尚紀, 田口聖, 乙井天希

愛媛大・院医・分子細胞生理

Mechanisms underlying ameliorative and aggravating effects of physical exercise during

acute phase after ischemic and traumatic brain injury

Tanaka Junya, Abe Naoki, Taguchi Satoshi, Otoi Takaki

Dept Mol Cell Physiol, Grad Sch Med, Ehime Univ791-0

Aim and Scope

"Rehabilitation is the surest therapy for the patients with brain injury, and beneficial effects of physical exercise

on brain function are widely noticed nowadays. Exercise enhances neuroplasticity and improves functional

outcome in various brain injury models, partly through stimulating neurogenesis and/or anti-inflammatory

actions. However, the mechanisms underlying the beneficial effects are largely still to be elucidated.

The aim of this symposium is to present recent advances in this research field for fruitful discussion on

therapeutic benefits of exercise on the molecular and cellular basis. Four researchers will demonstrate updated

data on beneficial effects of exercise for the brain; Dr. Soya will talk about various effects of aerobic exercise

for the normal brain, especially for cognitive function, Dr. Ishida will talk about the improvement in

anxiety/depressive-like behaviors by treadmill exercise, Dr. Okabe will talk about effects of several types of

rehabilitation on axonal remodeling in the corticospinal tract in the post-stroke brain, and Dr. Tanaka will talk

about the effect of acute phase exercise after traumatic brain injury. Through the discussion, we will explore

the possibility of translation of research results to clinical application of the neurorehabilitation."


64



フィジオーム・システムバイオロジー推進特別委員会生体システムの構築と破綻の統合的理論研究

Committee for Promotion of Physiome and Systems Biology

Integrative and theoretical research on the architecture of biological system and its disorder


倉智嘉久（大阪大学大学院医学系研究科）

Kurachi Yoshihisa（Graduate School of Medicine, Osaka University

井上隆司（福岡大学医学部）

Inoue Ryuji（Fukuoka University School of Medicine）

1PS-02PM-1 分子標的薬の毒性予測法の開発

苅谷嘉顕, 〇鈴木洋史

東大病院・薬剤部

Development of method to predict the toxicity of molecular target drugs

Kariya Yoshiaki, Suzuki Hiroshi

Dept Pharmacy, The Univ of Tokyo Hospital, Tokyo, Japan

1PS-02PM-2 慢性腎臓病に対するマルチオミックス解析

〇内田信一

東京医科歯科大学・腎臓内科学

Multi-omics approaches to chronic kidney disease

Uchida Shinichi

Department of Nephrology, Tokyo Medical and Dental University

1PS-02PM-3 内耳の上皮が駆動するイオン輸送システムの成立機構

〇日比野浩 1, 任書晃 1, 倉智嘉久 2

1:新潟大・院医歯総合・分子生理, 2:大阪大・院医・薬・分子細胞薬理

Physiological architecture of ion transport system in the epithelial tissue of the inner ear

Hibino Hiroshi1, Nin Fumiaki1, Kurachi Yoshihisa2

1:Dept Mol Physiol, Sch Med, Niigata Univ, Niigata, Japan, 2:Div Mol Cell Pharm, Dept

Pharm Grad Sch Med, Osaka Univ, Osaka, Japan


65

1PS-02PM-4 心臓電気生理学的システムにおけるロバストネスと脆弱性：力学系理論の観点から

〇津元国親 1, 倉田康孝 2, 古谷和春 1,3, 倉智嘉久 1

1:阪大・院医・分子細胞薬理, 2:金沢医大・医・生理 II, 3:カリフォルニア大・医・生理

Robustness and vulnerability in cardiac electrophysiological system: from a viewpoint of

dynamical system theory

Tsumoto Kunichika1, Kurata Yasutaka2, Furutani Kazuharu1,3, Kurachi Yoshihisa1

1:Div Pharma, Grad Sch Med, Osaka Univ, Osaka, Japan, 2:Dept Physiol, Kanazawa Med

Univ, Ishikawa, Japan, 3:Dept Physiol, Univ California Davis, Davis, USA

1PS-02PM-5 多階層システム生理学モデリングプラットフォームとその応用

〇浅井義之 1, 安部武志 2, 北野宏明 2,3

1:山口大・院医・システムバイオ, 2:沖科技大・統合オープンシステム, 3:システムバイオ

ロジー研究機構

Platform for multilevel systems physiology and its applications

Asai Yoshiyuki1, Abe Takeshi2, Kitano Hiroaki2,3

1:Dept Sys Bioinf, Grad Sch Med, Yamaguchi Univ, Yamaguchi, Japan, 2:Integrated Open

Systems, OIST, Okinawa Japan, 3:SBI, Tokyo, Japan

Aim and Scope

An organism stems from an assembly of a variety of elements and their networks. This complex system serves

as a unit and exhibits highly sophisticated functions as responding to exogenous stimuli that would change

over time. Elucidation of the physiological architecture and coordination of the system as well as the triggers

and processes impairing its activity is crucial for basic and clinical medicine but has not yet been fully

addressed. In the symposium, five speakers who are integratively studying this key issue by theoretical and/or

experimental approaches will show their recent achievements and discuss next-generation life science based

on the systems biology.


66



日本リハビリテーション医学会連携シンポジウム食べること・動くことが人生を変える

Joint Symposium with the Japanese Association of Rehabilitation Medicine

Eating and Exercise changes your Life.


山内克哉（遠州病院リハビリテーション科）

Yamauchi Katsuya（Departments of Rehabilitation Medicine, Enshu Hospital）

上田陽一（産業医科大学医学部第１生理学）

Ueta Yoichi（Department of Physiology, School of Medicine, University of Occupational and Environmental Health）

1PS-03PM-1 「インターバル速歩＋乳製品摂取の生活習慣病改善効果」

〇増木静江 1,2, 内田晃司 1, 森川真悠子 1,2,3, 能勢博 1,2,3

1:信州大学・院医・スポーツ医科学, 2:信州大学バイオメディカル研究所, 3:熟年体育大学

リサーチセンター

Effects of milk product intake during interval walking training on lifestyle-related

diseases in older people

Masuki Shizue1,2, Uchida Koji1, Morikawa Mayuko1,2,3, Nose Hiroshi1,2,3

1:Dept Sports Med Sci, Shinshu Univ Sch of Med, Matsumoto, Japan, 2:Inst Biomed Sci,

Shinshu Univ, Matsumoto, Japan, 3:JTRC, Matsumoto, Japan

1PS-03PM-2 なぜ運動は必要か。健常者も障がい者もがん患者にも。

〇荒川英樹 1, 中村健 1, 田島文博 2

1:横浜市立大学・医学部・リハ科学, 2:和歌山県立医科大学・医学部・リハ医学

Why everyone must exercise: Benefits for the healthy, the specially challenged, and

cancer patients

Arakawa Hideki1, Nakamura Takeshi1, Tajima Fumihiro2

1:Dept of Rehabilitation Medicine, Yokohama City Univ, Yokohama, Japan, 2:Dept of

Rehabilitation Medicine, Wakayama Medical Univ, Wakayama, Japan

日本語/JP


67

1PS-03PM-3 鼻科生理学における Pannexin-1

〇大淵豊明 1, 上田陽一 2, 鈴木秀明 1

1:産業医科大学・医・耳喉頭頸, 2:産業医科大学・医・生理

Pannexin-1 in rhino-physiology

Ohbuchi Toyoaki1, Ueta Yoichi2, Suzuki Hideaki1

1:Dept Otorhinolaryngol-Head and Neck Surgery, Sch Med, Univ Occup Environ Health,

2:Dept Physiol, Sch Med, Univ Occup Environ Health

1PS-03PM-4 感覚刺激による嚥下反射の制御機構

〇海老原覚

東邦大・院医・リハ医学

Regulation of swallowing and cough reflexes by sensory stimuli

Ebihara Satoru

Dept. Reha. Med, Toho Univ Grad Sch of Med, Tokyo, Japan

Aim and Scope

我々の生活の基本は、食べる事で栄養をとり、そして動く事が可能になります。加齢とともに栄養面や運動

面の低下を来たし、様々な疾病を起因とした障害が発生し、嚥下障害、ロコモティブシンドローム、サルコ

ペニアへの対応などが必要となります。食事・運動に対する問題を生理学とリハビリテーション医学の両分

野で連携して対応していく事が学術的・臨床的に非常に重要であり、高齢化社会において更なる飛躍が望ま

れます。食べる事に関しては、リハビリテーション医学からは、嚥下機能のリハビリと生理学からは鼻粘膜

の生理機能についての議題、動く事に関しては、生理学からは水中インターバル速歩の応用とリハビリテー

ション医学からは高負荷リハビリの効果について両学会で活躍していただいている先生方と討論する事で、

今後の高齢化社会に対する新たなる視点や発想に基づく研究・臨床につながる有意義なシンポジウムになる

事を期待しています。

※本シンポジウムは全て日本語で開催されます。

This symposium will be held in Japanese.


68



第 95 回日本生理学会大会本部、日本生理学会教育委員会共同企画高大連携シンポジウム～垣根を乗り越えた協働へ～

Joint organization by the 95th Annual Meeting and

Education Committee of the Physiological Society of Japan

Cooperation between high schools and universities: We can go beyond the fence


平野勝也（香川大学医学部自律機能生理学）

Hirano Katsuya（Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University）

南沢享（東京慈恵会医科大学細胞生理学講座）

Minamisawa Susumu（Department of Cell Physiology, The Jikei University School of Medicine）

1PS-10PM-1 市民の科学リテラシーのための理科教育と諸学会の役割について

〇笠潤平

香川大学教育学部

Science Education for citizenship and the role of learned societies

Ryu Jumpei

Faculty of Education, Kagawa University

1PS-10PM-2 高等学校生物教育の現状と授業実践例の紹介

〇大野智久

都立国立高校生物学

Present state of biology education in high school and introduction of active learning in a

class

Oono Tomohisa

Tokyo Metropolitan Kunitachi High School

1PS-10PM-3 なぜ新たな「達成度試験」が高大連携に導入されるのか

〇坂本尚志

旭川医科大学入学センター

Why new "Achievement tests" are introduced for cooperation between high schools and

universities.

Sakamoto Takashi

Admission Center, Asahikawa Medical University.

日本語/JP


69

1PS-10PM-4 高校と医療系高等教育機関とにおける用語の違い

〇渋谷まさと

女子栄養大学短期大学部生理学

Differences between terminology in high school education and that used in health-

related higher education

Shibuya Masato

Department of Physiology, Kagawa Nutrition Junior College

1PS-10PM-5 誰のために何を伝えるか – 研究所の広報としてできること

〇坂本貴和子

生理学研究所研究力強化戦略室

For whom do I tell? – What can be done as Publicity at Researh Institute –

Sakamoto Kiwako

Department of Integrative Physiology, Research Enhancement Strategy Office, National

Institute for Physiological Sciences

Aim and Scope

1999 年の中央教育審議会の答申「初等中等教育と高等教育との接続の改善について」以降、高等学校と大

学との連携（高大連携）が積極的に進められるようになってきている。教育が生涯にわたり連続性を持つと

いう基本的な性格からは、高等学校教育と大学教育との間に垣根（断層）が存在することは不自然なことで

あり、その流れは歓迎されるべきものであるに違いない。しかし、個々の高等学校、大学の様々な取り組み

が点から線へ、さらにより大きな広がりをみせている例がある一方で、目指す方向性が必ずしも一致してい

るとは言えない例もみられる。本シンポジウムでは、特に高校における生物教育と大学における生理学教育

をより良く連携させ、学習者が生涯にわたり、生物学、生理学に興味を持って学ぶことを可能とする方策を

議論するため、企画した。高等学校教育、大学教育、大学入試、アウトリーチ活動に関わる演者による講演

と演者・来場者との総合討論を行い、相互理解と協調作業を進展させることを期待したい。




70


大会 2 日目：3 月 29 日（木）／March 29 (Thu) 8:30～10:20

日本理学療法士協会連携シンポジウム理学療法・リハビリテーションの生理的基礎メカニズムを探る

Joint Symposium with the Japanese Physical Therapy Association

Physiological mechanisms for physical therapy and rehabilitation


小峰秀彦（産業技術総合研究所自動車ヒューマンファクター研究センター生理機能研究チーム）

Komine Hidehiko（Automotive Human Factors Research Center, National Institute of Advanced Industrial Science and Technology）

金子文成（札幌医科大学保健医療学部理学療法学科）

Kaneko Fuminari（School of Health Science, Sapporo Medical University）

2PS-03AM-1 リウマチ性関節炎に伴う筋弱化のメカニズム：収縮機能改善のための標的因子

〇山田崇史

札幌医科大学保健医療学部

Cellular mechanisms behind skeletal muscle weakness in rheumatoid arthritis:

therapeutic targets for counteracting contractile dysfunction

Yamada Takashi

School of Health Sciences, Sapporo Medical University

2PS-03AM-2 脳磁図による理学療法の神経生理的基礎メカニズムの探索

〇菅田陽怜

大分大・福祉健康科学・理学療法

Investigation of basic neurophysiological mechanism for physical therapy by

magnetoencephalography

Sugata Hisato

Faculty of Welfare & Health Sci, Oita Univ, Oita, Japan

2PS-03AM-3 脳損傷後の運動機能回復に伴う可塑的変化

〇山本竜也 1,2, 村田弓 2, 肥後範行 2

1:つく国大・医療保健, 2:産総研・人間情報

Neural plasticity in motor recovery after brain lesion

Yamamoto Tatsuya1,2, Murata Yumi2, Higo Noriyuki2

1:Fac Med & Health Sci, Tsukuba Int Univ, Tsuchiura, Japan, 2:Human Informatics Res

Inst, AIST, Tsukuba, Japan

日本語/JP


71

2PS-03AM-4 心不全における交感神経過活性を担う中枢神経メカニズム

〇木場智史

鳥取大・医・統合生理

Central neural mechanisms underlying sympathetic hyperactivity in heart failure

Satoshi Koba

Div Integr Physiol, Tottori Univ Fac Med, Yonago, Japan

Aim and Scope

"高齢化社会の進行に伴い、様々な疾患の後遺症による心身の障害や加齢に伴う身体機能の低下等に対する

理学療法・リハビリテーションの重要性が高まっている。理学療法・リハビリテーションの効果は示されて

きているが、効果の裏付けや、より効果的な理学療法・リハビリテーションの開発を実施していくためには、

基礎的・生理学的な知見にもとづくエビデンスが必要となる。

本シンポジウムでは日本基礎理学療法学会と日本生理学会との連携により、理学療法・リハビリテーション

の基礎的メカニズムを探ることを目的とする。理学療法・リハビリテーションにおける様々な治療や介入に

対して基礎的、生理学的な視点を通すことによる、理学療法・リハビリテーションと生理学の相乗効果と発

展を期待する。"




72



電気化学会連携シンポジウム最先端電気化学プローブによる生命科学の開拓

Joint Symposium with the Electrochemical Society of Japan

Opening a new research filed by state-of-the-art electrochemical probes


日比野浩（新潟大学大学院医歯学総合研究科）

Hibino Hiroshi（Niigata University School of Medicine）

珠玖仁（東北大学大学院工学研究科）

Shiku Hitoshi（Graduate School of Engineering, Tohoku University）

2PS-04AM-1 走査型プローブ顕微鏡による細胞表面でのケミカルセンシング

〇高橋康史 1,2, 井田大貴 3, 周縁殊 1, 藤井拓人 4, 酒井秀紀 4, 珠玖仁 5, 福間剛士 1

1:金沢大院・理工, 2:JST さきがけ, 3:東北大院・環境, 4:富山大院・薬, 5:東北大院・工

Chemical sensing by using scanning probe microscopy

Takahashi Yasufumi1,2, Ida Hiroki3, Zhou Yuanshu1, Fujii Takuto4, Sakai Hideki4, Shiku

Hitoshi5, Fukuma Takeshi1

1:Div Elec. Eng. Computer Sci., Kanazawa Univ., Japan, 2:JST PRESTO, 3:Grad Sch Env,

Tohoku Univ., Japan., 4:Grad Sch Med Pharm Sci, Univ Toyama, Japan., 5:Grad Sch Eng,

Tohoku Univ, Japan.

2PS-04AM-2 走査型イオンコンダクタンス顕微鏡を用いた胃酸分泌細胞頂端膜形態のナノスケールダ

イナミクス解析

〇藤井拓人 1, 周縁殊 2, 清水貴浩 1, 高橋康史 2, 酒井秀紀 1

1:富山大・院薬・薬物生理, 2:金沢大・院理工・電子情報

Analysis of nanoscale dynamics of the apical membrane morphology in gastric parietal

cells using scanning ion conductance microscopy

Fujii Takuto1, Zhou Yuanshu2, Shimizu Takahiro1, Takahashi Yasufumi2, Sakai Hideki1

1:Dept Pharm Physiol, Grad Sch Med Pharm Sci, Univ Toyama, Toyama, Japan, 2:Div

Electr Eng & Comput Sci, Kanazawa Univ, Kanazawa, Japan


73

2PS-04AM-3 電気化学イメージングによる細胞塊、胚様体の機能評価

〇珠玖仁

東北大・院工

Characterization of multicellular spheroids spheroids and embryoid bodies by

electrochemical imaging

Shiku Hitoshi

Grad Sch Eng, Tohoku Univ, Sendai, Japan

2PS-04AM-4 生体内局所の薬物の濃度動態とその作用をリアルタイムモニターするシステムの創出

〇緒方元気 1,2, 浅井開 3, 佐野大和 4, 高井まどか 5, 楠原洋之 4, 栄長泰明 3,6, 日比

野浩 1,2

1:新潟大・院医歯総合・分子生理, 2:新潟大・超域学術院, 3:慶應大・理工・化学, 4:東京

大・院薬・分子薬物動態, 5:東京大・院工・バイオエンジニアリング, 6:JST-ACCEL

A microsensing system for the in vivo real-time detection of local kinetics of drug and its

physiological relevance.

Ogata Genki1,2, Asai Kai3, Sano Yamato4, Takai Madoka5, Kusuhara Hiroyuki4, Einaga

Yasuaki3,6, Hibino Hiroshi1,2

1:Dept Mol Physiol, Sch Med, Niigata Univ, Niigata, Japan, 2:Ctr for Transdisciplinary

Res, Niigata Univ, Niigata, Japan, 3:Dept of Chem, Fac of Sci and Tech, Keio Univ,

Yokohama, Japan, 4:Lab of Mol Pharmacokinet, Grad Sch of Pharmaceut Sci, Univ of

Tokyo, Tokyo, Japan, 5:Dept of Bioeng, Grad Sch of Eng, Univ of Tokyo, Tokyo, Japan,

6:JST-ACCEL, Yokohama, Japan

Aim and Scope

Electrochemical techniques have been used to measure concentrations of chemical compounds and their

dynamics in a variety of engineering fields. In biological and medical studies as well, carbon microelectrodes

have been applied to the brain in order to pursue neurotransmitter release. Recently, development of

materials for electrodes and methodologies for electrochemical detection has been accelerated; the

achievement allows us to stably monitor a number of substances. In this symposium, we will not only show

state-of-the-art electrochemical probes and their applications to detection of biological active substances and

drugs in vitro or in vivo but also discuss perspectives of interdisciplinary researches using these technologies

in life science.


74



神経幹細胞の可塑性と異常

The Molecular Basis for Plasticity and Dysregulation of the Neural Stem Cells


松井秀樹（岡山大学大学院医歯薬学総合研究科細胞生理学）

Matsui Hideki（Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Physiology）

岡野栄之（慶應義塾大学医学部生理学教室）

Okano Hideyuki（Keio University, School of Medicine, Department of Physiology）

2PS-05AM-1 神経系のエピジェネティクスとその変遷

〇中島欽一

九大院医・応用幹・基盤幹

Epigenetic research on the nervous systems and its transition

Nakashima Kinichi

Dep Stem Cell Biol Med, Grad Sch Med Sci, Kyushu Univ, Fukuoka, Japan

2PS-05AM-2 YAP-TAZ による神経細胞から神経幹細胞への限定的脱分化制御

〇藤村篤史

岡山大・医歯薬学・細胞生理

Lineage-restricted dedifferentiation of neurons by transient expression of YAP-TAZ

Fujimura Atsushi

Dept Physiol, Grad Sch Med, Dent, Pharm, Okayama Univ, Okayama, Japan

2PS-05AM-3 神経幹細胞と脳腫瘍幹細胞の差についての最新の知見

〇道上宏之 1,2, 藤村篤史 2, 松下博昭 2, 西木禎一 2, 松井秀樹 2

1:岡山大学中性子医療研究センター, 2:岡山大学・院医歯薬・生理

The function of brain turmo stem cell

Michiue Hiroyuki1,2, Fujimura Atsushi2, Matsushita Hiroaki2, Nishiki Tei-ichi2, Matsui

Hideki2

1:Neutron Therapy Research Center, Okayama Univ, Okayama, Japan, 2:Dept Physiol,

Grad Sch Med, Okayama Univ, Okayama ,Japan


75

2PS-05AM-4 ヒト多能性幹細胞を用いた神経発生・疾患モデリング

〇岡野栄之, 今泉研人

慶應義塾大学・医学部・生理学

Modelling human neurodevelopment and neurological diseases using human pluripotent

stem cells

Okano Hideyuki, Imaizumi Kent

Department of Physiology, Keio University School of Medicine, Tokyo, Japan

Aim and Scope

Neural tissues are composed of well-differentiated and functionally developed cells. To maintain this organized

system, neural stem cells should control the differentiation steps spatially and temporally, and neurons must

sustain the differentiated state and avoid their spontaneous dedifferentiation. In this symposium, we discuss

the molecular mechanisms by which regulate differentiated/undifferentiated states in the central nervous

system. First, we introduce up-to-date knowledge about the epigenetic control of the cellular plasticity of

neural stem cells. Specifically, we will learn how neural stem cells can sensitize to the cues of differentiation.

Second, we move to a neuron part: neurons were once believed to firmly sustain their differentiated state, but

recently shown to be dedifferentiated by several signals such as Hippo pathway or oncogenic signals. Then, we

focus on glioma biology as a dysregulated state of differentiation. Particularly, we will discuss the molecular

mechanism by which distinguish the glioma stem cells from normal neural stem cells. Finally, we will learn the

leading-edge insights into the molecular control of neuronal differentiation, based on the studies of multi-

potent stem cells.


76



若手の会運営委員会企画シンポジウム理想的な研究環境作り～研究室の立ち上げと知識マネジメント～

Committee for Young Physiologists

Making ideal research environment -Lab launching and knowledge management-


井手正和（国立障害者リハビリテーションセンター研究所脳機能系障害研究部）

Ide Masakazu（Research Institute of National Rehabilitation Center for Persons with Disabilities）

中島龍一（韓国科学技術研究院（ＫＩＳＴ）機能コネクトミクス研究センター）

Nakajima Ryuichi（Center for Functional Connectomics, KIST））

2PS-06AM-1 研究室立ち上げにおける様々な困難と工夫

〇和田真

国リハ研・脳機能部・発達障害

My experiences of difficulties in launching a laboratory

Wada Makoto

Dev Disorders Sect, Dept Brain Rehab, Res Inst of NRCD, Tokorozawa, Japan

2PS-06AM-2 研究室生活の楽しみ方

〇村山正宜

理研 BSI 行動神経生理

How I enjoy my laboratory life

Murayama Masanori

Lab for Behavioral Neurophysiology, Brain Science Institute RIKEN

2PS-06AM-3 研究室のナレッジマネジメント

〇梅本勝博

北陸先端大・院先端科学技術

Knowledge Management for Start-Up Laboratories

Umemoto Katsuhiro

Sch Knowledge Sci, JAIST, Ishikawa, Japan

日本語/JP


77

Aim and Scope

"将来、独立した研究室を持ち、独自の着想のもと自由に研究を行なうことは、多くの若手研究者にとっての

夢である。しかし、それまで主に実験を行なうことで能力を発揮してきた研究者が、研究室主宰者としての

役割を与えられた際に、多かれ少なかれ困難な状況を経験することは想像に難くない。とりわけ、研究環境

の構築、研究費の獲得、人材育成、組織作り等でリーダーシップを発揮して、グループ全体である一つの目

標に進んで行くには、それまでの研究とは全く別の能力が必要とされる。

本シンポジウムでは、気鋭の若手研究者が、研究室の立ち上げで苦労した点や、それをいかに乗り越えたか

といった対処法など、研究室運営の実践を紹介することに加え、知識経営を中心とした組織マネジメントの

重要性について議論を展開する。これにより、研究室を持とうとしている研究者に限らず、現在研究室を運

営する研究室主宰者にとって、活性の高い、楽しい研究室作りのために役立つことを狙いとする。"




78



希少糖 D-アルロースの魅力：心も体も癒す糖

Fascination of “D-allulose”; a rare sugar which heals us physically and spiritually


矢田俊彦（自治医科大学医学部生理学）

Yada Toshihiko（Jichi Medical University, Faculty of Medicine, Department of Physiology）

德田雅明（香川大学医学部細胞情報生理学）

Tokuda Masaaki（Kagawa University, Faculty of Medicine, Department of Cell Physiology）

2PS-09AM-1 Naturally Occurring Rare Sugars are Free Radical Scavengers and Can Ameliorate

Endoplasmic Reticulum Stress

Mooradian D Arshag1, Haas J Michael1, Onstaed-Haas Luisa1, Tani Yuma2, Iida Tetsuo2,3,

Tokuda Masaaki3

1:Department of Medicine; University of Florida College of Medicine; Jacksonville, FL,

USA, 2:Matsutani Chemical Industry, CO., LTD, Hyogo, Japan, 3:Department of Cell

Physiology, Faculty of Medicine, Kagawa University, Kagawa, Japan

2PS-09AM-2 Rare sugars: natural zero calorie sweeteners in relation to obesity and diabetes to change

our life style

Hossain Akram, Yamaguchi Fuminori, Kamitori Kazuyo, Dong Youyi, Tsukamoto Ikuko,

Iida Tetsuo, Tokuda Masaaki

Dept. of Physiology, Faculty of Medicine, Kagawa University

2PS-09AM-3 D-allulose と脂質代謝

〇永田保夫

長崎大・産学官連携戦略本部

D-Alluose and Lipid Metabolism

Nagata Yasuo

Center for Industry, University and Government Cooperation, Nagasaki University


79

2PS-09AM-4 希少糖 D-Allulose は GLP-1 分泌と求心性迷走神経を介した脳作用により過食、肥満、

糖尿病を改善する

〇岩崎有作, 矢田俊彦

自治医大・医・統合生理

Rare sugar D-allulose ameliorates arrhythmic-overeating, obesity and diabetes via GLP-

1 and vagal afferents

Iwasaki Yusaku, Yada Toshihiko

Dept Physiol, Jichi Med Univ, Tochigi, Japan

Aim and Scope

Rare sugars are defined as monosaccharides and their derivatives which are rarely existing in nature. Many of

rare sugars have become available in a large amount after the discovery of mass production method from

abundantly-existing sugars such as glucose, fructose and sucrose. This allows us to use these rare sugars to

seek for their basic characters and functions in various scientific fields including medicine, agriculture and

food science. D-allulose (also called D-psicose) is a hexose and one of rare sugars. D-allulose has characters

similar to fructose, and has zero-calorie and 70% sweetness of sucrose. Functional studies in the last 2 decades

have shown that D-allulose may be beneficial for human health, especially for prevention and treatment of life-

style related diseases such as diabetes mellitus and obesity. Recent study also elucidated that D-allulose may

be active to psychological disorders. Multidisciplinary challenges elucidated the mechanisms which underlie

these functions, and various novel and attractive functions have been discovered. In this symposium, we try to

introduce our recent findings of D-allulose and discuss its potential for foods and medicines.


80



カルシウムシグナル伝達の新潮流とその生理的意義

Novel regulation of Ca2+ signaling in physiology


渡邊泰男（昭和薬科大学薬理学研究室）

Watanabe Yasuo（Showa Pharmaceutical University, Department of Pharmacology）

山口文徳（香川大学医学部細胞情報生理学）

Yamaguchi Fuminori（Kagawa University, Faculty of Medicine, Department of Cell Physiology）

2PS-02AM-1 S100 タンパク質の新規標的分子とその生理機能

〇山口文徳 1, 徳光浩 2, 德田雅明 1

1:香川大・医・細胞情報生理, 2:岡山大・自然科学研・生命医工

Identification of novel targets of S100 proteins and consequent physiological phenomena

Yamaguchi Fuminori1, Tokumitsu Hiroshi2, Tokuda Masaaki1

1:Dept Cell Physiol, Fac of Med, Kagawa Univ, Kagawa, Japan, 2:Div Med Bioeng, Grad

Sch Nat Sci Tech, Okayama Univ, Okayama, Japan

2PS-02AM-2 CaM キナーゼカスケードの自己リン酸化およびフィードバックリン酸化による新たな

調節メカニズム

〇徳光浩

岡山大・院自然科学・生命医用工

Molecular mechanism of calmodulin-kinase cascade regulated by autophosphorylation

and feedback phosphorylation

Tokumitsu Hiroshi

Div Med Bioeng, Grad Sch Nat Sci & Tech, Okayama Univ, Okayama, Japan

2PS-02AM-3 IRBIT は、細胞内の Ca2+シグナルと pH 環境とを統合的に調節する。

〇水谷顕洋 1, 河合克宏 2, 安東英明 2, 山田秀臣 3, 関常司 3, 御子柴克彦 2

1:昭和薬科大学・薬物治療学, 2:理科学研究所・脳科学総合研究せンター・発生神経生物

研究室, 3:東京大学・腎臓内分泌内科

IRBIT, an integrative regulator of intracellular Ca2+ signals and pH environment

Mizutani Akihiro1, Kawa-ai Katsuhiro2, Ando Hideaki2, Yamada Hideomi3, Seki George3,

Mikoshiba Katsuhiko2

1:Dept. Pharmacotherap. Showa Pharmaceutical Univ. Machida, Japan, 2:Lab. for

Developmental Neurobiology, BSI, RIKEN, Wako, Japan, 3:Div. of Nephrology and

Endocrinology, The Univ. of Tokyo, Tokyo, Japan


81

2PS-02AM-4 酸化ストレス制御型 CaM 受容タンパク質とその生理機能

〇渡邊泰男

昭薬大・薬理

Redox dependent regulation of CaM-pedendent enzymes and its physiological

significance

Watanabe Yasuo

Dept Pharmacol, Showa Pharmaceut. Univ, Tokyo, Japan

Aim and Scope

Calcium signaling is crucial for several aspects of cellular functions in most cells. Inside cells, changes in Ca2+

levels are often sensed by Ca2+-binding proteins. S100 protein family, containing two Ca2+ binding domains,

is composed of at least 25 members and involved in numerous important processes. However, its precise

physiological roles are not fully elucidated because the target proteins of individual S100 proteins have not

been completely identified. Meanwhile, the actions of calmodulin (CaM), containing four Ca2+ binding

domains, are well characterized and mediated by its association with specific target proteins, some of which

are known as CaM-binding proteins, such as Ca2+ /CaM dependent protein kinases (CaMKs). This session

will provide participants with discussions on the most up-to-date research on novel regulation of Ca2+ signal

transduction in physiology. Areas of focuses include identification of individual S100 proteins targets and

consequent physiological phenomena, molecular mechanism of CaMKs cascades and a diverse array of

intracellular regulatory functions, novel CaMKs binding partner and new insight into neuronal function, and

redox dependent regulation of CaMKs and its physiological significance.


82



日豪合同シンポジウム―FAOPS2019 に向けて― 骨格筋、心筋、平滑筋における Ca 動態、情報伝達の

生理学/病態生理学の最近の話題

Australia-Japan Joint Symposium (-Towards FAOPS2019-)

Recent advances in physiology/pathophysiology of Ca dynamics and signaling

in skeletal, cardiac and smooth muscles


井上隆司（福岡大学医学部生理学）

Inoue Ryuji（Department of Physiology, Fukuoka University School of Medicine）

Bradley Launikonis（The University of Queensland）

2PS-01PM-1 様々な催不整脈性 RyR2 変異が心筋細胞および非心筋細胞の Ca2+動態におよぼす影響

〇呉林なごみ

順天堂大・医・薬理

Divergent effects of disease-linked mutations in RyR2 on Ca2+ dynamics in cardiac and

non-cardiac cells

Kurebayashi Nagomi

Dept Pharmacol, Fac Med, Juntendo Univ, Tokyo, Japan

2PS-01PM-2 カルシウムイメージングと形態学の融合による平滑筋ペースメーカー細胞の同定

〇橋谷光 1, ラングリチャード 2, 三井烈 1

1:名古屋市立大・院医・細胞生理, 2:モナッシュ大・生理

Linking Ca2+ dynamics with morphological aspects to identify smooth muscle pacemaker

cells

Hashitani Hikaru1, Lang Richard2, Mitsui Retsu1

1:Dept Cell Physiol, Grad Sch Med Sci, Nagoya City Univ, Nagoya, Japan, 2:Dept Physiol,

Monash Univ, Melbourne, Australia

2PS-01PM-3 肺動脈性肺高血圧症における Ca2+感受性受容体と PDGF シグナル

〇山村彩, 佐藤元彦

愛知医大・医・生理

Ca2+-sensing receptor and PDGF signals in pulmonary arterial hypertension

Yamamura Aya, Sato Motohiko

Dept Physiol, Aichi Med Univ, Nagoya, Japan


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2PS-01PM-4 Ca2+ handling in human skeletal muscle with ryanodine receptor and orai1 variants

Launikonis S Bradley

School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia

Aim and Scope

Because of its ancient origin in the evolution, Ca2+ occupies a preeminent position in cell biology. Ca2+

exquisitely controls an enormous range of biological functions in all aspects of the life, as a highly versatile

signal/regulator of cellular dynamics, homeostasis and remodeling. Thus, dysregulation of Ca2+-mediated

signal transduction leads to a broad spectrum of disorders and diseases. This symposium revisits this well-

established but still challenging field with most recent topics including; emerging players regulating skeletal

muscle contraction; arrhythmogenic mutations responsible for cardiac diastolic Ca leak; exciting attempts of

directly correlating morphological information obtained by FIB-SEM tomography with Ca2+ dynamics in

smooth muscle pacemaker; and finally, newly-uncovered Ca-dependent pathomechanisms for pulmonary

arterial hypertension.


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[JSPS 科研費基盤研究 S 「メカノメディスン」／ AMED-CREST/PRIME「メカノバイオ」領域協賛]

メカノメディスン

[In association with JSPS Scientific Research (S): Mechanomedicine

AMED-CREST/PRIME: Mechanobiology]

Mechanomedicine


成瀬恵治（岡山大学大学院医歯薬学総合研究科システム生理学）

Naruse Keiji（Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences）

曽我部正博（名古屋大学大学院・医学系研究科・メカノバイオロジー・ラボ）

Sokabe Masahiro（Mechanobiology Lab Nagoya University Graduate School of Medicine）

2PS-02PM-1 メカノメディスン

〇成瀬恵治

岡大・院医歯薬・システム生理学

Mechanomedicine

Naruse Keiji

Dept Cardiovascular Physiol, Grad Sch Med Dent Pharm Sci, Okayama Univ, Okayama,

Japan

2PS-02PM-2 Mkx を介した腱・靭帯のメカノシグナルの調節機構

〇浅原弘嗣 1,2,3, 片岡健輔 1, 伊藤義晃 1, 千葉朋希 1, 松島隆英 1

1:東京医歯大・院医・システム医学, 2:CREST, AMED, 3:Dept Molecular Med, The

Scripps Research Institute

Mechano-signal pathway regulating tendon and ligament via Mkx

Asahara Hiroshi1,2,3, Kataoka Kensuke1, Ito Yoshiaki1, Chiba Tomoki1, Matsuhima Takahide1

1:Dept Systems BioMed, TMDU, Tokyo, Japan, 2:CREST, AMED, 3:Dept Molecular Med,

The Scripps Research Institute

2PS-02PM-3 骨恒常性とメカノメディスン

〇中島友紀

医歯大・院医歯学総合・分子情報

Bone homeostasis and Mechanomedicine

Nakashima Tomoki

Dep Cell Signaling, TMDU, Tokyo, Japan


85

2PS-02PM-4 間質多様性と硬さの観点から腫瘍を理解するメカノパソロジーの重要性

〇榎本篤

名古屋大・院医・病理

Importance of mechanopathology that sees cancer from the perspective of stroma

diversity and stiffness

Enomoto Atsushi

Dept Pathol, Grad Sch Med, Nagoya Univ, Japan

2PS-02PM-5 呼吸器のメカノメディスン

〇伊藤理

愛知医大・呼吸器アレルギー内科

Mechanomedicine of the lung

Ito Satoru

Respir Med Allergology, Aichi Med Univ, Nagakute, Japan

2PS-02PM-6 メカノバイオロジーにおける喫緊の課題

〇曽我部正博

名古屋大・院医・メカノバイオ

Urgent problems to be solved in mechanobiology

Sokabe Masahiro

Mechanobiology Lab, Nagoya Univ Grad Sch Med, Nagoya, Japan

Aim and Scope

"Mechanical stress sensing and response mechanisms contribute to the regulation of various physiological

functions, including cell division, developmental processes, and organ-specific functions, on a broad space-

time scale. Evidence has accumulated that the collapse of these mechanisms is involved in various

pathologies.

Mechanomedicine is an emerging field to understand the etiology of diseases by way of mechanobiology at

the molecular, cellular, tissue, organ, and individual levels and to apply the gained knowledge and technologies

to cure diseases.

This seminar provides an overview of basic medical research on mechanobiology, followed by lectures on

mechanomedicine, specifically focusing on its application in reproductive medicine, bone research, tendon

regeneration, the respiratory system, and tumorigenesis."


86



日本生物物理学会連携シンポジウム生物物理学的手法による熱産生・応答の生理学研究の新展開

Joint Symposium with the Biophysical Society of Japan

Cutting-edge interdisciplinary physiology for heat production and sensing


福田紀男（東京慈恵会医科大学）

Fukuda Norio（The Jikei University School of Medicine）

鈴木団（大阪大学蛋白質研究所）

Suzuki Madoka（Inst Protein Res, Osaka Univ, Osaka, Japan）

2PS-04PM-1 光熱変換顕微鏡を用いた温度センシングの一細胞解析

〇大山廣太郎 1,2, Zeeb Vadim3, 新井智実 2, 伊藤秀城 4,5, 新谷正嶺 6, 鈴木団 1,7, 福田

紀男 2, 石渡信一 4

1:科学技術振興機構・さきがけ, 2:慈恵医大・細胞生理, 3:理論実験生物物理研・ロシア科

学アカデミー, 4:早大・先進理工・物理, 5:シンガポール科学技術研究庁・医学生物学研, 6:

東京大・理学・物理, 7:大阪大・蛋白研

Single-cell analysis of temperature-sensing mechanisms under a photo-thermal

conversion microscope

Oyama Kotaro1,2, Zeeb Vadim3, Arai Tomomi2, Itoh Hideki4,5, Shintani A Seine6, Suzuki

Madoka1,7, Fukuda Norio2, Ishiwata Shinichi4

1:PRESTO, JST, Saitama, Japan, 2:Dept Cell Physiol, Jikei Univ Sch Med, Tokyo, Japan,

3:ITEB, Russian Acad Sci, Pushchino, Russia, 4:Dept Phys, Fac Sci Eng, Waseda Univ,

Tokyo, Japan, 5:Inst Med Biol, A*STAR, Singapore, Singapore, 6:Dept Phys, Sch Sci, Univ

Tokyo, Tokyo, Japan, 7:Inst Protein Res, Osaka Univ, Osaka, Japan

2PS-04PM-2 変異 1 型リアノジン受容体における分子動力学シミュレーションとカルシウムイメー

ジング

〇山澤徳志子

慈恵医大・分子生理

Analysis of disease mutants of type 1 ryanodine receptor by molecular dynamics

simulation and calcum imaging

Yamazawa Toshiko

Dept Mol Physiol, Jikei Univ Sch Med, Tokyo, Japan


87

2PS-04PM-3 温度応答性分子による生体イメージングの基礎研究

〇唐澤悟 1, 青木伊知男 2, 村山周平 2, 臼井一晃 3

1:昭和薬科大・薬・分析化学, 2:量子研, 3:九大院薬

Tumor Bio-imaging Using Thermo-responsive Molecules

Karasawa Satoru1, Aoki Ichio2, Murayama Shuhei2, Usui Kazuteru3

1:Showa Pharm. Univ. Tokyo Japan, 2:QST, Chiba Japan, 3:Kyushu Univ. Fukuoka Japan

2PS-04PM-4 数理と実験でせまる体内時計が温度に影響されない仕組み

〇黒澤元

理研・望月理論生物学研究室

Theoretical and experimental approach for mechanisms of temperature compensation in

circadian clocks

Kurosawa Gen

Theoretical Biology Lab, RIKEN

2PS-04PM-5 熱産生の生理学のための 1 細胞温度イメージング

〇鈴木団 1,2

1:阪大・蛋白研, 2:JST さきがけ

Single-cell thermometry under optical microscope for the physiology of thermogenesis

Suzuki Madoka1,2

1:Inst Protein Res, Osaka Univ, Osaka, Japan, 2:PRESTO, JST, Saitama, Japan

Aim and Scope

Physiologists have investigated heat for decades. While it is well established that heat plays a pivotal role in the

maintenance of homeostasis in mammals, recent studies have revealed its novel functions in various

physiological processes, such as circadian rhythm and muscular contraction. This symposium brings together

top scientists across Japan applying cutting-edge biophysical technologies in various fields of physiology. We

will discuss the novel roles of heat in molecular and cellular functions, as well as the potential applications of

endogenous heat production for advanced therapies, such as the following: 1) molecular dynamics of ion

channels, 2) single-cell fluorescence microscopy, 3) drug delivery by nanomaterials, and 4) mathematical

model analyses.


88



睡眠・覚醒の制御と機能をどうとらえるのか？

How do we understand the control and function of sleep/arousal?


勢井宏義（徳島大学大学院医歯薬学研究部統合生理学分野）

Sei Hiroyoshi（Department of Integrative Physiology, Institute of Biomedcal Sciences, Tokushima University Graduate School）

小山純正（福島大学共生システム理工学類人間支援システム専攻）

Koyama Yoshimasa（Department of Science and Technology，Fukushima University）

2PS-05PM-1 睡眠障害モデルマウスとその表現系

〇近久幸子, 勢井宏義

徳島大・院・医歯薬学・統合生理

A mouse model of sleep disturbance and their phenotype

Chikahisa Sachiko, Sei Hiroyoshi

Dept Integ Physiol, Inst Biomed Sci, Tokushima Univ Grad Sch, Tokushima, Japan

2PS-05PM-2 レム睡眠中の自律神経系の変動を引き起こすメカニズム

〇小山純正

福島大学・共生システム理工

Mechanisms for inducing fluctuation of autonomic nervous system during REM sleep

Koyama Yoshimasa

Dept Sci Technol, Fukushima Univ, Fukushima, Japan

2PS-05PM-3 大脳辺縁系と覚醒系を結ぶオレキシンの役割

〇櫻井武

筑波大学・医学医療系/WPI-IIIS

Role of orexin as a link between the limbic system and arousal

Sakurai Takeshi

WPI-IIIS/Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan


89

2PS-05PM-4 個人の睡眠･覚醒リズム特性と社会時刻との不調和による心身の異常とその病態生理

〇三島和夫

国立精神・神経医療研究センター

Mental and physical disorders attributable to desynchronization between social time

requirements and an individuals sleep-wake rhythm

Mishima Kazuo

National Center of Neurology & Psychiatry, Tokyo, Japan

Aim and Scope

The Japanese sleeping time is reported to be shorter compared to the international one. Also, recently, as the

concept of "sleep debt" is well discussed in the field of sleep medicine, evidence has been accumulated that

insufficient sleep causes mentally and/or physically impaired state in both animal and human. Therefore, in

this symposium, approaching the control mechanism of sleep/wakefulness, we will share the recent findings

from four speakers; 1) a pathophysiological mechanism in sleep disorder model mice, 2) intracerebral neuronal

activity controlling fluctuation of autonomous system occurring during sleep, 3) "sleep debt" in human and its

influence, 4) arousal mechanism related with orexinergic neurons linked wih emotion. Sharing the results of

these recent studies, I would like to make it an opportunity to consider the physiological function of

sleep/wakefulness.


90



日本薬理学会連携シンポジウムセンシングチャネル研究へのセンシブルなアプローチ：生理学から薬理学へ

Joint Symposium with the Japanese Pharmacological Society

Sensible approaches for sensing channels: From physiology to pharmacology


檜山武史（基礎生物学研究所）

Hiyama Takeshi（National Institute for Basic Biology）

中川貴之（京都大学医学部附属病院薬剤部）

Nakagawa Takayuki（Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital）

2PS-06PM-1 Na センシングチャネル Nax の生理機能

〇檜山武史 1

1:基礎生物学研・統合神経, 2:総研大・生命科学

Physiological roles of the Na+ sensing channel, Nax

Hiyama Y Takeshi1

1:Nat'l Inst Basic Biol, Okazaki, Japan, 2:SOKENDAI

2PS-06PM-2

(AP2)

ヘテロメリック CALHM1/CALHM3 チャネルが味覚のプリン作動性神経伝達を担う

〇樽野陽幸 1, マジャンミン 2, 應本真 3, 松本一朗 3, トードフマイケル 3, フォスケ

ットケビン 2, 丸中良典 1

1:京都府立医大・院医・細胞生理, 2:ペンシルバニア大・生理, 3:モネル化学感覚研

A CALHM1/CALHM3 heteromeric channel mediates purinergic neurotransmission of

sweet, bitter, and umami tastes

Taruno Akiyuki1, Ma Zhongming2, Ohmoto Makoto3, Matsumoto Ichiro3, Tordoff G

Michael3, Foskett Kevin J2, Marunaka Yoshinori1

1:Dept Mol Cell Physiol, Kyoto Pref Univ Med, Kyoto, Japan, 2:Dept Physiol, Univ

Pennsylvania, Philadelphia, PA, USA, 3:Monell Chemical Senses Center, Philadelphia, PA,

USA


91

2PS-06PM-3 プロリン水酸化による TRPA1 の冷感受性制御機構

〇中川貴之 1, 金子周司 2

1:京大病院・薬剤部, 2:京大・薬・生体機能解析

Unveiled cold sensitivity of TRPA1 by the prolyl hydroxylation inhibition-induced

sensitization to ROS

Nakagawa Takayuki1, Kaneko Shuji2

1:Dept Clin Pharmacol & Ther, Kyoto Univ Hosp, 2:Dept Mol Pharmacol, Grad Sch

Pharmaceu Sci, Kyoto Univ

2PS-06PM-4 心筋細胞の介在板形成と維持における TRPV2 の役割

〇片野坂友紀

岡山大院・医歯薬・システム生理

Critical roles for TRPV2 in the formation and maintenance of intercalated discs in

cardiomyocytes

Katanosaka Yuki

Dept Physiol, Grad Sch Med, Den, Pharm, Okayama Univ, Okayama, Japan

2PS-06PM-5 メカノセンシングチャネル Piezo2 による呼吸パターンの制御

〇野々村恵子 1,2

1:基礎生物学研究所・初期発生, 2:ハワードヒューズ医学研究所・スプリプス研究所, 3:ハ

ーバード大・医, 4:スタンフォード大, 5:ノバルティス研究所

Breathing patterns regulated by mechano-sensing channel Piezo2

Nonomura Keiko1,2

1:Div Embryology, NIBB, Okazaki, Japan, 2:Howard Hughes Medical Institute, TSRI,

USA, 3:Harvard Medical School, USA, 4:Stanford University, USA, 5:The Novartus

Research Foundation, San Diego, USA

Aim and Scope

Sensing mechanisms for extracellular chemical and physical signals are critical for physiological functions such

as sensory perception, homeostasis, and development. In most cases, the sensors are ion channels, which

have been major research targets in both physiology and pharmacology. Such sensor channels (hereinafter

called “Sensing channels”) often exhibit rapid activation kinetics because of direct activation by extracellular

stimulants without the participation of second messenger; the rapid kinetics may contribute to fast perceptions

and quick responses of animals. The dependency of the kinetics on the stimulus strength may determine the

strength of sensations and physiological responses. Furthermore, the threshold of a sensing channel may

determine an intrinsic homeostatic set point. In this joint symposium with the Japanese Pharmacological

Society, five front-runner scientists studying mammalian sensing channels will share their latest findings.

They will also discuss novel approaches for studying sensing channels.


92


大会 3 日目：3 月 30 日（金）／March 30 (Fri) 8:30～10:20

日台合同シンポジウム―FAOPS2019 に向けて― 消化管生理の統合的理解～腸内細菌、消化管運動、膜輸送～

Taiwan-Japan Joint Symposium (-Towards FAOPS2019-)

Integrated Understanding of Gastrointestinal Physiology

- Microbiome, Motility and Membrane Transport


酒井秀紀（富山大学大学院医学薬学研究部薬物生理学）

Sakai Hideki（Department of Pharmaceutical Physiology, Graduate School of Medicine and Pharmaceutical

Physiology, University of Toyama）

Chia-Hui Yu（Graduate Institute of Physiology, National Taiwan University College of Medicine）

3PS-01AM-1 ヒト大腸上皮の K+および Cl-チャネルの機能

〇酒井秀紀, 藤井拓人, 清水貴浩

富山大・院薬・薬物生理学

Function of epithelial K+ and Cl- channels in the human colon

Sakai Hideki, Fujii Takuto, Shimizu Takahiro

Dept Pharm Physiol, Grad Sch Med Pharm, Univ Toyama, Toyama, Japan

3PS-01AM-2 腸電気興奮の空間的協調性は、セロトニン信号系と炎症因子で修飾される。

〇中山晋介

名古屋大・院医・細胞生理

Spatial coordination of gut electrical activity is modulated by serotonin signaling and

inflammatory factors.

Nakayama Shinsuke

Dept Cell Physiol, Grad Sch Med, Nagoya Univ, Nagoya, Japan

3PS-01AM-3 Interplay between gut bacteria and epithelial innate immunity in barrier defects and

colon tumorigenesis

Yu C Linda

Graduate Institute of Physiology, National Taiwan University College of Medicine


93

3PS-01AM-4 腸内細菌叢由来代謝物質がもたらす宿主恒常性

〇福田真嗣 1,2,3,4,5

1:慶大・先端生命研, 2:JST・さきがけ, 3:神奈川産技総研, 4:筑波大・トランスボーダー医

学研究センター, 5:メタジェン

Gut microbiota-derived metabolites shape host physiological homeostasis

Fukuda Shinji1,2,3,4,5

1:Inst. Adv. Biosci., Keio Univ., Yamagata, Japan, 2:JST PRESTO, Saitama, Japan,

3:KISTEC-KAST, Kanagawa, Japan, 4:TMRC, Univ. Tsukuba, Ibaraki, Japan,

5:Metabologenomics, Inc., Yamagata, Japan

Aim and Scope

The gastrointestinal tract such as stomach and intestine has four functions for treating ingested foods;

digestion, secretion, absorption, and motility. Secretion and absorption are mediated by the membrane

transporting system. Other than these properties, the intestinal epithelium serves as the primary border

between the immune system and the external environment in which more than 100 trillion commensal

microbes are involved. The microbiome contributes to the development and maintenance of the host immune

system. The metabolites produced by it may be essential for keeping host physiological homeostasis. Imbalance

of the microbiome leads to various disorders including inflammatory bowel disease, colorectal cancer, allergy

and obesity. In this symposium, we focused on recent scientific progress in the field of the microbiome,

gastrointestinal motility and membrane transport, and aim for an integrated understanding of gastrointestinal

physiology.


94



JPS 編集委員会企画 JPS オープンアクセス化を控えてー論文受理と上手な査読の勘どころー

Editorial Board of the Journal of Physiological Sciences

How to get your paper accepted or review other people’s papers


石川義弘（横浜市立大学大学院医学研究科）

Ishikawa Yoshihiro （Yokohama City University School of Medicine）

富永真琴（自然科学研究機構岡崎統合バイオサイエンスセンター）

Tominaga Makoto（Okazaki Institute for Integrative Bioscience）

3PS-02AM-1 JPS オープンアクセス化を控えてー論文受理と上手な査読の勘どころー

〇石川義弘 1, 佐藤元彦 2, 富永真琴 3

1:横浜市大・院医・循環制御医学, 2:愛知医科大学・生理学, 3:岡崎生理学研究所・岡崎統合

バイオサイエンスセンター

How to get your paper accepted or review other people's papers

Ishikawa Yoshihiro1, Sato Motohiko2, Tominaga Makoto3

1:CVRI, Sch Med, Yokohama City Univ, Yokohama, Japan, 2:Aichi Med Univ, Nagakute,

Aichi, Japan, 3:NIPS, Okazaki, Aichi, Japan

Aim and Scope

研究者、特に若手にとって、自分の研究論文を雑誌投稿から受理に持っていくことは、最大の課題である。

本シンポジウムでは、論文受理のコツを、若手研究者に分かりやすいように解説する。また雑誌受理のコツ

の一つは、査読がどのように行われるかを知ることである。そこで査読のプロセスを説明するとともに、中

堅研究者を対象に、雑誌を査読する際のコツの解説を行う。長年にわたって学術雑誌の編集活動を経験して

きたベテラン研究者が、後進研究者に向けてわかりやすく解説を行う。日本生理学会の英文誌である JPS は

インパクトファクターが 2 年連続して 2.0 以上を維持し、数年以内のオープンアクセス化を予定している。

そこで先行するオープンアクセス雑誌である Scientific Reports や Molecular Pain の編集者の立場から、

それぞれの雑誌の特徴と、投稿受理や査読の勘どころを説明する。



日本語/JP


95


96



日本病態生理学会連携シンポジウム新しい循環調節機構とその破綻による病気の発症

Joint symposium with the Japanese Society of Pathophysiology

Newly identified circulatory regulation mechanisms and induction of diseases caused by their

disruptions.


奥村敏（鶴見大学歯学部生理学講座）

Okumura Satoshi（Department of Physiology, Tsurumi University of Dental Medicine）

藤田孝之（横浜市立大学医学部循環制御医学）

Fujita Takayuki（Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine）

3PS-03AM-1 心不全におけるカベオリンの調節機構

〇市川泰広 1,2,3

1:UCSD・麻酔, 2:横浜市大・医・循環制御, 3:横須賀共済病院・小児

Mechanism of Caveolin in Heart Failure

Ichikawa Yasuhiro1,2,3

1:Dept of Anesthesiology, UCSD, San Diego, U.S.A., 2:Cardiovascular Research Institute,

Yokohama City Univ, Yokohama, Japan, 3:Department of Pediatrics, Yokosuka Kyosai

Hospital

3PS-03AM-2 不整脈発症における Epac1 の役割

〇藤田孝之 1, プラジャパティラジェシュ 1, 中村隆 1, 蔡文倩 1, 日高祐子 1, 吹田憲

治 1,2, 奥村敏 2, 石川義弘 1

1:横浜市立大学医学部循環制御医学, 2:鶴見大学歯学部生理学講座

The role of exchanged protein directly activated by cAMP 1 (Epac1) in the development

of arrhythmias.

Fujita Takayuki1, Prajapati Rajesh1, Nakamura Takashi1, Cai Wenqian1, Hidaka Yuko1,

Suita Kenji1,2, Okumura Satoshi2, Ishikawa Yoshihiro1

1:Cardiovascular Research Institute, Yokohama City University Graduate School of

Medicine, 2:Department of Physiology, Tsurumi University of Dental Medicine


97

3PS-03AM-3 Epac1 トランスジェニックマウスにおける心筋線維の収縮特性

〇大貫芳樹, 奥村敏

鶴見大・歯・生理

Cardiac myofilament function in transgenic mice overexpressing Epac1 in the heart

Ohnuki Yoshiki, Okumura Satoshi

Dept Physiol, Tsurumi Univ Sch Dent Med, Yokohama, Japan

3PS-03AM-4 胎盤血流動態が胎盤機能や胎児発育に与える影響の研究

〇柴田英治, 愛甲悠希代, 荒牧聡, 森博士, 蜂須賀徹, アスキューデービッド, 稲

垣博英, 岡部佳介

産業医科大学産科婦人科

Impact of altered uteroplacental circulation on placental function and fetal growth.

Shibata Eiji, Aiko Yukiyo, Aramaki Satoshi, Mori Hiroshi, Hachisuga Toru, Askew David,

Inagaki Hirohide, Okabe Keisuke

Dept. of Obstetrics & Gynecology, University of Occupational Environmental Health,

School of Medicine, Kitakyushu, Japan

3PS-03AM-5 高血圧・動脈硬化症の分子病態生理の解明

〇石上友章, 陳琳, 峯岸慎太郎, 木野旅人, 佐々木理恵, 土肥宏志, 荒川健太郎, 寺

中紗絵, 田村功一

横浜市立大学医学部

Molecular pathophysiological insight into hypertension induced by oral-salt intake and

atherosclerosis by commensal microbes and high fat diet.

Ishigami Tomoaki, Chin Lin, Minegishi Shintaro, Kino Tabito, Sasaki Rie, Doi Hiroshi,

Arakawa Kentaro, Teranaka Sae, Tamura Kouichi

Yokohama City University Graduate School of Medicine, Department of Medical Science

and Cardiorenal Medicine

Aim and Scope

The circulatory system maintains the quality of the intracellular environment in response to various stimuli

including mechanical, metabolic, and neuro/hormonal, aging stresses, which might be mediated through the

signaling such as autonomic nervous system, hypertrophy, apoptosis and autophagy. However, inappropriate

activation or termination of these signaling has been demonstrated to decrease the quality of the intracellular

environment and disrupt the homeostasis in the organ, leading to the development of diseases. This

symposium invites five active scientists about the field of autonomic nervous system, muscle physiology,

uteroplacental circulation and cardio-renal medicine. We asked them to review their interested regulatory

mechanisms to preserve the homogeneity in the organ and how alteration of these regulations might cause

diseases with their newly identified findings.


98



日韓合同シンポジウム―FAOPS2019 に向けて―

Korea-Japan Joint Symposium (-Towards FAOPS2019-)

Exquisite mechanisms for sensing and orchestrating mechanical signals


赤羽悟美（東邦大学医学部生理学講座統合生理学分野）

Adachi-Akahane Satomi（Department of Physiology, Faculty of Medicine, Toho University）

Sun-Hee Woo（Laboratory of Physiology, College of Pharmacy, Chungnam National University）

3PS-01PM-1 Regulation of cardiac calcium by shear stress signaling

Woo Sun-Hee, Kim Joon-Chul, Son Min-Jeong

Lab. Physiol., Coll of Pharm, Chungnam Natl. Univ, Daejeon, Republic of Korea

3PS-01PM-2 血管内皮細胞におけるずり応力誘発性プリナジック・シグナリング

〇山本希美子 1, 安藤譲二 2

1:東大・院医・システム生理, 2:獨協医大・医・生体医工学

Shear stress-mediated purinergic signaling in vascular endothelial cells

Yamamoto Kimiko1, Ando Joji2

1:System Physiol, Grad Sch Med, The Univ Tokyo, Tokyo, Japan, 2:Biomed Eng, Sch Med,

Dokkyo Med Univ, Tochigi, Japan

3PS-01PM-3 心筋細胞の機械感受性反応と心臓統合機能

〇入部玄太郎

岡山大・院医歯薬・システム生理

Role of myocardial subcellular mechano-sensitivity in integrative cardiac function

Iribe Gentaro

Dept Cardiovasc Physiol, Grad Sch Med Dent Pharm, Okayama Univ, Okayama, Japan

3PS-01PM-4 肝硬変由来門脈圧亢進症と Ca2+活性化 Cl-チャネル TMEM16A

〇山村寿男, 近藤るびい, 古川奈美, 鈴木良明, 今泉祐治

名市大・院薬・細胞分子薬効解析

Ca2+-activated Cl- channel TMEM16A in cirrhotic portal hypertension

Yamamura Hisao, Kondo Rubii, Furukawa Nami, Suzuki Yoshiaki, Imaizumi Yuji

Dept Mol Cell Pharmacol, Grad Sch Pharmaceut Sci, Nagoya City Univ, Nagoya, Japan


99

Aim and Scope

Cells maintain homeostasis by sensing mechanical stimuli and properly responding to them. In particular, in

the cardiovascular system, cells such as cardiac myocytes, smooth muscle cells, and endothelial cells respond

appropriately to the mechanical stimulation, while they are deformed due to blood flow and exposed to friction

with surrounding cells due to mechanical motion. On the other hand, the failure of mechanosensing system

gives rise to serious cardiovascular diseases. In recent years, advances in imaging and analytical techniques

have enabled us to elucidate exquisite mechanisms to sense mechanical stimuli and orchestrate those signals

into adaptive responses. In this symposium, the four expert speakers will review their late-breaking studies on

the mechanosensing mechanisms in the cardiovascular system.


100



日本体力医学会連携シンポジウム情動や行動を支える中枢性循環調節機構

Joint symposium with the Japanese Society of Physical Fitness and Sports Medicine

Central cardiovascular regulation supporting emotion and behavior


和気秀文（順天堂大学大学院スポーツ健康科学研究科）

Waki Hidefumi（Graduate School of Health and Sports Science, JUNTENDO University）

吉本光佐（奈良女子大学生活環境学部）

Yoshimoto Misa（Nara Women’s University, Faculty of Human Life and Environment）

3PS-03PM-1 睡眠、運動、メンタルストレス時の動脈圧受容器反射による交感神経活動の調節

〇三木健寿, 吉本光佐

奈良女子大学・大学院・統御生理

Acute shifts of baroreflex control of sympathetic nerve activity during sleep, exercise and

mental stress

Miki Kenju, Yoshimoto Misa

Dept Integrative Physiology, Nara Women's University, Nara, Japan

3PS-03PM-2 運動時の中枢性循環調節機構

〇浅原亮太, 松川寛二

広島大・医学部保健学科・生理

Feedforward control of the cardiovascular system during exercise: insight from animal

and human studies

Asahara Ryota, Matsukawa Kanji

Dept Integrative Physiol, Grad Sch Biomed and Health Sci, Hiroshima Univ, Hirsohima,

Japan

3PS-03PM-3 モチベーションと血圧の関係―意欲的な行動を支える循環応答制御―

〇山中航, 和気秀文

順天堂大・院スポ健・生理

Does motivation affect blood pressure? Cardiovascular regulation during reward-

oriented behaviors in rats

Yamanaka Ko, Waki Hidefumi

Dept Physiol, Grad Sch Health and Sports Sci, Juntendo Univ, Chiba, Japan


101

3PS-03PM-4 社会的敗北ストレスが引き起こす心血管反応の中枢性調節機構

〇吉岡優海 1, 山本瑛那 2, 堀内崇利 1, 堀内城司 1,2

1:東洋大・院理工・生体医工, 2:東洋大・理工・生体医工

Central regulation of the cardiovascular reaction during temporal and repeated social

defeat stresses

Yoshioka Yumi1, Yamamoto Ena2, Horiuchi Takatoshi1, Horiuchi Jyouji1,2

1:Dept Biomedical Engineering, Toyo Univ, Saitama, Japan, 2:Dept Biomedical

Engineering, Toyo Univ, Saitama, Japan

3PS-03PM-5 運動時交感神経活性を担う中枢回路の探索

〇木場智史

鳥取大・医・統合生理

Central neural circuitries underlying sympathetic adjustments to exercise

Koba Satoshi

Div Integr Physiol, Tottori Univ Fac Med, Yonago, Japan

Aim and Scope

Any physical behavior in response to motivation or any other stimulus induces hemodynamic alterations in

humans and other animals. Cardiovascular responses contribute by supplying sufficient blood to support

increased skeletal muscle activities and by maintaining cerebral blood flow to meet the oxygen demand of the

brain. These responses are mainly controlled by the autonomic cardiovascular regulatory system. While

hemodynamic alterations are also observed during mental activities, including feeling nervous and stressed or

motivated and excited, they are important for pursuing physical events, such as fight and flight. Central

regulatory mechanisms underlying cardiovascular control in response to physical and mental activities are

extremely complicated; therefore, in the fields of cardiovascular physiology, environmental physiology, and

sports medicine, investigating these central regulatory mechanisms has been an attractive topic worldwide.

Because of the development of experimental techniques, new findings demonstrating the central regulatory

mechanisms underlying behavior and cardiovascular control have recently been reported in these research

fields. In this symposium, representative members of the Physiological Society of Japan and the Japanese

Society of Physical Fitness and Sports Medicine working on this topic will present their recent findings, and

we will share the latest knowledge and discuss future prospective. We believe that this symposium will provide

us with an important opportunity to facilitate the discovery of central mechanisms underlying cardiovascular

regulation supporting emotion and behavior.


102



日本行動神経内分泌研究会連携シンポジウム異種・同種間コミュニケーションの生理学

Joint symposium with the Japanese Society for Behavioral Neuroendocrinology

Neurophysiology underlying intra- or inter-species communication


竹内秀明（岡山大学大学院自然科学研究科）

Takeuchi Hideaki（Graduate School of Natural Science and Technology, Okayama University）

尾仲達史（自治医科大学生理学講座神経脳生理学部門）

Onaka Tatsushi（Division of Brain and Neurophysiology, Department of Physiology, Jichi Medical University）

3PS-04PM-1 メダカは「顔」を見て仲間を見分ける-メダカ顔認識機構は、他の物体認識機構と異な

っている？

〇王牧芸 1, 竹内秀明 2

1:東京大学・総合文化研究科, 2:岡山大学・大学院自然科学研究科

Individual recognition and the 'face inversion effect' in medaka fish

Wang Mu-Yun1, Takeuchi Hideaki2

1:Grad Sch Arts Sci, Tokyo Univ, Japan, 2:Grad Sch of Nat Sci and Tech, Okayama Uni,

Japan

3PS-04PM-2 モルミリド科弱電気魚の電気コミュニケーションを担う、時間計算の神経回路機構

〇小橋常彦

名古屋大・理・生命

Neuronal mechanisms of temporal processing for electric communication in mormyrid

weakly electricfish

Kohashi Tsunehiko

Neurosci. Inst., Div. Biol. Sci., Grad. Sch. Sci., Nagoya Univ, Nagoya, Japan

3PS-04PM-3 ヒトになつくマウスの行動・生理・神経および遺伝的基盤

〇小出剛

国立遺伝学研究所・マウス開発

Behavioral, physiological, neurological and genetic bases of tameness in mice

Koide Tsuyoshi

MGRL, Nat Inst Genet, Mishima, Japan


103

3PS-04PM-4 異種間における親和的関係性構築のメカニズム解明に向けてーラットを用いた研究ー

〇岡部祥太, 高柳友紀, 吉田匡秀, 尾仲達史

自治医大・医学・生理

Toward the elucidation of the mechanism of affiliative relationship among interspecific

species

Okabe Shota, Takayanagi Yuki, Yoshida Masahide, Onaka Tatsushi

Dept Physiol, Jichi Medi Univ, Tochigi, Japan

3PS-04PM-5 相互注視とオキシトシン神経系を介したヒトとイヌとの絆形成

〇永澤美保 1, 小川美里 1, 圓史緒理 1, 尾仲達史 2, 佐久間康夫 3, 茂木一孝 1, 菊水

健史 1

1:麻布大学, 2:自治医科大学, 3:東京医療学院大学

Mutual gaze induces reciprocal human-dog communication via endocrine alterations

Nagasawa Miho1, Ogawa Misato1, En Shiori1, Onaka Tatsushi2, Sakuma Yasuo3, Mogi

Kazutaka1, Kikusui Takefumi1

1:Azabu Univ, Sagamihara, Japan, 2:Jichi Medical Univ, 3:Univ of Tokyo Health Sciences

Aim and Scope

Mutual understanding among individuals is an important factor to form and maintain a group. However,

mechanisms for mutual understanding remain largely unknown. Communications between dogs and humans,

rodents and human, and fishes are performed in multimodal fashions. Comparative examination of these intra-

or inter-species communications may lead to better understanding of human communications.

Documents

日中合同シンポジウム―FAOPS2019 に向けて―...formation in various cell types. In addition, many cell biological phenomena, such as vesicular transport, cytoskeletal