• Overview of research in Biophysics Institute @NCU. 中央大學生物物理所

• From DNA to collective behavior of organisms

http://www.phy.ncu.edu.tw/ibp/

Soft Condensed Matter

Biophysics

Institute of BioPhysics at NCU中央大學生物物理所

Physics Dept. Center for Complex Systems複雜系統中心

Brain Research Center,UST聯合大學腦科學中心

Life Science生命科學系

Institute of Phys., Academia Sinica

中研院物理所

Inst. Systems Biology & Bioinformatics系統生物所

Why BioPhysics ?

• Material Nature of Bio-substances affect Biological properties. (Evolution made use of the physical properties of bio-materials)

• Physical principles & Laws holds from microscopic level macroscopic level

• Traditional Biology is descriptive, non-quantitative

Why BioPhysics ?

• Physics is universal. • Rise of molecular biology: DNA, RNA, protein ar

e universal in all living matters• Universality in Central Dogma: DNARNApro

teinBiological functions…• New, interesting, exciting & useful.• Lots of unsolved important problems.• Techniques & Methodology in physics can probe

the fundamental principles in bio-systems of a wide spectrum of scales in a quantitative way.

國立中央大學 生物物理研究所 • Officially established in 2004• 教授 : 6 副教授 : 1 助理教授 3• 合聘教授 : 2 合聘助理教授 : 1• 現有從事生物物理領域在學研究生 碩士班： 23 博士班： 8 • 博士後 : 3 • 以物理之技術或方法去探討生物系統中存在之

基本原理，從而對生物過程提供深入及定量之了解。

• 「 5年 500 億」頂尖中心經費建立生物物理共用核心設施

• 歡迎物理與非物理背景同學加入 .中大及中研院提供獎學金

BioPhysics Institute @NCU • Officially established in 2004• Professors: 6 Assoc. Prof.: 1 Assist. Prof. 3• Adj. Prof.: 2 Adj. assist.prof.: 1• Graduate students working on areas in biophysics M.S. ： 23 Ph. D. ： 8 • Postdocs: 5• aims at achieving some quantitative description of bi

ological processes and search for the fundamental principles buried in these highly complex biological phenomena

• 「 5 years 500B 」 grant to support research & building of core facility labs.

• Cross-disciplinary: researchers/students from physics & non-physics background

師資 職 稱 Ph.D 研究專長 Email Address

李 弘 謙Hoong-Chien Lee

教 授Professor

McGill University計算生物 / 生物物理 / 生物訊息 ( 理論 ) hclee@sansan.phy.ncu.edu.tw

伊 林Lin I

教 授Professor

Rutgers University複雜系統 / 生物物理 ( 實驗 ) lini@phy.ncu.edu.tw

陳 方 玉Fang-Yu Chen

教 授Professor

Rice University生物物理 / 生物膜 ( 實驗 ) fychen@phy.ncu.edu.tw

黎 璧 賢Pik-Yin Lai

教 授Professor

University of Pittsburgh 生物物理 / 軟凝態物理 / 神經元網路 / 生物材料 ( 理論 / 實驗 )

pylai@phy.ncu.edu.tw

王 敏 生Min-Sheng Wang

教 授Professor

University of Pittsburgh腦科學 ( 理論 ) mswang@phy.ncu.edu.tw

高 仲 明Chung-Ming Ko

教 授 Professor

University of Arizona演化的模擬 ( 理論 ) cmko@phy.ncu.edu.tw

陳 培 亮Peilong Chen

副 教 授Associate Professor

Caltech生物圖案形成 / 軟物質 / 生物力學 ( 理論 / 實驗 ) peilong@phy.ncu.edu.tw

陳 宣 毅Hsuan-Yi Chen

助理教授Assistant Professor

University of Pittsburgh軟凝態物理 / 生物物理 ( 理論 ) hschen@phy.ncu.edu.tw

薛 雅 薇Ya-Wei Hsueh

助理教授Assistant Professor

University of Toronto生物膜物理 / 核磁共振 ( 實驗 ) yhsueh@phy.ncu.edu.tw

李 紀 倫Chi-lun Lee

助理教授Assistant Professor

SUNY Stony Brook軟凝態物理 / 生物物理 ( 理論 ) chilun@kali.pse.umass.edu

陳 志 強Chi-Keung Chan

合聘教授Joint Appointment Prof

essor

University of Pittsburgh軟物質 / 生物物理 / 神經元網路 ( 實驗 ) phckchan@ccvax.sinica.edu.tw

梁 鈞 泰Kwan-tai Leung

合聘教授Joint Appointment Prof

essor

UC Santa Barbara統計物理與軟物質 / 生物集體行為 ( 理論 ) leungkt@phys.sinica.edu.tw

林 耿 慧Keng-Hui Lin

合聘助理教授Joint Appointment Assi

stant Professor

University of Pennsylvania 軟物質 / 生物材料 ( 實驗 ) khlin@phys.sinica.edu.tw

Wide Spectrum• Length Scales:nm m mm cm m kmDNA,RNA,protein, intracellular, virus, bacteria, Intercellular, collective motion, insects, animanls/plants, migration

• Time Scales: fs ps s ms s e transfer,H-bonding,water DNA,RNA,protein rearrangement , protein folding DNA transcription

hr day year Byr cell division Earth organisms , animal migration evolution

• Knowledge: Interdisciplinary 跨越各學科領域 MathematicsPhysicsChemistryBiologyMedical• Biophysicist is a TRUE Scientist !

• 需要物理與非物理背景人材加入 !

BioPhysics Theory Groups at NCU

• 陳培亮 Peilong Chen: bio-hydrodynamics, mechanics of propulsion in living organisms, pattern formation in biology

• 陳宣毅 Hsuen-Yi Chen: complex fluids, cell adhesion, collective motion in flocks

• 黎璧賢 Pik-Yin Lai: DNA physics, biomolecular chain models, neurons, biological networks 

• 李紀倫 Chi-Lun Lee: protein folding, charged biomolecules• 梁鈞泰 Kwan-tai Leung: self-propelling motion in organisms,

flocking, non-equilibrium bio-processes• 高仲明 Chung-ming Ko: Evolution models, astrobiology• 王敏生 Min-Sheng Wang: Neural Networks, brain wave &

MEG analysis• 李弘謙 Hoong-Chien Lee: Bioinformatics, protein physics, g

enome/DNA sequence analysis

Soft matters

Biophysics

BioPhysics Experimental Labs at NCU

• Complex System Lab. 伊林 Lin I: micro-motion of bio- and soft materials in confined spots, dynamics of neuronal system, laser pulse-soft matter interaction

• Biophysics Lab. 陳方玉 Fang Yu Chen: Biomembrane, Membrane-active Peptides, Effect of peptide-forming pore on neuron function

• Soft-condensed Matter Lab. 陳培亮 Peilong Chen: bio-hydrodynamics, mechanics of propulsion in living organisms

• Bio-Soft Matters Lab. 黎璧賢 Pik-Yin Lai, 陳志強 C.K. Chan & 林耿慧 K.H.Lin:

interactions in cells, neuronal networks, DNA mechanics & hydrodynamics, biomaterials

• Bio-Soft Core Facilities Lab. : BioAFM, Confocal microscopy, Wet Labs, Bio samples, fast imaging systems, fluorescence microscopy…

• Bio-membrane Lab. 薛雅薇 Ya-Wei Hsueh: lipid rafts in cell membranes, NMR spectroscopy, AFM measurement

E