Product Guide 2016

UNIQUE · COMPACT · MODULAR

Easy to configure. Fast installation. Safe and easy to operate. Easy to service.

Kim Byrum Sales Director and Owner kb@zystm.dk

Zystm A/S Lillelundvej 18 DK 7400 Herning

Esben Vognsen PACTA Developer and Specialist esben.vognsen@pactalab.com

PACTALAB ApS Æblevangen 17 2765 Smørum

PACTA™ is… | 3

PACTA™ is…

PACTA is a series of cabinets.

PACTA is dedicated to provide uncompromized safety, to save space and energy, and to easy handling from specification through installation to operation and service.

PACTA is for chromatography: UPLC HPLC GC.

PACTA is for stacking lab equipment to save space: CO2-incubators, vacuum ovens, other.

PACTA serves pharmaceutical, biomedical, clinical and university laboratories, industry and science, R&D and QC.

PACTA is for all LC-systems from all major chromatography manufacturers.

PACTA is as simple as possible, but not simpler. Safety is inparallel. Ergonomics are best in class. Simply! OHS is applied according to corporate OHS guidelines. Pull-outs provide easy access from sides and rear, at all times, with no heavy lifts. Working height is adjustable.

PACTA supports housekeeping. Compared to mobile bench solutions, PACTA is lighter, smaller, better ventilated, easier to keep clean and provides better sound abatement.

PACTA offers up to 50% savings in footprint and 60% in ventilation capacity per LC-system, great when expanding capacity in existing facilities. Installed cost is reduced, lifetime operational savings are achieved.

PACTA has a short time RoI. Last, but not least: it is stylish.

4 | Zystm 2016

« AfterPACTA

• Well organized.

• Easy to overview. Backlit enclosures allow easy supervision

• Easy system access, both for operation (front) and for maintenance (back)

• Bottles in adequate height, e.g. 5 liter bottles below shoulder

• Heat is ventilated efficently, out of room

• Solvents are ventilated safely, out of room

• Easy pull-outs

• Optimal ergonomics: No risk for back injuries. Minimum casualty risk when handling bottles. Cabinet is height-adjustable to meet all needs during operation, service and maintenance.

• Easy to keep tidy and clean.

• Stainless steel surfaces when risk for solvent spillage

• Space for housekeeping; tool drawer also serves as PC-pad

Before and After PACTA

« BeforeLeft

• Disorganized. Not easy to overview• Solvents and waste not vented; risk for exposures to gasses and

vapours• No or non-effective system ventilation to remove system heat. Room

temperature is impacted• Unsafe routing of tubes• Data acquisition server takes up priority space, can be exposed to

liquids and impacts room temperatur

Right

• Bottles stand very high, only reachable from footstool

Both

• No immediate system access for maintenance• Poor ergonomics; risk for back injuries; casualty risk when handling

bottles. Heavy pull-outs (stainless steel roller table)• Impossible to keep tidy and clean• No proper space for housekeeping

Before and After PACTA | 5

6 | Zystm 2016

Space/FootprintSpace utilization is crucial. Space optimization is the biggest contributor to cost savings in lab facilities. Facilities equipped with PACTAs have room for up to 50% more systems than comparable solutions.

Energy/CO2 footprintEnergy focus is crucial. HVAC is the second biggest contributor to cost savings in lab facilities. Due to integrated and focused ventilation, PACTA reduces HVAC needs with up to 60% – at time of installation and 24/7/365 thereafter.

PACTA emits solvents in one exhaust, and system heat in another exhaust. The solvent exhaust is normally app. 20% of the total ventilation capacity.

Safety/OHSPersonal safety is paramount. Exposure to harmful substances, gasses and vapours, must be avoided. PACTA has local exhausts above bottles and above the waste bin. Air velocity matches requirements from fume cupboards.

Venting is split into two: ducts to remove heat from the LC-systems heat, and ducts for harmful gasses. In case not needed, ducts are merged. Low air flow generates alarm.

Ergonomics/MMHPACTA is safe and simple. During manual materials handling, occupational health injuries must be prevented. With PACTA, no heavy lifts are needed. No harmful liquids need handling above eye level. Pull-outs and adjustable height support create appropriate working positions.

Overview/HousekeepingPACTA is focus and simplicity. The LC-system is accessible at all times, and all functions are easy to overview.

PACTA provides sufficient and well-organized space for housekeeping. It is easy to clean and keep tidy.PA

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PACTA is developed by... | 7

8 | Zystm 2016

PACTA-LC is for chromatography Dimensions Load How to proceed

UPLC Ultra High Performance Liquid Chromatography; narrower; smaller volumes.Units in 1-2 stacks, optionally a tower for oven or sample organizer

Depending on brand and no. of stacks typically 35-80 cm

Depending of type and brand typically 65-200 kg

Contact your local PACTA distributor to select the right PACTA regime for your purpose.

Brand, type, dimensions and load is needed for the specification.

Corporate COHS rules are needed too.

HPLC High Performance Liquid Chromatography; wider; larger volumes.Units in 1-2 stacks, optionally a tower for oven or sample organizer

Depending on brand and no. of stacks typically 45-80 cm

Depending of type and brand typically 65-200 kg

GC Gas Chromatography; often connected units, produces more heat.MS solution may be integrated as a module

Depending on brand and no. of stacks 60-120 cm

Depending of type and brand typically 65-150 kg

MS Mass Spectrometry; two-or-three stack system, LC/GC and a MS-detector. The detector has vacuum pump(s) and a gas supply.

Depending on LC/GC and MS-detector. A big variety exists.

Depending of type and brand up to 450 kg

FPLC Fast Protein Purificatio; often has more eluents, and more frequent user interactions.

Depending on brand and no. of stacks 65-90 cm

LC LC no waste FLY

PACTA 40

PACTA 60

PACTA 70

LC Single cabinet with bottles above LC-system

FlyTriple cabinet: Two cabinets for LC, one in centre for solvents. Solvent bottles are thus kept in a lower position. Waste bins are in drawers below LC-systems.

LC no waste

Single cabinet, for facilies with remote waste collection

For LC/GC: Height adjustable programme

Products | 9

Example are: Vacuum ovens, CO2 incubators, GC’s (Gas chromatographs with head space on lower shelf)...

FIRE BASIC BASIC DATA BASIC FLY

PACTA 40

PACTA 60

PACTA 70

BASIC Single cabinet with bottles above LC-system.

BASIC FLYTriple cabinet: Two cabinets for LC, one in centre for solvents.Solvent bottles are thus kept in a lower position.Waste containers are in drawers below LC-systems.

FIREA Fly with the centre cabinet in compliance with DS/EN 14470-1,2004. Both solvents and waste is collected in the centre cabinet.

BASIC DATA A simple cabinet for PC and housekeeping tools.

VC/GC

PACTA 40

PACTA 60

PACTA 70

VC/GC

Single cabinet, for stacked equipment.

Examples are: Vacuum ovens, CO2 incubators, GC’s (Gas chromatographs with head space on lower shelf)...

For LC/GC: Fixed height programme

For VC/GC: Height adjustable programme

10 | Zystm 2016

SPACE UTILITY CAPACITY CONSTRUCT-ABILITY PERMITS RISK COST

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• No room for new LC

• Not room for LC’s along both walls in a std 3 metre grid

• Not sufficient handling space in front of LC’s

• No space for ducts for new HVAC (refurbish)

• HVAC capacity is limited

• New HVAC capacity is too expensive for the LC case

• EHS issues occur due to noise in existing and overloaded ventilation systems; air velocities are high

• Complex installation

• 3D space management

• Fire permits

• Limitations on allowed quantities of flammable liquids

• Requirements dealing with EX conditions and enforced shut-downs

• Unexpected derived tasks during refurbishing may create more jobs, with no notice

• Installation in QC-areas are restricted in time and frequency

• Space utilization is cost driver no. 1 in labs

• Venting/cooling is cost driver no. 2 in labs

• Designers do expensive tailored solutions

• Few standard products on the market

PACT

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• Minimum footprint

• ONLY the footprint required by EHS and LC-system is needed

• Ventilation may be less than 60% of capacities used in comparable solutions

• Depends on case

• Off-the-shelf PACTAs for most LC-systems

• Few and simple interfaces

• PACTA Fuego is used where quantity restrictions re. flammable liquids are applied

• PACTA comes, pre-tested and as knock-down solution

• Cost

PACT

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SE II

• Or less! As focused heat venting reduces the installation depth needed.

• This may open for LC-system installations along both walls in the same room, the safety corridor is place

• 25% is for ventilating solvents

• 75% is for ventilation of heat exhaust from LC-system

• Ventilation can be split into two, and the heat can be cooled and recirculated

• KD Knock down installation

• Refer to PACTA Site Preparation Guide. Note floor load requirements

• Request for information

• Cooperation with fire authorities are needed prior to final design and approval

• ”First time right“ by upfront alignment w. Corporate Health and Safety

• Space & HVAC savings makes TIC favourable

• Use of std solution reduces design costs

• Install two-for-one = two PACTAs - one for new LC and one for existing LC.

• No extra HVAC may be needed!

• Easy to configure• Easy to install

• Complies to rules and standards

• The simplicity reduces overall risk

• Depends on case and alternative

FAQ: Planners & facility managers

Facility Considerations | 11

Facility Considerations

PACTA Site Preparation Guide

The PACTA Site Preparation Guide shows how to use the PACTA in the lab. Few factors are to be considered:• Outer dimensions• Duct connection• Floor and/or wall mounting• Electrical connections• Load considerations

Rebuild/Retrofit

Space needs are reduced with up to 50%. Ventilation needs are reduced with 40-60% depending on the case. Pacta comes KD – Knock Down. Fast installation can be crucial in validated environments. PACTA is ideal for retrofit.

New build/Greenfield

Space needs are reduced with up to 50%. Ventilation needs are reduced with 40-60% depending on the case. PACTA allows for LC-systems along both walls in narrow rooms. PACTA may dramatically increase the space utilization. Storage space is provided at the same small footprint. PACTA is ideal for new build.

Open Labs

PACTA reduces the sound from system fans. Housekeeping is supported. PACTA fits standard laboratory dimensions and fits perfectly in open labs.

Core Labs Equipment Farms

PACTA is ideal for core labs, dense with a lot of equipment. PACTA is ideal in dedicated equipment farms, with condensed equipment and a need for efficient ventilation.

Supported LC- and GC-systems

PACTA can be used with any system from major manufacturers, e.g.

12 | Zystm 2016

Facility Considerations | 13

1. PACTA-Fly for two LC-stacks. The Fly is used when the height of the LC-stack positions solvent bottles higher that the COHS-rules for maximum lifting height of the bottles. The bottles are put in a shared cabinet.

2. PACTA LC-70. HPLC with detector located on separate shelf for top HPLC access. Oven is hinged for HPLC side access.

3. PACTA-VC/GC for stacked equipment. Two ovens or CO2-incubators or alike are located on top of eachother. The lower is operated while the PACTA is raised. Utilities are supplied from the back; like gasses, destilled water, power.

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Your PACTA

Your Daily Operations – OHSPACTA provides easy access, easy overview, space for tools and supports housekeeping initiatives. Focus is key.

When raised, the PACTA cabinet brings the pump and the auto sampler in the best position for preparation, check of needle flush and sealwash function, removal of old samples, check of waste. For control for untight connections.

When lowered, PACTA is in position for solvents check, for control for untight connections. For equilibration.

Your Corporate PACTA ProgrammeIn order to obtain homogene inparallel solutions throughout your organisation, your Corporate Health and Safety Organiszation can define corporate set of EHS-criteria to be met, like: allowed lifting height for 5-litres bottles, same for 3-litres bottles, same for 1-litres bottles; required air changes in drawers for capped and non-capped solvents, and recommended work bench height for different users.

When a corporate standard is built, PACTA’s are configured accordingly.

Your Pacta | 15

Service. Maintenance.OHS PACTA allows most service functions and maintenance functions to be executed without disconnecting any utility.

This is why PACTA offers maximum up-time for your LC-systems.

Pull-outs are used to give side access, top access and rear access to the stacked LC-units.

When the HPLC-oven is located at a side, PACTA places the oven in a hinged bracket, and the oven can then be turned aside to provide access to the revealed “innerside unit”.

Stainless steel drip trays are standard.

Ethernet and power connections are available on the front of the Fly for easy maintenance.

PACTA does not need regular service. Annually air change ratio checks are recommended.

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1. HPLC. Pull-out for side access, and - hidden in view - to swing the oven right for access to the hidden right side of the HPLC.

2. Regular service does not need any pull-out of the cabinet/rack. Solvents are in drawers.

3. PACTA VC/GC saves space and allows access from front sides and rear for operation and service.

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When Personal Safety is Paramount.When Space is Key.When HVAC capacity matters.When Cost is important: TIC and lifetime running costs. Short-term RoI.For QC and R&D Labs. For new-build and retrofit.Safe and simple.Simply.

PACTA® HistoryPACTA® is developed by PACTALAB ApS. PACTALAB is an innovative lab development company, founded in 2014.

PACTALAB portfolio also holds a modular furniture system PORTA, a reservation and UseAnalysis tool TRACKLOG. PACTALAB focuses on safety, ergonomics, optimization in configuration, in installation, in user operation and in facility management.

PACTA as MTOPACTA is licensed to Zystm A/S. PACTA is manufactured as MTO – Make-To-Order. Manufacturing starts after a customer’s order is receivedfrom the local distributor.

™ © PATENTS PENDINGPACTA® REGISTERED TRADEMARKPATENTS PENDINGREGISTERED COMMUNITY DESIGN

Your Pacta | 19

Zystm AS ∙ Lillelundvej 18 ∙ DK 7400 HerningTel +45 96 66 66 60 ∙ Fax +45 96 66 66 70

info@zystm.com ∙ www.zystm.com

Zystm AS ∙ Bjørnstadveien 2 ∙ N 1712 GraalumTel +47 41 53 88 00 ∙ Fax +47 41 53 88 01

post@zystm.com ∙ www.zystm.no