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IMPACT OF NUTRITIONAL
SUPPLEMENTS ON
HEMATOLOGICAL PROFILE
OF PREGNANT WOMEN
P.K. Chawla
R. Puri
ABSTRACT
Eighty one pregnant women (202 weeks of
gestation) were assessed for their nutritional sta-tus. They
were divided into three groups; Group I
women (n=30) were given 200 mg ferrous
sulphate (FeSO4 tablet per day for 15 weeks,
Group II women (n=25) were given FeSO4 tab-
lets along with 2,00,000 IU of vitamin A as
single dose in beginning of study; and Group III
women (n=26) were not given any supplements
and served as controls. To study impact of sup-
plements on hematological profile of pregnant
women, Hb, PCV, RBC, TS%, TIBC and serum
levels of iron, zinc, copper, manganese and vita-
min A were assessed at 202 weeks and 362
weeks of gestation by standard techniques. Preg-
nant women in Group I (Fe suppl) and group II(Fe + vitamin A
suppl) had significantly (p
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INDIAN PEDIATRICS
niques. Serum minerals (iron, Zn, Cuand Mn) were determined by
atomic ab-sorption spectrophotometer after wet di-gestion by the
method of Piper(4). TIBC
was estimated by the method of Teitz(5).Serum vitamin A was
determined bymethod of Kimbe(6). The subjects weredivided into
three groups making surethat each group had pregnant womenwith more
or less identical nutritionalstatus at 202 weeks of gestation.
Pregnant women who were willingto come to the hospitals/centres
once aweek to collect iron supplements andconsume them regularly
were includedin Groups I and II. Rest of the subjectswho were not
willing to take supple-
ments were included in the controlgroup. The various groups
were: (i)Group I: Iron supplemented (Fe suppl) - 30
women were given one tablet of 200 mgFeSO4 per day (containing
60 mg ele-mental iron and 500 jug folk acid) for a
period of 15 weeks; (ii) Group II: Iron +
vitamin A suplemented (Fe + vit A suppl) -
25 women were given 2,00,000 IU of vi-tamin A as a single dose
along with 200mg FeSO4 per day for a period of 15weeks; and (iii)
Group III: Control - 26
women who did not receive any supple-ments served as
controls.
The mean and standard errors ofmean were computed for all the
parame-ters. The significance of difference in themeans of various
indices was first testedby analysis of variance (F test), when
thevalues of 'F' were significant, it was fol-lowed by a modified
'ttest.
Results
In the present investigation, the he-moglobin (Hb) levels of
subjects varied
from 8.0 to 13.5 g/dl at T1 and 7.8 to 13.2g/dl at T2. The mean
value of Hb at T1
VOLUME32-AUGUST1995
was 10.12 g/dl in subjects of all the threegroups. At T2 the Hb
values increased to10.4 and 10.7 g/dl in iron supplementedand
iron+vit A supplemented groups,
respectively. However, Hb levels de-creased to 9.5 g/dl in
control group. Asimilar trend was observed in case ofpacked cell
volume (PCV) and red bloodcell (RBC) count (Table I). The values
ofHb, PCV and RBC count were below thenormal range both at T1and
T2
At T1, the mean total iron binding ca-pacity (TIBC) was 346 g/dl
in all thethree groups. At T2 the TIBC values sig-nificantly (p
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en. Whenever iron supplementation iscontemplated for expectant
mothers, vi-tamin A supplementation should gohand in hand to
achieve maximum bene-
fit.
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CHAWLA AND PURI NUTRITIONAL SUPPLEMENT & HEMATOLOGICAL
PROFILE
