Reactions 1484, p28 - 18 Jan 2014 S Prednisolone Psychiatric disturbances in a child: case report An 8-year-old boy developed psychiatric disturbances following treatment with prednisolone. The boy presented to a hospital with pallor, malaise and a sore throat. He also had splenomegaly. Investigations revealed anaemia and reticulocytosis. His haemoglobin stabilised during his hospital stay, but he continued to have haemolysis. Years later, he experienced decompensated haemolysis with malaise, lethargy, marked splenomegaly and a fall in haemoglobin. He was started on prednisolone 1 mg/kg [route and frequency not stated]. His blood count stabilised, but treatment was complicated by psychiatric disturbances [duration of treatment to reaction onset not stated]. At a routine follow-up appointment, the boy reported keeping over 100 racing pigeons in his home. He had a case of a pigeon allergy causing severe haemolytic anaemia. Observation and immunosuppressant therapy had been ineffective in controlling the disease, and attempts at reducing antigen exposure did not work as well. Once the birds were culled, his haemoglobin level started to increase. The reticulocytosis continued to fall, and steroids were discontinued. [Outcome of ADR not stated.] Author comment: "He was commenced on prednisolone (1 mg/kg) which stabilised his blood count but was complicated by psychiatric disturbances." David T, et al. Severe haemolytic anaemia secondary to avian allergy. Blood 122: No. 21, 21 Oct 2013 [abstract] - United Kingdom 803098306 1 Reactions 18 Jan 2014 No. 1484 0114-9954/14/1484-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved

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Reactions 1484, p28 - 18 Jan 2014

SPrednisolone

Psychiatric disturbances in a child: case reportAn 8-year-old boy developed psychiatric disturbances

following treatment with prednisolone.The boy presented to a hospital with pallor, malaise and a

sore throat. He also had splenomegaly. Investigations revealedanaemia and reticulocytosis. His haemoglobin stabilisedduring his hospital stay, but he continued to have haemolysis.Years later, he experienced decompensated haemolysis withmalaise, lethargy, marked splenomegaly and a fall inhaemoglobin. He was started on prednisolone 1 mg/kg [routeand frequency not stated]. His blood count stabilised, buttreatment was complicated by psychiatric disturbances[duration of treatment to reaction onset not stated].

At a routine follow-up appointment, the boy reportedkeeping over 100 racing pigeons in his home. He had a case ofa pigeon allergy causing severe haemolytic anaemia.Observation and immunosuppressant therapy had beenineffective in controlling the disease, and attempts at reducingantigen exposure did not work as well. Once the birds wereculled, his haemoglobin level started to increase. Thereticulocytosis continued to fall, and steroids werediscontinued. [Outcome of ADR not stated.]

Author comment: "He was commenced on prednisolone(1 mg/kg) which stabilised his blood count but wascomplicated by psychiatric disturbances."David T, et al. Severe haemolytic anaemia secondary to avian allergy. Blood 122:No. 21, 21 Oct 2013 [abstract] - United Kingdom 803098306