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Prof. Dr. Axel A. Brakhage
Phone: +49 3641 532-1000 Email: [email protected] Website: www.leibniz-hki.de/en/molekulare-und-angewandte-mikrobiol
ProjectsCurrent Projects
Oxidative inactivation of primary metabolism pathways in the human pathogenic fungus AspergillusfumigatusDetails
N.N. 2Details
Discovery of new antifungal compounds from the social amoeba Dictyostelium discoideumDetails
New antifungal compoundsDetails
The impact of redox regulation on the stress response of Aspergillus fumigatus and its role in host-pathogeninteractionDetails
Communication via extracellular vesicles between immune cells and the human-pathogenic fungus
Aspergillus fumigatusDetails
Mechanisms of microbial communication leading to activation of silent gene clustersDetails
N. N. 7Details
N.N.Details
Molecular Mechanisms of lipid raft formationDetails
Communication between bacteria and fungi by secondary metabolitesDetails
Former Projects
Acute and chronic Aspergillus infection in mice studied by PET-CT and comparative gene expressionDetails
Lysine biosynthesis in Aspergillus fumigatusDetails
Post-translational modifications and pathogenicity of the human pathogenic fungus Aspergillus fumigatusDetails
Cryo-stress of filamentous fungiDetails
Secretome analysis/pathogenicity mechanisms of Arthroderma benhamiaeDetails
Prediction of gene regulatory networks involved in the differentiation, secondary metabolism and crosstalk of Aspergillus nidulansDetails
Regulation of cell wall integrity signalling by mitogen-activated protein kinase MpkA in AspergillusfumigatusDetails
The hypoxic (low-oxygen) response of the pathogenic mould Aspergillus fumigatus and its relevance topathogenicityDetails
The genome of the endofungal bacterium Burkholderia rhizoxinicaDetails
Bioinformatic investigation and prediction of gene regulatory elements in pathogenic fungiDetails
Integrated genome-wide data analysis by ensemble learning methods to understand infection processesDetails
Identification of immunogenic components of Aspergillus fumigatus for vaccine developmentDetails
Identifying the pulmonary phagocytic network of mice infected with Aspergillus fumigatusDetails
A surface hydrophobin in ectomycorrhiza interactionDetails
Molecular mechanisms of the interaction between Aspergillus fumigatus and alveolar macrophagesDetails
Novel molecular mechanisms of iron sensing and homeostasis in Aspergillus fumigatusDetails
Functionality and plasticity of bacterial polyketide synthasesDetails
The role of virulence determinants of the human pathogenic fungus Aspergillus fumigatus in the defenseagainst fungivorous amoebaDetails
Heterologous expression of silent gene clusters in fungiDetails
Developing molecular tools for the de novo assembling of biosynthetic routesDetails
Development of a user-friendly heterologous expression system and its applications for natural productbiosynthesisDetails
Adhäsionsmechanismen von Escherichia coli auf TitanoberflächenDetails
Publications
Horn F, Habel A, Scharf DH, Dworschak J, Brakhage AA, Guthke R, Hertweck C, Linde J (2015) DraftGenome Sequence and Gene Annotation of the Entomopathogenic Fungus Verticillium hemipterigenum. Genome Announc 3(1), Details PubMed
Horn F, Linde J, Mattern DJ, Walther G, Guthke R, Brakhage AA, Valiante V (2015) Draft GenomeSequence of the Fungus Penicillium brasilianum MG11. Genome Announc 3(5), Details PubMed
Macheleidt J, Scherlach K, Neuwirth T, Schmidt-Heck W, Straßburger M, Spraker J, Baccile JA,Schroeder FC, Keller NP, Hertweck C, Heinekamp T, Brakhage AA (2015) Transcriptome analysis of
cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel naturalcompound fumipyrrole by Aspergillus fumigatus. Mol Microbiol 96(1), 148-162. Details PubMed
Netzker T, Fischer J, Weber J, Mattern DJ, König CC, Valiante V, Schroeckh V, Brakhage AA (2015) Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters. Front Microbiol 6, 299. Details PubMed
Horn F, Schroeckh V, Netzker T, Guthke R, Brakhage AA, Linde J (2014) Draft Genome Sequence of Streptomyces iranensis. Genome Announc 2(4), Details PubMed
Lapp K, Vödisch M, Kroll K, Strassburger M, Kniemeyer O, Heinekamp T, Brakhage AA (2014) Characterization of the Aspergillus fumigatus detoxification systems for reactive nitrogen intermediatesand their impact on virulence. Front Microbiol 5, 469. Details PubMed
König CC, Scherlach K, Schroeckh V, Horn F, Nietzsche S, Brakhage AA, Hertweck C (2013) Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus. Chembiochem 14(8), 938-942. Details PubMed
Nützmann HW, Fischer J, Scherlach K, Hertweck C, Brakhage AA (2013) Distinct amino acids ofhistone H3 control secondary metabolism in Aspergillus nidulans. Appl Environ Microbiol 79(19),6102-6109. Details PubMed
Shopova I, Bruns S, Thywissen A, Kniemeyer O, Brakhage AA, Hillmann F (2013) Extrinsicextracellular DNA leads to biofilm formation and colocalizes with matrix polysaccharides in the humanpathogenic fungus Aspergillus fumigatus. Front Microbiol 4, 141. Details PubMed
Heddergott C, Bruns S, Nietzsche S, Leonhardt I, Kurzai O, Kniemeyer O, Brakhage AA (2012) The Arthroderma benhamiae hydrophobin HypA mediates hydrophobicity and influences recognition byhuman immune effector cells. Eukaryot Cell 11(5), 673-682. Details PubMed
Heinekamp T, Thywißen A, Macheleidt J, Keller S, Valiante V, Brakhage AA (2012) Aspergillusfumigatus melanins: interference with the host endocytosis pathway and impact on virulence. FrontMicrobiol 3, 440. Details PubMed
Horn F, Heinekamp T, Kniemeyer O, Pollmächer J, Valiante V, Brakhage AA (2012) Systems biology offungal infection. Front Microbiol 3, 108. Details PubMed
Müller S, Baldin C, Groth M, Guthke R, Kniemeyer O, Brakhage AA, Valiante V (2012) Comparison oftranscriptome technologies in the pathogenic fungus Aspergillus fumigatus reveals novel insights into thegenome and MpkA dependent gene expression. BMC Genomics 13, 519. Details PubMed
Sarkar A, Funk AN, Scherlach K, Horn F, Schroeckh V, Chankhamjon P, Westermann M, Roth M,Brakhage AA, Hertweck C, Horn U (2012) Differential expression of silent polyketide biosynthesis geneclusters in chemostat cultures of Aspergillus nidulans. J Biotechnol 160(1-2), 64-71. Details PubMed
Wallwey C, Heddergott C, Xie X, Brakhage AA, Li SM (2012) Genome mining reveals the presence of aconserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal familyArthrodermataceae. Microbiology 158(Pt 6), 1634-1644. Details PubMed
Albrecht D, Kniemeyer O, Mech F, Gunzer M, Brakhage A, Guthke R (2011) On the way towardsystems biology of Aspergillus fumigatus infection. Int J Med Microbiol 301(5), 453-459. Details PubMed
Burmester A, Shelest E, Glöckner G, Heddergott C, Schindler S, Staib P, Heidel A, Felder M, Petzold A,Szafranski K, Feuermann M, Pedruzzi I, Priebe S, Groth M, Winkler R, Li W, Kniemeyer O, SchroeckhV, Hertweck C, Hube B, White TC, Platzer M, Guthke R, Heitman J, Wöstemeyer J, Zipfel PF, MonodM, Brakhage AA (2011) Comparative and functional genomics provide insights into the pathogenicity ofdermatophytic fungi. Genome Biol 12(1), R7. Details PubMed
Jain R, Valiante V, Remme N, Docimo T, Heinekamp T, Hertweck C, Gershenzon J, Haas H, BrakhageAA (2011) The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxinproduction and iron adaptation in Aspergillus fumigatus. Mol Microbiol 82(1), 39-53. Details PubMed
Mech F, Thywissen A, Guthke R, Brakhage AA, Figge MT (2011) Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus. PLoS One 6(5), e19591. Details PubMed
Nützmann HW, Reyes-Dominguez Y, Scherlach K, Schroeckh V, Horn F, Gacek A, Schümann J,Hertweck C, Strauss J, Brakhage AA (2011) Bacteria-induced natural product formation in the fungusAspergillus nidulans requires Saga/Ada-mediated histone acetylation. Proc Natl Acad Sci U S A 108(34),14282-14287. Details PubMed
Priebe S, Linde J, Albrecht D, Guthke R, Brakhage AA (2011) FungiFun: a web-based application forfunctional categorization of fungal genes and proteins. Fungal Genet Biol 48(4), 353-358. Details PubMed
Thywißen A, Heinekamp T, Dahse HM, Schmaler-Ripcke J, Nietzsche S, Zipfel PF, Brakhage AA (2011) Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatusInterferes with the Host Endocytosis Pathway. Front Microbiol 2, 96. Details PubMed
Volling K, Thywissen A, Brakhage AA, Saluz HP (2011) Phagocytosis of melanized Aspergillus conidiaby macrophages exerts cytoprotective effects by sustained PI3K/Akt signalling. Cell Microbiol 13(8),1130-1148. Details PubMed
Bruns S, Kniemeyer O, Hasenberg M, Aimanianda V, Nietzsche S, Thywissen A, Jeron A, Latgé JP,Brakhage AA, Gunzer M (2010) Production of extracellular traps against Aspergillus fumigatus in vitro andin infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA. PLoSPathog 6(4), e1000873. Details PubMed
Bruns S, Seidler M, Albrecht D, Salvenmoser S, Remme N, Hertweck C, Brakhage AA, Kniemeyer O,Müller FM (2010) Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhancedproduction of the mycotoxin gliotoxin. Proteomics 10(17), 3097-3107. Details PubMed
Teutschbein J, Albrecht D, Pötsch M, Guthke R, Aimanianda V, Clavaud C, Latgé JP, Brakhage AA,Kniemeyer O (2010) Proteome profiling and functional classification of intracellular proteins fromconidia of the human-pathogenic mold Aspergillus fumigatus. J Proteome Res 9(7), 3427-3442. Details PubMed
Valiante V, Jain R, Heinekamp T, Brakhage AA (2009) The MpkA MAP kinase module regulates cellwall integrity signaling and pyomelanin formation in Aspergillus fumigatus. Fungal Genet Biol 46(12),909-918. Details PubMed
Vödisch M, Albrecht D, Lessing F, Schmidt AD, Winkler R, Guthke R, Brakhage AA, Kniemeyer O (2009) Two-dimensional proteome reference maps for the human pathogenic filamentous fungus Aspergillus fumigatus. Proteomics 9(5), 1407-1415. Details PubMed
Albrecht D, Kniemeyer O, Brakhage AA, Guthke R (2008) Normalisation of 2D DIGE data - on the wayto a standard operating procedure. BIRD08 Schriftenreihe Informatik 26, 55-64. Details
Valiante V, Heinekamp T, Jain R, Härtl A, Brakhage AA (2008) The mitogen-activated protein kinaseMpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response. Fungal GenetBiol 45(5), 618-627. Details PubMed
Guthke R, Kniemeyer O, Albrecht D, Brakhage AA, Moeller U (2007) Discovery of gene regulatorynetworks in Aspergillus fumigatus. Lect Notes Bioinf 4366, 22-41. Details
Schöbel F, Ibrahim-Granet O, Avé P, Latgé JP, Brakhage AA, Brock M (2007) Aspergillus fumigatusdoes not require fatty acid metabolism via isocitrate lyase for development of invasive aspergillosis. InfectImmun 75(3), 1237-1244. Details PubMed
Volling K, Brakhage AA, Saluz HP (2007) Apoptosis inhibition of alveolar macrophages upon interactionwith conidia of Aspergillus fumigatus. FEMS Microbiol Lett 275(2), 250-254. Details PubMed
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