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7/23/2019 REAKSI IMUN
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PURNOMO SURYOHUDOYO
DEPT. OF BIOCHEMISTRYSCHOOL OF MEDICINE
AIRLANGGA UNIVERSITY
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IMMUNITY
INNATE (NATURAL) IMMUNITY
ACQUIRED (ADAPTIVE) IMMUNITY
Nonspecific
Does not epen on !nti"en # !nti$o% inte&!ction
Fi&st 'ine efence( !cts $efo&e !c)*i&e +!!pti,e- i*nit%
P&esent in p'!nts( in,e&te$&!tes !n ,e&te$&!tes
A'/!%s p&esent
Specific
Depens on !nti"en # !nti$o% inte&!ctions
On'% p&esent in ,e&te$&!tes t!0es tie to e,e'op
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ADAPTIVE
IMMUNORESPONSE
1. HUMORAL B LYMPHOCYTES
2. CELLULAR
T LYMPHOCYTESTc (Cytotoxic) CD8+
TH (Hele!) CD"+
TR (Re#$l%to!) CD"+
T Cell Receto! (TCR)M%&o! Hi'toco%tiility Colex !otei*' (MHC) MHC ( HLA ) MHC (HLA )
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CLO,AL SELECTO, THEORY
B LymphocytesDisplaying
Different lgs
Antigen
Antigen bind
to complementarylg
Proliferation
B Lymphocytes
displaying samelg
differentation
Plasma Cells
lg secreted
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Lymphocytes suspension from
unimmunised animal
Antigen (A) imbedded in gelatin
wash
Digest with enzyme and resuspend
Place in culture medium & obsere
under microscope
Add Antigen AAdd Antigen B
!o Proliferation Proliferation
P"##$ #$ CL#!AL %LC'#! '#"*
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IMMUNOGLOBULIN (Ig)
inge "egionCleaage by
Papain
+ $ab
+ $c
, heay dhain - , ariable domainL , light chain C , constant domain C# , carbohydrate
, disuliphide lin.$ab/ , antibody binding fragment$c/ , crystralline fragment
(does not bind Ab)L Chain ,
(lambda0 or ( .appa) Chain , 1 21 3 41 535+1 6
MMU,-LOBUL,S ARE ,AMED ATER TS H CHA,S /l#M0 l#D0 l# -0 l# A0 l# E
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OR-A,SATO, O - -E,ES
LCHA,
LCHA,
H LCHA,
7C
87A!
C HCHA,7 , membrane
(only transcribed in membrane
bound lg)
L , Leader(untranslated)
%ignal for translation in ribosomesbound to /"/ (membrane bound
& secreted proteins)
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-E,E REARRA,-EME,TPRETRA,SCRPTO,AL PROCESS,-MMU,O-LOBUL, L-HT CHA,
-ERM L,E D,A
MMU,O-LOBUL,
L-HT CHA,
LYMPHOCYTE D,A
MMU,O-LOBUL, SY,THESS , B LYMPHOCYTES
Y / -E,ES OR ARABLE RE-O,
3 / -E,ES OR 3O,,- SE-ME,TS
C / -E,E OR CO,STA,T RE-O,
CELL DERE,TATO, ( &-E,E REARRA,-EME,T)
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HCHA, -E,E REARRA,-EME,T
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ALLELIC EXCLUSION (1)
MMU,O-LOBUL, -E,ES H 4 CHA, / CHR 1"
L CHA, / CHR 5
L CHA, / CHR 15
H CHA, CHA,
CHA,
l# M
l# M
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ALLELIC EXCLUSION (2)
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S6TCH,- (MO,OU,CTO,AL LYMPHOCYTE)
S6TCH,- (BU,CTO,AL LYMPHOCYTE)
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MEMBRA,E &SECRETED .-.
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-E,ETC BASS OR A,TBODY DERSTY
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ARABLTY DUE TO 3 &D3 3O,,-
3U,CTO,SE7UE,CE
CODO,S-E,ERATED
A.A.
RAMESHT DUE TO3 D3 3O,,-
RAMESHT 6LL RESULT , A ,O,U,CTO,ALREARRE,-ED -E,E CELL DES
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B CELL S-,AL,-
URTHEREECT
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T CELL RECEPTOR ( TCR)
TCR CHA,S
TCR -E,ES
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MHC &MA3OR HSTOCOMPTABLTY COMPLE9 CLASS I & II
MHC i' :o$*; o* o't cellMHC i' o*ly :o$*; o* BLy
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PERPHERY
MEDULLA
CORTE9
T 4 LYMPHOCYTE DERE,TATO,
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A,T-E, PROCESS,- PRESE,TATO,Cytol%'ici!%l !otei*
,$cle%te;Ti''$e Cell
BLYMPHOCYTE
MACROPHA-ESA,T-E, PRESE,T,-
CELL (APC)
MHC
MHC
MHC
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T CELLS ,TERACTO,S
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Tc ,TERACTO,
TAR-ET CELL
TAR-ET CELL
Tc PROLERATO,
CELL DES BYAPOPTOSS
CELL DES BY ,ECROSS
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T HELPER ,TERACTO,
CELL MEDATED MMU,TY (DTH) HUMORAL MMU,TY
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T HELPER (T CD"+) ,TERACTO,
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RE-ULATORY T CELL (TR)
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B CELL ,TERACTO, (1)T CELL ,DEPE,DE,T A,T-E,>
> ALSO CALLED / THYMUS ,DEPE,DE,T A,T-E,
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B CELL ,TERACTO, (2)T CELL DEPE,DE,T A,T-E,>
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T CELL S-,AL,-
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