7
[email protected] دریافت:9 / 3 / 99 پذیزش:51 / 9 / 99

Sepehr 2006 [email protected] 9/9/51 شزیذپ 9/3/ تفایردzums.ac.ir/journal/article-1-5414-fa.pdf · E-mail: [email protected] Received: 30 May 2017 Accepted: 6 Sep 2017

  • Upload
    others

  • View
    0

  • Download
    0

Embed Size (px)

Citation preview

Page 2: Sepehr 2006 70@yahoo.com 9/9/51 شزیذپ 9/3/ تفایردzums.ac.ir/journal/article-1-5414-fa.pdf · E-mail: Sepehr_2006_70@yahoo.com Received: 30 May 2017 Accepted: 6 Sep 2017

مسعود کیخب و همكبران

Nocardia cyriacigeorgica

NTM

NAOH

Lowenstein-Jensen

A

BAL

B

C

D

Page 3: Sepehr 2006 70@yahoo.com 9/9/51 شزیذپ 9/3/ تفایردzums.ac.ir/journal/article-1-5414-fa.pdf · E-mail: Sepehr_2006_70@yahoo.com Received: 30 May 2017 Accepted: 6 Sep 2017

از بیمبر مشكوک به سل نوکبرديب سیريبسیجئورجیكبجذاسبزي 041

A B C

D

AB

CD

Page 4: Sepehr 2006 70@yahoo.com 9/9/51 شزیذپ 9/3/ تفایردzums.ac.ir/journal/article-1-5414-fa.pdf · E-mail: Sepehr_2006_70@yahoo.com Received: 30 May 2017 Accepted: 6 Sep 2017

مسعود کیخب و همكبران

COPD

In vitro

Page 5: Sepehr 2006 70@yahoo.com 9/9/51 شزیذپ 9/3/ تفایردzums.ac.ir/journal/article-1-5414-fa.pdf · E-mail: Sepehr_2006_70@yahoo.com Received: 30 May 2017 Accepted: 6 Sep 2017

از بیمبر مشكوک به سل نوکبرديب سیريبسیجئورجیكبجذاسبزي 041

References

1- Brown-Elliott BA, Brown JM, Conville PS,

Wallace RJ. Clinical and laboratory features of the

Nocardia spp. based on current molecular

taxonomy. Clin Microb Rev. 2006; 19: 259-82.

2- Wang HK, Sheng WH, Hung CC, et al. Clinical

characteristics, microbiology, and outcomes for

patients with lung and disseminated nocardiosis in

a tertiary hospital. J Formosan Med Assoc. 2015;

114: 742-9.

3- Ercibengoa M, Pérez-Trallero E, Marimón JM.

Autochthonous Nocardia cerradoensis infection

in humans, Spain, 2011 and 2014. Emerg Infect

Dis. 2016; 22: 109.

4- Fleetwood IG, Embil JM, Ross IB. Nocardia

asteroides cerebral abscess in immunocompetent

hosts: report of three cases and review of surgical

recommendations. Surg Neurol. 2000; 53: 605-10.

5- Salehipour M, Zaker Bostanabad S, Rezaee S,

Hashemi-Shahraki A. Species spectrum of

pathogenic Nocardia isolated from patients. New

Cell Molec Biotedn J. 2016; 6: 75-84.

6- Schlaberg R, Huard RC, Della-Latta P.

Nocardia cyriacigeorgica, an emerging pathogen

in the United States. J Clin Microbiol. 2008; 46:

265-73.

7- Yassin A, Rainey F, Steiner U. Nocardia

cyriacigeorgici sp. nov. Int J System Evolunt

Microb. 2001; 51: 1419-23.

8- Cargill JS, Boyd GJ, Weightman NC. Nocardia

cyriacigeorgica: a case of endocarditis with

disseminated soft-tissue infection. J Med

Microbiol. 2010; 59: 224-30.

9- Lalitha P, Srinivasan M, Rajaraman R, et al.

Nocardia keratitis: clinical course and effect of

corticosteroids. Am J Ophthalmol. 2012; 154:

934-9. e1.

10- Menkü A, Kurtsoy A, Tucer B, Yıldız O,

Akdemir H. Nocardia brain abscess mimicking

brain tumour in immunocompetent patients: report

of two cases and review of the literature. Acta

Neurochirurgica. 2004; 146: 411-4.

11- Thirouvengadame S, Muthusamy S, Balaji

VK, Easow JM. Unfolding of a Clinically

Page 6: Sepehr 2006 70@yahoo.com 9/9/51 شزیذپ 9/3/ تفایردzums.ac.ir/journal/article-1-5414-fa.pdf · E-mail: Sepehr_2006_70@yahoo.com Received: 30 May 2017 Accepted: 6 Sep 2017

مسعود کیخب و همكبران

Suspected Case of Pulmonary Tuberculosis. J

Clin Diagn Res. 2017; 11: 1-3.

12- Eshraghi SS, Bafghi MF, Ghafouri A, et al.

Isolation and identification of Nocardia asteroids

complex isolated from thigh abscess in a patient

with Behçet\'s syndrome: the first report from

Iran. Tehran Univ Med Sci J. 2013; 71: 476-749.

13- Zaker Bostanabad S, Hashemi-Shahraki A,

Heidarieh P, Sheikhi N, Sharifi A, Seyri Fouron

Abad M. Charactrization and isolation of

Nocardia from clinical sample Patient suspected

to active tuberculosis. New Cell Molee Biotechnal

J. 2014; 4: 19-23.

14- Kageyama A, Hoshino Y, Yazawa K, et al.

Nocardia cyriacigeorgica is a significant

pathogen responsible for nocardiosis in Japan and

Thailand. Mycopathologia. 2005; 160: 15-9.

15- Riviere F, Billhot M, Soler C, Vaylet F,

Margery J. Pulmonary nocardiosis in

immunocompetent patients: can COPD be the

only risk factor? Europ Respirat Rev. 2011; 20:

210-2.

16- Garcia-Bellmunt L, Sibila O, Solanes I,

Sanchez-Reus F, Plaza V. Pulmonary nocardiosis

in patients with COPD: characteristics and

prognostic factors. Arch Bronconeumología

(English Edition). 2012; 48: 280-5.

17- Chavez TT, Fraser SL, Kassop D, Bowden III

LP, Skidmore PJ. Disseminated Nocardia

cyriacigeorgica presenting as right lung abscess

and skin nodule. Mili Med. 2011; 176: 586-8.

18- Abu-Gazala M, Engel A, Stern A, Guralnik L.

An unusual case of nocardiosis presented as a

mediastinal mass in an immunocompetent patient.

Am J Respirat Crit Care Med. 2014; 189: 492-3.

19- Fujita T, Ikari J, Watanabe A, Tatsumi K.

Clinical characteristics of pulmonary nocardiosis

in immunocompetent patients. J Infect

Chemother. 2016; 22: 738-43.

Page 7: Sepehr 2006 70@yahoo.com 9/9/51 شزیذپ 9/3/ تفایردzums.ac.ir/journal/article-1-5414-fa.pdf · E-mail: Sepehr_2006_70@yahoo.com Received: 30 May 2017 Accepted: 6 Sep 2017

از بیمبر مشكوک به سل نوکبرديب سیريبسیجئورجیكبجذاسبزي 044

Isolation of Nocardia cyriacigeorgica from Patient Suspected to Tuberculosis

Keikha M1, Khorshidi M

1, Shamsipour E

2, Navid S

1

1Dept of Microbiology and Virology, Faculty of Medicine, University of Medical Sciences, Isfahan, Iran.

Dept. of Infectious Diseases, Hajar Hospital, Shahrekord, Iran

Corresponding Author: Navid S, Dept. of Microbiology and Virology, Faculty of Medicine, University of Medical

Sciences, Isfahan, Iran

E-mail: [email protected]

Received: 30 May 2017 Accepted: 6 Sep 2017

Nocardia are gram-positive and partially acid-fast bacteria with saprophytic lives in the environment. These

groups of bacteria are able to enter the human body through traumatic inhalation and may consequently

cause Nocardiosis infections.

Case Presentation: A 32-year-old man was referred to Al-Zahra Hospital with symptoms such as fever,

gradual weight loss, and persistent coughing. First, the patient was speculated to have Tuberculosis, but

Mycobacterium tuberculosis was not isolated in any sputum samples. Ultimately, a broncho-alveolar lavage

sample was acquired from the patient and according to the patient's clinical presentation and microbial

assessments, the cause of illness was found to be Nocardia cyriacigeorgica.

Conclusion: According to this report, Nocardiosis infections may occur in immune-compromised patients

and even healthy individuals. Given the similarities between the clinical manifestations and radiological

findings of Tuberculosis and Nocardia pulmonary infections, medical laboratories should identify Nocardial

infections in suspected TB patients.

Keywords: Nocardia cyriacigeorgica, Isolation methods, Antimicrobial susceptibility tests