SILABUS RANCANGAN OBAT

7/17/2019 SILABUS RANCANGAN OBAT

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SILABUS MATA KULIAH

Program Studi : FARMASIKode Mata Kuliah : 8023221Nama Mata Kuliah : RANCANGAN OA! "umlah SKS : #ua $2%Seme&ter : Satu $1%Mata Kuliah Pra S'arat : KIMIA M(#ISINA)

Deskripsi Mata Kuliah :Mata *uliah ra+,a+ga+ o-at meru.a*a+ *ela+/uta+ mata *uliah *imia medi&i+al Mata *uliah ra+,a+ga+ o-at me+di&*u&i*a+te+ta+g da&arda&ar te*+i* .era+,a+ga+ o-at -ai* *la&i* mau.u+ +o+ *la&i* !e*+i* .era+,a+ga+ o-at &e,ara *la&i*dida&ar*a+ .ada .e+garuh &iat &i*a *imia terhada. a*ti4ita& -iologi& materi 'a+g didi&*u&i*a+ meli.uti: *elaruta+ da+a*ti4ita& -ilogi&5 &iat &i*a *imia da+ a*ti4ita& -iologi&5 &tereo*imia da+ i*ata+ -iologi&5 i*ata+ *imia da+ a*ti4ita& -iologi&5la+g*ahla+g*ah mera+,a+g o-at &erta metode o.tima&i mole*ul da+ hu-u+ga+ *ua+titati &tru*tur da+ a*ti4ita& !e*+i* +o+

*la&i* meli.uti: de&ai+ &e+'a6a .e+u+tu+ -er-a&i& .rotei+ target5 .e+e+tua+ liga+ de+ga+ -er-era.a &ot6are da+ te*+i*do,*i+g dalam .era+,a+ga+ o-atStandar Kompetensi :

Maha&i&6a mam.u memahami *o+&e. da&ar .era+,a+ga+ o-at da+ mela*u*a+ de&ai+ ra+,a+ga+ o-at &ederha+a de+ga+te*+i* *la&i* mau.u+ +o+ *la&i*

Kompetensi Dasar :

Setelah me+gi*uti .er*uliaha+ i+i dihara.*a+ maha&i&6a da.at:

1. Memahami .e+garuh &iat &i*a *imia terhada. a*ti4ita& -iologi& &e+'a6a o-at2. Memahami la+g*ahla+g*ah .era+,a+ga+ o-at3. Memahami -e-era.a metode o.tima&i &e+'a6a .e+u+tu+

4. Memahami hu-u+ga+ *ua+titati &tru*tur da+ a*ti4ita&5. Mam.u mem-eda*a+ metode de&ai+ o-at *la&i* $non-computational method% da+ *om.uta&i $C##%6. Mam.u me+/ela&*a+ da+ me+da.at*a+ &e+'a6a .e+u+tu+ da+ .rotei+ target me+ggu+a*a+ online screening databases7. Mam.u me+/ela&*a+ da+ mela*u*a+ taha.a+ molecular docking me+ggu+a*a+ &ot6are 'a+g -er*aita+8. Mam.u me+/ela&*a+5 da+ me+ga+ali&i& &e+'a6a7liga+ me+ggu+a*a+ Mar4i+ea+: mar4i+&*et,h5 mar4i+&.a,e5 da+

mar4i+4ie69. Mam.u me+/ela&*a+ da+ mela*u*a+ a+ali&i& -er-agai &e+'a6a7liga+ me+ggu+a*a+ &ot6are -er-a&i& Gau&&ia+ method10. Mam.u me+/ela&*a+ da+ mela*u*a+ a+ali&i& -er-agai &e+'a6a7liga+ me+ggu+a*a+ '.er,hem rial !ersion



11. Mam.u me+/ela&*a+ da+ mela*u*a+ a+ali&i& -er-agai &e+'a6a7liga+ da+ .em-uata+ .ro&edur docking me+ggu+a*a+Argu&)a-

Kom.ete+&i #a&ar I+di*atorPe+galama+Pem-ela/ara+

Materi A/ar 9a*tuAlat7aha+7Sum-er

ela/arPe+ilaia+

Memahami.e+garuh &iat&i*a *imiaterhada. a*ti4ita&-iologi& &e+'a6ao-at

Maha&i&6a da.atme+e+tu*a+ &iat&at &i*ia *imia&tru*tur &e+'a6ao-at 'a+gmem.er+garuhia*ti4ita& -iologi&

Maha&i&6ame+g*a/i &iat&iat&i*ia *imia da+me+e+tu*a+.e+garuh+'aterhada. a*ti4ita&-iologi& &e+'a6ao-at

- Kelaruta+ a*ti4ita&-ilogi&

- Io+i&a&i da+a*ti4ita& -iologi&

- Stereo*imia da+a*ti4ita& -iologi&

- I*ata+ *imia da+a*ti4ita& -iologi&

100 )C#5 )a.to.5 .a.a+tuli&5 &.idol Sum-er:Si&6a+do+o et al518

Memahamila+g*ahla+g*ah.era+,a+ga+ o-at

Maha&i&6a da.atme+e+tu*a+la+g*ahla+g*ah.era+,a+ga+ o-at

Maha&i&6amem.ela/arila+g*ahla+g*ahdalam mera+,a+go-at dari.e+e+tua+&e+'a6a .e+u+tu+&am.ai .e+e+tua+u/i *li+i*

- Pe+e+tua+&e+'a6a .e+u+tu+

- Modi*a&i mole*ul&e+'a6a .e+u+tu+

- Pro&edurmoodi*a&i

- Mera+,a+g -e+tu*.ema*aia+

- Ra+,a+ga+ do&i&- (4alua&i *li+i*

100; )C#5 )a.to.5 .a.a+tuli&5 &.idol Sum-er:Fe&&e+de+ da+Fe&&e+de+5Si&6a+do+o et al518

Memahami-e-era.a metodeo.tima&i &e+'a6a

.e+u+tu+

Mahai&6a da.atmela*u*a+o.tima&i mole*ul

o-at de+ga+.e+de*ata+ !o.li&&5 Fi-o+a,i5O.tima&i Sim.le*&da+ A+ali&i& Kla&ter

Maha&i&6amem.ela/ari-er-agai la+g*ah

o.tima&i mole*ul

- Metode o.tima&i !o.li&&

- Metode o.tima&i

Fi-o+a,i- Metode a+ali&i&

*la&ter- Metode O.tima&i

Sim.le*&

200; )C#5 )a.to.5 .a.a+tuli&5 &.idol Sum-er:Si&6a+do+o et al5

18

Pe+uga&a+.ri-adi

Memahamihu-u+ga+*ua+titati &tru*tur da+

- Maha&i&6ame+ge+al te+ta+gKSA Free 9il&o+

- Maha&i&6a da.at

Maha&i&6amem-eda*a+KASA Free 9il&o+da+ a+&,h

- Metode KSA Free9il&o+

- Metode KSAa+&,h

200; )C#5 )a.to.5 .a.a+tuli&5 &.idol Sum-er:Si&6a+do+o et al518

Pe+uga&a+Kelom.o*.era+,a+ga+o-at



a*ti4ita& mela*u*a+.era+,a+ga+ o-atde+ga+ KSAA+&,h

Maha&i&6amela*u*a+.e+gem-a+ga+mole*ul de+ga+KSA a+&,h

- Per-edaa+ da+.er-a+di+ga+*edua metode

Mam.umem-eda*a+metode de&ai+o-at *la&i* $non-computationalmethod% da+*om.uta&i $C##%da+ mam.ume+/ela&*a+ da+me+da.at*a+&e+'a6a.e+u+tu+ da+.rotei+ targetme+ggu+a*a+online screeningdatabases

- Me+/ela&*a+"omputational#rug #esign $C##%

- Me+/ela&*a+*la&i*a&i dalammetode"omputational#rug #esign $C##%

- Me+/ela&*a+*eu+tu+ga+ da+*erugia+ metode"omputational#rug #esign $C##%

- Me+/ela&*a+te*+i* .emiliha+model"omputational#rug #esign $C##%

- Me+/ela&*a+ ,aramela*u*a+de&ai+ o-atde+ga+"omputational#rug #esign $C##%

- Me+/ela&*a+o.tima&i de&ai+

- Me+di&*u*&i*a+te+ta+g.er-edaa+metode *la&i*da+ +o+ *la&i*dalam.era+,a+ga+o-at

- Maha&i&6amela*u*a+.e+elu&ura+o+li+e u+tu*me+da.at*a+.rotei+ targetda+me+e+tu+*a+&e+'a6a liga+'a+g &e&uai

- Pe+gertia+ da+de+i&i"omputational#rug #esign $C##%

- )atar -ela*a+g5ala&a+5 da+ tu/ua+di.erlu*a++'a"omputational#rug #esign $C##%

- Kla&i*a&i atau.e+g*elom.o**a+"omputational#rug #esign $C##%

- !e*+i* .emiliha+model da+o.tima&i"omputational#rug #esign $C##%

- #e&ai+ o-atter.ilih de+ga+"omputational#rug #esign $C##%

- Ide+ti*a&i&e+'a6a .e+u+tu+da+ .rotei+ targetu+tu* &uatu.e+'a*it

- !e*+i* se$uencematching da+chemicalcompound

100; )C#5 )a.to.5 .a.a+tuli&5 &.idol5)a-oratoriumKom.uter

Pe+gua&aa+o.era&io+al



o-at ter.ilih- Me+/ela&*a+

%eb-accessibledatabases

-Me+/ela&*a+la+g*ahla+g*ahscreening de+ga+ %eb-accessibledatabases

- Me+/ela&*a+6a*tu ter-ai*u+tu* %eb-accessibledatabases

- Me+/ela&*a+*eu+tu+ga+ da+*erugia+ %eb-accessibledatabases

- Me+/ela&*a+ ,arame+da.at*a+&e+'a6a.e+u+tu+ da+.rotei+ targetmelalui %eb-accessibledatabasesscreening

- Me+/ela&*a+4alida&i ha&il&,ree+i+gde+ga+ %eb-accessibledatabases

matching- Pe+ggu+aa+ 6eb-

accessibledatabases site

-A.li*a&i metode.ada 4iru&

- #a&arda&ar.e+era.a++'a.ada modella+/uta+: docking

Mam.u - Me+/ela&*a+ Maha&i&6a - Pe+gertia+ 100; )C#5 )a.to.5 .a.a+



me+/ela&*a+ da+mela*u*a+taha.a+molecular docking

me+ggu+a*a+&ot6are 'a+g-er*aita+

.e+gertia+ da+de+i&i darimoleculardocking dalam

de&ai+ o-at- Me+/ela&*a+

*elemaha+ da+*ele-iha+-er-agai&ot6are u+tu*moleculardocking

- Me+gide+ti*a&i5me+ga+ali&i& da+&i+*ro+i&a&ia+tara hard%arespeci&cation de+ga+ technicalre$uirement dalam moleculardocking

- Me+/ela&*a+6a*tu ter-ai*.e+ggu+aa+moleculardocking

- Me+/ela&*a+*eu+tu+ga+ da+*erugia+.e+ggu+aa+moleculardocking

- Me+/ela&*a+la+g*ahla+g*ahdocking &e+'a6a.e+u+tu+ da+re&e.tor de+ga+

mem.ela/aritaha.a+ mole,ulardo,*i+g da+me+e+tu*a+

&ot6are&ot6are'a+g da.atdigu+a*a+ dalammole,ular do,*i+g

molecular docking- Parameter *imia

&i*a dalammolecular docking

tools- 'olecular docking

tools: /e+i&5re$uirement da+a.li*a&i+'a

- (le)ible #ocking a+tara scoring*unction da+optimi+ationmethod

- )a+g*ahla+g*ahdocking

-(4alua&i ha&ildocking

- Pe+gem-a+ga+la+/uta+ dari ha&ildocking

tuli&5 &.idol Sum-er:i+ter+et



me+ggu+a*a+&atu atau-e-era.amolecular

docking toolsMam.ume+/ela&*a+5 da+me+ga+ali&i&&e+'a6a7liga+me+ggu+a*a+Mar4i+ea+:mar4i+&*et,h5mar4i+&.a,e5 da+mar4i+4ie6

oMela*u*a+

i+&tala&iMar4i+ea+

oMe+/ela&*a+

*om.o+e+*om.o+e+ 'a+gter&edia dalamMar4i+ea+

oMe+ggam-ar

&e+'a6a $-ai* 2#

da+7atau 3#% da+mem.u-li*a&i*a++'a

oMe+/ela&*a+ ,ara

a+ali&i& &e+'a6adalamMar4i+ea+ da+mem.u-li*a&i*a++'a

- Mela*u*a+ .ro&e&.em-aharua+Mar4i+ea+

- Me+ggu+a*a+&ot6are mar4i+u+tu* a+ali&i&&tru*tur liga+

Mar4i+ea+:s,stemre$uirement s da+i+&tala&i+'aKom.o+e+atau a&ilita&dalamMar4i+ea+Pe+ggu+aa+Mar4i+S*et,hPe+ggu+aa+Mar4i+S.a,ePe+ggu+aa+Mar4i+<ie6

- Pe+ggu+aa+ti+g*at la+/ut dariMa4i+ea+ da+.em-aharua++'a

100; )a.to.5)a-oratorium,om.uter da+&ot6are Mar4i+

Pe+gua&aa+&ot6are

Mam.ume+/ela&*a+ da+mela*u*a+a+ali&i& -er-agai&e+'a6a7liga+me+ggu+a*a+&ot6are -er-a&i&Gau&&ia+ method

-

Mela*u*a+i+&tala&i &ot6are-er-a&i& Gau&&ia+

- Me+/ela&*a+*om.o+e+*om.o+e+ 'a+gter&edia dalam&ot6are -er-a&i&Gau&&ia+

-

Me+ggu+a*a+&ot6areGau&&ia+ u+tu*a+ali&i& &tru*turliga+

-

Sot6are -er-a&i&Gau&&ia+: s,stemre$uirements da+i+&tala&i+'a

- Kom.o+e+ ataua&ilita& dalam&ot6are -er-a&i&Gau&&ia+

- a-i+itio da+

100; )a.to.5)a-oratorium,om.uter da+&ot6are '.er,hem

Pe+gua&aa+&ot6are



- Me+ggu+a*a+.eri+tah a-i+itioda+ densit,*unction theor,

$#F!% da+ ,aramem.u-li*a&i*a++'a

- Me+/ela&*a+ ,araa+ali&i& ha&il.erhitu+ga+Gau&&ia+ da+mem.u-li*a&i*a++'a

- Mela*u*a+ .ro&e&.em-aharua+&ot6are -er-a&i&Gau&&ia+

densit, *unctiontheor, $#F!%

- Pe+ggu+aa+.eri+tah a-i+itio

-Pe+ggu+aa+.eri+tah densit,*unction theor, $#F!%

- Pe+ggu+aa+.eri+tah &le t,pecon!erter

- Pe+ggu+aa+ti+g*at la+/ut dari&ot6are -er-a&i&Gau&&ia+ da+.em-aharua++'a

Mam.ume+/ela&*a+ da+mela*u*a+a+ali&i& -er-agai&e+'a6a7liga+me+ggu+a*a+'.er,hem rial!ersion

- Mela*u*a+i+&tala&i'.er,hem rial!ersion

- Me+/ela&*a+*om.o+e+*om.o+e+ 'a+gter&edia dalam'.er,hem rial!ersion

- Me+/ela&*a+ da+me+ggam-ar&e+'a6a liga+da+ .rotei+target $re&e.tor%da+mem.u-li*a&i*a++'a

- Me+/ela&*a+ da+

Me+ggu+a*a+&ot6are'.er,hem u+tu*a+ali&i& &tru*turliga+

- '.er,hem rial!ersion: s,stemre$uirements da+i+&tala&i+'a

- Kom.o+e+ ataua&ilita& dalam'.er,hem rial!ersion

- Me+ggam-ar&e+'a6a *imiade+ga+'.er,hem rial!ersion

- Pe+ggu+aa+.eri+tah chemicalstructurecustomi+ation

- Pe+ggu+aa+.eri+tah

100 )a.to.5)a-oratorium,om.uter da+&ot6are '.er,hem

Pe+gua&aa+&ot6are



mela*u*a+.erhitu+ga+*om.uta&ide+ga+ -a+tua+

'.er,hem rial!ersion

- Me+/ela&*a+,ara a+ali&i&ha&il.erhitu+ga+'.er,hem rial!ersion da+mem.u-li*a&i*a++'a

- Mela*u*a+.ro&e&

.em-aharua+'.er,hem rial!ersion

.erhitu+ga+*om.uta&i

- Pe+ggu+aa+.eri+tah &le t,pe

con!erter - Pe+ggu+aa+

ti+g*at la+/ut dari'.er,hem rial!ersion da+.em-aharua++'a

Mam.ume+/ela&*a+ da+mela*u*a+a+ali&i& -er-agai&e+'a6a7liga+da+ .em-uata+.ro&edur dockingme+ggu+a*a+Argu&)a-

- Mela*u*a+i+&tala&iArgu&)a-

- Me+/ela&*a+*om.o+e+*om.o+e+ 'a+gter&edia dalamArgu&)a-

- Me+/ela&*a+ da+me+uli&*a+*em-ali la+g*ahla+g*ah docking a+tara &e+'a6aliga+ da+ .rotei+target $re&e.tor%me+ggu+a*a+Argu&)a- da+

Maha&i&6amela*u*a+ a+ali&i&do,*i+g &uatu liga+de+ga+ &ot6areArgu&)a-

- Argu&)a-: s,stemre$uirements da+i+&tala&i+'a

- Kom.o+e+ ataua&ilita& dalamArgu&)a-

- Pe+e+tua+re&e.tor da+ liga+u+tu* Argu&)a-

- Modi*a&i re&e.torde+ga+ Argu&)a-

- A.li*a&i .eri+tahu+tu* docking me+ggu+a*a+Argu&)a-

- Pu-li*a&i ha&ildocking

100; )C#5 )a.to.5 .a.a+tuli&5 &.idol5Sot6are Argu& #o,*

Kemam.ua+do,*i+g



mem.u-li*a&i*a++'a

- Me+/ela&*a+ ,araa+ali&i& ha&il

do,*i+g de+ga+Argu&)a-

- Me+/ela&*a+docking tools lai++'a

- Mela*u*a+.ro&e&.em-aharua+Argu&)a-

me+ggu+a*a+Argu&)a-

- Pe+ggu+aa+ti+g*at la+/ut dari

Argu&)a- da+.em-aharua++'a

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SILABUS RANCANGAN OBAT