Upload
rosaline-quinn
View
214
Download
0
Embed Size (px)
Citation preview
Synergic effect of exercise and nutrition intervention on
disease model
Wook Song, Ph.D.
Health & Exercise Science Labora-tory
Institute of Sport ScienceSeoul National University
DefinitionSynergic effect VS. Additive effect
Synergic effectThe interaction of two or more agents or forces so that their combined effect is greater than the sum of their individual effects.
Additive effectAn effect in which two substances or actions used in combination produce a total effect the same as the sum of the individual ef-fects.
C.K.Ashok Kumar et al. 2008
Improved insulin sensitivity by activation of PPAR and AMPK signaling pathway
Target signaling of drug for type 2 DM
(TZD & Metformin)
J Renal Nutr 2011
Animal Pharm 2008
evolutionaryhealthperspective.wordpress.com 2013
Target signaling of exercise train-
ing: PPARs, AMPK, PGC-
1α
Synergic ef-fect?
Additive ef-fect?
Exer-cise
Nutri-tion Drug
CommonMecha-
nisms for action
DiabetesObesity
Hyperten-sion
DyslipidemiaCVD
Osteoporosis
Synergic effect of anti-con-vulsant agents and regular exercise on kainic acid in-
duced seizure
Introduc-tion
What is seizure ?"Seizure" is a general term that refers to a sudden malfunction in the brain that causes someone to collapse, convulse, or have another temporary disturbance of normal brain function, often with a loss or change in consciousness.
Purpose
The purpose of this study was to investigate the synergic effect of regular exercise and therapy with an anticonvulsant agents could be a more efficient method for the prevention and/or treat-ment of epilepsy than exercise alone.
Materials and Methods
Drugs
Kainic acid (30 mg/kg; i.p.) to induce seizure activity
Resveratrol (250 mg/kg, orally) - a type of nat-ural phenol
Riluzole (5 mg/kg, i.p.) - a potent neuroprotec-tive drug
Clonidine (4 mg/kg, i.p.) - α2 adrenoreceptor agonist
Materials and Methods
Experimental groups
Experimental group nControl 11-13
KA only 11-13
Exercise + KA 11-13
Drugs + KA 11-13
Exercise + Drugs + KA 11-13
Adult male ICR mice weighing approximately 35 g each (8 week-old)
Materials and Methods
Physical exercise train-ing6 weeks swimming training (60 min sessions, 5 times per week)1st week: adaptation to swimming without weights
After the water-adaptation period, the mice were made to swim with weights (5% of body weight) in order to improve endurance exercise capacity. (Arida et al., 1991).
Materials and Methods
Experimental procedure
6 weeks swimming KA
(seizure induc-tion)
Measuring seizure activity
for 2 hours
Riluzole, Cloni-dine
(1 hour prior to KA)
Resvera-trol(6 weeks)
Results
Neuronal injury in hip-pocampus
KA (30 mg/kg, i.p.), Cresyl Vi-olet Hippocampus CA3 region
Results
Seizure activity lev-els
Results
Seizure activity lev-els
Ex : Swimming training for 6 weeksRes : ResveratrolRilu : Riluzole
Results
Chimney test (motor per-formance)
Results
Effect on oxidative stress
Results
Effect on mortality
These results indicate that the combina-tion of regular exercise and therapy with an anticonvulsant agent could be a more efficient method for the prevention and/or treatment of epilepsy than exercise alone.
Conclusion
Implication & Future Direction Potential synergistic effect of diet and exercise in
the prevention and treatment of chronic diseases.
Mechanisms of action and optimal diet and exer-cise prescription needed for benefit remain elusive. Nutrients are directed to specific tissues and cells via
physiologic processes that require much more research
Need to understand how diet (drug) and exercise interact to promote health, how changes in one af-fect the other.
What comprehensive prescription will be optimal in disease prevention?