2003 Terpenes

TerpenesU 0200 Synthesis of a Novel Family of Diterpenes and Their Evaluation as Antiinflamma-

tory Agents. — Several members of a new family of diterpenes, non-natural analogues of acanthoic acid, are synthesized and examined as potent antiinflammatory agents. Among them, derivative (IX) exhibits a low non-specific cytotoxicity, inhibits TNF-α synthesis and displays good specificity in suppressing cytokine expression. — (LAM, T.; LING, T.; CHOWDHURY, C.; CHAO, T.-H.; BAHJAT, F. R.; LLOYD, G. K.; MOLDAWER, L. L.; PALLADINO, M. A.; THEODORAKIS*, E. A.; Bioorg. Med. Chem. Lett. 13 (2003) 19, 3217-3221; Dep. Chem. Biochem., Univ. Calif., San Diego, La Jolla, CA 92093, USA; Eng.) — D. Singer

51- 173